Age-related changes in laboratory test results. Clinical implications.

abstract：BACKGROUND:Falls are a primary cause of injury and disability in the nursing home environment and can be costly to treat. We propose a taxonomy of nursing home falls that accounts for both the severity of fall consequences and the duration of the treatment episode. No other systematic approach of this kind has been pre...

journal_title：Drugs & aging

authors： Sorensen SV,de Lissovoy G,Kunaprayoon D,Resnick B,Rupnow MF,Studenski S

更新日期：2006-01-01 00:00:00

abstract：:Pneumococcal polysaccharide conjugate vaccine (13-valent, adsorbed) (PCV13; Prevenar 13(®); Prevnar 13(®)) is approved in adults aged ≥50 years (focus of review) and in children aged 6 weeks to 5 years for protection against pneumococcal diseases caused by Streptococcus pneumoniae in numerous countries worldwide, incl...

journal_title：Drugs & aging

authors： Scott LJ,Sanford M

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not prev...

journal_title：Drugs & aging

authors： Corsonello A,Pedone C,Lattanzio F,Onder G,Antonelli Incalzi R,Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA).

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Poor medication adherence is a major public health problem in older adults often resulting in negative health outcomes. OBJECTIVE:The objective of this review was to provide an updated summary of evidence from randomized controlled studies to determine whether interventions aimed at improving medication adh...

journal_title：Drugs & aging

authors： Marcum ZA,Hanlon JT,Murray MD

更新日期：2017-03-01 00:00:00

abstract：:While hormonal therapy has been the usual and appropriate treatment of advanced or metastatic prostatic cancer for the past 50 years, the recent development of new therapeutic agents as medical alternatives to orchidectomy has drastically altered the options and perspectives in the treatment of this disease. Estrogens...

journal_title：Drugs & aging

authors： Huben RP,Perrapato SD

更新日期：1991-09-01 00:00:00

abstract：:Disease-modifying antirheumatic drugs (DMARDs) are frequently used in rheumatoid arthritis. A number of physiological changes occur in the elderly which may modify the use of these medications. The most commonly used DMARDs are antimalarial drugs (particularly hydroxychloroquine), sulfasalazine and methotrexate. The p...

journal_title：Drugs & aging

authors： Gardner G,Furst DE

更新日期：1995-12-01 00:00:00

abstract：:Aging is associated with a myriad of hormonal changes. The mechanisms underlying these changes are variable. Aging is associated with anatomic changes of the endocrine glands, notably as a result of programmed cell death, autoimmune mediated destruction of the gland, or neoplastic transformation of glandular tissue. A...

journal_title：Drugs & aging

authors： Mooradian AD

更新日期：1993-03-01 00:00:00

abstract：:Urothelial carcinoma, or bladder cancer, is a malignancy that most commonly affects older patients. The median age at diagnosis is 73 years, and care of these patients requires consideration not just of the disease-related factors such as stage and histology, but also of patient-related factors. Many of these patients...

journal_title：Drugs & aging

authors： Jodon G,Fischer SM,Kessler ER

更新日期：2018-05-01 00:00:00

abstract：:The elderly patient may show normal physiological changes of the cardiovascular and respiratory systems that accompany aging, as well as features of intrinsic cardiac disease. The latter include: a past history of myocardial infarction or ischaemic heart disease; history of congestive cardiac failure; angina; arterial...

journal_title：Drugs & aging

authors： Sear JW,Higham H

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Older adults receiving cytotoxic agents may be more susceptible to hematologic toxicities because of progressive reduction in organ functions and multiple co-morbidities. Because older adults are under-represented in clinical trials, this retrospective study aims to evaluate hematologic toxicity of gemcitabine-...

journal_title：Drugs & aging

authors： Crombag MR,de Vries Schultink AH,Schellens JH,Beijnen JH,Huitema AD

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Certain medications have been linked to falls. One of the most severe fall-related injuries in the elderly is a hip fracture. OBJECTIVE:The objective of this study was to examine the use of medications known to increase fall risk that were prescribed on an outpatient basis to veterans prior to hospital admi...

journal_title：Drugs & aging

authors： French DD,Campbell R,Spehar A,Cunningham F,Foulis P

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Withdrawal of fall-risk-increasing drugs has been proven to be effective in older persons. However, given the enormous rise in healthcare costs in recent decades, the effect of such withdrawals on healthcare costs also needs to be considered. METHOD:Within a common geriatric outpatient population, patients ...

journal_title：Drugs & aging

authors： van der Velde N,Meerding WJ,Looman CW,Pols HA,van der Cammen TJ

更新日期：2008-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic movement disorder typically coupled to progressive degeneration of dopaminergic neurons in the substantia nigra (SN). The treatments currently available are satisfactory for symptomatic management, but the efficacy tends to decrease as neuronal loss progresses. Neurotrophic factor...

journal_title：Drugs & aging

authors： Rodrigues TM,Jerónimo-Santos A,Outeiro TF,Sebastião AM,Diógenes MJ

更新日期：2014-04-01 00:00:00

abstract：:This paper reviews the burden and economic consequences of glaucoma upon healthcare systems and patients, especially elderly patients. An extensive review of the literature was conducted, primarily using MEDLINE, but also by examining selected article reference lists, relevant websites and the proceedings of specialis...

journal_title：Drugs & aging

authors： Rouland JF,Berdeaux G,Lafuma A

更新日期：2005-01-01 00:00:00

abstract：:Restenosis in the months following a successful percutaneous transluminal coronary angioplasty (PTCA) remains the main limitation to this technique for myocardial revascularisation. Despite intensive investigation in this area, no pharmacological therapy has yet been found to be useful in preventing restenosis after c...

journal_title：Drugs & aging

authors： Hamon M,Lécluse E,Monassier JP,Grollier G,Potier JC

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:To determine the association between changes in complete blood counts and grade 3 or 4 toxicities from cycle 1 to cycle 2 during adjuvant chemotherapy in women > or =65 years of age with breast cancer. DESIGN AND METHODS:A retrospective review was performed on 1405 patients > or =65 years of age who were treat...

journal_title：Drugs & aging

authors： Hurria A,Brogan K,Panageas KS,Jakubowski A,Zauderer M,Pearce C,Norton L,Howard J,Hudis C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Medication non-adherence can exacerbate disease severity, leading to impairments that interfere with self-care activities in older adults, and, ultimately, death. Elder self-neglect is the most common report to Adult Protective Services (APS) across the USA and is a significant risk factor for early mortalit...

journal_title：Drugs & aging

authors： Turner A,Hochschild A,Burnett J,Zulfiqar A,Dyer CB

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Optimal use of digoxin in the elderly population requires information about the drug's pharmacokinetics and the influence of various factors on the drug's disposition. However, because of sampling restrictions, it is often difficult to perform traditional pharmacokinetic studies in elderly patients. OBJECTI...

journal_title：Drugs & aging

authors： Yukawa M,Yukawa E,Suematsu F,Takiguchi T,Ikeda H,Aki H,Mimemoto M

更新日期：2011-10-01 00:00:00

abstract：:The prevalence of neuropathic pain in the older population has been reported to be very high and is most commonly localized to a circumscribed area. Treatment failure is frequent in neuropathic pain and is accompanied by central side effects with recommended oral drugs acting on the central nervous system. A number of...

journal_title：Drugs & aging

authors： Pickering G,Lucchini C

更新日期：2020-02-01 00:00:00

abstract：:The elderly population is more likely to have urinary catheters used than younger populations. Most patients with short term indwelling catheters (those in place less than 30 days) will be residents of acute care institutions. The frequency of catheter-acquired bacteriuria is greater with longer durations of catheteri...

journal_title：Drugs & aging

authors： Nicolle LE

更新日期：1994-05-01 00:00:00

abstract：:Pharmacological treatment of depression in old age is associated with an increased risk of adverse pharmacokinetic and pharmacodynamic drug interactions. Elderly patients may have multiple disease states and, therefore, may require a variety of other drugs. In addition to polypharmacy, other factors such as age-relate...

journal_title：Drugs & aging

authors： Spina E,Scordo MG

更新日期：2002-01-01 00:00:00

abstract：:Faecal incontinence occurs in up to 10% of community dwelling persons > or = 65 years of age and approximately 50% of nursing home residents. It is a vastly under-reported problem that has a devastating effect on those who experience it as well as their spouses and caregivers. There are three broad categories of faeca...

journal_title：Drugs & aging

authors： Wald A

更新日期：2005-01-01 00:00:00

abstract：:Alzheimer's disease is the most common major neurocognitive disorder with substantial social and economic impacts. This article is an update on current pharmacotherapy, advancements in biomarker use, and drugs in the pipeline for this disease. To date, no new drug has qualified to be added to the current therapeutic a...

journal_title：Drugs & aging

authors： Khoury R,Patel K,Gold J,Hinds S,Grossberg GT

更新日期：2017-11-01 00:00:00

abstract：:Despite advances in antimicrobial chemotherapy over recent decades, morbidity and mortality secondary to infection continues to rise. In addition, the incidence of infection caused by resistant organisms has also increased. Concurrently, the elderly are living longer than prior generations, often with disabling chroni...

journal_title：Drugs & aging

authors： Lomaestro BM,Briceland LL

更新日期：1998-12-01 00:00:00

abstract：:Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug reg...

journal_title：Drugs & aging

authors： Petrovic M,van der Cammen T,Onder G

更新日期：2012-06-01 00:00:00

abstract：:Psychotropic medications have a high risk of serious adverse events and small effect size for changed behaviours for people with dementia. Non-pharmacological approaches are recommended as first-line treatment for changed behaviours, yet psychotropic medications remain highly prevalent in long-term aged care settings....

journal_title：Drugs & aging

authors： Harrison SL,Cations M,Jessop T,Hilmer SN,Sawan M,Brodaty H

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The choice of induction immunosuppression for kidney transplantation in elderly recipients is dictated by the consideration of the risk of infection as well as efficacy in the prevention of acute rejection, thus allowing a reduction in subsequent maintenance immunosuppression and its attendant long-term adve...

journal_title：Drugs & aging

authors： Heifets M,Saeed MI,Parikh MH,Sierka D,Kumar MS

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Although compelling evidence exists supporting statins (HMG-CoA reductase inhibitors) for secondary prevention in older patients with clinical atherosclerotic diseases, the same cannot be said for primary prevention. OBJECTIVES:The objectives of this study were to estimate the frequency of potential statin ...

journal_title：Drugs & aging

authors： Borne E,Meyer N,Rybarczyck-Vigouret MC,Blanchard O,Lombard M,Lang PO,Vogel T,Michel B

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The public health burden of osteoporosis is high, principally because of increased risk of fractures and associated morbidity, handicap and mortality. Osteoporotic fracture prevention is therefore an important public health goal. General practitioners (GPs) play a key role in the management of osteoporosis, ...

journal_title：Drugs & aging

authors： Blotman F,Cortet B,Hilliquin P,Avouac B,Allaert FA,Pouchain D,Gaudin AF,Cotté FE,El Hasnaoui A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE:The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors assoc...

journal_title：Drugs & aging

authors： Musich S,Wang SS,Slindee LB,Saphire L,Wicker E

更新日期：2018-05-01 00:00:00