Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis.

abstract：BACKGROUND:Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation. RESULTS:Here, we showed that plasmid DNA (pcDNA3) at low doses inhibits the production of IL-6 and TNF-α ...

journal_title：BMC immunology

authors： Malardo T,Batalhão ME,Panunto-Castelo A,Almeida LP,Padilha E,Fontoura IC,Silva CL,Carnio EC,Coelho-Castelo AA

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Pro-inflammatory cytokines can affect intracellular lipid metabolism. A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1beta (IL-1beta) reduces intracellular cholesterol levels in fibroblasts. Levels o...

journal_title：BMC immunology

authors： Persson J,Nilsson J,Lindholm MW

更新日期：2008-11-25 00:00:00

abstract：BACKGROUND:The functional immaturity of T cells contributes to the susceptibility of neonates to infections and the less severe graft-versus-host disease associated with cord blood (CB) transplantation. We have previously reported that insulin-like growth factor - I (IGF-I) promotes the phytohaemagglutinin (PHA)-induce...

journal_title：BMC immunology

authors： Law HK,Tu W,Liu E,Lau YL

更新日期：2008-12-17 00:00:00

abstract：BACKGROUND:While dendritic cells (DCs) can induce tolerance in T cells, little is known about tolerance induction in DCs themselves. We have analysed tolerance induced in human in-vitro generated DCs by repeated stimulation with ligands for TLR4 and TLR2. RESULTS:DCs stimulated with the TLR4 ligand LPS did show a rapi...

journal_title：BMC immunology

authors： Albrecht V,Hofer TP,Foxwell B,Frankenberger M,Ziegler-Heitbrock L

更新日期：2008-11-24 00:00:00

abstract：BACKGROUND:Human memory CD4+ T cells can be either CD300a/c+ or CD300a/c- and subsequent analyses showed that CD4+ effector memory T (T(EM)) cells are mostly CD300a/c+, whereas CD4+ central memory T (T(CM)) cells have similar frequencies of CD300a/c+ and CD300a/c- cells. RESULTS:Extensive phenotypical and functional c...

journal_title：BMC immunology

authors： Simhadri VR,Mariano JL,Zhou Q,DeBell KE,Borrego F

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:To understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1(-/-) mice that are resistant to spontaneous arthritis into BALB...

journal_title：BMC immunology

authors： Deng N,Jiao Y,Cao Y,Liu X,Ma Y,Hasty KA,Brand DD,Stuart JM,Gu W

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in cap...

journal_title：BMC immunology

authors： Kim H,Darwish I,Monroy MF,Prockop DJ,Liles WC,Kain KC

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:Egg white must provide nutrients and protection to the developing avian embryo. One way in which this is achieved is an arsenal of antimicrobial proteins and peptides which are essentially extensions of the innate immune system. Gallin is a recently identified member of a family of peptides that are found in...

journal_title：BMC immunology

authors： Gong D,Wilson PW,Bain MM,McDade K,Kalina J,Hervé-Grépinet V,Nys Y,Dunn IC

更新日期：2010-03-12 00:00:00

abstract：BACKGROUND:Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral vectors are an attractive alternative for gene delivery. However, naive lymphocytes are not readily susceptible to infection with adenovi...

journal_title：BMC immunology

authors： Hurez V,Dzialo-Hatton R,Oliver J,Matthews RJ,Weaver CT

更新日期：2002-05-02 00:00:00

abstract：BACKGROUND:Toll-like receptor 2 (TLR2) plays a critical role in mediating inflammatory/immune responses against bacterial pathogens in lung. Streptococcus pneumoniae (S. pneumoniae) and nontypeable Haemophilus influenzae (NTHi) were previously reported to synergize with each other to induce inflammatory responses. Desp...

journal_title：BMC immunology

authors： Lim JH,Ha U,Sakai A,Woo CH,Kweon SM,Xu H,Li JD

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae is a human pathogenic bacteria and a major cause of severe invasive diseases, including pneumonia, bacteremia, and meningitis. Infections with S. pneumoniae evoke a strong inflammatory response, which plays a major role in the pathogenesis of pneumococcal disease. RESULTS:In this st...

journal_title：BMC immunology

authors： Mogensen TH,Berg RS,Ostergaard L,Paludan SR

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Functioning of the immune system requires the coordinated expression and action of many genes and proteins. With the emergence of high-throughput technologies, a great amount of molecular data is available for the genes and proteins of the immune system. However, these data are scattered into several databas...

journal_title：BMC immunology

authors： Ortutay C,Vihinen M

更新日期：2009-01-09 00:00:00

abstract：BACKGROUND:Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles through modulation of the expression of genes, especially those encoding cytokines. Murine bone marrow derived macrophages (BMDMs) are commonly used as a m...

journal_title：BMC immunology

authors： Tanaka A,To J,O'Brien B,Donnelly S,Lund M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on the myelo-depletive effects of certain chemotherapy agents. We have shown previously that decitabine ...

journal_title：BMC immunology

authors： Luker AJ,Graham LJ,Smith TM Jr,Camarena C,Zellner MP,Gilmer JS,Damle SR,Conrad DH,Bear HD,Martin RK

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisation with glutaraldehyde to reduce IgE binding. It is suggested that these allergoid extracts also have...

journal_title：BMC immunology

authors： Urry ZL,Richards DF,Black C,Morales M,Carnés J,Hawrylowicz CM,Robinson DS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:The bacterial biofilm at the gingival margin induces a host immune reaction. In this local inflammation epithelial cells defend the host against bacterial challenge. Porphyromonas gingivalis (P. gingivalis), a keystone pathogen, infects epithelial cells. The aim of this study was to investigate the activatio...

journal_title：BMC immunology

authors： Groeger S,Jarzina F,Domann E,Meyle J

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Recognition of pathogens by dendritic cells (DCs) through interaction with pattern recognition receptors, including Toll like receptors (TLR), is crucial for the initiation of appropriate polarized T helper (Th) cell responses. Yet, the characteristics and differences in molecular profiles of DCs with differ...

journal_title：BMC immunology

authors： van Riet E,Everts B,Retra K,Phylipsen M,van Hellemond JJ,Tielens AG,van der Kleij D,Hartgers FC,Yazdanbakhsh M

更新日期：2009-02-04 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation is one of the contributing factors to the severe clinical outcomes in the susceptible hosts. The C57BL/6 and BALB/c mice have been established as a differential model of susceptibility in m...

journal_title：BMC immunology

authors： Koo GC,Gan YH

更新日期：2006-08-18 00:00:00

abstract：BACKGROUND:The potential utility of dendritic cells (DC) as cancer vaccines has been established in early trials in human cancers. The concomitant administration of cytotoxic agents and DC vaccines has been previously avoided due to potential immune suppression by chemotherapeutics. Recent studies show that common chem...

journal_title：BMC immunology

authors： John J,Ismail M,Riley C,Askham J,Morgan R,Melcher A,Pandha H

更新日期：2010-03-19 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by the novel coronavirus SARS-CoV. The T cell epitopes of the SARS CoV spike protein are well known, but no systematic evaluation of the functional and structural roles of each residue has been reported for these antigenic epit...

journal_title：BMC immunology

authors： Huang J,Cao Y,Bu X,Wu C

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Streptococcus sanguinis (S.sanguinis), a predominant bacterium in the human oral cavity, has been widely associated with the development of infective endocarditis. Platelets play both a haemostatic function and can influence both innate and adaptive immune responses. Previous studies have shown that S.sangui...

journal_title：BMC immunology

authors： Cognasse F,Hamzeh-Cognasse H,Chabert A,Jackson E,Arthaud CA,Garraud O,McNicol A

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Interleukin 7 (IL-7) signals via the IL-7 receptor (IL-7R) and drives homeostatic T-cell proliferation in patients after allogeneic hematopoietic stem cell transplantation (aHSCT). PURPOSE:We performed a prospective study in adults (n = 33) and children (n = 29) undergoing aHSCT measuring plasma IL-7 and so...

journal_title：BMC immunology

authors： Poiret T,Rane L,Remberger M,Omazic B,Gustafsson-Jernberg A,Vudattu NK,Ahmed R,Ernberg I,Winiarski J,Magalhaes I,Ringden O,Maeurer M

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 inflammatory response. Recent studies strongly support that the CXCR3 receptor is a very attractive therapeutic target for treating autoimmune diseases, s...

journal_title：BMC immunology

authors： Jenh CH,Cox MA,Cui L,Reich EP,Sullivan L,Chen SC,Kinsley D,Qian S,Kim SH,Rosenblum S,Kozlowski J,Fine JS,Zavodny PJ,Lundell D

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:Inappropriate responses to normal intestinal bacteria may be involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn's Disease (CD), Ulcerative Colitis (UC)) and variations in the host genome may mediate this process. IL-10 gene-deficient (Il10-/-) mice develop CD-like colitis mainly in t...

journal_title：BMC immunology

authors： Barnett MP,McNabb WC,Cookson AL,Zhu S,Davy M,Knoch B,Nones K,Hodgkinson AJ,Roy NC

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:The USDA, Wildlife Services cooperative oral rabies vaccination (ORV) program uses a live vaccinia virus-vectored (genus Orthopoxvirus) vaccine, Raboral V-RG (V-RG), to vaccinate specific wildlife species against rabies virus in several regions of the U.S. Several naturally occurring orthopoxviruses have bee...

journal_title：BMC immunology

authors： Root JJ,McLean RG,Slate D,MacCarthy KA,Osorio JE

更新日期：2008-10-03 00:00:00

abstract：BACKGROUND:Active cancer immunotherapies are beginning to yield clinical benefit, especially those using peptide-pulsed dendritic cells (DCs). Different adjuvants, including Toll-like receptor (TLR) agonists, commonly co-administered to cancer patients as part of a DC-based vaccine, are being widely tested in the clini...

journal_title：BMC immunology

authors： Ioannou K,Derhovanessian E,Tsakiri E,Samara P,Kalbacher H,Voelter W,Trougakos IP,Pawelec G,Tsitsilonis OE

更新日期：2013-09-22 00:00:00

abstract：BACKGROUND:Symptomatic Primary Humoral Immunodeficiency Diseases (PHID) constitute a highly heterogeneous group of diseases characterized by a shared hypogammaglobulinemia, resulting in increased risk of recurrent or severe infections. Associations have been described with a variety of immunological abnormalities invol...

journal_title：BMC immunology

authors： Picat MQ,Thiébaut R,Lifermann F,Delbrel X,Adoue D,Wittkop L,Fauchais AL,Rispal P,Moreau JF,Viallard JF

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology...

journal_title：BMC immunology

authors： Lohrberg M,Pabst R,Wilting J

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Here, we have demonstrated th...

journal_title：BMC immunology

authors： Dawson HD,Collins G,Pyle R,Key M,Taub DD

更新日期：2008-04-16 00:00:00

abstract：BACKGROUND:Expressed in embryonic development, matrix metalloprotein-9 (MMP-9) is absent in most of developed adult tissues, but recurs in inflammation during tissue injury, wound healing, tumor formation and metastasis. Expression of MMP-9 is tightly controlled by extracellular cues including pro-inflammatory cytokine...

journal_title：BMC immunology

authors： Zhou L,Yan C,Gieling RG,Kida Y,Garner W,Li W,Han YP

更新日期：2009-03-19 00:00:00