Polypharmacy in Home Care in Europe: Cross-Sectional Data from the IBenC Study.

abstract：BACKGROUND:Clinical validation studies of the Healthcare Effectiveness Data and Information Set (HEDIS®) measures of inappropriate prescribing in the elderly are limited. OBJECTIVES:The objective of this study was to examine associations of new exposure to high-risk medication in the elderly (HRME) and drug-disease in...

journal_title：Drugs & aging

authors： Pugh MJ,Marcum ZA,Copeland LA,Mortensen EM,Zeber JE,Noël PH,Berlowitz DR,Downs JR,Good CB,Alvarez C,Amuan ME,Hanlon JT

更新日期：2013-08-01 00:00:00

abstract：:Nitric oxide (NO) is involved in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity. Depending on the redox state of NO, it can act as a neurotoxin or it can have a neuroprotective action. Data suggest that NO may have a role in the pathogenesis of neurodegenerati...

journal_title：Drugs & aging

authors： Molina JA,Jiménez-Jiménez FJ,Ortí-Pareja M,Navarro JA

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to gain insights into the attitudes of men with lower urinary tract symptoms towards deprescribing alpha-blockers and to assess their willingness to participate in a planned discontinuation trial. METHODS:This was a cross-sectional questionnaire study. Men aged 30 years and ol...

journal_title：Drugs & aging

authors： Edelman M,Jellema P,Hak E,Denig P,Blanker MH

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Adverse drug reactions are a major cause of hospital admissions in older individuals, with the majority potentially preventable. Despite the apparent magnitude of this problem, little is known about rates of repeat admission to hospital as a result of adverse drug reactions. OBJECTIVES:The objectives of thi...

journal_title：Drugs & aging

authors： Parameswaran Nair N,Chalmers L,Bereznicki BJ,Curtain CM,Bereznicki LR

更新日期：2017-10-01 00:00:00

abstract：:Restenosis in the months following a successful percutaneous transluminal coronary angioplasty (PTCA) remains the main limitation to this technique for myocardial revascularisation. Despite intensive investigation in this area, no pharmacological therapy has yet been found to be useful in preventing restenosis after c...

journal_title：Drugs & aging

authors： Hamon M,Lécluse E,Monassier JP,Grollier G,Potier JC

更新日期：1998-10-01 00:00:00

abstract：:Sleep problems are an under-emphasised cause of disability in Parkinson's disease (PD) and may be seen independently of PD, associated with primary PD pathology, or as a result of antiparkinsonian medications. Common sleep disorders include excessive daytime sleepiness, rapid eye movement (REM) sleep behaviour disorde...

journal_title：Drugs & aging

authors： Stacy M

更新日期：2002-01-01 00:00:00

abstract：:Xerostomia and salivary gland hypofunction (SGH) are prevalent in elderly populations, causing much discomfort and even difficulties in eating. SGH also increases the occurrence and severity of oral diseases and makes the patient susceptible to candidiasis. The principal causes of SGH and xerostomia are systemic disea...

journal_title：Drugs & aging

authors： Närhi TO,Meurman JH,Ainamo A

更新日期：1999-08-01 00:00:00

abstract：:Lisinopril, the lysine analogue of enalaprilat, is a long-acting angiotensin converting enzyme (ACE) inhibitor which is administered once daily by mouth. The efficacy of lisinopril in reducing blood pressure is well established in younger populations, and many trials now show it to be effective in lowering blood press...

journal_title：Drugs & aging

authors： Langtry HD,Markham A

更新日期：1997-02-01 00:00:00

abstract：:Although inflammatory bowel disease (IBD) is generally considered a disease of young adults, it can occur in elderly individuals. The clinical features and treatment considerations in older patients are similar to those in younger patients, with some notable exceptions, which are reviewed in this article. Consideratio...

journal_title：Drugs & aging

authors： Hussain SW,Pardi DS

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Limited data are available on the prevalence of inappropriate prescribing of renally cleared drugs in elderly patients in Australia. OBJECTIVES:To quantify and compare the extent of inappropriate prescribing (defined as at least one drug prescribed in an excessive dose or when contraindicated with respect t...

journal_title：Drugs & aging

authors： Khanal A,Peterson GM,Castelino RL,Jose MD

更新日期：2015-05-01 00:00:00

abstract：:The main characteristic of acute lymphoblastic leukaemia (ALL) in the elderly is its dismal prognosis. However, other than a lower incidence of T-cell ALL and a greater likelihood of unfavourable chromosomal abnormalities, the clinical and biological characteristics of Philadelphia chromosome-negative (Ph-) ALL in the...

journal_title：Drugs & aging

authors： Rousselot P,Delannoy A

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Temporal changes in the dispensing of glucose-lowering drugs (GLD) and their associated costs among elderly populations is unclear. This information is especially relevant to countries in which medications are partly or fully government subsidized. OBJECTIVE:Our objective was to estimate the trends in preva...

journal_title：Drugs & aging

authors： Chin KL,Hidayat FM,Ofori-Asenso R,Ilomäki J,Bell JS,Zoungas S,Liew D

更新日期：2020-05-01 00:00:00

abstract：:Constipation is a common problem in elderly persons, with prevalence ranging from 15% to 20% in the community-dwelling elderly population and up to 50% in some studies of nursing home residents. In these patients, constipation results from a combination of risk factors, such as reduced fibre and fluid intake, decrease...

journal_title：Drugs & aging

authors： Bosshard W,Dreher R,Schnegg JF,Büla CJ

更新日期：2004-01-01 00:00:00

abstract：:Older adults with chronic kidney disease (CKD) often experience polypharmacy, a recognized predictor of prescribing problems including inappropriately dosed medications, drug-drug and drug-disease interactions, morbidity and mortality. Polypharmacy is also associated with nonadherence, which leads to recurrent hospita...

journal_title：Drugs & aging

authors： Triantafylidis LK,Hawley CE,Perry LP,Paik JM

更新日期：2018-11-01 00:00:00

abstract：:Chronic pain occurs in 45-85% of the geriatric population and the need to treat chronic pain is growing substantially. Unfortunately, treatment for chronic pain is not always correctly targeted, which leads to a reduced quality of life, with decreased socialization, depression, sleep disturbances, cognitive impairment...

journal_title：Drugs & aging

authors： Gianni W,Ceci M,Bustacchini S,Corsonello A,Abbatecola AM,Brancati AM,Assisi A,Scuteri A,Cipriani L,Lattanzio F

更新日期：2009-12-01 00:00:00

abstract：:Lithium salts have a well-established role in the treatment of major affective disorders. More recently, experimental and clinical studies have provided evidence that lithium may also exert neuroprotective effects. In animal and cell culture models, lithium has been shown to increase neuronal viability through a combi...

journal_title：Drugs & aging

authors： Forlenza OV,de Paula VJ,Machado-Vieira R,Diniz BS,Gattaz WF

更新日期：2012-05-01 00:00:00

abstract：:Attempts to control pneumococcal infection by vaccination, undertaken initially in 1911, have gone through 3 phases during the subsequent 8 decades. Initially, vaccines of killed pneumococcal cells prepared in a variety of ways were used in epidemic settings with inconclusive results, although administered to approxim...

journal_title：Drugs & aging

authors： Austrian R

更新日期：1999-01-01 00:00:00

abstract：:Spasticity following stroke reflects a spectrum of clinical problems including increased muscle tone, abnormal limb posture, excessive contraction of antagonist muscles and hyperactive cutaneous and tendon reflexes. The prevalence of stroke-related disability in stroke survivors is high, and spasticity may be a signif...

journal_title：Drugs & aging

authors： O'Brien CF,Seeberger LC,Smith DB

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:To determine the association between changes in complete blood counts and grade 3 or 4 toxicities from cycle 1 to cycle 2 during adjuvant chemotherapy in women > or =65 years of age with breast cancer. DESIGN AND METHODS:A retrospective review was performed on 1405 patients > or =65 years of age who were treat...

journal_title：Drugs & aging

authors： Hurria A,Brogan K,Panageas KS,Jakubowski A,Zauderer M,Pearce C,Norton L,Howard J,Hudis C

更新日期：2005-01-01 00:00:00

abstract：:Nadroparin (nadroparin calcium) is a low molecular weight heparin with a mean molecular weight of 4.5 kD. Compared with unfractionated heparin (UFH), nadroparin has a greater ratio of anti-factor Xa to anti-factor Ha activity, greater bioavailability and a longer duration of action, allowing it to be administered by s...

journal_title：Drugs & aging

authors： Davis R,Faulds D

更新日期：1997-04-01 00:00:00

abstract：:Type 2 diabetes mellitus is a complex heterogenous metabolic disorder in which peripheral insulin resistance and impaired insulin release are the main pathogenetic factors. The rapid response of the pancreatic beta-cells to glucose is already markedly disturbed in the early stages of type 2 diabetes mellitus. The cons...

journal_title：Drugs & aging

authors： Landgraf R

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:There is poor evidence supporting the use of any pharmacologic treatments for neuropsychiatric disorders following traumatic brain injury (TBI), especially among older adults. Informed by our recent characterization of psychotropic medication use among Medicare beneficiaries with TBI, the objective of this st...

journal_title：Drugs & aging

authors： Albrecht JS,Rao V,Perfetto EM,Daniel Mullins C

更新日期：2018-08-01 00:00:00

abstract：:Etidronic acid is an orally and intravenously active bisphosphonate, which is believed to inhibit resorption of bone via a number of cellular mechanisms, including alteration of osteoclastic activity. In studies of patients with symptomatic Paget's disease, etidronic acid 5 to 20 mg/kg/day administered orally rapidly ...

journal_title：Drugs & aging

authors： Dunn CJ,Fitton A,Sorkin EM

更新日期：1994-12-01 00:00:00

abstract：INTRODUCTION:Older cancer patients are possibly at an increased risk of medication-related problems because, typically, they receive many medications during their cancer treatment, both for the cancer itself and for supportive care. OBJECTIVES:The aim of this study was to describe the number and severity of potential ...

journal_title：Drugs & aging

authors： Puts MT,Monette J,Girre V,Costa-Lima B,Wolfson C,Batist G,Bergman H

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Although compelling evidence exists supporting statins (HMG-CoA reductase inhibitors) for secondary prevention in older patients with clinical atherosclerotic diseases, the same cannot be said for primary prevention. OBJECTIVES:The objectives of this study were to estimate the frequency of potential statin ...

journal_title：Drugs & aging

authors： Borne E,Meyer N,Rybarczyck-Vigouret MC,Blanchard O,Lombard M,Lang PO,Vogel T,Michel B

更新日期：2019-10-01 00:00:00

abstract：:Large bowel cancer is not only the third most frequent cancer in the world but is one of the most common human malignancies in Western countries, including North America. In recent years, multidisciplinary research in epidemiology, molecular biology, and laboratory animal model studies have contributed much to our und...

journal_title：Drugs & aging

authors： Reddy BS,Rao CV

更新日期：2000-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic movement disorder typically coupled to progressive degeneration of dopaminergic neurons in the substantia nigra (SN). The treatments currently available are satisfactory for symptomatic management, but the efficacy tends to decrease as neuronal loss progresses. Neurotrophic factor...

journal_title：Drugs & aging

authors： Rodrigues TM,Jerónimo-Santos A,Outeiro TF,Sebastião AM,Diógenes MJ

更新日期：2014-04-01 00:00:00

abstract：:NSAIDs are a widely used class of analgesic and anti-inflammatory drugs that act by inhibiting the cyclo-oxygenase (COX) enzyme. However, because of their nonspecificity of action, use of these agents as long-term therapy for chronic pain in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA) is often d...

journal_title：Drugs & aging

authors： Bansal SS,Joshi A,Bansal AK

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Previous studies of antihypertensive treatment of older patients have focused on blood pressure control, cardiovascular risk or adherence, whereas data on inappropriate antihypertensive prescriptions to older patients are scarce. OBJECTIVES:The aim of the study was to assess inappropriate antihypertensive...

journal_title：Drugs & aging

authors： Márquez PHP,Torres OH,San-José A,Vidal X,Agustí A,Formiga F,López-Soto A,Ramírez-Duque N,Fernández-Moyano A,Garcia-Moreno J,Arroyo JA,Ruiz D,Potentially Inappropriate Prescription in Older Patients in Spain (PIPOPS) Investigators

更新日期：2017-06-01 00:00:00

abstract：:The prevalence of intermittent claudication (IC) increases with age; when questioned, older patients consider increased difficulty in walking to be a normal consequence of aging. Although the prognosis for the involved limb with IC is relatively good, IC is an important clinical predictor of increased cardiovascular m...

journal_title：Drugs & aging

authors： Boccalon H

更新日期：1999-04-01 00:00:00