Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics.

abstract：BACKGROUND:Withdrawal of fall-risk-increasing drugs has been proven to be effective in older persons. However, given the enormous rise in healthcare costs in recent decades, the effect of such withdrawals on healthcare costs also needs to be considered. METHOD:Within a common geriatric outpatient population, patients ...

journal_title：Drugs & aging

authors： van der Velde N,Meerding WJ,Looman CW,Pols HA,van der Cammen TJ

更新日期：2008-01-01 00:00:00

abstract：:The prevalence of neuropathic pain in the older population has been reported to be very high and is most commonly localized to a circumscribed area. Treatment failure is frequent in neuropathic pain and is accompanied by central side effects with recommended oral drugs acting on the central nervous system. A number of...

journal_title：Drugs & aging

authors： Pickering G,Lucchini C

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:In the presence of multimorbidity and limited life expectancy (LLE), the need for continued use of preventive medicines becomes uncertain as they may neither improve health nor confer continued health benefits. OBJECTIVE:Our objective was to systematically review the literature to examine the discontinuatio...

journal_title：Drugs & aging

authors： Narayan SW,Nishtala PS

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not prev...

journal_title：Drugs & aging

authors： Corsonello A,Pedone C,Lattanzio F,Onder G,Antonelli Incalzi R,Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA).

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Older adults receiving cytotoxic agents may be more susceptible to hematologic toxicities because of progressive reduction in organ functions and multiple co-morbidities. Because older adults are under-represented in clinical trials, this retrospective study aims to evaluate hematologic toxicity of gemcitabine-...

journal_title：Drugs & aging

authors： Crombag MR,de Vries Schultink AH,Schellens JH,Beijnen JH,Huitema AD

更新日期：2014-10-01 00:00:00

abstract：:Xerostomia and salivary gland hypofunction (SGH) are prevalent in elderly populations, causing much discomfort and even difficulties in eating. SGH also increases the occurrence and severity of oral diseases and makes the patient susceptible to candidiasis. The principal causes of SGH and xerostomia are systemic disea...

journal_title：Drugs & aging

authors： Närhi TO,Meurman JH,Ainamo A

更新日期：1999-08-01 00:00:00

abstract：:Globally, the number of drug prescriptions is increasing causing more adverse drug events, which is now a significant cause of mortality, morbidity, and disability that has reached epidemic proportions. The risk of adverse drug events is correlated to very old age, multiple co-morbidities, dementia, frailty, and limit...

journal_title：Drugs & aging

authors： Mangin D,Bahat G,Golomb BA,Mallery LH,Moorhouse P,Onder G,Petrovic M,Garfinkel D

更新日期：2018-07-01 00:00:00

abstract：:Complex interactive effects of genetic predisposition, neurochemical changes and disease comorbidity have been elucidated in the genesis of dementia syndromes. Alzheimer's disease is the most prevalent type of dementia in developed Western countries. In Alzheimer's disease, pharmacological treatment aims at symptomati...

journal_title：Drugs & aging

authors： Marksteiner J,Schmidt R

更新日期：2004-01-01 00:00:00

abstract：:Psychotropic medications have a high risk of serious adverse events and small effect size for changed behaviours for people with dementia. Non-pharmacological approaches are recommended as first-line treatment for changed behaviours, yet psychotropic medications remain highly prevalent in long-term aged care settings....

journal_title：Drugs & aging

authors： Harrison SL,Cations M,Jessop T,Hilmer SN,Sawan M,Brodaty H

更新日期：2019-02-01 00:00:00

abstract：:Melatonin prolonged release (PR) 2 mg is approved for the treatment of primary insomnia characterized by poor sleep quality in patients aged ≥55 years in the EU and elsewhere. Patients may receive treatment with melatonin PR for up to 13 weeks. Production of endogenous nocturnal melatonin, which helps regulate circadi...

journal_title：Drugs & aging

authors： Lyseng-Williamson KA

更新日期：2012-11-01 00:00:00

abstract：:Blood pressure levels are strongly predictive of the risks of first-ever and recurrent stroke. The benefits of blood pressure-lowering therapy for the prevention of fatal and non-fatal stroke in middle-aged individuals are well established. However, until recently, there has been uncertainty about the consistency of s...

journal_title：Drugs & aging

authors： Ratnasabapathy Y,Lawes CM,Anderson CS

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Patients hospitalised with severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2; coronavirus 2019 disease (COVID-19)] infection are frequently older with co-morbidities and receiving polypharmacy, all of which are known risk factors for drug-drug interactions (DDIs). The pharmacological burden may be ...

journal_title：Drugs & aging

authors： Cattaneo D,Pasina L,Maggioni AP,Giacomelli A,Oreni L,Covizzi A,Bradanini L,Schiuma M,Antinori S,Ridolfo A,Gervasoni C

更新日期：2020-12-01 00:00:00

abstract：:The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1)...

journal_title：Drugs & aging

authors： Andrès E,Vogel T,Federici L,Zimmer J,Kaltenbach G

更新日期：2008-01-01 00:00:00

abstract：:Vitreous haemorrhage can be caused by a disruption of normal retinal vessels, bleeding from diseased retinal vessels, bleeding from abnormal new vessels or extension of haemorrhage through the retina from other sources. In the elderly, vitreous haemorrhage usually occurs spontaneously and only occurs occasionally as a...

journal_title：Drugs & aging

authors： Manuchehri K,Kirkby G

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Statins have been associated with later life, long-term care admission in observational studies. However, by preventing vascular events, statins may also prevent or delay admission. We wished to determine statin and long-term care admission associations in a randomised controlled trial context, and describe ...

journal_title：Drugs & aging

authors： Burton JK,Papworth R,Haig C,McCowan C,Ford I,Stott DJ,Quinn TJ

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:In response to concerns about, and issues pertaining to, medication use practices in residential aged-care facilities (RACFs), the Australian Pharmaceutical Advisory Council (APAC) established a working party on quality use of medicines (QUM) in nursing homes and hostels. The APAC is a representative ministe...

journal_title：Drugs & aging

authors： Cheek J,Gilbert A,Ballantyne A,Penhall R

更新日期：2004-01-01 00:00:00

abstract：:Although the frequency of physician consultations and the sale of over-the-counter remedies establish the high prevalence of acute cough in the elderly, epidemiological studies have tended to be imprecise. However, respiratory tract infections in nose, larynx and/or bronchi, either viral or bacterial or both, are by f...

journal_title：Drugs & aging

authors： Widdicombe J,Kamath S

更新日期：2004-01-01 00:00:00

abstract：:Although a significant proportion of patients receiving nitrates are elderly, surprisingly little published work is available describing the pharmacokinetics and pharmacodynamics of these agents in elderly patients. The lack of pharmacokinetic data is related to the difficulty in assaying nitrates and there are at pre...

journal_title：Drugs & aging

authors： Kelly JG,O'Malley K

更新日期：1992-01-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting 1 to 3% of individuals over the age of 65 years. While effective therapy exists for treating the bradykinesia, rigidity and tremor associated with the disease, the cause is unknown. There is no treatment available to prevent or slo...

journal_title：Drugs & aging

authors： Ross GW,Petrovitch H

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Previous studies have investigated the prevalence of drug-drug interactions (DDIs) among the elderly in different care settings, but data describing the frequency and management of DDIs among acute geriatric patients appear to be absent. OBJECTIVE:The aim of this study was to investigate the severity and in...

journal_title：Drugs & aging

authors： Lea M,Rognan SE,Koristovic R,Wyller TB,Molden E

更新日期：2013-09-01 00:00:00

abstract：:It is inevitable that publicly funded, technically sophisticated medical treatments will be increasingly rationed. Other things being equal, there is a greater duty to use them to prolong the lives of younger than older people. Age is therefore an ethical rationing criterion. Denial of this may actually harm older peo...

journal_title：Drugs & aging

authors： Shaw AB

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:By using the findings obtained from the PREPARED study, we aimed to estimate the cost effectiveness of ropinirole prolonged release (PR) [Requip-Modutab(®)] in Parkinson's disease (PD) versus ropinirole immediate release (IR). In the PREPARED study, ropinirole PR provided a significantly greater improvement ...

journal_title：Drugs & aging

authors： van Boven JF,Novak A,Driessen MT,Boersma C,Boomsma MM,Postma MJ

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...

journal_title：Drugs & aging

authors： Harrison SL,Kouladjian O'Donnell L,Bradley CE,Milte R,Dyer SM,Gnanamanickam ES,Liu E,Hilmer SN,Crotty M

更新日期：2018-01-01 00:00:00

abstract：:Alzheimer's disease is the most common major neurocognitive disorder with substantial social and economic impacts. This article is an update on current pharmacotherapy, advancements in biomarker use, and drugs in the pipeline for this disease. To date, no new drug has qualified to be added to the current therapeutic a...

journal_title：Drugs & aging

authors： Khoury R,Patel K,Gold J,Hinds S,Grossberg GT

更新日期：2017-11-01 00:00:00

abstract：:In contrast with women, who experience a complete and abrupt cessation of ovarian function during the menopause, aging men largely maintain their testicular androgen production. Nevertheless, most cross-sectional studies indicate that there is a partial decrease in testosterone levels with aging, although this has not...

journal_title：Drugs & aging

authors： Maas D,Jochen A,Lalande B

更新日期：1997-07-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) usually affect adults and older populations. The well recognized clinical (i.e., granulomatosis with polyangiitis [GPA], microscopic polyangiitis, and eosinophilic GPA) and serological phenotypes (i.e., anti-MPO-ANCA, anti-PR3-ANCA and ANCA nega...

journal_title：Drugs & aging

authors： Berti A,Caporali R,Montecucco C,Paolazzi G,Monti S

更新日期：2019-01-01 00:00:00

abstract：:The prevalence of intermittent claudication (IC) increases with age; when questioned, older patients consider increased difficulty in walking to be a normal consequence of aging. Although the prognosis for the involved limb with IC is relatively good, IC is an important clinical predictor of increased cardiovascular m...

journal_title：Drugs & aging

authors： Boccalon H

更新日期：1999-04-01 00:00:00

abstract：:Pharmacological treatment of depression in old age is associated with an increased risk of adverse pharmacokinetic and pharmacodynamic drug interactions. Elderly patients may have multiple disease states and, therefore, may require a variety of other drugs. In addition to polypharmacy, other factors such as age-relate...

journal_title：Drugs & aging

authors： Spina E,Scordo MG

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Patient transitions, such as transfers between acute and long-term care (LTC), aposare times when the likelihood of communication failure between healthcare providers is increased. Employing appropriate health quality indicators helps support improvement efforts. To date, few quality indicators that evaluate...

journal_title：Drugs & aging

authors： Bell CM,Brener SS,Comrie R,Anderson GM,Bronskill SE

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Medication-related admissions are an important cause of hospital admissions in older people. The scope for prevention is less clear. OBJECTIVES:To characterize medication-related hospital admissions in older people and assess their preventability. METHODS:This was a cross-sectional, observational study con...

journal_title：Drugs & aging

authors： Rogers S,Wilson D,Wan S,Griffin M,Rai G,Farrell J

更新日期：2009-01-01 00:00:00