当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Neuroendocrine-thymus interactions. I. In vitro modulation of thymic factor secretion by thyroid hormones.

Neuroendocrine-thymus interactions. I. In vitro modulation of thymic factor secretion by thyroid hormones.

Abstract：

:Several in vivo experimental and clinical studies suggest that the production of thymic hormones, such as thymulin (Zn-FTS), is modulated by thyroid hormones. It was not determined in these studies, however whether such modulation is exerted directly on the thymic epithelial cells which synthesize and secrete thymic hormones. In order to discriminate between direct and indirect modulation, the effect of thyroid hormones on the in vitro production of thymulin by whole thymic organ culture, as detected by the rosette inhibition assay, has been investigated. Donors of thymuses were young 6N-propyl-2 thiouracil (PTU)-treated hypothyroid Balb/c mice and normal littermates. Thymuses from hypothyroid mice were shown to produce concentrations in vitro nearly undetectable of thymic hormone, when compared to thymuses from normal mice. The in vitro addition of triiodothyronine (T3) caused a complete recovery of the thymic hormone production by thymuses from hypothyroid mice and an increased synthesis even by normal thymuses over control values. The complete blockade of in vitro thymic hormone production with cycloheximide, which inhibits mRNA and protein synthesis but not thyroid hormone permissive actions, suggests that the T3 induced increment of thymic hormone level in the supernatant is due to de novo synthesis. Furthermore, the number of thymulin-producing cells, as detected by immunofluorescence using a specific antithymulin monoclonal antibody, which is quite low in thymuses from hypothyroid mice, is completely regained after in vitro incubation with T3. These findings support the idea that the modulation of thyroid hormones on thymic endocrine activity is directly exerted at thymic level.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Mocchegiani E,Amadio L,Fabris N

doi

10.1007/BF03349524

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

139-47

issue

2

eissn

0391-4097

issn

1720-8386

journal_volume

13

pub_type

杂志文章

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • 25-Hydroxycholecalciferol as an antagonist of adverse corticosteroid effects on phosphate and calcium metabolism in man.

    abstract：:The present study was performed in 30 patients who needed steroid therapy: courses of triamcinolone or DTM 8-15 given orally lasted 30 days. In 15 of these patients glucoactive corticosteroids were administered in combination with 5 micrograms/day of 25OH-vitamin D3 (25OHD3). 47Calcium oral test and 99mTc-MDP kinetics...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348448

    authors： Nuti R,Vattimo A,Turchetti V,Righi G

    更新日期：1984-10-01 00:00:00

  • Adverse effects of media reports on the treatment of osteoporosis.

    abstract：PURPOSE:The review focused on the role that media reporting plays in the level of public awareness about osteoporosis and its influence on osteoporosis treatment decisions. METHODS:We reviewed the literature on the role of media on three main aspects influencing patient adherence to osteoporosis treatment: the awarene...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40618-018-0898-9

    authors： Cipriani C,Pepe J,Minisola S,Lewiecki EM

    更新日期：2018-12-01 00:00:00

  • Impairment of AVP regulation in 17alpha-hydroxylase deficiency, a unique form of adrenal insufficiency.

    abstract：:17alpha-hydroxylase deficiency (17alpha-OHDS) results in decreased production of cortisol and sex steroids and hypokalemia secondary to excess mineralocorticoids. It has long been known that glucocorticoid deficiency is associated with impaired urinary dilution and increased secretion of vasopressin (AVP). On the othe...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345089

    authors： Leal AM,Elias PC,Moreira AC

    更新日期：2002-07-01 00:00:00

  • Presence of endothelin-1 in the normal and pathological human thyroid.

    abstract：:An immunohistochemical study with two rabbit polyclonal antibodies I-AR76 and CA-08-351 against Endothelin-1 (ET-1) was performed in 133 human thyroid specimens: 5 normal thyroids, 30 multinodular goiters (15 toxic and 15 nontoxic), 20 Graves' diseases, 5 Hashimoto's thyroiditis, 26 adenomas (6 Hürthle cell, 16 toxic ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347834

    authors： Lenziardi M,Viacava P,Fiorini I,Castagna M,Nardini V,Pollina L,De Negri F,Goletti O,Di Coscio G,Bevilacqua G

    更新日期：1995-05-01 00:00:00

  • Fasting and post-prandial glycemia and their correlation with glycated hemoglobin in Type 2 diabetes.

    abstract：OBJECTIVE:The relative contribution of fasting and post-prandial glucose to glycated hemoglobin (HbA1c) is controversial. In the present study, we assessed the relationship with HbA1c of fasting and post-prandial glucose measured in a more naturalistic setting, through home glucose self-monitoring or with a continuous ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03344161

    authors： Monami M,Lamanna C,Lambertucci L,Longo R,Cocca C,Addante F,Lotti E,Masotti G,Marchionni N,Mannucci E

    更新日期：2006-07-01 00:00:00

  • Enhanced iodine concentrating capacity by the mammary gland in iodine deficient lactating women of an endemic goiter region in Sicily.

    abstract：:Iodine balance during pregnancy and lactation was investigated by measuring iodine concentration in the urine of 11 pregnant women, born and living in a moderately iodine deficient endemic goiter area in Northeastern Sicily, collected during the last week of pregnancy, and between the 5th and 7th day after delivery, a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348681

    authors： Vermiglio F,Lo Presti VP,Finocchiaro MD,Battiato S,Grasso L,Ardita FV,Mancuso A,Trimarchi F

    更新日期：1992-02-01 00:00:00

  • Lack of association between autonomously functioning thyroid nodules and germline polymorphisms of the thyrotropin receptor and Gαs genes in a mild to moderate iodine-deficient Caucasian population.

    abstract：BACKGROUND:Mutations of the thyrotropin receptor (TSHR) and/or Gαs gene have been found in a number of, but not all, autonomously functioning thyroid nodules (AFTNs). Recently, in a 15-year-old girl with a hyperfunctioning papillary thyroid carcinoma, we found two somatic and germline single nucleotide polymorphisms (S...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-014-0081-x

    authors： Vicchio TM,Giovinazzo S,Certo R,Cucinotta M,Micali C,Baldari S,Benvenga S,Trimarchi F,Campennì A,Ruggeri RM

    更新日期：2014-07-01 00:00:00

  • Parathyroidectomy slows renal function decline in patients with primary hyperparathyroidism.

    abstract：PURPOSE:Primary hyperparathyroidism has deleterious effects on health and causes nephrolithiasis and osteoporosis. However, it remains unclear whether parathyroidectomy benefits kidney function among patients with primary hyperparathyroidism. METHODS:In this retrospective study, patients with primary hyperparathyroidi...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-020-01369-4

    authors： Liang CC,Yeh HC,Lo YC,Chou CY,Yen TH,Tsai HC,Hsu SP,Kuo CC

    更新日期：2020-07-29 00:00:00

  • P53 mutations in thyroid carcinoma: tidings from an old foe.

    abstract：:The underlying mechanism leading to carcinogenesis involves genomic instability, likely related to aneuploidy. While p53 as a "guardian of the genome" is an appealing candidate as an initiator of genomic instability, its mutations or deletions usually occur late in the course of tumor progression. P53 may, however, be...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03343889

    authors： Farid NR

    更新日期：2001-07-01 00:00:00

  • Female pseudohermaphroditism and inefficient peak bone mass in an untreated subject affected by 21-hydroxylase congenital adrenal hyperplasia.

    abstract：:Here we describe a subject with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-CAH), in its classical virilizing form, who presented at birth ambiguous genitalia and subsequently was assigned by the parents as male. At the age of 8 years, he underwent a two-step surgical correction of hypospadia a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343729

    authors： Valentino R,Savastano S,Tommaselli AP,Dorato M,Scarpitta MT,Calvanese E,Del Puente A,Lombardi G

    更新日期：2000-05-01 00:00:00

  • Remission of acromegaly after treatment withdrawal in patients controlled by cabergoline alone or in combination with octreotide: results from a multicenter study.

    abstract：PURPOSE:Remission of acromegaly has been reported after somatostatin analogs withdrawal, but not after withdrawal of combination therapy with cabergoline, and only in case reports of patients controlled by cabergoline alone. METHODS:To establish the remission rates (normal IGF-1 for age/sex: IGF-1 ≤ 1.00 xULN) after w...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s40618-016-0595-5

    authors： Casagrande A,Bronstein MD,Jallad RS,Mota JI,Tabet A,Abucham J

    更新日期：2017-05-01 00:00:00

  • Non-invasive and real-time proliferative activity estimation based on a quantitative radiomics approach for patients with acromegaly: a multicenter study.

    abstract：BACKGROUND:Proliferative activity prediction is important for determining individual treatment strategies for patients with acromegaly, and tumor proliferative activity is usually measured by the expression of Ki-67. OBJECTIVE:This study aimed to assess the value of a magnetic resonance imaging (MRI)-based radiomics a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-019-01159-7

    authors： Fan Y,Chai Y,Li K,Fang H,Mou A,Feng S,Feng M,Wang R

    更新日期：2020-06-01 00:00:00

  • Endemic goiter in Morocco (Skoura-Toundoute areas in the high atlas).

    abstract：:Endemic goiter in Morocco is localized in the Rif and Atlas mountains. In this study, performed in the Skoura-Toundoute areas (high Atlas), we demonstrate that iodine deficiency is the main factor involved in the development of endemic goiter. However it may not constitute the only etiological factor. The median urina...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345821

    authors： Aquaron R,Zarrouck K,el Jarari M,Ababou R,Talibi A,Ardissone JP

    更新日期：1993-01-01 00:00:00

  • A multimodality therapeutic approach in anaplastic thyroid carcinoma: study on 39 patients.

    abstract：:The aim of this study was to investigate the role of multimodality treatment in patients with anaplastic thyroid carcinoma. From 1992 to 1999, 39 consecutive patients with a histologically or cytologically proven anaplastic thyroid carcinoma were referred to the Thyroid Center of Padua General Hospital. There were 28 ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345066

    authors： Busnardo B,Daniele O,Pelizzo MR,Mazzarotto R,Nacamulli D,Devido D,Mian C,Girelli ME

    更新日期：2000-12-01 00:00:00

  • Spontaneous regression of hypercalcemia in a patient with primary hyperparathyroidism and prolactinoma.

    abstract：:We describe a unique case of spontaneous resolution of hyperparathyroidism in a lady with combined parathyroid adenoma and prolactinoma, raising the possibility of underlying multiple endocrine neoplasia (MEN) 1 syndrome. We also discuss the mechanism and natural history of such spontaneous remission. ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345292

    authors： Baskar V,Kamalakannan D,Singh BM,Odum J

    更新日期：2004-05-01 00:00:00

  • Chronic stress causes neuroendocrine-immune disturbances without affecting renal vitamin D metabolism in rats.

    abstract：INTRODUCTION:Vitamin D (VD) insufficiency has been repeatedly observed in the medical conditions associated with inflammation, such as cardiovascular disease, diabetes and depression. However, contrasting to the observational evidence, randomized trials of VD supplementation failed to demonstrate such link. Given the r...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-014-0191-5

    authors： Jiang P,Zhang L,Zhu W,Li H,Dang R,Tang M

    更新日期：2014-11-01 00:00:00

  • Long-term follow-up of patients with hyperthyroidism due to Graves' disease treated with methimazole. Comparison of usual treatment schedule with drug discontinuation vs continuous treatment with low methimazole doses: a retrospective study.

    abstract：:Antithyroid drugs may be proposed as the firstline therapy for hyperthyroidism due to Graves' disease since some patients undergo prolonged remission after drug withdrawal. On the other hand, some studies, though controversial, indicated that methimazole (MMI) has some immunomodulating activity. We retrospectively ana...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346433

    authors： Mazza E,Carlini M,Flecchia D,Blatto A,Zuccarini O,Gamba S,Beninati S,Messina M

    更新日期：2008-10-01 00:00:00

  • Leptin, insulin and TNF-alpha in weight loss.

    abstract：:Forty-eight morbidly obese patients were placed on a very low calorie (800 kcal) formula diet (OPTIFAST) for a 10-week period with the goal of achieving 10% weight loss within this time. Weekly serum leptin measurements were performed to determine whether changes in this adipose protein would serve as a useful marker ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343943

    authors： Xenachis C,Samojlik E,Raghuwanshi MP,Kirschner MA

    更新日期：2001-12-01 00:00:00

  • Recombinant human thyroid-stimulating hormone (rhTSH): clinical development.

    abstract：:Recombinant human thyroid-stimulating hormone (rhTSH) was developed to safely provide exogenous TSH stimulation in patients on thyroid hormone suppression therapy (THST), which is integral to long-term management of well-differentiated thyroid cancer. Such stimulation allows detection of thyroid remnant and neoplastic...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Incerti C

    更新日期：1999-01-01 00:00:00

  • Concentrations of somatomedin-C and triiodothyronine in patients with thyroid dysfunction and nonthyroidal illnesses.

    abstract：:We studied the possibility of an association between serum somatomedin-C (Sm-C) and thyroid hormone concentrations. For this purpose 34 hyperthyroid patients, 39 patients with primary hypothyroidism, 36 patients with severe nonthyroidal illnesses (NTI), and 63 euthyroid healthy control subjects were examined. The mean...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349528

    authors： Välimäki M,Liewendahl,Karonen SL,Helenius T,Suikkari AM

    更新日期：1990-02-01 00:00:00

  • Raloxifene: bone and cardiovascular effects.

    abstract：:Raloxifene (RLX), a selective estrogen receptor modulator (SERM), is currently indicated for the prevention and treatment of post-menopausal osteoporosis. At present, RLX is evaluated in other areas of study that include the reduction of the risk of breast cancer and cardiovascular (CV) disease in post-menopausal wome...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Francucci CM,Romagni P,Boscaro M

    更新日期：2005-01-01 00:00:00

  • Dyshormonogenetic goiter: presence of an inhibitor of normal human thyroid peroxidase.

    abstract：:A dialyzable, thermostable inhibitor of normal thyroid peroxidase (TPO), with UV absorption maximum at 250-260 nm, was found in the digitonized, washed particulate fraction of two dyshormonogenetic goiters. No intrinsic TPO iodide-oxidation activity was detectable in either of these goiters, and their TPO iodination a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349651

    authors： Rosenthal D,Carvalho-Guimarães DP,Knobel M,Medeiros-Neto GA

    更新日期：1990-12-01 00:00:00

  • Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome.

    abstract：BACKGROUND:Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. OBJECTIVE:To investigate the possible differences of pl...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346300

    authors： Filippatos TD,Derdemezis CS,Kiortsis DN,Tselepis AD,Elisaf MS

    更新日期：2007-04-01 00:00:00

  • Primary hyperparathyroidism in pregnancy: observations from the Indian PHPT registry.

    abstract：PURPOSE:To present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years. METHODS:We retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-020-01441-z

    authors： Pal R,Bhadada SK,Gupta N,Behera A,Aggarwal N,Aggarwal A,Raviteja KV,Saikia UN,Kaur G,Arvindbhai SM,Walia R

    更新日期：2020-10-09 00:00:00

  • Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology.

    abstract：OBJECTIVE:We developed clinical practice guidelines to assess the individual risk-benefit profile of androgen replacement therapy in adult male hypogonadism (HG), defined by the presence of specific signs and symptoms and serum testosterone (T) below 12 nmol/L. PARTICIPANTS:The task force consisted of eight clinicians...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40618-014-0155-9

    authors： Isidori AM,Balercia G,Calogero AE,Corona G,Ferlin A,Francavilla S,Santi D,Maggi M

    更新日期：2015-01-01 00:00:00

  • Testosterone, body composition and aging.

    abstract：:In addition to growth hormone (GH), sex hormones are important determinants of body composition. Aging is accompanied by a decrease in free testosterone levels and, as BMI as well as fat mass increase with age (with a redistribution of body fat), whereas muscle mass decreases, it is tempting to attribute a causal role...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Vermeulen A,Goemaere S,Kaufman JM

    更新日期：1999-01-01 00:00:00

  • Intake of seaweed as part of a single sushi meal, iodine excretion and thyroid function in euthyroid subjects: a randomized dinner study.

    abstract：OBJECTIVE:Globalisation has extended to the kitchen and the Asian cuisine has gained international popularity with sushi and seaweed now being widespread. We explored the possible acute adverse effects of an iodine load from a single sushi-and-seaweed meal as seaweed iodine may induce thyroid dysfunction. METHODS:Nine...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40618-019-01122-6

    authors： Noahsen P,Kleist I,Larsen HM,Andersen S

    更新日期：2020-04-01 00:00:00

  • Usefulness of a chromatographic method to detect circulating antithyroid hormone autoantibodies in canine serum.

    abstract：:Antithyroid hormone autoantibodies (THBA), described in both humans and animals, result in variable interference when thyroid hormone plasma levels are measured by immunoassays. We previously described a quick chromatographic method to detect circulating THBA in humans. In the present experience, we applied the method...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347880

    authors： Savastano S,Tommaselli AP,Valentino R,Dorato M,Scarpitta MT,Persechino A,Ciaramella P,Lombardi G

    更新日期：1996-12-01 00:00:00

  • Cardiac structure and functions in patients with asymptomatic primary hyperparathyroidism.

    abstract：BACKGROUND:The data about cardiovascular (CV) changes in patients with asymptomatic primary hyperparathyroidism (PHPT) are scarce. AIM:The aim of this study is to compare cardiac structure and functions in patients with asymptomatic PHPT and controls by using tissue Doppler echocardiography. SUBJECTS AND METHODS:Thir...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/8961

    authors： Aktas Yılmaz B,Akyel A,Kan E,Ercin U,Tavil Y,Bilgihan A,Cakır N,Arslan M,Balos Toruner F

    更新日期：2013-11-01 00:00:00

  • A preliminary study: proteomic analysis of exosomes derived from thyroid-stimulating hormone-stimulated HepG2 cells.

    abstract：BACKGROUND:Thyroid-stimulating hormone (TSH) plays an important role in the regulation of lipid metabolism. However, little is known about the role that exosomes play in the process of TSH-induced lipotoxicity in non-alcoholic fatty liver disease (NAFLD). As a preliminary step, the present study set out to investigate ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-020-01210-y

    authors： Ma S,Shao S,Yang C,Yao Z,Gao L,Chen W

    更新日期：2020-09-01 00:00:00