The Role of Deprescribing in Older Adults with Chronic Kidney Disease.

abstract：:The atypical antipsychotics are a new class of agents with great promise for use in the elderly because of their reduced propensity to cause acute extrapyramidal adverse effects. Treatment of older patients with these agents, however, needs to take into consideration age-related changes in pharmacokinetics and the ris...

journal_title：Drugs & aging

authors： Sweet RA,Pollock BG

更新日期：1998-02-01 00:00:00

abstract：:The incidence of and mortality from both chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) increase with age. In addition, the average age of patients with COPD and CVD is also increasing as a result of improvements in both pharmacological and non-pharmacological treatments. Coronary artery...

journal_title：Drugs & aging

authors： Andrus MR,Loyed JV

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Falls are a primary cause of injury and disability in the nursing home environment and can be costly to treat. We propose a taxonomy of nursing home falls that accounts for both the severity of fall consequences and the duration of the treatment episode. No other systematic approach of this kind has been pre...

journal_title：Drugs & aging

authors： Sorensen SV,de Lissovoy G,Kunaprayoon D,Resnick B,Rupnow MF,Studenski S

更新日期：2006-01-01 00:00:00

abstract：:Electronic storage of and access to medical data is becoming increasingly common. Advances in computer technology and telecommunications have made it possible to store vast amounts of information in databases and transmit this information rapidly to any place on the globe. At the forefront of this technology is the In...

journal_title：Drugs & aging

authors： Glowniak J

更新日期：1997-03-01 00:00:00

abstract：:Seasonal influenza causes significant morbidity and mortality in the elderly, the very young and those with chronic illness, despite the availability of effective vaccines. The mortality and morbidity attributed annually to seasonal influenza are small in comparison to the potential mortality and morbidity of a novel ...

journal_title：Drugs & aging

authors： Kasten MJ,Poland GA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...

journal_title：Drugs & aging

authors： Pariente A,Dartigues JF,Benichou J,Letenneur L,Moore N,Fourrier-Réglat A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Age-related changes in the concentration-effect relationship of (+)-O-desmethyl-tramadol [(+)-ODM], tramadol's active metabolite, are not documented in the elderly. OBJECTIVE:The objective of this study was to characterize, in elderly and young subjects, the (+)-ODM pharmacokinetic and pharmacodynamic relat...

journal_title：Drugs & aging

authors： Robertson SS,Mouksassi MS,Varin F

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Use of combination pharmacotherapy, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor antagonists (angiotensin receptor blockers) and β-adrenoceptor antagonists (β-blockers) in the management of heart failure (HF) can reduce mortality, prevent functional decline and red...

journal_title：Drugs & aging

authors： Foebel AD,Heckman GA,Hirdes JP,Tyas SL,Tjam EY,McKelvie RS,Maxwell CJ

更新日期：2011-07-01 00:00:00

abstract：:Despite a sharp decline in the incidence of gastric cancer during the second half of the 20th century, this malignancy remains the second leading cause of cancer mortality in the world. The incidence and mortality rate of gastric cancer increase with age; at present, the median ages at diagnosis are 67 years for men a...

journal_title：Drugs & aging

authors： Wagner AD,Wedding U

更新日期：2009-01-01 00:00:00

abstract：:Erectile dysfunction (ED) is a common medical condition that affects the sexual life of millions of men worldwide. First-line oral therapy for ED includes the use of phosphodiesterase type 5 inhibitors (sildenafil, tadalafil and vardenafil) and sublingual apomorphine. Apomorphine is a dopamine D(1) and D(2) receptor a...

journal_title：Drugs & aging

authors： Briganti A,Chun FK,Salonia A,Zanni G,Dehò F,Barbieri L,Karakiewicz PI,Rigatti P,Montorsi F

更新日期：2006-01-01 00:00:00

abstract：:The 2013 American College of Cardiology (ACC) and American Heart Association (AHA) practice guidelines for the treatment of blood cholesterol significantly changed the paradigm of how providers should prescribe statin therapy, especially for older adults. While the evidence supports statin therapy for older adults wit...

journal_title：Drugs & aging

authors： Weinberger Y,Han BH

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...

journal_title：Drugs & aging

authors： Harrison SL,Kouladjian O'Donnell L,Bradley CE,Milte R,Dyer SM,Gnanamanickam ES,Liu E,Hilmer SN,Crotty M

更新日期：2018-01-01 00:00:00

abstract：:Large bowel cancer is not only the third most frequent cancer in the world but is one of the most common human malignancies in Western countries, including North America. In recent years, multidisciplinary research in epidemiology, molecular biology, and laboratory animal model studies have contributed much to our und...

journal_title：Drugs & aging

authors： Reddy BS,Rao CV

更新日期：2000-05-01 00:00:00

abstract：:The scabies mite is an ectoparasite able to infest humans. Its clinical presentation is typical, although in immunocompromised, mentally retarded and elderly patients the clinical presentation may be altered. Diagnosis may therefore be difficult in such patient groups, who often reside in nursing homes. Because delay ...

journal_title：Drugs & aging

authors： Tjioe M,Vissers WH

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Patients hospitalised with severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2; coronavirus 2019 disease (COVID-19)] infection are frequently older with co-morbidities and receiving polypharmacy, all of which are known risk factors for drug-drug interactions (DDIs). The pharmacological burden may be ...

journal_title：Drugs & aging

authors： Cattaneo D,Pasina L,Maggioni AP,Giacomelli A,Oreni L,Covizzi A,Bradanini L,Schiuma M,Antinori S,Ridolfo A,Gervasoni C

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Because of co-morbidity, older persons are often exposed to use of an excessive number of drugs, which per se implies also use of inappropriate drugs or of potentially interacting drugs ('suboptimal prescribing'). Time trends of suboptimal prescribing in older, community dwellers have been poorly investigate...

journal_title：Drugs & aging

authors： Lapi F,Pozzi C,Mazzaglia G,Ungar A,Fumagalli S,Marchionni N,Geppetti P,Mugelli A,Di Bari M

更新日期：2009-01-01 00:00:00

abstract：:Elderly rheumatoid arthritis (RA) is classified into two clinical subsets, elderly-onset RA (EORA) and younger-onset elderly RA. With the improvement of life expectancy in the general population and advent of the super-aging society, the number of patients with EORA is anticipated to increase. Both large and small joi...

journal_title：Drugs & aging

authors： Sugihara T,Harigai M

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Our objectives were to (1) describe the evolution of the underuse of anticoagulants in older people with atrial fibrillation (AF) and a CHADS2 score ≥ 2 since direct oral anticoagulants (DOACs) were introduced to the market and (2) describe factors associated with this underuse. METHODS:We conducted a retros...

journal_title：Drugs & aging

authors： Henrard S,Vandenabeele C,Marien S,Boland B,Dalleur O

更新日期：2017-11-01 00:00:00

abstract：:Many quantities assayed in clinical laboratories demonstrate age-related changes. Particularly important periods are early life, adolescence, old age, and after the menopause in females. The changes that occur until adulthood are well documented. Fewer data are available on elderly people even though they consume a la...

journal_title：Drugs & aging

authors： Fraser CG

更新日期：1993-05-01 00:00:00

abstract：:Atrial fibrillation confers a 5-fold increase in risk of stroke. A number of drugs aimed at reducing this risk have been tested in randomized controlled trials. These include antiplatelet agents (singly and in combination); anticoagulants, including vitamin K antagonists and direct thrombin inhibitors; and anticoagula...

journal_title：Drugs & aging

authors： Mant J,Edwards D

更新日期：2010-11-01 00:00:00

abstract：:Primary hyperparathyroidism is a common metabolic bone disease and currently presents a significant management dilemma. Most of the patients have few relevant symptoms and surgical parathyroidectomy offers the prospect of cure with freedom from the risk of long-term complications or the need for a follow-up. However, ...

journal_title：Drugs & aging

authors： Sims R,Ubhi C,Hosking D

更新日期：2004-01-01 00:00:00

abstract：:It is inevitable that publicly funded, technically sophisticated medical treatments will be increasingly rationed. Other things being equal, there is a greater duty to use them to prolong the lives of younger than older people. Age is therefore an ethical rationing criterion. Denial of this may actually harm older peo...

journal_title：Drugs & aging

authors： Shaw AB

更新日期：1996-12-01 00:00:00

abstract：:New treatments and treatment protocols for diseases affecting the elderly are evolving as we strive to meet the needs of an aging society. To help you keep up to date with the latest advances worldwide on all aspects of drug therapy and patient management, this section of the journal brings you information selected fr...

journal_title：Drugs & aging

authors：

更新日期：2006-01-01 00:00:00

abstract：:Problems associated with aging will become one of the leading health dilemmas of the next century. Age-associated diseases, including those affecting the neuronal system, are increasing in frequency. Age-related deficiencies in the brain result in impaired motor functions, sleep, behaviour and cognitive functions. Goo...

journal_title：Drugs & aging

authors： Fülöp T Jr,Seres I

更新日期：1994-11-01 00:00:00

abstract：:Healthcare systems worldwide are facing an unprecedented demographic change as globally, the number of older people will triple to 2 billion by the year 2050. The resulting pressures on acute services have been instrumental in the development of intermediate care (IC) as a new healthcare model, which has its origins i...

journal_title：Drugs & aging

authors： Millar AN,Hughes CM,Passmore AP,Ryan C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE:The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors assoc...

journal_title：Drugs & aging

authors： Musich S,Wang SS,Slindee LB,Saphire L,Wicker E

更新日期：2018-05-01 00:00:00

abstract：:Psychotropic medications have a high risk of serious adverse events and small effect size for changed behaviours for people with dementia. Non-pharmacological approaches are recommended as first-line treatment for changed behaviours, yet psychotropic medications remain highly prevalent in long-term aged care settings....

journal_title：Drugs & aging

authors： Harrison SL,Cations M,Jessop T,Hilmer SN,Sawan M,Brodaty H

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Patient transitions, such as transfers between acute and long-term care (LTC), aposare times when the likelihood of communication failure between healthcare providers is increased. Employing appropriate health quality indicators helps support improvement efforts. To date, few quality indicators that evaluate...

journal_title：Drugs & aging

authors： Bell CM,Brener SS,Comrie R,Anderson GM,Bronskill SE

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Evidence regarding differences in outcomes between angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) among older nursing home (NH) residents after acute myocardial infarction (AMI) is limited. OBJECTIVES:The purpose of our study was to estimate the post-AMI effects...

journal_title：Drugs & aging

authors： Zullo AR,Riester MR,Erqou S,Wu WC,Rudolph JL,Steinman MA

更新日期：2020-10-01 00:00:00

abstract：:Age is a major source of variation in drug response. Social, medical and physiological heterogeneity intertwines to complicate geriatric pharmacotherapy. Inappropriate and excessive use of medication may be the most significant treatable health problem in the elderly. Older people are especially sensitive to antipsych...

journal_title：Drugs & aging

authors： Pollock BG,Mulsant BH

更新日期：1995-04-01 00:00:00