Abstract:
:Acute promyelocytic leukemia (APL) is highly curable with the combination of all-transretinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypic, cytogenetic and molecular characteristics and outcome of APL patients diagnosed and treated in various Hospitals of Greece and Cyprus.We describe the data of ninety-five APL patients who were diagnosed during the last 15 years. Seven (7.4%) newly diagnosed APL patients died due to intracranial hemorrhage within 72 hours of presentation. All but two patients were induced with ATRA alone or ATRA plus chemotherapy. The early death rate was 14.9%. After induction all 80 evaluable patients achieved complete hematologic remission. The cumulative incidence of relapse was 18.3%. Eight of the ten relapsed patients were successfully salvaged, while both patients with molecularly resistant disease died during salvage treatment. Overall survival (OS) at 5 years was 78.4% and disease free survival (DFS) 73.6%. In multivariate analysis of OS age over 60 years, DIC at diagnosis and marginally major hemorrhage at presentation were identified as adverse prognostic factors. In the subgroup of patients with available data on FLT3 mutation status (49 out of 94), ITD positivity also remained as an independent prognostic factor in the final model of OS, together with major hemorrhage and marginally high Sanz score. We found a close correlation between the CD2 expression and the development of the differentiation syndrome (DS). In conclusion, the main problem in managing patients with APL is still the high early death rate.
journal_name
Mediterr J Hematol Infect Disauthors
Pagoni M,Garofalaki M,Panitsas F,Manola K,Psarra K,Economopoulos P,Vourtsi A,Antoniades M,Gkirkas K,Tzouvara E,Katis F,Prokopiou C,Tziotziou I,Balta A,Lemissiou E,Tsirigotis P,Repoussis P,Harhalakis Ndoi
10.4084/MJHID.2011.053subject
Has Abstractpub_date
2011-01-01 00:00:00pages
e2011053issue
1issn
2035-3006pii
mjhid-3-1-e2011053journal_volume
3pub_type
杂志文章abstract:OBJECTIVES:This study aimed to compare polymerase chain reaction (PCR) and IgM detection using enzyme linked immune-sorbent assay (ELISA) in diagnosis of congenital cytomegalovirus (CMV) infection. METHODS:This study was conducted from May 2009 to December 2010. Urine and blood samples were collected from 94 neonates ...
journal_title:Mediterranean journal of hematology and infectious diseases
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journal_title:Mediterranean journal of hematology and infectious diseases
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2012.056
更新日期:2012-01-01 00:00:00
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journal_title:Mediterranean journal of hematology and infectious diseases
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更新日期:2016-07-01 00:00:00
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更新日期:2010-01-01 00:00:00
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更新日期:2010-08-05 00:00:00
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pub_type: 杂志文章
doi:10.4084/MJHID.2015.051
更新日期:2015-08-24 00:00:00
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更新日期:2009-12-26 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
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更新日期:2013-11-04 00:00:00
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pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章,评审
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