Abstract:
:Hypoxia in human tumors is associated with poor prognosis, but the molecular mechanisms underlying this association are poorly understood. One possibility is that hypoxia is linked to malignant progression through vascular endothelial growth factor (VEGF) induction and the associated angiogenesis and metastasis. The present clinical study measures hypoxia and VEGF expression on a cell-by-cell basis in human squamous cell carcinomas to test the hypothesis that hypoxia and VEGF protein expression are coupled in human tumors. Eighteen patients with invasive squamous cell carcinoma of the uterine cervix and head and neck have been investigated by a quantitative image analysis of immunostained sections from their tumors. The hypoxia marker pimonidazole was used to measure tumor hypoxia, and a commercially available antibody was used to measure VEGF protein expression. A quantitative immunohistochemical comparison of hypoxia and VEGF protein expression revealed no correlation between the two factors.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Raleigh JA,Calkins-Adams DP,Rinker LH,Ballenger CA,Weissler MC,Fowler WC Jr,Novotny DB,Varia MAsubject
Has Abstractpub_date
1998-09-01 00:00:00pages
3765-8issue
17eissn
0008-5472issn
1538-7445journal_volume
58pub_type
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