Abstract:
:Nitric oxide (NO) is involved in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity. Depending on the redox state of NO, it can act as a neurotoxin or it can have a neuroprotective action. Data suggest that NO may have a role in the pathogenesis of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease. Additionally, these data indicate that inhibitors of the NO-synthesising enzyme, NO synthase, may be useful as neuroprotective agents in these diseases. In animal models, NOS inhibitors have been shown to prevent the neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and other dopaminergic toxins. However, the clinical effects of NOS inhibitors remain unknown.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Molina JA,Jiménez-Jiménez FJ,Ortí-Pareja M,Navarro JAdoi
10.2165/00002512-199812040-00001subject
Has Abstractpub_date
1998-04-01 00:00:00pages
251-9issue
4eissn
1170-229Xissn
1179-1969journal_volume
12pub_type
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