Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver.

abstract：:Hepatic involvement in familial Mediterranean fever (FMF) ranges from a nonspecific increase in liver enzymes to cryptogenic cirrhosis, and the liver is mostly involved in patients bearing the M694V MEFV mutation in homozygosis. A 44-year-old Jewish woman with FMF developed nonalcoholic steatohepatitis during colchici...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Massaro MG,Pompili M,Sicignano LL,Pizzolante F,Verrecchia E,Vecchio FM,Rigante D,Manna R

更新日期：2020-09-01 00:00:00

abstract：:This is the report of the clinical case of a patient who presents the association of a JAK-2 positive chronic myeloproliferative neoplasia to a subsequent 5q- myelodysplastic syndrome, developed after about 14 years from the first diagnosis. Patient's symptoms had rapidly worsened, and she became transfusion-dependent...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Vaccarino A,Dogliotti I,Marletto F,Demarchi A,Bazzan M

更新日期：2016-10-20 00:00:00

abstract：:Human coronaviruses (HCoVs) commonly cause mild upper-respiratory tract illnesses but can lead to more severe and diffusive diseases. A variety of signs and symptoms may be present, and infections can range in severity from the common cold and sore throat to more serious laryngeal or tracheal infections, bronchitis, a...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Lassandro G,Palladino V,Amoruso A,Palmieri VV,Russo G,Giordano P

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Low-dose cytarabine (LD-AraC) is still regarded as the standard of care in elderly patients with acute myeloid leukemia (AML) 'unfit' for intensive chemotherapy. In this study, we reported our experience with LD-AraC in patients ≥ 70 years old and compared the results to those of intensive chemotherapy, best...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Heiblig M,Elhamri M,Tigaud I,Plesa A,Barraco F,Labussière H,Ducastelle S,Michallet M,Nicolini F,Plesa C,Wattel E,Salles G,Thomas X

更新日期：2016-01-01 00:00:00

abstract：:Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed. During the last five years, the landscape of the pharmacotherapy of SCD has changed dramatically. Currently, 54 drugs have been used o...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Ballas SK

更新日期：2020-01-01 00:00:00

abstract：:HIV-associated PBL is an AIDS-defining cancer, classified by WHO as a distinct entity of aggressive DLBCL. To date less than 250 cases have been published, of them 17 are pediatric. The pathogenesis of this rare disease is related to immunodeficiency, chronic immune stimulation and EBV. Clinically is a rapid growing d...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Bibas M,Castillo JJ

更新日期：2014-11-01 00:00:00

abstract：:Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis [corrected], is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue. There is a higher incidence of KFD in women aged 20-35 years and in Asian popu...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Deaver D,Naghashpour M,Sokol L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Homozygous or double heterozygous factor XIII (FXIII) deficiency is characterized by soft tissue hematomas, intracranial and delayed spontaneous bleeding. Alterations of thromboelastography (TEG) parameters in these patients have been reported. The aim of the study was to show results of TEG, TEG Lysis (Lys ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Martinuzzo M,Barrera L,Altuna D,Baña FT,Bieti J,Amigo Q,D'Adamo M,López MS,Oyhamburu J,Otaso JC

更新日期：2016-08-16 00:00:00

abstract：Background:Although bronchoalveolar lavage (BAL) measurements of galactomannan antigen (GM) seems to be more sensitive than serum testing to detect invasive fungal infection (IFI), a consensus on the most appropriate diagnostic threshold of the BAL GM test is still unclear. Moreover, there is uncertainty as to whether ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Cefalo M,Puxeddu E,Sarmati L,Paterno G,Fontana C,Nasso D,Pane G,De Bellis E,Palmieri R,Buzzati E,Meconi F,Laureana R,Casciani P,Zizzari AG,Rogliani P,de Fabritiis P,Maurillo L,Buccisano F,Cantonetti M,Arcese W,Ven

更新日期：2019-11-01 00:00:00

abstract：:The recent focus on the potential link between periodontal and cardiovascular disease (PD and CVD) is part of the larger renewed interest on the role of infection and inflammation in the etiology of atherosclerosis and its clinical manifestations. Periodontal Disease is an inflammatory process affecting the periodonti...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Trevisan M,Dorn J

更新日期：2010-10-01 00:00:00

abstract：:Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder predominantly of the lymph nodes, which mostly occurs in children and young adults typically presenting with lymphadenopathy. Our case is of a 63 year-old African-American male who presented with subjective fever, weight loss, bilateral ax...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sachdeva M,Abdulhaq H

更新日期：2013-04-10 00:00:00

abstract：:This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Buonsenso D,Macchiarulo G,Supino MC,La Penna F,Scateni S,Marchesi A,Reale A,Boccuzzi E

更新日期：2018-05-01 00:00:00

abstract：:We report the first case of multiple brain abscesses caused by Nocardia paucivorans in a patient suffering from multiple myeloma on treatment with lenalidomide and dexamethasone. N. paucivorans is a recently described species of the genus Nocardia, which is supposed to have a heightened neurotropism in cases of dissem...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Monticelli J,Luzzati R,Maurel C,Rosin C,Valentinotti R,Farina C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a haematological malignancy associated with kidney injury resulting from cast nephropathy, which can be caused by monoclonal free light chains (FLC). It has been demonstrated that early reduction of FLC can lead to a higher proportion of patients recovering renal function with a bett...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Khalafallah AA,Loi SW,Love S,Mohamed M,Mace R,Khalil R,Girgs M,Raj R,Mathew M

更新日期：2013-01-01 00:00:00

abstract：:Acquired aplastic anemia (aAA) is a severe and rare disease, characterized by hematopoietic bone marrow failure and peripheral cytopenia. The pathophysiology is immune mediated in most cases, activated T1 lymphocytes have been identified as effector cells. The disease can be successfully treated with combined immunosu...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Cudillo L

更新日期：2009-12-26 00:00:00

abstract：:One case of acute panmyelosis with myelofibrosis (APMF) is here reported. A 45 year old male presented with abrupt onset of rapidly progressing low backache, weakness and pancytopenia. On examination there was no organomegaly. Peripheral blood examination revealed normocytic normochromic red blood cells with 10% circu...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Chatterjee T,Gupta S,Sharma A,Sharma S,Gupta D

更新日期：2013-06-04 00:00:00

abstract：Background:Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell disease (SCD) severity. Despite this, HbF estimation is not routinely done in Nigeria. The relationship between HbF and SCD severity among affected children is also poorly studied. Methods:In this descriptive cross-sectional study,...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Adeodu OO,Akinlosotu MA,Adegoke SA,Oseni SBA

更新日期：2017-11-01 00:00:00

abstract：:Hemophagocytic Lymphohistiocytosis (HLH) is an indicator of an exaggerated immune response and eventually adverse outcomes. This study aimed to investigate the clinical and laboratory features and outcomes of patients with HLH. The medical records of 26 HLH adult patients (≥ 16 years of age) were retrospectively analy...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Arslan F,Alp S,Büyükasık Y,Ozkan MC,Şahin F,Basaran S,Cagatay AA,Eraksoy ÖH,Aksu K,Ertunç B,Korten V,Ceylan B,Mert A

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Better survival of thalassemia patients allowed previously unrecognized renal complications to emerge. OBJECTIVES:Assess prevalence and early predictors of renal dysfunction in young β-thalassemia major (β-TM) and intermedia (β-TI) patients. SUBJECTS:66 β-TM (group I), 26 β-TI (group II) Egyptian patients ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Tantawy AA,El Bablawy N,Adly AA,Ebeid FS

更新日期：2014-09-01 00:00:00

abstract：:About 95% of cases and 98% of deaths due to tuberculosis (TB) occur in tropical countries while, in temperate low incidence countries, a disproportionate portion of TB cases is diagnosed in immigrants. Urbanization, poverty, poor housing conditions and ventilation, poor nutritional status, low education level, the HIV...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Zammarchi L,Bartalesi F,Bartoloni A

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Iron overload in patients with beta-thalassemia major (BTM) lead to alterations in the arterial structures and the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and relatively quick to perform and may identify children at increased r...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Abdelsamei HA,El-Sherif AM,Ismail AM,Abdel Hakeem GL

更新日期：2015-03-01 00:00:00

abstract：Objective:This study focused on the efficacy and safety of thalidomide for patients with β-thalassemia in a multicenter trial. Methods:Patients with non-transfusion-dependent thalassemia (NTDT) or transfusion-dependent thalassemia (TDT), who were unable to pursue conventional therapy with transfusion and chelation, we...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yang K,Wu Y,Zhou Y,Long B,Lu Q,Zhou T,Wang L,Geng Z,Yin X

更新日期：2020-05-01 00:00:00

abstract：:In the last 15 years, highly active antiretroviral therapy (HAART) has determined a dramatic reduction of both morbidity and mortality in human immunodeficiency virus (HIV)-infected subjects, transforming this infection in a chronic and manageable disease. Patients surviving with HIV in the developed world, in larger ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： de Gaetano Donati K,Cauda R,Iacoviello L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Bone marrow aspiration and biopsy still remains as one of the vital tests for confirmation of diagnosis of visceral Leishmaniasis. The aim of the present study is to assess the relative frequency of common, uncommon and atypical hematological findings in cases of Visceral Leishmaniasis. MATERIALS #ENTITYS...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Bhatia P,Haldar D,Varma N,Marwaha R,Varma S

更新日期：2011-01-01 00:00:00

abstract：:Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However, there is a paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM). This retrospective case series of five patie...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Zonoozi S,Barnard M,Prescott E,Jones R,Shah FT,Tzoulis P

更新日期：2017-01-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with myelodysplastic syndromes (MDS). Most patients with MDS are older than 60 years and age-associated morbidities limit the patients' options for curative transplant therapy. Since the development of conditioning regimens...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Field T,Anasetti C

更新日期：2010-08-05 00:00:00

abstract：:MTB ranks as the first worldwide pathogen latently infecting one third of the population and the second leading cause of death from a single infectious agent, after the human immunodeficiency virus (HIV). The development of vigorous and apparently appropriate immune response upon infection with M. tuberculosis in huma...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Bozzano F,Marras F,De Maria A

更新日期：2014-04-07 00:00:00

abstract：:The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlling angiogenesis, wh...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Randi AM,Laffan MA,Starke RD

更新日期：2013-09-02 00:00:00

abstract：:The B-cell receptor (BCR) signaling inhibitors ibrutinib and idelalisib are revolutionizing the treatment of chronic lymphocytic leukemia (CLL) and other B-cell malignancies. These oral agents, both alone and in combination with other drugs, have shown remarkable clinical activity in relapsed or refractory CLL across ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Falchi L,Baron JM,Orlikowski CA,Ferrajoli A

更新日期：2016-02-10 00:00:00

abstract：:Idiopathic thrombocytopenic purpura (ITP) is an autoimmune hematological disorder characterized by auto antibody-mediated platelet destruction. Although the main cause of ITP remains unclear, but its relationship with some infection was demonstrated. In recent years, many studies have demonstrated improvement of plate...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Payandeh M,Sohrabi N,Zare ME,Kansestani AN,Hashemian AH

更新日期：2012-01-01 00:00:00