Abstract:
:Antithyroid drugs may be proposed as the firstline therapy for hyperthyroidism due to Graves' disease since some patients undergo prolonged remission after drug withdrawal. On the other hand, some studies, though controversial, indicated that methimazole (MMI) has some immunomodulating activity. We retrospectively analyzed 384 consecutive patients newly diagnosed with Graves' disease in the years 1990-2002 to ascertain whether long-term therapy with low doses of MMI may prevent relapse of thyrotoxicosis. Two hundred and forty-nine patients were included in our study. The date of reduction of MMI dose to 5 mg/day was considered time 0 for survival analysis. In 121 MMI was discontinued in less than 15 months after time 0 (group D), while in the remaining 128 a daily MMI 2.5-5 mg dose was maintained (group M). One hundred and thirty-five patients were excluded for inadequate response to MMI, relapse of thyrotoxicosis that could be related to an improper withdrawal or reduction of MMI, inadequate or too short followup, iodide contamination, steroid or interferon therapy, pregnancy or post-partum. D and M groups did not differ for clinical and hormonal parameters except age, which was lower in D (p=0.019). Age > vs < 35 yr was relevant in survival analysis; therefore patients were divided in 2 groups according to this age cut-off. In younger patients relapse of thyrotoxicosis occurred in 15 patients of group D 2.4-39.6 months (median 19.0) after time 0, and 8 M after 5.9-40.0 (21.3) months, while 14 D and 5 M maintained euthyroidism until the end of the observation after 31.8-95.3 (56.6) months and 30.4-62.1 (46.5) months, respectively. Survival analysis indicated that the risk of relapse was similar in group D and M. In older patients relapse of thyrotoxicosis occurred in 40 patients of group D after 8.2-65.8 (25.4) months and 29 M after 5.8-62.5 (22.4) months, while 52 D and 86 M maintained euthyroidism until the end of the observation, 20.1-168.0 (46.7) months and 24.1-117.4 (53.4) months respectively. Survival analysis indicated that the risk of relapse was increased in group D. Therefore long-term treatment with low doses of MMI seems to prevent relapse in Graves' disease in patients above 35 yr of age. This should be confirmed in a prospective study.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Mazza E,Carlini M,Flecchia D,Blatto A,Zuccarini O,Gamba S,Beninati S,Messina Mdoi
10.1007/BF03346433subject
Has Abstractpub_date
2008-10-01 00:00:00pages
866-72issue
10eissn
0391-4097issn
1720-8386pii
5009journal_volume
31pub_type
杂志文章abstract::Silver-Russell syndrome (SRS) is both clinically and genetically a heterogeneous congenital disorder. Patients are characterised by severe intrauterine and post-natal growth retardation, dysmorphic facial features and, asymmetry. Various chromosome abnormalities have been associated with the disease, involving most of...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
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journal_title:Journal of endocrinological investigation
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abstract::Liver function is well maintained with increasing age. The aim of our study was to investigate if long-term moderate ( journal_title:Journal of endocrinological investigation pub_type: 临床试验,杂志文章 doi: 更新日期:2005-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
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doi:10.1007/BF03349569
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abstract::Cimetidine, an H2 receptor antagonist, is a potent stimulant of PRL secretion in normal women. In the present study, the PRL response to cimetidine was studied in 34 normal pregnant women and their fetuses during labor. Serum maternal PRL levels increased significantly after the acute iv injection of 400 mg cimetidine...
journal_title:Journal of endocrinological investigation
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doi:10.1007/BF03350225
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abstract::To assess the role of the renin-angiotensin system in the control of aldosterone reease in response to heat exposure, 6 sodium restricted subjects were studied on three random experimental days: a control day and two heat exposure days (46C, 35 mbar, 90 min) with and without propranolol. Plasma aldosterone, renin acti...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample prepa...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
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更新日期:2013-04-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-015-0265-z
更新日期:2015-09-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350319
更新日期:1998-02-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347683
更新日期:1993-09-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-020-01439-7
更新日期:2020-10-07 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348241
更新日期:1980-04-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343715
更新日期:2000-04-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346863
更新日期:1991-07-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343544
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:The review focused on the role that media reporting plays in the level of public awareness about osteoporosis and its influence on osteoporosis treatment decisions. METHODS:We reviewed the literature on the role of media on three main aspects influencing patient adherence to osteoporosis treatment: the awarene...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-018-0898-9
更新日期:2018-12-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348448
更新日期:1984-10-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
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更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,多中心研究
doi:10.1007/s40618-016-0604-8
更新日期:2017-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8959
更新日期:2013-11-01 00:00:00
abstract::Cushing's Syndrome (CS) may sometimes lead to dilated cardiomyopathy, even though this condition can be partially or completely reversed after treatment. In this article we report the case of a 28-yr-old woman with CS secondary to adrenal adenoma who exhibited congestive heart failure as an initial symptom. Two weeks ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346339
更新日期:2007-06-01 00:00:00
abstract::The AA. studied the glycometabolic activity of prazosin, a hypotensive drug with an adrenergic blocking activity of alpha-1-selective type. Twenty-two moderately hypertensive subjects were studied. Their ages ranged from 37 to 57 years; 10 of the patients had non-insulin dependent diabetes mellitus. After overnight fa...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF03350608
更新日期:1983-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-015-0327-2
更新日期:2016-01-01 00:00:00
abstract::Plasma insulin immunoreactivity (IRI) results from high molecular weight substances with insulin immunoreactivity (HWIRI), proinsulin (PI) and insulin (I). Their respective concentrations and percentages of IRI were determined preoperatively in the hepatic and peripheral circulations and after surgery in the latter tw...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350520
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVE:To investigate the inflammatory markers in polycystic ovary syndrome (PCOS) and associations of these markers with obesity and in vitro fertilization (IVF) outcomes. METHODS:A total of 292 women underwent IVF procedure either with PCOS (n = 146) or without PCOS (n = 146, age, and body mass index (BMI) matche...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-016-0446-4
更新日期:2016-08-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03347217
更新日期:2005-05-01 00:00:00
abstract::An equimolar mixture of 3H-E1-S2 and 14C-E1 was injected in one shot into the inferior vena cava near the heart of female Japanese monkey. Following the injection, blood was collected from the aortic arch at intervals of 15 s over a period of 10 min. The concentration of radioactivities in the whole blood and serum wa...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348447
更新日期:1984-10-01 00:00:00
abstract::Unfortunately, the author name and his affiliation were published in the original publication. They have now been removed. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,已发布勘误
doi:10.1007/s40618-019-01012-x
更新日期:2019-02-01 00:00:00