Follicular Lymphoma: A Clinicopathological Analysis from a Tertiary Care Institute in Southern India.

Abstract:

INTRODUCTION:Follicular lymphoma (FL) is an indolent lymphoproliferative disorder of B-cells with variable clinical behavior. It is the second most common subtype of Non-Hodgkin lymphoma in western countries but reported to have a lower incidence in Asia. MATERIALS AND METHODS:Cases of FL diagnosed in the Department of Pathology of our Institute from January 2009 to June 2015 were included in the study. The clinicopathological parameters including staging, histological details, and immunohistochemical markers CD20, CD10 and BCL-2 were recorded in all the cases. RESULTS:Of the 497 cases of Non-Hodgkin Lymphoma reported during the study period, 36 (7.2%) cases were follicular lymphoma. The mean age was 50 years with male to female ratio of 3.2:1. Grade 1/2 was seen in 70% cases. 22 % cases had low grade with high proliferation index (Ki67 > 40%). Granulomatous response was seen in two cases. Diffuse large cell lymphoma component was present in four cases. Bone marrow involvement and peripheral blood spill were seen in 12 (37.5%) and six cases (18.8%) respectively. 72% cases were in stage 3 or 4. CONCLUSION:The incidence of FL was lower in our study than other Indian studies. FL presented in the elderly, with male predominance and disseminated stage. The study highlights features of low grade with high proliferation index, granulomatous response, leukemic involvement, and transformation to high grade lymphoma.

authors

Sylvia MT,Dey B,Basu D,Jacob SE,Kar R,Dubashi B

doi

10.4084/MJHID.2016.060

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

e2016060

issue

1

issn

2035-3006

pii

mjhid-8-1-e2016060

journal_volume

8

pub_type

杂志文章
  • Liver Iron Content (LIC) in Adults with Sickle Cell Disease (SCD): Correlation with Serum Ferritin and Liver Enzymes Concentrations in Trasfusion Dependent (TD-SCD) and Non-Transfusion Dependent (NT-SCD) Patients.

    abstract:INTRODUCTION:Sickle cell disease (SCD) is one of the leading causes of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time challenging its man...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2017.037

    authors: Yassin M,Soliman A,De Sanctis V,Nashwan A,Abusamaan S,Moustafa A,Kohla S,Soliman D

    更新日期:2017-06-20 00:00:00

  • Early Predictors of Renal Dysfunction in Egyptian Patients with β-Thalassemia Major and Intermedia.

    abstract:BACKGROUND:Better survival of thalassemia patients allowed previously unrecognized renal complications to emerge. OBJECTIVES:Assess prevalence and early predictors of renal dysfunction in young β-thalassemia major (β-TM) and intermedia (β-TI) patients. SUBJECTS:66 β-TM (group I), 26 β-TI (group II) Egyptian patients ...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2014.057

    authors: Tantawy AA,El Bablawy N,Adly AA,Ebeid FS

    更新日期:2014-09-01 00:00:00

  • Detection of Common Deletional of α-Thalassemia 3.7 Kb from Metropolitan Region of Manaus, Amazonas, Brazil.

    abstract:Background:Alpha Thalassemia (α-thal) is a heterogeneous group of hereditary alterations caused by deletions that affect alpha regulatory genes, and the 3.7Kb deletion is the most frequent worldwide. The prevalence ranges from 20% and 35% in Brazil, depending mainly on race, predominant in Afro-descendants. Purpose:Th...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2021.001

    authors: Anselmo FC,Soumanou AG,de Aguiar Ferreira C,Sobrinha FMV,Castro ACS,Brito RO,da Mota AJ,de Souza Gonçalves M,de Moura Neto JP

    更新日期:2021-01-01 00:00:00

  • Early Application of High Cut-Off Haemodialysis for de-Novo Myeloma Nephropathy is Associated with Long-Term Dialysis-Independency and Renal Recovery.

    abstract:BACKGROUND:Multiple myeloma (MM) is a haematological malignancy associated with kidney injury resulting from cast nephropathy, which can be caused by monoclonal free light chains (FLC). It has been demonstrated that early reduction of FLC can lead to a higher proportion of patients recovering renal function with a bett...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type:

    doi:10.4084/MJHID.2013.007

    authors: Khalafallah AA,Loi SW,Love S,Mohamed M,Mace R,Khalil R,Girgs M,Raj R,Mathew M

    更新日期:2013-01-01 00:00:00

  • Tuberculosis in tropical areas and immigrants.

    abstract::About 95% of cases and 98% of deaths due to tuberculosis (TB) occur in tropical countries while, in temperate low incidence countries, a disproportionate portion of TB cases is diagnosed in immigrants. Urbanization, poverty, poor housing conditions and ventilation, poor nutritional status, low education level, the HIV...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章,评审

    doi:10.4084/MJHID.2014.043

    authors: Zammarchi L,Bartalesi F,Bartoloni A

    更新日期:2014-06-01 00:00:00

  • Diagnosis of del(5q) MDS, 14 Years after JAK-2 Positive PV Appearance: Complete Remission of both Diseases with Lenalidomide Monotherapy.

    abstract::This is the report of the clinical case of a patient who presents the association of a JAK-2 positive chronic myeloproliferative neoplasia to a subsequent 5q- myelodysplastic syndrome, developed after about 14 years from the first diagnosis. Patient's symptoms had rapidly worsened, and she became transfusion-dependent...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type:

    doi:10.4084/MJHID.2016.050

    authors: Vaccarino A,Dogliotti I,Marletto F,Demarchi A,Bazzan M

    更新日期:2016-10-20 00:00:00

  • Bacterial Infections in Hematopoietic Stem Cell Transplant Recipients.

    abstract::Bacterial infections are major complications after Hematopoietic Stem Cell Transplant (HSCT). They consist mainly of bloodstream infections (BSI), followed by pneumonia and gastrointestinal infections, including typhlitis and Clostridium difficile infection. Microbiological data come mostly from BSI. Coagulase negativ...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章,评审

    doi:10.4084/MJHID.2015.045

    authors: Balletto E,Mikulska M

    更新日期:2015-07-01 00:00:00

  • BCR Signaling Inhibitors: an Overview of Toxicities Associated with Ibrutinib and Idelalisib in Patients with Chronic Lymphocytic Leukemia.

    abstract::The B-cell receptor (BCR) signaling inhibitors ibrutinib and idelalisib are revolutionizing the treatment of chronic lymphocytic leukemia (CLL) and other B-cell malignancies. These oral agents, both alone and in combination with other drugs, have shown remarkable clinical activity in relapsed or refractory CLL across ...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章,评审

    doi:10.4084/MJHID.2016.011

    authors: Falchi L,Baron JM,Orlikowski CA,Ferrajoli A

    更新日期:2016-02-10 00:00:00

  • Bortezomib a safe treatment for patients with multiple myeloma and cystic fibrosis.

    abstract:INTRODUCTION:Bortezomib is a proteasome inhibitor that targets myeloma cell and its bone marrow microenvironment. Intravenous Bortezomib with or without dexamethasone, is effective and well tolerated in patients with relapsed/refractory multiple myeloma (MM). METHODS:We used Bortezomib without corticosteroids, to avoi...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type:

    doi:10.4084/MJHID.2012.035

    authors: Gentilini F,Levi A,Federico V,Russo E,Foà R,Petrucci MT

    更新日期:2012-01-01 00:00:00

  • Treatment with Low-Dose Cytarabine in Elderly Patients (Age 70 Years or Older) with Acute Myeloid Leukemia: A Single Institution Experience.

    abstract:OBJECTIVES:Low-dose cytarabine (LD-AraC) is still regarded as the standard of care in elderly patients with acute myeloid leukemia (AML) 'unfit' for intensive chemotherapy. In this study, we reported our experience with LD-AraC in patients ≥ 70 years old and compared the results to those of intensive chemotherapy, best...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2016.009

    authors: Heiblig M,Elhamri M,Tigaud I,Plesa A,Barraco F,Labussière H,Ducastelle S,Michallet M,Nicolini F,Plesa C,Wattel E,Salles G,Thomas X

    更新日期:2016-01-01 00:00:00

  • Acute panmyelosis with myelofibrosis - a rare subtype of acute myeloid leukemia.

    abstract::One case of acute panmyelosis with myelofibrosis (APMF) is here reported. A 45 year old male presented with abrupt onset of rapidly progressing low backache, weakness and pancytopenia. On examination there was no organomegaly. Peripheral blood examination revealed normocytic normochromic red blood cells with 10% circu...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type:

    doi:10.4084/MJHID.2013.042

    authors: Chatterjee T,Gupta S,Sharma A,Sharma S,Gupta D

    更新日期:2013-06-04 00:00:00

  • The JAK2V617F Point Mutation Increases the Osteoclast Forming Ability of Monocytes in Patients with Chronic Myeloproliferative Neoplasms and Makes their Osteoclasts more Susceptible to JAK2 Inhibition.

    abstract::JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched nor...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2018.058

    authors: Spanoudakis E,Papoutselis M,Bazdiara I,Lamprianidi E,Kordella X,Tilkeridis C,Tsatalas C,Kotsianidis I

    更新日期:2018-11-01 00:00:00

  • Treatment of acute myeloid leukemia with 20-30% bone marrow blasts.

    abstract::The transition of patients with ≥20% <30% bone marrow (BM) blast from the FAB category of myelodysplasia to the family of acute myeloid leukemia (AML) according to the recent WHO classification has not resolved the argument as to whether the natural history and responsiveness to therapy of these diseases is comparable...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2013.032

    authors: Maurillo L,Buccisano F,Del Principe MI,Sarlo C,Di Caprio L,Ditto C,Giannotti F,Nasso D,Ceresoli E,Postorino M,Refrigeri M,Amadori S,Venditti A

    更新日期:2013-06-03 00:00:00

  • Kikuchi-fujimoto disease in the United States: three case reports and review of the literature [corrected].

    abstract::Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis [corrected], is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue. There is a higher incidence of KFD in women aged 20-35 years and in Asian popu...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type:

    doi:10.4084/MJHID.2014.001

    authors: Deaver D,Naghashpour M,Sokol L

    更新日期:2014-01-01 00:00:00

  • Effect of nebulized colistin on the ventilator circuit: a prospective pilot case- control study from a single cancer center.

    abstract::Nebulized colistin (NC) is used for the treatment of pneumonia due to multidrug- resistant Gram-negative bacteria. In this one-year case-control study, our objective was to evaluate the effect of NC on the ventilator circuit (VC) components. The case group consisted of 25 mechanically-ventilated patients who received ...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2015.032

    authors: Ghonimat IM,Nazer LH,Aqel F,Mohammad MK,Hawari FI,Le J

    更新日期:2015-04-20 00:00:00

  • Massive Pulmonary Embolism at the Onset of Acute Promyelocytic Leukemia.

    abstract::Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with ...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type:

    doi:10.4084/MJHID.2016.027

    authors: Sorà F,Chiusolo P,Laurenti L,Autore F,Giammarco S,Sica S

    更新日期:2016-07-01 00:00:00

  • Current knowledge on HIV-associated Plasmablastic Lymphoma.

    abstract::HIV-associated PBL is an AIDS-defining cancer, classified by WHO as a distinct entity of aggressive DLBCL. To date less than 250 cases have been published, of them 17 are pediatric. The pathogenesis of this rare disease is related to immunodeficiency, chronic immune stimulation and EBV. Clinically is a rapid growing d...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章,评审

    doi:10.4084/MJHID.2014.064

    authors: Bibas M,Castillo JJ

    更新日期:2014-11-01 00:00:00

  • Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver.

    abstract::In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. T...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章,评审

    doi:10.4084/MJHID.2018.068

    authors: Malara A,Abbonante V,Zingariello M,Migliaccio A,Balduini A

    更新日期:2018-11-01 00:00:00

  • Peripheral Nervous System Involvement in Lymphoproliferative Disorders.

    abstract::Peripheral neuropathies are a vast group of diseases with heterogeneous aetiologies, including genetic and acquired causes. Several haematological disorders may cause an impairment of the peripheral nervous system, with diverse mechanisms and variable clinical, electrophysiological and pathological manifestations. In ...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章,评审

    doi:10.4084/MJHID.2018.057

    authors: Sabatelli M,Laurenti L,Luigetti M

    更新日期:2018-09-01 00:00:00

  • Fine Mapping of Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency in a Rural Malaria Area of South West Odisha Using the Clinical, Hematological and Molecular Approach.

    abstract:Introduction:The aim of the study was to enumerate the clinical, hematological, and molecular spectrum of G6PD deficiency in malaria endemic regions of south west Odisha. Methods:Diagnosis of G6PD deficiency was made by using the Di-chloroindophenol Dye test in two south west districts (Kalahandi and Rayagada) of Odis...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2020.015

    authors: Kumar R,Singh MPSS,Mahapatra S,Chaurasia S,Tripathi MK,Oommen J,Bharti PK,Shanmugam R

    更新日期:2020-03-01 00:00:00

  • Improvement of Liver Involvement in Familial Mediterranean Fever After the Introduction of Canakinumab: A Case Report.

    abstract::Hepatic involvement in familial Mediterranean fever (FMF) ranges from a nonspecific increase in liver enzymes to cryptogenic cirrhosis, and the liver is mostly involved in patients bearing the M694V MEFV mutation in homozygosis. A 44-year-old Jewish woman with FMF developed nonalcoholic steatohepatitis during colchici...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type:

    doi:10.4084/MJHID.2020.059

    authors: Massaro MG,Pompili M,Sicignano LL,Pizzolante F,Verrecchia E,Vecchio FM,Rigante D,Manna R

    更新日期:2020-09-01 00:00:00

  • Role and timing of hematopoietic cell transplantation for myelodysplastic syndrome.

    abstract::Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with myelodysplastic syndromes (MDS). Most patients with MDS are older than 60 years and age-associated morbidities limit the patients' options for curative transplant therapy. Since the development of conditioning regimens...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2010.019

    authors: Field T,Anasetti C

    更新日期:2010-08-05 00:00:00

  • The Role of the Carotid Doppler Examination in the Evaluation of Atherosclerotic Changes in β-Thalassemia Patients.

    abstract:BACKGROUND:Iron overload in patients with beta-thalassemia major (BTM) lead to alterations in the arterial structures and the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and relatively quick to perform and may identify children at increased r...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2015.023

    authors: Abdelsamei HA,El-Sherif AM,Ismail AM,Abdel Hakeem GL

    更新日期:2015-03-01 00:00:00

  • Pathogenesis of malaria in tissues and blood.

    abstract::The clinical manifestations of severe malaria are several and occur in different anatomical sites. Both parasite- and host-related factors contribute to the pathogenicity of the severe forms of the disease. Cytoadherence of infected red blood cells to the vascular endothelium of different organs and rosetting are uniq...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2012.061

    authors: Autino B,Corbett Y,Castelli F,Taramelli D

    更新日期:2012-01-01 00:00:00

  • Diagnosis of congenital cytomegalovirus infection in high risk neonates.

    abstract:OBJECTIVES:This study aimed to compare polymerase chain reaction (PCR) and IgM detection using enzyme linked immune-sorbent assay (ELISA) in diagnosis of congenital cytomegalovirus (CMV) infection. METHODS:This study was conducted from May 2009 to December 2010. Urine and blood samples were collected from 94 neonates ...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2013.049

    authors: Albanna EA,El-Latif RS,Sharaf HA,Gohar MK,Ibrahim BM

    更新日期:2013-07-10 00:00:00

  • Brief Tale of a Bacteraemia by Rhodococcus equi, With Concomitant Lung Mass: What Came First, the Chicken or The Egg?

    abstract::Rhodococcus equi is an uncommon Gram positive, variably acid-fast pathogen, that appears as hard to treat mostly owing to the establishment of intracellular niches. Lack of interpretive criteria for susceptibility testing may lead to under-reporting or overestimation of resistances, whereas knowledge about this pathog...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type:

    doi:10.4084/MJHID.2011.006

    authors: Savini V,Salutari P,Sborgia M,Mancini I,Masciarelli G,Catavitello C,Astolfi D,D'Amario C,Fioritoni G,Spadaro A,D'Antonio D

    更新日期:2011-01-01 00:00:00

  • The relationship between periodontal disease (pd) and cardiovascular disease (cvd).

    abstract::The recent focus on the potential link between periodontal and cardiovascular disease (PD and CVD) is part of the larger renewed interest on the role of infection and inflammation in the etiology of atherosclerosis and its clinical manifestations. Periodontal Disease is an inflammatory process affecting the periodonti...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2010.030

    authors: Trevisan M,Dorn J

    更新日期:2010-10-01 00:00:00

  • POEMS SYNDROME: an Update.

    abstract::POEMS syndrome is a rare, chronic and disabling condition. The causes of this condition remain unknown; however, chronic overproduction of proinflammatory cytokines appears to be a major contributor. Early diagnosis is essential to start treatment before the clinical state of the patient becomes compromised. A complet...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章,评审

    doi:10.4084/MJHID.2017.051

    authors: Nozza A

    更新日期:2017-09-01 00:00:00

  • Hematology Patient Protection During the COVID-19 Pandemic in Italy: A Nationwide Nursing Survey.

    abstract:Background:Italy has been one of the first European countries hit by the COVID-19 pandemic, with many patients dying from severe respiratory issues, especially frail subjects. Hematology patients are generally thought to be at high risk of developing severe COVID-19-associated complications. The aim of this work was to...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2021.011

    authors: Botti S,Serra N,Castagnetti F,Chiaretti S,Mordini N,Gargiulo G,Orlando L

    更新日期:2021-01-01 00:00:00

  • Factors influencing adherence to imatinib in Indian chronic myeloid leukemia patients: a cross-sectional study.

    abstract::Adherence to imatinib(IM) is of utmost importance in patients with chronic myeloid leukemia (CML) to maximise treatment effectiveness. The main objective is to measure adherence to IM by evaluating individual patient characteristics, personal behaviour and, treatment related psychological factors influencing adherence...

    journal_title:Mediterranean journal of hematology and infectious diseases

    pub_type: 杂志文章

    doi:10.4084/MJHID.2015.013

    authors: Kapoor J,Agrawal N,Ahmed R,Sharma SK,Gupta A,Bhurani D

    更新日期:2015-02-20 00:00:00