Abstract:
BACKGROUND:Temporal changes in the dispensing of glucose-lowering drugs (GLD) and their associated costs among elderly populations is unclear. This information is especially relevant to countries in which medications are partly or fully government subsidized. OBJECTIVE:Our objective was to estimate the trends in prevalence, incidence and costs associated with GLD dispensed to older Australians. METHODS:We analysed Pharmaceutical Benefits Scheme data for 76,906 people aged ≥ 65 years dispensed diabetes medications over the period 2013-2016. RESULTS:Older males were dispensed more GLD than were older females, with the marginal difference increasing from 3.2% in 2013 (age-sex adjusted incidence rate ratio [aIRR] 1.032; 95% confidence interval [CI] 1.024-1.041; p < 0.001) to 3.9% in 2016 (aIRR 1.039; 95% CI 1.030-1.047; p < 0.001). The number of GLD dispensed per person was consistently lower in those aged ≥ 75 years than in those aged 65-74 years, with the gap widening over the years. More patients were initiated with sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors over the study period, at the expense of older GLD. The proportion of users and attributed costs associated with the use of metformin, sulfonylureas, α-glucosidase inhibitors and thiazolidinediones decreased over time. The total subsidized costs of GLD is forecast to increase to $A395 million by 2020. CONCLUSIONS:The treatment landscape for diabetes in Australia is undergoing dynamic change. More patients were initiated with the newer but costlier GLD over the study period.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Chin KL,Hidayat FM,Ofori-Asenso R,Ilomäki J,Bell JS,Zoungas S,Liew Ddoi
10.1007/s40266-020-00759-wsubject
Has Abstractpub_date
2020-05-01 00:00:00pages
393-398issue
5eissn
1170-229Xissn
1179-1969pii
10.1007/s40266-020-00759-wjournal_volume
37pub_type
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