Abstract:
:A 71 year old female with multiple myeloma presented with back pain seven year after autologous stem cell transplant. Skeletal bone survey and magnetic resonance imaging did not show a relapse that was evidenced by CT/PET. Lenalidomide as single agent induced a complete disappearance of the lesions 6 months later and confirmed after one year at CT/PET.
journal_name
Mediterr J Hematol Infect Disauthors
Gozzetti A,Rossi V,Cerase A,Papini G,Defina M,Bocchia Mdoi
10.4084/MJHID.2012.041subject
Has Abstractpub_date
2012-01-01 00:00:00pages
e2012041issue
1issn
2035-3006pii
mjhid-4-1-e2012041journal_volume
4pub_type
abstract:Background:β-thalassemia intermedia (TI) spans a wide spectrum of severity and carries higher morbidity than previously recognized, including extramedullary hematopoiesis, leg ulcers, gallstones, thrombosis, secondary heart failure, pulmonary hypertension, skeletal deformity, growth retardation and endocrine abnormalit...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2019.026
更新日期:2019-05-01 00:00:00
abstract::Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with myelodysplastic syndromes (MDS). Most patients with MDS are older than 60 years and age-associated morbidities limit the patients' options for curative transplant therapy. Since the development of conditioning regimens...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2010.019
更新日期:2010-08-05 00:00:00
abstract::The transition of patients with ≥20% <30% bone marrow (BM) blast from the FAB category of myelodysplasia to the family of acute myeloid leukemia (AML) according to the recent WHO classification has not resolved the argument as to whether the natural history and responsiveness to therapy of these diseases is comparable...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2013.032
更新日期:2013-06-03 00:00:00
abstract::We describe the case of a 17- year old female who developed fatal haemophagocytic syndrome (HPS) one month following acute infection caused by Epstein-Barr virus (EBV). Despite initiation of treatment and reduction of EBV load, laboratory signs of HPS as severe cytopenia, hypofibrinogenemia, hyperferritinemia and hype...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2012.008
更新日期:2012-01-01 00:00:00
abstract::The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significa...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2018.013
更新日期:2018-02-15 00:00:00
abstract::The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlling angiogenesis, wh...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2013.060
更新日期:2013-09-02 00:00:00
abstract::The introduction of newer cytotoxic monoclonal antibodies and chimeric antigen receptor modified T cells is opening a new age in the management of B-lineage adult acute lymphoblastic leukemia. This therapeutic change must be very positively acknowledged because of the limits of intensive chemotherapy programs and allo...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2015.001
更新日期:2015-01-01 00:00:00
abstract::Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis [corrected], is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue. There is a higher incidence of KFD in women aged 20-35 years and in Asian popu...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2014.001
更新日期:2014-01-01 00:00:00
abstract:Background:The distribution of human parvovirus B19 (HPV B19) infection is ubiquitous and occurs worldwide. The virus has high tropism to red blood cells progenitor's cells leading to temporary infection of bone marrow and transient arrest of erythropoiesis. People with frequent episodes of hemolytic anemia including s...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2019.054
更新日期:2019-09-01 00:00:00
abstract::Sickle cell disease (SCD) and ß-thalassemia represent the most common hemoglobinopathies caused, respectively, by the alteration of structural features or deficient production of the ß-chain of the Hb molecule. Other hemoglobinopathies are characterized by different mutations in the α- or ß-globin genes and are associ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2009.008
更新日期:2009-11-13 00:00:00
abstract::The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian patients with SCA. Data of patients with SCA who were seen and follo...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2019.022
更新日期:2019-03-01 00:00:00
abstract::Hemophagocytic Lymphohistiocytosis (HLH) is an indicator of an exaggerated immune response and eventually adverse outcomes. This study aimed to investigate the clinical and laboratory features and outcomes of patients with HLH. The medical records of 26 HLH adult patients (≥ 16 years of age) were retrospectively analy...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2018.047
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Better survival of thalassemia patients allowed previously unrecognized renal complications to emerge. OBJECTIVES:Assess prevalence and early predictors of renal dysfunction in young β-thalassemia major (β-TM) and intermedia (β-TI) patients. SUBJECTS:66 β-TM (group I), 26 β-TI (group II) Egyptian patients ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2014.057
更新日期:2014-09-01 00:00:00
abstract::We report the first case of multiple brain abscesses caused by Nocardia paucivorans in a patient suffering from multiple myeloma on treatment with lenalidomide and dexamethasone. N. paucivorans is a recently described species of the genus Nocardia, which is supposed to have a heightened neurotropism in cases of dissem...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2015.011
更新日期:2015-01-01 00:00:00
abstract::Rhodococcus equi is an uncommon Gram positive, variably acid-fast pathogen, that appears as hard to treat mostly owing to the establishment of intracellular niches. Lack of interpretive criteria for susceptibility testing may lead to under-reporting or overestimation of resistances, whereas knowledge about this pathog...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2011.006
更新日期:2011-01-01 00:00:00
abstract::The clinical presentation of β-thalassemia intermedia phenotypes are influenced by many factors. The persistence of fetal hemoglobin and several polymorphisms located in the promoters of γ- and β-globin genes are some of them. The aim of this study was to evaluate the combined effect of the -158 Gγ (C→T) polymorphism ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2013.012
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Iron overload in patients with beta-thalassemia major (BTM) lead to alterations in the arterial structures and the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and relatively quick to perform and may identify children at increased r...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2015.023
更新日期:2015-03-01 00:00:00
abstract::The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (BCS), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis.Risk factors can be local or systemic. A local precipitating factor is rare in BCS, while it is common in patients with portal vein thrombosis. Chronic myeloprolifera...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2011.063
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Bortezomib is a proteasome inhibitor that targets myeloma cell and its bone marrow microenvironment. Intravenous Bortezomib with or without dexamethasone, is effective and well tolerated in patients with relapsed/refractory multiple myeloma (MM). METHODS:We used Bortezomib without corticosteroids, to avoi...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2012.035
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Homozygous or double heterozygous factor XIII (FXIII) deficiency is characterized by soft tissue hematomas, intracranial and delayed spontaneous bleeding. Alterations of thromboelastography (TEG) parameters in these patients have been reported. The aim of the study was to show results of TEG, TEG Lysis (Lys ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2016.037
更新日期:2016-08-16 00:00:00
abstract:BACKGROUND:Beta thalassemia is an inherited hemoglobin disorder resulting in a severe, chronic anemia requiring life-long blood transfusion that induces iron overload. Silymarin is a flavonoid complex isolated from Silybin marianum with a strong antioxidant activity, inducing an hepatoprotective action, and probably, a...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2013.065
更新日期:2013-11-04 00:00:00
abstract:INTRODUCTION:Sickle cell disease (SCD) is one of the leading causes of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time challenging its man...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2017.037
更新日期:2017-06-20 00:00:00
abstract:BACKGROUND:Cardiac iron toxicity is the leading cause of death among β-halassaemia major (TM) patients. Once heart failure becomes overt, it is difficult to reverse. OBJECTIVES:To investigate non-overt cardiac dysfunctions in TM patients using pulsed wave Tissue Doppler Imaging (TD I) and its relation to iron overload...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2015.051
更新日期:2015-08-24 00:00:00
abstract::Peripheral neuropathies are a vast group of diseases with heterogeneous aetiologies, including genetic and acquired causes. Several haematological disorders may cause an impairment of the peripheral nervous system, with diverse mechanisms and variable clinical, electrophysiological and pathological manifestations. In ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2018.057
更新日期:2018-09-01 00:00:00
abstract::JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched nor...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2018.058
更新日期:2018-11-01 00:00:00
abstract::The primary objective of this review was to update and discuss the current concepts and the results of the treatment of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA). After a brief consideration of the epidemiologic and clinicobiologic characteristics of ALL in the AYA population, the main r...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2014.052
更新日期:2014-07-02 00:00:00
abstract:INTRODUCTION:Bone marrow aspiration and biopsy still remains as one of the vital tests for confirmation of diagnosis of visceral Leishmaniasis. The aim of the present study is to assess the relative frequency of common, uncommon and atypical hematological findings in cases of Visceral Leishmaniasis. MATERIALS #ENTITYS...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2011.035
更新日期:2011-01-01 00:00:00
abstract::Long-term survival of relapsed/refractory acute myeloid leukemia (AML) remains a major problem, particularly in patients not eligible for transplantation.We hereby evaluated the feasibility and efficacy of adding Gemtuzumab Ozogamicin to salvage chemotherapy (Ara-C, Idarubicine, Peg-Filgrastim) in relapsed/refractory ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2012.072
更新日期:2012-01-01 00:00:00
abstract::Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However, there is a paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM). This retrospective case series of five patie...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2017.004
更新日期:2017-01-01 00:00:00
abstract::Hepatic involvement in familial Mediterranean fever (FMF) ranges from a nonspecific increase in liver enzymes to cryptogenic cirrhosis, and the liver is mostly involved in patients bearing the M694V MEFV mutation in homozygosis. A 44-year-old Jewish woman with FMF developed nonalcoholic steatohepatitis during colchici...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2020.059
更新日期:2020-09-01 00:00:00