The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease.

abstract：:JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched nor...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Spanoudakis E,Papoutselis M,Bazdiara I,Lamprianidi E,Kordella X,Tilkeridis C,Tsatalas C,Kotsianidis I

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Beta thalassemia is an inherited hemoglobin disorder resulting in a severe, chronic anemia requiring life-long blood transfusion that induces iron overload. Silymarin is a flavonoid complex isolated from Silybin marianum with a strong antioxidant activity, inducing an hepatoprotective action, and probably, a...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Hagag AA,Elfrargy MS,Gazar RA,El-Lateef AE

更新日期：2013-11-04 00:00:00

abstract：:The primary objective of this review was to update and discuss the current concepts and the results of the treatment of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA). After a brief consideration of the epidemiologic and clinicobiologic characteristics of ALL in the AYA population, the main r...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Ribera JM,Ribera J,Genescà E

更新日期：2014-07-02 00:00:00

abstract：INTRODUCTION:IGF-1 deficiency in TM patients in children and adolescents has been attributed to chronic anemia and hypoxia, chronic liver disease, iron overload and other associated endocrinopathies, e.g. growth hormone deficiency (GHD). Few data are available in the literature regarding adult TM patients and growth di...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： De Sanctis V,Soliman AT,Candini G,Yassin M,Raiola G,Galati MC,Elalaily R,Elsedfy H,Skordis N,Garofalo P,Anastasi S,Campisi S,Karimi M,Kattamis C,Canatan D,Kilinc Y,Sobti P,Fiscina B,El Kholy M

更新日期：2014-11-01 00:00:00

abstract：:Hepatic involvement in familial Mediterranean fever (FMF) ranges from a nonspecific increase in liver enzymes to cryptogenic cirrhosis, and the liver is mostly involved in patients bearing the M694V MEFV mutation in homozygosis. A 44-year-old Jewish woman with FMF developed nonalcoholic steatohepatitis during colchici...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Massaro MG,Pompili M,Sicignano LL,Pizzolante F,Verrecchia E,Vecchio FM,Rigante D,Manna R

更新日期：2020-09-01 00:00:00

abstract：:Human coronaviruses (HCoVs) commonly cause mild upper-respiratory tract illnesses but can lead to more severe and diffusive diseases. A variety of signs and symptoms may be present, and infections can range in severity from the common cold and sore throat to more serious laryngeal or tracheal infections, bronchitis, a...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Lassandro G,Palladino V,Amoruso A,Palmieri VV,Russo G,Giordano P

更新日期：2020-07-01 00:00:00

abstract：:We describe the case of a 17- year old female who developed fatal haemophagocytic syndrome (HPS) one month following acute infection caused by Epstein-Barr virus (EBV). Despite initiation of treatment and reduction of EBV load, laboratory signs of HPS as severe cytopenia, hypofibrinogenemia, hyperferritinemia and hype...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Torti L,Larocca LM,Massini G,Cuccaro A,Maiolo E,Santangelo R,Bianchi M,Pennisi MA,Hohaus S,Teofili L

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Sickle cell disease (SCD) is one of the leading causes of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time challenging its man...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yassin M,Soliman A,De Sanctis V,Nashwan A,Abusamaan S,Moustafa A,Kohla S,Soliman D

更新日期：2017-06-20 00:00:00

abstract：:Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder predominantly of the lymph nodes, which mostly occurs in children and young adults typically presenting with lymphadenopathy. Our case is of a 63 year-old African-American male who presented with subjective fever, weight loss, bilateral ax...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sachdeva M,Abdulhaq H

更新日期：2013-04-10 00:00:00

abstract：:Acquired aplastic anemia (aAA) is a severe and rare disease, characterized by hematopoietic bone marrow failure and peripheral cytopenia. The pathophysiology is immune mediated in most cases, activated T1 lymphocytes have been identified as effector cells. The disease can be successfully treated with combined immunosu...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Cudillo L

更新日期：2009-12-26 00:00:00

abstract：:Therapy for hemophilia has evolved in the last 40 years from plasma-based concentrates to recombinant proteins and, more recently, to non-factor therapeutics. Along this same timeline, research in adeno-associated viral (AAV) based gene therapy vectors has provided the framework for early phase clinical trials initial...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Arruda VR,Doshi BS

更新日期：2020-09-01 00:00:00

abstract：:We report the first case of multiple brain abscesses caused by Nocardia paucivorans in a patient suffering from multiple myeloma on treatment with lenalidomide and dexamethasone. N. paucivorans is a recently described species of the genus Nocardia, which is supposed to have a heightened neurotropism in cases of dissem...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Monticelli J,Luzzati R,Maurel C,Rosin C,Valentinotti R,Farina C

更新日期：2015-01-01 00:00:00

abstract：:About 95% of cases and 98% of deaths due to tuberculosis (TB) occur in tropical countries while, in temperate low incidence countries, a disproportionate portion of TB cases is diagnosed in immigrants. Urbanization, poverty, poor housing conditions and ventilation, poor nutritional status, low education level, the HIV...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Zammarchi L,Bartalesi F,Bartoloni A

更新日期：2014-06-01 00:00:00

abstract：:This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Buonsenso D,Macchiarulo G,Supino MC,La Penna F,Scateni S,Marchesi A,Reale A,Boccuzzi E

更新日期：2018-05-01 00:00:00

abstract：:Hemophagocytic Lymphohistiocytosis (HLH) is an indicator of an exaggerated immune response and eventually adverse outcomes. This study aimed to investigate the clinical and laboratory features and outcomes of patients with HLH. The medical records of 26 HLH adult patients (≥ 16 years of age) were retrospectively analy...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Arslan F,Alp S,Büyükasık Y,Ozkan MC,Şahin F,Basaran S,Cagatay AA,Eraksoy ÖH,Aksu K,Ertunç B,Korten V,Ceylan B,Mert A

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a haematological malignancy associated with kidney injury resulting from cast nephropathy, which can be caused by monoclonal free light chains (FLC). It has been demonstrated that early reduction of FLC can lead to a higher proportion of patients recovering renal function with a bett...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Khalafallah AA,Loi SW,Love S,Mohamed M,Mace R,Khalil R,Girgs M,Raj R,Mathew M

更新日期：2013-01-01 00:00:00

abstract：:The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significa...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Mineri R,Mariotti J,Sarina B,Morabito L,Crocchiolo R,Bramanti S,Sarno T,Tordato F,Carlo-Stella C,Santoro A,Castagna L

更新日期：2018-02-15 00:00:00

abstract：:HIV-associated PBL is an AIDS-defining cancer, classified by WHO as a distinct entity of aggressive DLBCL. To date less than 250 cases have been published, of them 17 are pediatric. The pathogenesis of this rare disease is related to immunodeficiency, chronic immune stimulation and EBV. Clinically is a rapid growing d...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Bibas M,Castillo JJ

更新日期：2014-11-01 00:00:00

abstract：:Nebulized colistin (NC) is used for the treatment of pneumonia due to multidrug- resistant Gram-negative bacteria. In this one-year case-control study, our objective was to evaluate the effect of NC on the ventilator circuit (VC) components. The case group consisted of 25 mechanically-ventilated patients who received ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Ghonimat IM,Nazer LH,Aqel F,Mohammad MK,Hawari FI,Le J

更新日期：2015-04-20 00:00:00

abstract：:Tenofovir is widely used as first-line treatment of HIV infection, although its use is sometimes complicated by a reversible proximal renal tubulopathy.We report the case of a 45-year-old woman with chronic HIV infection and personality disorder, who after 12 months of tenofovir, complained of fatigue, diffuse bone pa...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： De Socio GV,Fabbriciani G,Massarotti M,Messina S,Cecchini E,Marasini B

更新日期：2012-01-01 00:00:00

abstract：:The B-cell receptor (BCR) signaling inhibitors ibrutinib and idelalisib are revolutionizing the treatment of chronic lymphocytic leukemia (CLL) and other B-cell malignancies. These oral agents, both alone and in combination with other drugs, have shown remarkable clinical activity in relapsed or refractory CLL across ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Falchi L,Baron JM,Orlikowski CA,Ferrajoli A

更新日期：2016-02-10 00:00:00

abstract：:The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlling angiogenesis, wh...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Randi AM,Laffan MA,Starke RD

更新日期：2013-09-02 00:00:00

abstract：:Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sorà F,Chiusolo P,Laurenti L,Autore F,Giammarco S,Sica S

更新日期：2016-07-01 00:00:00

abstract：Background:Italy has been one of the first European countries hit by the COVID-19 pandemic, with many patients dying from severe respiratory issues, especially frail subjects. Hematology patients are generally thought to be at high risk of developing severe COVID-19-associated complications. The aim of this work was to...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Botti S,Serra N,Castagnetti F,Chiaretti S,Mordini N,Gargiulo G,Orlando L

更新日期：2021-01-01 00:00:00

abstract：:In the last 15 years, highly active antiretroviral therapy (HAART) has determined a dramatic reduction of both morbidity and mortality in human immunodeficiency virus (HIV)-infected subjects, transforming this infection in a chronic and manageable disease. Patients surviving with HIV in the developed world, in larger ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： de Gaetano Donati K,Cauda R,Iacoviello L

更新日期：2010-01-01 00:00:00

abstract：:Idiopathic thrombocytopenic purpura (ITP) is an autoimmune hematological disorder characterized by auto antibody-mediated platelet destruction. Although the main cause of ITP remains unclear, but its relationship with some infection was demonstrated. In recent years, many studies have demonstrated improvement of plate...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Payandeh M,Sohrabi N,Zare ME,Kansestani AN,Hashemian AH

更新日期：2012-01-01 00:00:00

abstract：:In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. T...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Malara A,Abbonante V,Zingariello M,Migliaccio A,Balduini A

更新日期：2018-11-01 00:00:00

abstract：:Rhodococcus equi is an uncommon Gram positive, variably acid-fast pathogen, that appears as hard to treat mostly owing to the establishment of intracellular niches. Lack of interpretive criteria for susceptibility testing may lead to under-reporting or overestimation of resistances, whereas knowledge about this pathog...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Savini V,Salutari P,Sborgia M,Mancini I,Masciarelli G,Catavitello C,Astolfi D,D'Amario C,Fioritoni G,Spadaro A,D'Antonio D

更新日期：2011-01-01 00:00:00

abstract：Background:β-thalassemia intermedia (TI) spans a wide spectrum of severity and carries higher morbidity than previously recognized, including extramedullary hematopoiesis, leg ulcers, gallstones, thrombosis, secondary heart failure, pulmonary hypertension, skeletal deformity, growth retardation and endocrine abnormalit...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yassin MA,Soliman AT,De Sanctis V,Yassin KS,Abdulla MA

更新日期：2019-05-01 00:00:00

abstract：:Acinetobacter baumannii is an important opportunistic pathogen, responsible for approximately 10% of all gram-negative nosocomial infection. The aim of this study was to determine aminoglycoside and quinolone resistance genes and their antimicrobial susceptibility profile in the clinically A. baumannii. In this cross-...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Mirnejad R,Heidary M,Bahramian A,Goudarzi M,Pournajaf A

更新日期：2018-07-01 00:00:00