Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+) T lymphocyte cytokine production.

abstract：BACKGROUND:An ideal tumor vaccine should activate both effector and memory immune response against tumor-specific antigens. Beside the CD8+ T cells that play a central role in the generation of a protective immune response and of long-term memory, dendritic cells (DCs) are important for the induction, coordination and ...

journal_title：BMC immunology

authors： Cerkovnik P,Novakovic BJ,Stegel V,Novakovic S

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential biomarkers in various diseases. Human immunodeficiency virus type 1 (HIV) infects CD4+ T cells and induces immune dysfunction, inflammation, and EV secretion, but little is kno...

journal_title：BMC immunology

authors： Chettimada S,Lorenz DR,Misra V,Wolinsky SM,Gabuzda D

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder characterized by defective function of Fas, autoimmune manifestations that predominantly involve blood cells, polyclonal accumulation of lymphocytes in the spleen and lymph nodes with lymphoadenomegaly and/or splenomegaly, and expans...

journal_title：BMC immunology

authors： Cerutti E,Campagnoli MF,Ferretti M,Garelli E,Crescenzio N,Rosolen A,Chiocchetti A,Lenardo MJ,Ramenghi U,Dianzani U

更新日期：2007-11-13 00:00:00

abstract：BACKGROUND:The extracellular domains of cytokine receptors are released during inflammation, but little is known about the shedding of Toll-like receptors (TLR) and whether they can be used as diagnostic biomarkers. METHODS:The release of sTLR2 and sTLR4 was studied in in-vitro stimulations, as well as in-vivo during ...

journal_title：BMC immunology

authors： Ten Oever J,Kox M,van de Veerdonk FL,Mothapo KM,Slavcovici A,Jansen TL,Tweehuysen L,Giamarellos-Bourboulis EJ,Schneeberger PM,Wever PC,Stoffels M,Simon A,van der Meer JW,Johnson MD,Kullberg BJ,Pickkers P,Pachot A,Jooste

更新日期：2014-11-19 00:00:00

abstract：BACKGROUND:Shiga toxin 2 (Stx2), one of two Stx liberated by Stx-producing Escherichia coli, is composed of an A subunit monomer and a B subunit pentamer, and is directly linked with hemolytic uremic syndrome in children. The pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the...

journal_title：BMC immunology

authors： Jeong KI,Chapman-Bonofiglio S,Singh P,Lee J,Tzipori S,Sheoran AS

更新日期：2010-03-24 00:00:00

abstract：BACKGROUND:Molecular mimicry between microbial antigens and host-proteins is one of the etiological enigmas for the occurrence of autoimmune diseases. T cells that recognize cross-reactive epitopes may trigger autoimmune reactions. Intriguingly, autoimmune diseases have been reported to be prevalent in tuberculosis end...

journal_title：BMC immunology

authors： Chodisetti SB,Rai PK,Gowthaman U,Pahari S,Agrewala JN

更新日期：2012-03-21 00:00:00

abstract：BACKGROUND:Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS and inflammatory cytokines during the inflammatory phase (first day) in streptozotocin (STZ...

journal_title：BMC immunology

authors： Ebaid H,Ahmed OM,Mahmoud AM,Ahmed RR

更新日期：2013-07-25 00:00:00

abstract：BACKGROUND:While vaccination remains the most effective method to control hepatitis B virus (HBV) infection, 5-10% of recipients exhibit non-responsiveness to the HB vaccine. Immunological analysis of strong, weak or absent protective antibody responses to the HB vaccine should provide insights into the mechanisms that...

journal_title：BMC immunology

authors： Xu X,Li Y,Liang Y,Yin M,Yu Z,Zhang Y,Huang L,Ni J

更新日期：2018-07-28 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) play the key role in directing antigen-specific immune responses and manipulating their function may be a useful tool for immunotherapy. The balance between immune stimulation and tolerance is particularly important at mucosal interfaces, where discrimination between dangerous pathogens ...

journal_title：BMC immunology

authors： Polak ME,Borthwick NJ,Gabriel FG,Jager MJ,Cree IA

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they can be found deposited extracellularly below the epithelial baseme...

journal_title：BMC immunology

authors： Stenman SM,Lindfors K,Korponay-Szabo IR,Lohi O,Saavalainen P,Partanen J,Haimila K,Wieser H,Mäki M,Kaukinen K

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells (PBMCs) is a common and essential practice in conducting research. There are different reports in the literature as to whether cryopreserved PBMCs need to only be stored ≤ -150 °C or can be stored for a specified time at -80 °C. Therefore, we performed g...

journal_title：BMC immunology

authors： Yang J,Diaz N,Adelsberger J,Zhou X,Stevens R,Rupert A,Metcalf JA,Baseler M,Barbon C,Imamichi T,Lempicki R,Cosentino LM

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:CD33 is a membrane receptor containing a lectin domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) that is able to inhibit cytokine production. CD33 is expressed by monocytes, and reduced expression of CD33 correlates with augmented production of inflammatory cytokines, such as IL...

journal_title：BMC immunology

authors： Gonzalez Y,Herrera MT,Soldevila G,Garcia-Garcia L,Fabián G,Pérez-Armendariz EM,Bobadilla K,Guzmán-Beltrán S,Sada E,Torres M

更新日期：2012-04-14 00:00:00

abstract：BACKGROUND:Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis and self-tolerance. The immune suppressive effects of Tregs should however be limited in case effective immunity is required against pathogens or cancer cells. We previously found that the Toll-like receptor 2 (TLR2) agonist, Pam...

journal_title：BMC immunology

authors： van Maren WW,Nierkens S,Toonen LW,Bolscher JM,Sutmuller RP,Adema GJ

更新日期：2011-03-24 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation is one of the contributing factors to the severe clinical outcomes in the susceptible hosts. The C57BL/6 and BALB/c mice have been established as a differential model of susceptibility in m...

journal_title：BMC immunology

authors： Koo GC,Gan YH

更新日期：2006-08-18 00:00:00

abstract：BACKGROUND:The functional immaturity of T cells contributes to the susceptibility of neonates to infections and the less severe graft-versus-host disease associated with cord blood (CB) transplantation. We have previously reported that insulin-like growth factor - I (IGF-I) promotes the phytohaemagglutinin (PHA)-induce...

journal_title：BMC immunology

authors： Law HK,Tu W,Liu E,Lau YL

更新日期：2008-12-17 00:00:00

abstract：BACKGROUND:T-cells extravasation and CNS parenchyma infiltration during autoimmune neurodegenerative disease can be evoked by local antigen presenting cells. Studying the chemoattracting potential of spinal perivascular macrophages (SPM) during experimental allergic encephalomyelitis (EAE), we observed numerous infiltr...

journal_title：BMC immunology

authors： Hofmann N,Lachnit N,Streppel M,Witter B,Neiss WF,Guntinas-Lichius O,Angelov DN

更新日期：2002-08-26 00:00:00

abstract：BACKGROUND:Deer mice (Peromyscus maniculatus) are the most common mammals in North America and are reservoirs for several zoonotic agents, including Sin Nombre virus (SNV), the principal etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in North America. Unlike human HCPS patients, SNV-infected deer mice sh...

journal_title：BMC immunology

authors： Oko L,Aduddell-Swope B,Willis D,Hamor R,Coons TA,Hjelle B,Schountz T

更新日期：2006-08-17 00:00:00

abstract：BACKGROUND:Anthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis, is a highly effective zinc dependent metalloprotease that cleaves the N-terminus of mitogen-activated protein kinase kinases (MAPKK or MEKs) and is known to play a role in impairing the host immune system during an inhalat...

journal_title：BMC immunology

authors： Chauncey KM,Lopez MC,Sidhu G,Szarowicz SE,Baker HV,Quinn C,Southwick FS

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisation with glutaraldehyde to reduce IgE binding. It is suggested that these allergoid extracts also have...

journal_title：BMC immunology

authors： Urry ZL,Richards DF,Black C,Morales M,Carnés J,Hawrylowicz CM,Robinson DS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Symptomatic Primary Humoral Immunodeficiency Diseases (PHID) constitute a highly heterogeneous group of diseases characterized by a shared hypogammaglobulinemia, resulting in increased risk of recurrent or severe infections. Associations have been described with a variety of immunological abnormalities invol...

journal_title：BMC immunology

authors： Picat MQ,Thiébaut R,Lifermann F,Delbrel X,Adoue D,Wittkop L,Fauchais AL,Rispal P,Moreau JF,Viallard JF

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Pattern recognition receptors (PRRs) for double-stranded RNA (dsRNA) are components of innate immunity that recognize the presence of viral infection and initiate efficient defense mechanisms. In addition to previously well-characterized signaling pathways that are mediated by PKR and TLR3, new intracellular...

journal_title：BMC immunology

authors： Yun JJ,Tsao MS,Der SD

更新日期：2011-02-10 00:00:00

abstract：:The immunological roles of B-cells are being revealed as increasingly complex by functions that are largely beyond their commitment to differentiate into plasma cells and produce antibodies, the key molecular protagonists of innate immunity, and also by their compartmentalisation, a more recently acknowledged property...

journal_title：BMC immunology

authors： Garraud O,Borhis G,Badr G,Degrelle S,Pozzetto B,Cognasse F,Richard Y

更新日期：2012-11-29 00:00:00

abstract：BACKGROUND:We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Here, we have demonstrated th...

journal_title：BMC immunology

authors： Dawson HD,Collins G,Pyle R,Key M,Taub DD

更新日期：2008-04-16 00:00:00

abstract：BACKGROUND:Egg white must provide nutrients and protection to the developing avian embryo. One way in which this is achieved is an arsenal of antimicrobial proteins and peptides which are essentially extensions of the innate immune system. Gallin is a recently identified member of a family of peptides that are found in...

journal_title：BMC immunology

authors： Gong D,Wilson PW,Bain MM,McDade K,Kalina J,Hervé-Grépinet V,Nys Y,Dunn IC

更新日期：2010-03-12 00:00:00

abstract：BACKGROUND:Adenoviral vectors have provided effective methods for in vivo gene delivery in therapeutic applications. However, these vectors can induce immune responses that may severely affect the ability of vector re-application. There is limited information about the mechanisms and signal transduction pathways involv...

journal_title：BMC immunology

authors： Steinstraesser L,Sorkin M,Jacobsen F,Al-Benna S,Kesting MR,Niederbichler AD,Otte JM,Hirsch T,Stupka J,Steinau HU,Schulte M

更新日期：2011-01-21 00:00:00

abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells has been used to preserve and standardize immunologic measurements for multicenter studies, however, effects of cryopreservation on cytokine responses are incompletely understood. In designing immunologic studies for a new multicenter birth cohort study ...

journal_title：BMC immunology

authors： Shreffler WG,Visness CM,Burger M,Cruikshank WW,Lederman HM,de la Morena M,Grindle K,Calatroni A,Sampson HA,Gern JE

更新日期：2006-12-12 00:00:00

abstract：BACKGROUND:Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain ...

journal_title：BMC immunology

authors： Wang C,Yu X,Cao Q,Wang Y,Zheng G,Tan TK,Zhao H,Zhao Y,Wang Y,Harris DCh

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles through modulation of the expression of genes, especially those encoding cytokines. Murine bone marrow derived macrophages (BMDMs) are commonly used as a m...

journal_title：BMC immunology

authors： Tanaka A,To J,O'Brien B,Donnelly S,Lund M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...

journal_title：BMC immunology

authors： Jia L,Wang Y,Li J,Li S,Zhang Y,Shen J,Tan W,Wu C

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:The initiation of highly active antiretroviral therapy (HAART) plays a significant role in the clinical management of HIV infected people by preventing morbidity and mortality. This benefit becomes, the most terrible when treatment failure develops. Thus, this research aims to assess the prevalence and assoc...

journal_title：BMC immunology

authors： Ayele G,Tessema B,Amsalu A,Ferede G,Yismaw G

更新日期：2018-12-17 00:00:00