Role and timing of hematopoietic cell transplantation for myelodysplastic syndrome.

abstract：:Long-term survival of relapsed/refractory acute myeloid leukemia (AML) remains a major problem, particularly in patients not eligible for transplantation.We hereby evaluated the feasibility and efficacy of adding Gemtuzumab Ozogamicin to salvage chemotherapy (Ara-C, Idarubicine, Peg-Filgrastim) in relapsed/refractory ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Capria S,Trisolini SM,Minotti C,Stefanizzi C,Cardarelli L,Cartoni C,Diverio D,De Propris MS,Mancini M,Micozzi A,Foà R,Meloni G

更新日期：2012-01-01 00:00:00

abstract：:MTB ranks as the first worldwide pathogen latently infecting one third of the population and the second leading cause of death from a single infectious agent, after the human immunodeficiency virus (HIV). The development of vigorous and apparently appropriate immune response upon infection with M. tuberculosis in huma...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Bozzano F,Marras F,De Maria A

更新日期：2014-04-07 00:00:00

abstract：:The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (BCS), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis.Risk factors can be local or systemic. A local precipitating factor is rare in BCS, while it is common in patients with portal vein thrombosis. Chronic myeloprolifera...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： De Stefano V,Za T,Ciminello A,Betti S,Rossi E

更新日期：2011-01-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is highly curable with the combination of all-transretinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypic, cytogenetic and molecular characteristics and outcome of APL ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Pagoni M,Garofalaki M,Panitsas F,Manola K,Psarra K,Economopoulos P,Vourtsi A,Antoniades M,Gkirkas K,Tzouvara E,Katis F,Prokopiou C,Tziotziou I,Balta A,Lemissiou E,Tsirigotis P,Repoussis P,Harhalakis N

更新日期：2011-01-01 00:00:00

abstract：:The clinical manifestations of severe malaria are several and occur in different anatomical sites. Both parasite- and host-related factors contribute to the pathogenicity of the severe forms of the disease. Cytoadherence of infected red blood cells to the vascular endothelium of different organs and rosetting are uniq...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Autino B,Corbett Y,Castelli F,Taramelli D

更新日期：2012-01-01 00:00:00

abstract：:The inherited disorders of hemoglobin are by far the commonest monogenic diseases and there is considerable evidence that they have reached their very high frequencies due to heterozygote advantage against malaria. Recent studies have begun to clarify the effect of interactions between malaria and some of the more sev...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Weatherall DJ

更新日期：2009-12-20 00:00:00

abstract：:The primary objective of this review was to update and discuss the current concepts and the results of the treatment of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA). After a brief consideration of the epidemiologic and clinicobiologic characteristics of ALL in the AYA population, the main r...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Ribera JM,Ribera J,Genescà E

更新日期：2014-07-02 00:00:00

abstract：Background:Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell disease (SCD) severity. Despite this, HbF estimation is not routinely done in Nigeria. The relationship between HbF and SCD severity among affected children is also poorly studied. Methods:In this descriptive cross-sectional study,...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Adeodu OO,Akinlosotu MA,Adegoke SA,Oseni SBA

更新日期：2017-11-01 00:00:00

abstract：:We describe the case of a 17- year old female who developed fatal haemophagocytic syndrome (HPS) one month following acute infection caused by Epstein-Barr virus (EBV). Despite initiation of treatment and reduction of EBV load, laboratory signs of HPS as severe cytopenia, hypofibrinogenemia, hyperferritinemia and hype...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Torti L,Larocca LM,Massini G,Cuccaro A,Maiolo E,Santangelo R,Bianchi M,Pennisi MA,Hohaus S,Teofili L

更新日期：2012-01-01 00:00:00

abstract：Background:Although bronchoalveolar lavage (BAL) measurements of galactomannan antigen (GM) seems to be more sensitive than serum testing to detect invasive fungal infection (IFI), a consensus on the most appropriate diagnostic threshold of the BAL GM test is still unclear. Moreover, there is uncertainty as to whether ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Cefalo M,Puxeddu E,Sarmati L,Paterno G,Fontana C,Nasso D,Pane G,De Bellis E,Palmieri R,Buzzati E,Meconi F,Laureana R,Casciani P,Zizzari AG,Rogliani P,de Fabritiis P,Maurillo L,Buccisano F,Cantonetti M,Arcese W,Ven

更新日期：2019-11-01 00:00:00

abstract：:POEMS syndrome is a rare, chronic and disabling condition. The causes of this condition remain unknown; however, chronic overproduction of proinflammatory cytokines appears to be a major contributor. Early diagnosis is essential to start treatment before the clinical state of the patient becomes compromised. A complet...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Nozza A

更新日期：2017-09-01 00:00:00

abstract：:Acquired aplastic anemia (aAA) is a severe and rare disease, characterized by hematopoietic bone marrow failure and peripheral cytopenia. The pathophysiology is immune mediated in most cases, activated T1 lymphocytes have been identified as effector cells. The disease can be successfully treated with combined immunosu...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Cudillo L

更新日期：2009-12-26 00:00:00

abstract：:The transition of patients with ≥20% <30% bone marrow (BM) blast from the FAB category of myelodysplasia to the family of acute myeloid leukemia (AML) according to the recent WHO classification has not resolved the argument as to whether the natural history and responsiveness to therapy of these diseases is comparable...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Maurillo L,Buccisano F,Del Principe MI,Sarlo C,Di Caprio L,Ditto C,Giannotti F,Nasso D,Ceresoli E,Postorino M,Refrigeri M,Amadori S,Venditti A

更新日期：2013-06-03 00:00:00

abstract：:Bacterial infections are major complications after Hematopoietic Stem Cell Transplant (HSCT). They consist mainly of bloodstream infections (BSI), followed by pneumonia and gastrointestinal infections, including typhlitis and Clostridium difficile infection. Microbiological data come mostly from BSI. Coagulase negativ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Balletto E,Mikulska M

更新日期：2015-07-01 00:00:00

abstract：:Sickle cell disease (SCD) and ß-thalassemia represent the most common hemoglobinopathies caused, respectively, by the alteration of structural features or deficient production of the ß-chain of the Hb molecule. Other hemoglobinopathies are characterized by different mutations in the α- or ß-globin genes and are associ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Breda L,Gambari R,Rivella S

更新日期：2009-11-13 00:00:00

abstract：:JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched nor...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Spanoudakis E,Papoutselis M,Bazdiara I,Lamprianidi E,Kordella X,Tilkeridis C,Tsatalas C,Kotsianidis I

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Iron overload in patients with beta-thalassemia major (BTM) lead to alterations in the arterial structures and the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and relatively quick to perform and may identify children at increased r...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Abdelsamei HA,El-Sherif AM,Ismail AM,Abdel Hakeem GL

更新日期：2015-03-01 00:00:00

abstract：:The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian patients with SCA. Data of patients with SCA who were seen and follo...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： do Nascimento EM,de Castro Lobo CL,de Bragança Pereira B,Ballas SK

更新日期：2019-03-01 00:00:00

abstract：:The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significa...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Mineri R,Mariotti J,Sarina B,Morabito L,Crocchiolo R,Bramanti S,Sarno T,Tordato F,Carlo-Stella C,Santoro A,Castagna L

更新日期：2018-02-15 00:00:00

abstract：INTRODUCTION:Sickle cell disease (SCD) is one of the leading causes of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time challenging its man...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yassin M,Soliman A,De Sanctis V,Nashwan A,Abusamaan S,Moustafa A,Kohla S,Soliman D

更新日期：2017-06-20 00:00:00

abstract：:In the last 15 years, highly active antiretroviral therapy (HAART) has determined a dramatic reduction of both morbidity and mortality in human immunodeficiency virus (HIV)-infected subjects, transforming this infection in a chronic and manageable disease. Patients surviving with HIV in the developed world, in larger ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： de Gaetano Donati K,Cauda R,Iacoviello L

更新日期：2010-01-01 00:00:00

abstract：:Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sorà F,Chiusolo P,Laurenti L,Autore F,Giammarco S,Sica S

更新日期：2016-07-01 00:00:00

abstract：:The clinical presentation of β-thalassemia intermedia phenotypes are influenced by many factors. The persistence of fetal hemoglobin and several polymorphisms located in the promoters of γ- and β-globin genes are some of them. The aim of this study was to evaluate the combined effect of the -158 Gγ (C→T) polymorphism ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Dabke P,Colah R,Ghosh K,Nadkarni A

更新日期：2013-01-01 00:00:00

abstract：Introduction:The aim of the study was to enumerate the clinical, hematological, and molecular spectrum of G6PD deficiency in malaria endemic regions of south west Odisha. Methods:Diagnosis of G6PD deficiency was made by using the Di-chloroindophenol Dye test in two south west districts (Kalahandi and Rayagada) of Odis...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Kumar R,Singh MPSS,Mahapatra S,Chaurasia S,Tripathi MK,Oommen J,Bharti PK,Shanmugam R

更新日期：2020-03-01 00:00:00

abstract：:The recent focus on the potential link between periodontal and cardiovascular disease (PD and CVD) is part of the larger renewed interest on the role of infection and inflammation in the etiology of atherosclerosis and its clinical manifestations. Periodontal Disease is an inflammatory process affecting the periodonti...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Trevisan M,Dorn J

更新日期：2010-10-01 00:00:00

abstract：:The B-cell receptor (BCR) signaling inhibitors ibrutinib and idelalisib are revolutionizing the treatment of chronic lymphocytic leukemia (CLL) and other B-cell malignancies. These oral agents, both alone and in combination with other drugs, have shown remarkable clinical activity in relapsed or refractory CLL across ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Falchi L,Baron JM,Orlikowski CA,Ferrajoli A

更新日期：2016-02-10 00:00:00

abstract：Background:The distribution of human parvovirus B19 (HPV B19) infection is ubiquitous and occurs worldwide. The virus has high tropism to red blood cells progenitor's cells leading to temporary infection of bone marrow and transient arrest of erythropoiesis. People with frequent episodes of hemolytic anemia including s...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Urio F,George H,Tluway F,Nyambo TB,Mmbando BP,Makani J

更新日期：2019-09-01 00:00:00

abstract：:The introduction of newer cytotoxic monoclonal antibodies and chimeric antigen receptor modified T cells is opening a new age in the management of B-lineage adult acute lymphoblastic leukemia. This therapeutic change must be very positively acknowledged because of the limits of intensive chemotherapy programs and allo...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Maino E,Scattolin AM,Viero P,Sancetta R,Pascarella A,Vespignani M,Bassan R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cardiac iron toxicity is the leading cause of death among β-halassaemia major (TM) patients. Once heart failure becomes overt, it is difficult to reverse. OBJECTIVES:To investigate non-overt cardiac dysfunctions in TM patients using pulsed wave Tissue Doppler Imaging (TD I) and its relation to iron overload...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Ragab SM,Fathy WM,El-Aziz WF,Helal RT

更新日期：2015-08-24 00:00:00

abstract：:In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. T...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Malara A,Abbonante V,Zingariello M,Migliaccio A,Balduini A

更新日期：2018-11-01 00:00:00