Hypophosphatemic Osteomalacia Associated with Tenofovir: a Multidisciplinary Approach is Required.

abstract：Background:Thrombophilia is a condition that predisposes to a higher incidence of venous thromboembolisms (VTE), some also in atypical sites. Direct oral anticoagulants (DOACs) have proven to be effective in the treatment of deep vein thrombosis (DVT). However, their use can be sometimes challenging in particular setti...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Serrao A,Lucani B,Mansour D,Ferretti A,Baldacci E,Santoro C,Foà R,Chistolini A

更新日期：2019-07-01 00:00:00

abstract：:Developing an effective malaria vaccine has been the goal of the scientific community for many years. A malaria vaccine, added to existing tools and strategies, would further prevent infection and decrease the unacceptable malaria morbidity and mortality burden. Great progress has been made over the last decade and a ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： García-Basteiro AL,Bassat Q,Alonso PL

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:IGF-1 deficiency in TM patients in children and adolescents has been attributed to chronic anemia and hypoxia, chronic liver disease, iron overload and other associated endocrinopathies, e.g. growth hormone deficiency (GHD). Few data are available in the literature regarding adult TM patients and growth di...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： De Sanctis V,Soliman AT,Candini G,Yassin M,Raiola G,Galati MC,Elalaily R,Elsedfy H,Skordis N,Garofalo P,Anastasi S,Campisi S,Karimi M,Kattamis C,Canatan D,Kilinc Y,Sobti P,Fiscina B,El Kholy M

更新日期：2014-11-01 00:00:00

abstract：Objective:This study focused on the efficacy and safety of thalidomide for patients with β-thalassemia in a multicenter trial. Methods:Patients with non-transfusion-dependent thalassemia (NTDT) or transfusion-dependent thalassemia (TDT), who were unable to pursue conventional therapy with transfusion and chelation, we...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yang K,Wu Y,Zhou Y,Long B,Lu Q,Zhou T,Wang L,Geng Z,Yin X

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a haematological malignancy associated with kidney injury resulting from cast nephropathy, which can be caused by monoclonal free light chains (FLC). It has been demonstrated that early reduction of FLC can lead to a higher proportion of patients recovering renal function with a bett...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Khalafallah AA,Loi SW,Love S,Mohamed M,Mace R,Khalil R,Girgs M,Raj R,Mathew M

更新日期：2013-01-01 00:00:00

abstract：:The recent focus on the potential link between periodontal and cardiovascular disease (PD and CVD) is part of the larger renewed interest on the role of infection and inflammation in the etiology of atherosclerosis and its clinical manifestations. Periodontal Disease is an inflammatory process affecting the periodonti...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Trevisan M,Dorn J

更新日期：2010-10-01 00:00:00

abstract：:This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Buonsenso D,Macchiarulo G,Supino MC,La Penna F,Scateni S,Marchesi A,Reale A,Boccuzzi E

更新日期：2018-05-01 00:00:00

abstract：Background:Alpha Thalassemia (α-thal) is a heterogeneous group of hereditary alterations caused by deletions that affect alpha regulatory genes, and the 3.7Kb deletion is the most frequent worldwide. The prevalence ranges from 20% and 35% in Brazil, depending mainly on race, predominant in Afro-descendants. Purpose:Th...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Anselmo FC,Soumanou AG,de Aguiar Ferreira C,Sobrinha FMV,Castro ACS,Brito RO,da Mota AJ,de Souza Gonçalves M,de Moura Neto JP

更新日期：2021-01-01 00:00:00

abstract：Background:β-thalassemia intermedia (TI) spans a wide spectrum of severity and carries higher morbidity than previously recognized, including extramedullary hematopoiesis, leg ulcers, gallstones, thrombosis, secondary heart failure, pulmonary hypertension, skeletal deformity, growth retardation and endocrine abnormalit...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yassin MA,Soliman AT,De Sanctis V,Yassin KS,Abdulla MA

更新日期：2019-05-01 00:00:00

abstract：:Hepatic involvement in familial Mediterranean fever (FMF) ranges from a nonspecific increase in liver enzymes to cryptogenic cirrhosis, and the liver is mostly involved in patients bearing the M694V MEFV mutation in homozygosis. A 44-year-old Jewish woman with FMF developed nonalcoholic steatohepatitis during colchici...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Massaro MG,Pompili M,Sicignano LL,Pizzolante F,Verrecchia E,Vecchio FM,Rigante D,Manna R

更新日期：2020-09-01 00:00:00

abstract：Background:Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell disease (SCD) severity. Despite this, HbF estimation is not routinely done in Nigeria. The relationship between HbF and SCD severity among affected children is also poorly studied. Methods:In this descriptive cross-sectional study,...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Adeodu OO,Akinlosotu MA,Adegoke SA,Oseni SBA

更新日期：2017-11-01 00:00:00

abstract：:The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian patients with SCA. Data of patients with SCA who were seen and follo...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： do Nascimento EM,de Castro Lobo CL,de Bragança Pereira B,Ballas SK

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Follicular lymphoma (FL) is an indolent lymphoproliferative disorder of B-cells with variable clinical behavior. It is the second most common subtype of Non-Hodgkin lymphoma in western countries but reported to have a lower incidence in Asia. MATERIALS AND METHODS:Cases of FL diagnosed in the Department o...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sylvia MT,Dey B,Basu D,Jacob SE,Kar R,Dubashi B

更新日期：2016-11-01 00:00:00

abstract：:The B-cell receptor (BCR) signaling inhibitors ibrutinib and idelalisib are revolutionizing the treatment of chronic lymphocytic leukemia (CLL) and other B-cell malignancies. These oral agents, both alone and in combination with other drugs, have shown remarkable clinical activity in relapsed or refractory CLL across ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Falchi L,Baron JM,Orlikowski CA,Ferrajoli A

更新日期：2016-02-10 00:00:00

abstract：:The inherited disorders of hemoglobin are by far the commonest monogenic diseases and there is considerable evidence that they have reached their very high frequencies due to heterozygote advantage against malaria. Recent studies have begun to clarify the effect of interactions between malaria and some of the more sev...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Weatherall DJ

更新日期：2009-12-20 00:00:00

abstract：:Bacterial infections are major complications after Hematopoietic Stem Cell Transplant (HSCT). They consist mainly of bloodstream infections (BSI), followed by pneumonia and gastrointestinal infections, including typhlitis and Clostridium difficile infection. Microbiological data come mostly from BSI. Coagulase negativ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Balletto E,Mikulska M

更新日期：2015-07-01 00:00:00

abstract：:The transition of patients with ≥20% <30% bone marrow (BM) blast from the FAB category of myelodysplasia to the family of acute myeloid leukemia (AML) according to the recent WHO classification has not resolved the argument as to whether the natural history and responsiveness to therapy of these diseases is comparable...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Maurillo L,Buccisano F,Del Principe MI,Sarlo C,Di Caprio L,Ditto C,Giannotti F,Nasso D,Ceresoli E,Postorino M,Refrigeri M,Amadori S,Venditti A

更新日期：2013-06-03 00:00:00

abstract：:JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched nor...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Spanoudakis E,Papoutselis M,Bazdiara I,Lamprianidi E,Kordella X,Tilkeridis C,Tsatalas C,Kotsianidis I

更新日期：2018-11-01 00:00:00

abstract：:MTB ranks as the first worldwide pathogen latently infecting one third of the population and the second leading cause of death from a single infectious agent, after the human immunodeficiency virus (HIV). The development of vigorous and apparently appropriate immune response upon infection with M. tuberculosis in huma...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Bozzano F,Marras F,De Maria A

更新日期：2014-04-07 00:00:00

abstract：:In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. T...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Malara A,Abbonante V,Zingariello M,Migliaccio A,Balduini A

更新日期：2018-11-01 00:00:00

abstract：:We describe the entire process leading to the start-up of a hematopoietic stem cell transplantation center at the Hiwa Cancer Hospital, in the city of Sulaymaniyah, Kurdistan Iraqi Region. This capacity building project was funded by the Italian Development Cooperation Agency and implemented with the support of the vo...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Majolino I,Othman D,Rovelli A,Hassan D,Rasool L,Vacca M,Abdalrahman N,Abdullah C,Ahmed Z,Ali D,Ali K,Broggi C,Calabretta C,Canesi M,Ciabatti G,Del Fante C,De Sapio E,Dore G,Frigato A,Gabriel M,Ipsevich F,Kareem

更新日期：2017-04-15 00:00:00

abstract：:Therapy for hemophilia has evolved in the last 40 years from plasma-based concentrates to recombinant proteins and, more recently, to non-factor therapeutics. Along this same timeline, research in adeno-associated viral (AAV) based gene therapy vectors has provided the framework for early phase clinical trials initial...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Arruda VR,Doshi BS

更新日期：2020-09-01 00:00:00

abstract：:The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significa...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Mineri R,Mariotti J,Sarina B,Morabito L,Crocchiolo R,Bramanti S,Sarno T,Tordato F,Carlo-Stella C,Santoro A,Castagna L

更新日期：2018-02-15 00:00:00

abstract：:Acinetobacter baumannii is an important opportunistic pathogen, responsible for approximately 10% of all gram-negative nosocomial infection. The aim of this study was to determine aminoglycoside and quinolone resistance genes and their antimicrobial susceptibility profile in the clinically A. baumannii. In this cross-...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Mirnejad R,Heidary M,Bahramian A,Goudarzi M,Pournajaf A

更新日期：2018-07-01 00:00:00

abstract：:Peripheral neuropathies are a vast group of diseases with heterogeneous aetiologies, including genetic and acquired causes. Several haematological disorders may cause an impairment of the peripheral nervous system, with diverse mechanisms and variable clinical, electrophysiological and pathological manifestations. In ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sabatelli M,Laurenti L,Luigetti M

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Sickle cell disease (SCD) is one of the leading causes of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time challenging its man...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yassin M,Soliman A,De Sanctis V,Nashwan A,Abusamaan S,Moustafa A,Kohla S,Soliman D

更新日期：2017-06-20 00:00:00

abstract：:In the last 15 years, highly active antiretroviral therapy (HAART) has determined a dramatic reduction of both morbidity and mortality in human immunodeficiency virus (HIV)-infected subjects, transforming this infection in a chronic and manageable disease. Patients surviving with HIV in the developed world, in larger ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： de Gaetano Donati K,Cauda R,Iacoviello L

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Homozygous or double heterozygous factor XIII (FXIII) deficiency is characterized by soft tissue hematomas, intracranial and delayed spontaneous bleeding. Alterations of thromboelastography (TEG) parameters in these patients have been reported. The aim of the study was to show results of TEG, TEG Lysis (Lys ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Martinuzzo M,Barrera L,Altuna D,Baña FT,Bieti J,Amigo Q,D'Adamo M,López MS,Oyhamburu J,Otaso JC

更新日期：2016-08-16 00:00:00

abstract：:Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However, there is a paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM). This retrospective case series of five patie...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Zonoozi S,Barnard M,Prescott E,Jones R,Shah FT,Tzoulis P

更新日期：2017-01-01 00:00:00

abstract：:Adherence to imatinib(IM) is of utmost importance in patients with chronic myeloid leukemia (CML) to maximise treatment effectiveness. The main objective is to measure adherence to IM by evaluating individual patient characteristics, personal behaviour and, treatment related psychological factors influencing adherence...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Kapoor J,Agrawal N,Ahmed R,Sharma SK,Gupta A,Bhurani D

更新日期：2015-02-20 00:00:00