Abstract:
Background:Thrombophilia is a condition that predisposes to a higher incidence of venous thromboembolisms (VTE), some also in atypical sites. Direct oral anticoagulants (DOACs) have proven to be effective in the treatment of deep vein thrombosis (DVT). However, their use can be sometimes challenging in particular settings of patients such as those with major thrombophilia - antithrombin, protein C and protein S deficiency, homozygous mutation of Factor V Leiden, homozygous mutation of Factor II G20210A, combined heterozygous mutation of factor V Leiden and Factor II G20210A - carrying a high thrombotic risk. Patients and Methods:At our Center, 45 patients with major thrombophilia were treated with DOACs: 33 after an initial treatment with vitamin K antagonists (VKA) and 12 as first-line therapy for VTE. The median follow-up of DOACs treatment was 29 months. Conclusions:No patient presented hemorrhagic or thrombotic complications during DOAC therapy. DOACs have proven to be effective and safe in this real-life series of patients with major thrombophilia.
journal_name
Mediterr J Hematol Infect Disauthors
Serrao A,Lucani B,Mansour D,Ferretti A,Baldacci E,Santoro C,Foà R,Chistolini Adoi
10.4084/MJHID.2019.044subject
Has Abstractpub_date
2019-07-01 00:00:00pages
e2019044issue
1issn
2035-3006pii
mjhid-11-1-e2019044journal_volume
11pub_type
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