Abstract:
INTRODUCTION:Bone marrow aspiration and biopsy still remains as one of the vital tests for confirmation of diagnosis of visceral Leishmaniasis. The aim of the present study is to assess the relative frequency of common, uncommon and atypical hematological findings in cases of Visceral Leishmaniasis. MATERIALS #ENTITYSTARTX00026; METHODS:A total of 16 cases of Leishmaniasis diagnosed on Bone marrow examination over a period of two years (2008-2010), were retrieved from the archives and the peripheral blood smear, bone marrow aspiration smears and trephine biopsies were examined for the common, uncommon and atypical features as described in the literature. RESULTS:Out of the total of 16 cases, 10 were pediatric and 6 adult cases. The common findings like pancytopenia, peripheral blood monocytosis, increased histiocytes on aspirate smears and granulomas on biopsies were noted in 12/16 (75%), 9/16 (56.25%), 13/16 (81.2%) and 11/16 (69%) cases respectively. Amongst the uncommon findings, hemophagocytosis was noted in 12/16 (75%) cases, plasma cells with inclusions in 6/16 (37.5%) and LD bodies in cells other than histiocytes in 4/16 (25%) cases. The atypical findings included organism aggregates noted in 9/16 (56%) cases, Pelger-Heut cells seen in 4/16 (25%) cases and increased focal vascularity on biopsies in 10/16 (62.5%) cases. The average parasite density (APD) on smears was 3+ and the range of positivity was 1+ to 5+. CONCLUSION:The knowledge of these morphological clues can assist us in searching for LD bodies and correctly diagnosing the condition without excessive dependence on unnecessary and sophisticated tests.
journal_name
Mediterr J Hematol Infect Disauthors
Bhatia P,Haldar D,Varma N,Marwaha R,Varma Sdoi
10.4084/MJHID.2011.035subject
Has Abstractpub_date
2011-01-01 00:00:00pages
e2011035issue
1issn
2035-3006pii
mjhid-3-1-e2011035journal_volume
3pub_type
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journal_title:Mediterranean journal of hematology and infectious diseases
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
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abstract:INTRODUCTION:Bortezomib is a proteasome inhibitor that targets myeloma cell and its bone marrow microenvironment. Intravenous Bortezomib with or without dexamethasone, is effective and well tolerated in patients with relapsed/refractory multiple myeloma (MM). METHODS:We used Bortezomib without corticosteroids, to avoi...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2012.035
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
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更新日期:2013-09-02 00:00:00
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2012.015
更新日期:2012-01-01 00:00:00
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2014.057
更新日期:2014-09-01 00:00:00
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2015.023
更新日期:2015-03-01 00:00:00
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2013.042
更新日期:2013-06-04 00:00:00
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pub_type: 杂志文章
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journal_title:Mediterranean journal of hematology and infectious diseases
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journal_title:Mediterranean journal of hematology and infectious diseases
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doi:10.4084/MJHID.2014.001
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2018.057
更新日期:2018-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,评审
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