Abstract:
:Seasonal influenza causes significant morbidity and mortality in the elderly, the very young and those with chronic illness, despite the availability of effective vaccines. The mortality and morbidity attributed annually to seasonal influenza are small in comparison to the potential mortality and morbidity of a novel highly pathogenic human influenza A virus strain. The current influenza A/H5N1 virus that has caused epidemics in poultry and is evolving to find new niches needs only to become more efficiently transmitted from human to human to cause the next pandemic. Vaccination is the intervention with the potential to save the most lives when a pandemic occurs. Pandemic awareness and preparedness are essential to decrease the predicted chaos, death and illness arising from the next influenza pandemic.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Kasten MJ,Poland GAdoi
10.2165/00002512-200825030-00001subject
Has Abstractpub_date
2008-01-01 00:00:00pages
179-86issue
3eissn
1170-229Xissn
1179-1969pii
2531journal_volume
25pub_type
杂志文章相关文献
DRUGS & AGING文献大全abstract:BACKGROUND:Medicines are potentially modifiable risk factors for postoperative delirium. However, the extent to which preoperative medicines are included in risk prediction models (RPMs) is unknown. OBJECTIVE:This systematic review aimed to assess the extent of inclusion of preoperative medications in RPMs for postope...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-018-0526-6
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Despite evidence of effective combination drug therapy for secondary prevention of coronary heart disease (CHD), older adults with this condition remain undertreated. OBJECTIVE:To describe time trends (1992-2003) in the adoption of combination cardiac drug therapies (beta-blockers [beta-adrenoceptor antagon...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11532150-000000000-00000
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:In response to concerns about, and issues pertaining to, medication use practices in residential aged-care facilities (RACFs), the Australian Pharmaceutical Advisory Council (APAC) established a working party on quality use of medicines (QUM) in nursing homes and hostels. The APAC is a representative ministe...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421120-00005
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Over three-quarters of the older population take medications that can potentially cause dry mouth. Physicians or pharmacists rarely inform patients about this adverse effect and its potentially severe damage to the teeth, mouth and general health. OBJECTIVES:The objectives of this study were to (1) identify...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-013-0141-5
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-017-0513-3
更新日期:2018-01-01 00:00:00
abstract::Sleep problems are an under-emphasised cause of disability in Parkinson's disease (PD) and may be seen independently of PD, associated with primary PD pathology, or as a result of antiparkinsonian medications. Common sleep disorders include excessive daytime sleepiness, rapid eye movement (REM) sleep behaviour disorde...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219100-00002
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Our objectives were to (1) describe the evolution of the underuse of anticoagulants in older people with atrial fibrillation (AF) and a CHADS2 score ≥ 2 since direct oral anticoagulants (DOACs) were introduced to the market and (2) describe factors associated with this underuse. METHODS:We conducted a retros...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-017-0493-3
更新日期:2017-11-01 00:00:00
abstract::Despite the availability of angiotensin converting enzyme (ACE) inhibitors for patients with congestive heart failure (CHF), mortality and morbidity remains unacceptably high. CHF is thought to progress as a result of activation of endogenous neurohormonal systems which are activated by the initial myocardial injury. ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200016010-00001
更新日期:2000-01-01 00:00:00
abstract::Behavioural disturbances, also termed neuropsychiatric symptoms, are a frequent clinical feature of dementia in Alzheimer's disease (AD). Many AD patients receive treatment with cholinesterase inhibitors (ChEIs). This review examines the evidence for behavioural effects of the four ChEIs that have been approved for th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200623120-00003
更新日期:2006-01-01 00:00:00
abstract::Cutaneous adverse drug reactions comprise a significant proportion of all adverse drug reactions. They may mimic other dermatologic or systemic illnesses and may cause significant morbidity or mortality. Seven morphologic groups encompass the most commonly encountered cutaneous drug reaction syndromes: exanthematous (...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-017-0483-5
更新日期:2017-09-01 00:00:00
abstract::The alcohol withdrawal syndrome is common in elderly individuals who are alcohol dependent and who decrease or stop their alcohol intake. While there have been few clinical studies to directly support or refute the hypothesis that withdrawal symptom severity, delirium and seizures increase with advancing age, several ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199914060-00002
更新日期:1999-06-01 00:00:00
abstract::Aflibercept is a fully human, recombinant fusion protein that acts as a soluble decoy receptor for vascular endothelial growth factor (VEGF) family members, including VEGF-A, VEGF-B and placental growth factor (P1GF), thereby inhibiting downstream signalling mediated by these ligands. Aflibercept binds all isoforms of...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-014-0176-2
更新日期:2014-05-01 00:00:00
abstract::Nadroparin (nadroparin calcium) is a low molecular weight heparin with a mean molecular weight of 4.5 kD. Compared with unfractionated heparin (UFH), nadroparin has a greater ratio of anti-factor Xa to anti-factor Ha activity, greater bioavailability and a longer duration of action, allowing it to be administered by s...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199710040-00006
更新日期:1997-04-01 00:00:00
abstract::Streptococcus pneumoniae has been recognised as a major cause of pneumonia since the time of Sir William Osler. Drug-resistant S. pneumoniae (DRSP), which have gradually become resistant to penicillins as well as more recently developed macrolides and fluoroquinolones, have emerged as a consequence of indiscriminate u...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421130-00003
更新日期:2004-01-01 00:00:00
abstract::Healthcare systems worldwide are facing an unprecedented demographic change as globally, the number of older people will triple to 2 billion by the year 2050. The resulting pressures on acute services have been instrumental in the development of intermediate care (IC) as a new healthcare model, which has its origins i...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-013-0133-5
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The impact of multiple medication exposure on health outcomes among older patients with end-stage kidney disease (ESKD) is unknown. OBJECTIVE:The objective of this study was to identify the impact of medicine exposure on hospitalisation rates and mortality in a prospective longitudinal observational study o...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0582-y
更新日期:2018-11-01 00:00:00
abstract::It is inevitable that publicly funded, technically sophisticated medical treatments will be increasingly rationed. Other things being equal, there is a greater duty to use them to prolong the lives of younger than older people. Age is therefore an ethical rationing criterion. Denial of this may actually harm older peo...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-199609060-00003
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Increased life expectancy is associated with an increased prevalence of chronic diseases and drug consumption. Changes often occur in the medication regimen after hospitalization. The extent and nature of these changes and the adherence of elderly patients have not yet been fully investigated. OBJECTIVE:To ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825100-00005
更新日期:2008-01-01 00:00:00
abstract::The atypical antipsychotics are a new class of agents with great promise for use in the elderly because of their reduced propensity to cause acute extrapyramidal adverse effects. Treatment of older patients with these agents, however, needs to take into consideration age-related changes in pharmacokinetics and the ris...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812020-00004
更新日期:1998-02-01 00:00:00
abstract::Pharmacological treatment of depression in old age is associated with an increased risk of adverse pharmacokinetic and pharmacodynamic drug interactions. Elderly patients may have multiple disease states and, therefore, may require a variety of other drugs. In addition to polypharmacy, other factors such as age-relate...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219040-00004
更新日期:2002-01-01 00:00:00
abstract::Prostate cancer is a common disease in the elderly, and the number of older prostate cancer patients will probably increase with both the aging of the population and the increased rate of screening. In elderly patients with several co-morbidities, cancer management can be complex, and the risk of administering toxic t...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11537480-000000000-00000
更新日期:2010-09-01 00:00:00
abstract::The fluoroquinolones are antibiotics frequently used in infections that affect elderly individuals. The physiological aging process can profoundly affect the pharmacokinetics of drugs, necessitating adjustment of dosage regimens in the elderly. Changes in pharmacokinetics with age are mainly due to the progressive det...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199101040-00004
更新日期:1991-07-01 00:00:00
abstract::Donepezil (E-2020) is a reversible, noncompetitive, piperidine-type cholinesterase inhibitor. It is selective for acetylcholinesterase rather than butyrylcholinesterase. Donepezil 5 and 10 mg/day significantly improved cognition and global clinical function compared with placebo in well designed short term trials (14 ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200016030-00005
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:The use of proton pump inhibitors (PPIs) in older adults is high, often inappropriate, and may cause harm. Deprescribing is defined as the reduction, withdrawal, or discontinuation of inappropriate medication. OBJECTIVE:We conducted a systematic review to determine the effectiveness of interventions to depr...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-017-0442-1
更新日期:2017-04-01 00:00:00
abstract::NSAIDs are a widely used class of analgesic and anti-inflammatory drugs that act by inhibiting the cyclo-oxygenase (COX) enzyme. However, because of their nonspecificity of action, use of these agents as long-term therapy for chronic pain in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA) is often d...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724060-00001
更新日期:2007-01-01 00:00:00
abstract::The prevalence of neuropathic pain in the older population has been reported to be very high and is most commonly localized to a circumscribed area. Treatment failure is frequent in neuropathic pain and is accompanied by central side effects with recommended oral drugs acting on the central nervous system. A number of...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00739-9
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Poor medication adherence is a major public health problem in older adults often resulting in negative health outcomes. OBJECTIVE:The objective of this review was to provide an updated summary of evidence from randomized controlled studies to determine whether interventions aimed at improving medication adh...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-016-0433-7
更新日期:2017-03-01 00:00:00
abstract::A low bone mineral density (BMD) is presently regarded as the most important risk factor for the development of osteoporosis. BMD is a function of peak bone mass attained during growth and subsequent age-related bone loss. BMD can be measured accurately and precisely, although the rate of bone loss is more difficult t...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812001-00001
更新日期:1998-01-01 00:00:00
abstract::Antidepressants have long been recognized as a contributory factor to falls and many studies show an association between antidepressants and falls. There are extensive data for tricyclic antidepressants (TCAs) and related drugs, and for selective serotonin reuptake inhibitors (SSRIs), but few data for other classes of...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200926050-00002
更新日期:2009-01-01 00:00:00
abstract::While hormonal therapy has been the usual and appropriate treatment of advanced or metastatic prostatic cancer for the past 50 years, the recent development of new therapeutic agents as medical alternatives to orchidectomy has drastically altered the options and perspectives in the treatment of this disease. Estrogens...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199101050-00003
更新日期:1991-09-01 00:00:00