Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein.

abstract：BACKGROUND:The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 inflammatory response. Recent studies strongly support that the CXCR3 receptor is a very attractive therapeutic target for treating autoimmune diseases, s...

journal_title：BMC immunology

authors： Jenh CH,Cox MA,Cui L,Reich EP,Sullivan L,Chen SC,Kinsley D,Qian S,Kim SH,Rosenblum S,Kozlowski J,Fine JS,Zavodny PJ,Lundell D

更新日期：2012-01-10 00:00:00

abstract：:The immunological roles of B-cells are being revealed as increasingly complex by functions that are largely beyond their commitment to differentiate into plasma cells and produce antibodies, the key molecular protagonists of innate immunity, and also by their compartmentalisation, a more recently acknowledged property...

journal_title：BMC immunology

authors： Garraud O,Borhis G,Badr G,Degrelle S,Pozzetto B,Cognasse F,Richard Y

更新日期：2012-11-29 00:00:00

abstract：BACKGROUND:Active cancer immunotherapies are beginning to yield clinical benefit, especially those using peptide-pulsed dendritic cells (DCs). Different adjuvants, including Toll-like receptor (TLR) agonists, commonly co-administered to cancer patients as part of a DC-based vaccine, are being widely tested in the clini...

journal_title：BMC immunology

authors： Ioannou K,Derhovanessian E,Tsakiri E,Samara P,Kalbacher H,Voelter W,Trougakos IP,Pawelec G,Tsitsilonis OE

更新日期：2013-09-22 00:00:00

abstract：BACKGROUND:Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients wit...

journal_title：BMC immunology

authors： Qama D,Choi WI,Kwon KY

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions of th...

journal_title：BMC immunology

authors： Sidney J,Peters B,Frahm N,Brander C,Sette A

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology...

journal_title：BMC immunology

authors： Lohrberg M,Pabst R,Wilting J

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify whether the TNFi sometimes used to treat patients with rheumatoid arthritis (RA) complicated with huma...

journal_title：BMC immunology

authors： Fukui S,Nakamura H,Takahashi Y,Iwamoto N,Hasegawa H,Yanagihara K,Nakamura T,Okayama A,Kawakami A

更新日期：2017-02-03 00:00:00

abstract：BACKGROUND:We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL an...

journal_title：BMC immunology

authors： Parker AR,Skold M,Harding S,Barton JC,Bertoli LF,Barton JC

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the metabolic state or the presence of obesity. Hence, the present study aimed to compare Toll-Like Rece...

journal_title：BMC immunology

authors： Amiri P,Baradaran B,Saghafi-Asl M,Naghizadeh M,Shanehbandi D,Karamzad N,Vahed SZ

更新日期：2019-07-04 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation is one of the contributing factors to the severe clinical outcomes in the susceptible hosts. The C57BL/6 and BALB/c mice have been established as a differential model of susceptibility in m...

journal_title：BMC immunology

authors： Koo GC,Gan YH

更新日期：2006-08-18 00:00:00

abstract：BACKGROUND:Pattern recognition receptors (PRRs) for double-stranded RNA (dsRNA) are components of innate immunity that recognize the presence of viral infection and initiate efficient defense mechanisms. In addition to previously well-characterized signaling pathways that are mediated by PKR and TLR3, new intracellular...

journal_title：BMC immunology

authors： Yun JJ,Tsao MS,Der SD

更新日期：2011-02-10 00:00:00

abstract：BACKGROUND:Dysregulation of the immune system has been shown to occur during spaceflight, although the detailed nature of the phenomenon and the clinical risks for exploration class missions have yet to be established. Also, the growing clinical significance of immune system evaluation combined with epidemic infectious...

journal_title：BMC immunology

authors： Crucian B,Lee P,Stowe R,Jones J,Effenhauser R,Widen R,Sams C

更新日期：2007-05-23 00:00:00

abstract：BACKGROUND:The need for rapid and accurate comparison of panels of adjuvanted vaccine formulations and subsequent rational down selection, presents several challenges for modern vaccine development. Here we describe a method which may enable vaccine and adjuvant developers to compare antigen/adjuvant combinations in a ...

journal_title：BMC immunology

authors： Younis SY,Barnier-Quer C,Heuking S,Sommandas V,Brunner L,Vd Werff N,Dubois P,Friede M,Kocken C,Collin N,Remarque E

更新日期：2018-01-31 00:00:00

abstract：BACKGROUND:Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation. RESULTS:Here, we showed that plasmid DNA (pcDNA3) at low doses inhibits the production of IL-6 and TNF-α ...

journal_title：BMC immunology

authors： Malardo T,Batalhão ME,Panunto-Castelo A,Almeida LP,Padilha E,Fontoura IC,Silva CL,Carnio EC,Coelho-Castelo AA

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:There are three major B-cell compartments in peripheral lymphoid organs: the germinal center (GC), the mantle zone (MNZ) and the marginal zone (MGZ). Unique sets of B-cells reside in these compartments, and they have specific functional roles in humoral immune response. MNZ B cells are naive cells in a quies...

journal_title：BMC immunology

authors： Shen Y,Iqbal J,Xiao L,Lynch RC,Rosenwald A,Staudt LM,Sherman S,Dybkaer K,Zhou G,Eudy JD,Delabie J,McKeithan TW,Chan WC

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Egg white must provide nutrients and protection to the developing avian embryo. One way in which this is achieved is an arsenal of antimicrobial proteins and peptides which are essentially extensions of the innate immune system. Gallin is a recently identified member of a family of peptides that are found in...

journal_title：BMC immunology

authors： Gong D,Wilson PW,Bain MM,McDade K,Kalina J,Hervé-Grépinet V,Nys Y,Dunn IC

更新日期：2010-03-12 00:00:00

abstract：BACKGROUND:Myeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate immunity, and in the initiation and maintenance of adaptive immunity. While T cell-associated activation pathways and cytokines have been identified and evaluated in inf...

journal_title：BMC immunology

authors： Liu H,Dasgupta S,Fu Y,Bailey B,Roy C,Lightcap E,Faustin B

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Inappropriate responses to normal intestinal bacteria may be involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn's Disease (CD), Ulcerative Colitis (UC)) and variations in the host genome may mediate this process. IL-10 gene-deficient (Il10-/-) mice develop CD-like colitis mainly in t...

journal_title：BMC immunology

authors： Barnett MP,McNabb WC,Cookson AL,Zhu S,Davy M,Knoch B,Nones K,Hodgkinson AJ,Roy NC

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells (PBMCs) is a common and essential practice in conducting research. There are different reports in the literature as to whether cryopreserved PBMCs need to only be stored ≤ -150 °C or can be stored for a specified time at -80 °C. Therefore, we performed g...

journal_title：BMC immunology

authors： Yang J,Diaz N,Adelsberger J,Zhou X,Stevens R,Rupert A,Metcalf JA,Baseler M,Barbon C,Imamichi T,Lempicki R,Cosentino LM

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...

journal_title：BMC immunology

authors： Jia L,Wang Y,Li J,Li S,Zhang Y,Shen J,Tan W,Wu C

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as correlates of immunity during latent TB infection and further infer their...

journal_title：BMC immunology

authors： Alemnew B,Hoff ST,Abebe T,Abebe M,Aseffa A,Howe R,Wassie L

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in cap...

journal_title：BMC immunology

authors： Kim H,Darwish I,Monroy MF,Prockop DJ,Liles WC,Kain KC

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they can be found deposited extracellularly below the epithelial baseme...

journal_title：BMC immunology

authors： Stenman SM,Lindfors K,Korponay-Szabo IR,Lohi O,Saavalainen P,Partanen J,Haimila K,Wieser H,Mäki M,Kaukinen K

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:An ideal tumor vaccine should activate both effector and memory immune response against tumor-specific antigens. Beside the CD8+ T cells that play a central role in the generation of a protective immune response and of long-term memory, dendritic cells (DCs) are important for the induction, coordination and ...

journal_title：BMC immunology

authors： Cerkovnik P,Novakovic BJ,Stegel V,Novakovic S

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:Human Papillomavirus, HPV, is the main etiological factor for cervical cancer. Different studies show that in women infected with HPV there is a positive correlation between lesion grade and number of infiltrating macrophages, as well as with IL-10 higher expression. Using a HPV16 associated tumor model in m...

journal_title：BMC immunology

authors： Bolpetti A,Silva JS,Villa LL,Lepique AP

更新日期：2010-06-07 00:00:00

abstract：BACKGROUND:Pro-inflammatory cytokines can affect intracellular lipid metabolism. A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1beta (IL-1beta) reduces intracellular cholesterol levels in fibroblasts. Levels o...

journal_title：BMC immunology

authors： Persson J,Nilsson J,Lindholm MW

更新日期：2008-11-25 00:00:00

abstract：BACKGROUND:To understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1(-/-) mice that are resistant to spontaneous arthritis into BALB...

journal_title：BMC immunology

authors： Deng N,Jiao Y,Cao Y,Liu X,Ma Y,Hasty KA,Brand DD,Stuart JM,Gu W

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells has been used to preserve and standardize immunologic measurements for multicenter studies, however, effects of cryopreservation on cytokine responses are incompletely understood. In designing immunologic studies for a new multicenter birth cohort study ...

journal_title：BMC immunology

authors： Shreffler WG,Visness CM,Burger M,Cruikshank WW,Lederman HM,de la Morena M,Grindle K,Calatroni A,Sampson HA,Gern JE

更新日期：2006-12-12 00:00:00

abstract：BACKGROUND:Eosinophils are innate immune cells present in the intestine during steady state conditions. An intestinal eosinophilia is a hallmark of many infections and an accumulation of eosinophils is also observed in the intestine during inflammatory disorders. Classically the function of eosinophils has been associa...

journal_title：BMC immunology

authors： Forman R,Bramhall M,Logunova L,Svensson-Frej M,Cruickshank SM,Else KJ

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:Inappropriate activation of T lymphocytes plays an important role in perinatal complications. However, data on T lymphocyte activation markers of preterm infants is scarce. We investigated the association between gender, gestational and postnatal age, preeclampsia (PE), premature rupture of membranes (PROM) ...

journal_title：BMC immunology

authors： Sava F,Toldi G,Treszl A,Hajdú J,Harmath Á,Tulassay T,Vásárhelyi B

更新日期：2016-06-21 00:00:00