Use of beta-adrenoceptor antagonists in older patients with chronic obstructive pulmonary disease and cardiovascular co-morbidity: safety issues.

abstract：BACKGROUND:Improvement in renal function and decreases in serum uric acid (SUA) have been reported following prolonged high-intensity statin (HMG-CoA reductase inhibitor) therapy. This post hoc analysis of the SAGE trial examined the effect of intensive versus less intensive statin therapy on renal function, safety, an...

journal_title：Drugs & aging

authors： Deedwania PC,Stone PH,Fayyad RS,Laskey RE,Wilson DJ

更新日期：2015-12-01 00:00:00

abstract：:Management of hypertension in the elderly should take into account, in particular, the possible negative impact of antihypertensive drugs on the patient's quality of life, the deterioration of which may result in a loss of independence and reduced treatment compliance. Quality of life is recognised as a multifactorial...

journal_title：Drugs & aging

authors： Fogari R,Zoppi A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Temporal changes in the dispensing of glucose-lowering drugs (GLD) and their associated costs among elderly populations is unclear. This information is especially relevant to countries in which medications are partly or fully government subsidized. OBJECTIVE:Our objective was to estimate the trends in preva...

journal_title：Drugs & aging

authors： Chin KL,Hidayat FM,Ofori-Asenso R,Ilomäki J,Bell JS,Zoungas S,Liew D

更新日期：2020-05-01 00:00:00

abstract：:Globally, the number of drug prescriptions is increasing causing more adverse drug events, which is now a significant cause of mortality, morbidity, and disability that has reached epidemic proportions. The risk of adverse drug events is correlated to very old age, multiple co-morbidities, dementia, frailty, and limit...

journal_title：Drugs & aging

authors： Mangin D,Bahat G,Golomb BA,Mallery LH,Moorhouse P,Onder G,Petrovic M,Garfinkel D

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Frailty is a clinical phenotype that is associated with adverse health outcomes. Since frail patients may be more prone for adverse drug events and about 15-20 % of commonly prescribed drugs are metabolized by CYP2D6, we hypothesized that CYP2D6 metabolism is decreased in frail patients compared with healthy...

journal_title：Drugs & aging

authors： Opdam FL,Modak AS,Mooijaart SP,Louwerens M,de Waal MW,Gelderblom H,Guchelaar HJ

更新日期：2015-12-01 00:00:00

abstract：:While hormonal therapy has been the usual and appropriate treatment of advanced or metastatic prostatic cancer for the past 50 years, the recent development of new therapeutic agents as medical alternatives to orchidectomy has drastically altered the options and perspectives in the treatment of this disease. Estrogens...

journal_title：Drugs & aging

authors： Huben RP,Perrapato SD

更新日期：1991-09-01 00:00:00

abstract：:There has been a growing recognition that pulsatile stimulation of dopamine receptors may be an important mechanism in the generation of the motor fluctuations that often develop and compromise the effectiveness of long-term levodopa administration in persons with Parkinson's disease (PD). This has prompted investigat...

journal_title：Drugs & aging

authors： Pfeiffer RF

更新日期：2002-01-01 00:00:00

abstract：:The number of older adults with diabetes is rapidly increasing worldwide. A variety of factors contribute to the age-related increase in the incidence of diabetes. The lack of empiric evidence in the field has limited the management guidelines to mostly expert opinion. Given uncertainty over the rate at which to lower...

journal_title：Drugs & aging

authors： Mooradian AD

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Immunosenescence makes the elderly more susceptible to influenza complications and less responsive to vaccination. An intradermal formulation (IDflu) is one of several strategies being investigated to increase the immunogenicity of influenza vaccines. OBJECTIVE:The overall goal of the study was to assess ...

journal_title：Drugs & aging

authors： Pileggi C,Mascaro V,Bianco A,Nobile CG,Pavia M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Treatment of postherpetic neuralgia (PHN) is more complicated in elderly patients, and multiple daily dosing, complex titration, and high incidences of adverse events can be limiting for many pharmacological treatment options. OBJECTIVE:The aim of this study was to determine whether the efficacy and tolerab...

journal_title：Drugs & aging

authors： Gupta A,Li S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Poor medication adherence is a major public health problem in older adults often resulting in negative health outcomes. OBJECTIVE:The objective of this review was to provide an updated summary of evidence from randomized controlled studies to determine whether interventions aimed at improving medication adh...

journal_title：Drugs & aging

authors： Marcum ZA,Hanlon JT,Murray MD

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Clinical validation studies of the Healthcare Effectiveness Data and Information Set (HEDIS®) measures of inappropriate prescribing in the elderly are limited. OBJECTIVES:The objective of this study was to examine associations of new exposure to high-risk medication in the elderly (HRME) and drug-disease in...

journal_title：Drugs & aging

authors： Pugh MJ,Marcum ZA,Copeland LA,Mortensen EM,Zeber JE,Noël PH,Berlowitz DR,Downs JR,Good CB,Alvarez C,Amuan ME,Hanlon JT

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The practice of hiding medicines in nursing home patients' food or beverages is described in only a few scientific papers. An earlier study conducted in 1999/2000 showed that covert medication was common in Norwegian nursing homes, with 11% of patients in regular nursing home units (RUs) and 17...

journal_title：Drugs & aging

authors： Kirkevold O,Engedal K

更新日期：2009-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major problem in the elderly population, with approximately 10% of the population affected. Since COPD is an inflammatory disorder of the pulmonary system, corticosteroids might be expected to improve clinical outcomes of the disease. Data from large, well designed ran...

journal_title：Drugs & aging

authors： Sin DD,Man SF

更新日期：2003-01-01 00:00:00

abstract：:Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug reg...

journal_title：Drugs & aging

authors： Petrovic M,van der Cammen T,Onder G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:The public health burden of osteoporosis is high, principally because of increased risk of fractures and associated morbidity, handicap and mortality. Osteoporotic fracture prevention is therefore an important public health goal. General practitioners (GPs) play a key role in the management of osteoporosis, ...

journal_title：Drugs & aging

authors： Blotman F,Cortet B,Hilliquin P,Avouac B,Allaert FA,Pouchain D,Gaudin AF,Cotté FE,El Hasnaoui A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not prev...

journal_title：Drugs & aging

authors： Corsonello A,Pedone C,Lattanzio F,Onder G,Antonelli Incalzi R,Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA).

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Inappropriate medications are often used in older adults despite their unfavourable risk-to-benefit profile. Although many of the medications in the American Geriatrics Society (AGS) Beers list are potentially inappropriate because of their anticholinergic properties, little is known regarding the nature and...

journal_title：Drugs & aging

authors： Kachru N,Carnahan RM,Johnson ML,Aparasu RR

更新日期：2015-05-01 00:00:00

abstract：:The prevalence of neuropathic pain in the older population has been reported to be very high and is most commonly localized to a circumscribed area. Treatment failure is frequent in neuropathic pain and is accompanied by central side effects with recommended oral drugs acting on the central nervous system. A number of...

journal_title：Drugs & aging

authors： Pickering G,Lucchini C

更新日期：2020-02-01 00:00:00

abstract：:The selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor fluoxetine is an effective antidepressant in elderly patients. Its efficacy is similar to that of other frequently used antidepressants, such as the tricyclic antidepressants. However, compared with the tricyclic antidepressants, fluoxetine has a m...

journal_title：Drugs & aging

authors： Harris MG,Benfield P

更新日期：1995-01-01 00:00:00

abstract：:Behavioural disturbances, also termed neuropsychiatric symptoms, are a frequent clinical feature of dementia in Alzheimer's disease (AD). Many AD patients receive treatment with cholinesterase inhibitors (ChEIs). This review examines the evidence for behavioural effects of the four ChEIs that have been approved for th...

journal_title：Drugs & aging

authors： Grimmer T,Kurz A

更新日期：2006-01-01 00:00:00

abstract：:The focus of this review is hormone replacement therapy (HRT) with continuous oral 17 beta-estradiol (herein referred to as estradiol) 2 mg/day plus sequential oral dydrogesterone 10 or 20 mg/day for 14 days of each 28-day cycle. According to data from nonblind trials, this regimen relieves climacteric symptoms, prese...

journal_title：Drugs & aging

authors： Foster RH,Balfour JA

更新日期：1997-10-01 00:00:00

abstract：:In contrast with the earlier stages and, in particular, the predementia stage, of Alzheimer's disease (AD), severe dementia is often neglected. However, the advanced stages of dementia are just as important as the earlier stages because of their frequency, their impact on the lives of patients and their caregivers, an...

journal_title：Drugs & aging

authors： Voisin T,Vellas B

更新日期：2009-01-01 00:00:00

abstract：:Older adults with chronic kidney disease (CKD) often experience polypharmacy, a recognized predictor of prescribing problems including inappropriately dosed medications, drug-drug and drug-disease interactions, morbidity and mortality. Polypharmacy is also associated with nonadherence, which leads to recurrent hospita...

journal_title：Drugs & aging

authors： Triantafylidis LK,Hawley CE,Perry LP,Paik JM

更新日期：2018-11-01 00:00:00

abstract：:Osteoporosis is a common disease that affects 1 in 3 women. Family and twin studies have demonstrated that there is a strong genetic component to this condition. Potential candidate genes examined for their regulatory effect on bone mass include those for collagen type I, estrogen and vitamin D receptors, and various ...

journal_title：Drugs & aging

authors： Keen RW,Kelly PJ

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe. METHODS:We conducted a cross...

journal_title：Drugs & aging

authors： Giovannini S,van der Roest HG,Carfì A,Finne-Soveri H,Garms-Homolová V,Declercq A,Jónsson PV,van Hout H,Vetrano DL,Gravina EM,Bernabei R,Onder G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...

journal_title：Drugs & aging

authors： Harrison SL,Kouladjian O'Donnell L,Bradley CE,Milte R,Dyer SM,Gnanamanickam ES,Liu E,Hilmer SN,Crotty M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Withdrawal of fall-risk-increasing drugs has been proven to be effective in older persons. However, given the enormous rise in healthcare costs in recent decades, the effect of such withdrawals on healthcare costs also needs to be considered. METHOD:Within a common geriatric outpatient population, patients ...

journal_title：Drugs & aging

authors： van der Velde N,Meerding WJ,Looman CW,Pols HA,van der Cammen TJ

更新日期：2008-01-01 00:00:00

abstract：:Advances in our understanding of the structure, function and distribution of nicotinic acetylcholine receptors in the CNS have provided the impetus for new studies examining the role(s) that these receptors and associated processes may play in CNS functions. Further motivation has come from the realisation that such r...

journal_title：Drugs & aging

authors： Newhouse PA,Potter A,Levin ED

更新日期：1997-09-01 00:00:00

abstract：INTRODUCTION:Congestive heart failure (CHF), which typically affects older people, is characterized by high short- and mid-term mortality rates. However, despite accumulating evidence showing that administration of β-blockers (β-adrenoceptor antagonists) can improve the clinical status of CHF patients, use of these age...

journal_title：Drugs & aging

authors： Antonicelli R,Mazzanti I,Abbatecola AM,Parati G

更新日期：2010-10-01 00:00:00