Abstract:
INTRODUCTION:Older cancer patients are possibly at an increased risk of medication-related problems because, typically, they receive many medications during their cancer treatment, both for the cancer itself and for supportive care. OBJECTIVES:The aim of this study was to describe the number and severity of potential medication problems during treatment of cancer in the first year after diagnosis. We also sought to examine whether patients receiving systemic cancer treatment had more medication-related problems at 3, 6 and 12 months than those not receiving systemic cancer treatment. METHODS:This was a prospective pilot cohort study on health and vulnerability in older newly diagnosed cancer patients with 1-year follow-up. The study was conducted at Segal Cancer Centre, Jewish General Hospital, Montreal, Canada. Of 156 eligible patients, 112 agreed to participate (response 71.8%). The patients were aged >or=65 years and were newly diagnosed with breast, colorectal or lung cancer, lymphoma or multiple myeloma. Patients were asked for permission to obtain their list of medications from their pharmacist. The cancer treatment information was abstracted from the medical chart. Vigilance Santé software was used to identify the presence, type and severity of potential medication problems. RESULTS:The median number of medications was five at baseline, seven at 3 months and six at 6 and 12 months. At baseline, 247 potential medication problems were identified, followed by 273 at 3 months, 229 at 6 months and 188 at 12 months. About half of the patients at each follow-up had one or more moderate or severe potential medication problem. Patients receiving systemic cancer treatment had significantly fewer potential problems at 3 months than patients not receiving systemic cancer treatment, but no differences were observed at 6 and 12 months. The most common warnings were contraindications, interactions and miscellaneous warnings, and the cancer treatment was involved in 12% of all potential problems. CONCLUSION:This study showed that the majority of older newly diagnosed cancer patients take prescribed medication and about two-thirds have potential medication problems, of which about half are of at least moderate severity. The cancer treatment was involved in only a small proportion of all potential drug problems.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Puts MT,Monette J,Girre V,Costa-Lima B,Wolfson C,Batist G,Bergman Hdoi
10.2165/11537310-000000000-00000subject
Has Abstractpub_date
2010-07-01 00:00:00pages
559-72issue
7eissn
1170-229Xissn
1179-1969pii
4journal_volume
27pub_type
杂志文章相关文献
DRUGS & AGING文献大全abstract::The 2013 American College of Cardiology (ACC) and American Heart Association (AHA) practice guidelines for the treatment of blood cholesterol significantly changed the paradigm of how providers should prescribe statin therapy, especially for older adults. While the evidence supports statin therapy for older adults wit...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-014-0238-5
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:In the presence of multimorbidity and limited life expectancy (LLE), the need for continued use of preventive medicines becomes uncertain as they may neither improve health nor confer continued health benefits. OBJECTIVE:Our objective was to systematically review the literature to examine the discontinuatio...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-017-0487-1
更新日期:2017-10-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) has considerable morbidity and mortality in the older adult population. The role of antibiotics in the management of acute exacerbations of COPD (AECOPD) is currently evolving. Despite only mild benefits, most patients with AECOPD in ambulatory settings receive antibiotics ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-020-00786-7
更新日期:2020-09-01 00:00:00
abstract::In contrast with the earlier stages and, in particular, the predementia stage, of Alzheimer's disease (AD), severe dementia is often neglected. However, the advanced stages of dementia are just as important as the earlier stages because of their frequency, their impact on the lives of patients and their caregivers, an...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/0002512-200926020-00005
更新日期:2009-01-01 00:00:00
abstract::The prevalence of intermittent claudication (IC) increases with age; when questioned, older patients consider increased difficulty in walking to be a normal consequence of aging. Although the prognosis for the involved limb with IC is relatively good, IC is an important clinical predictor of increased cardiovascular m...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199914040-00002
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Remifentanil used in combination with propofol provides adequate conditions for tracheal intubation without muscle relaxants. Delivery of the optimal dose is important to prevent poor intubation conditions and drug-related complications. No previous study has investigated the use of a remifentanil-propofol c...
journal_title:Drugs & aging
pub_type: 临床试验,杂志文章
doi:10.1007/s40266-012-0019-y
更新日期:2012-11-01 00:00:00
abstract::Research into the use of clozapine in older people is somewhat scarce. Clozapine is associated with serious adverse effects such as agranulocytosis, seizures, myocarditis and metabolic syndrome. Other common undesirable effects such as sedation, constipation (which can be fatal), urinary incontinence and hypersalivati...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-013-0144-2
更新日期:2014-01-01 00:00:00
abstract::Overactive bladder (OAB) is a common constellation of lower urinary tract storage symptoms that causes a significant impact on a person's quality of life. The elderly may be disproportionally impacted by these symptoms due to concomitant poor mobility, comorbid conditions such as diabetes and heart failure, and polyph...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-015-0301-x
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Despite evidence of effective combination drug therapy for secondary prevention of coronary heart disease (CHD), older adults with this condition remain undertreated. OBJECTIVE:To describe time trends (1992-2003) in the adoption of combination cardiac drug therapies (beta-blockers [beta-adrenoceptor antagon...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11532150-000000000-00000
更新日期:2010-02-01 00:00:00
abstract::Patients with chronic kidney disease (CKD) are generally affected by secondary hyperparathyroidism (SHPT). High phosphate, low calcium and vitamin D deficiency represent the classical 'triad' involved into the pathogenesis of SHPT in renal insufficiency, in which downregulation of the parathyroid vitamin D receptor an...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200926060-00002
更新日期:2009-01-01 00:00:00
abstract::Restenosis in the months following a successful percutaneous transluminal coronary angioplasty (PTCA) remains the main limitation to this technique for myocardial revascularisation. Despite intensive investigation in this area, no pharmacological therapy has yet been found to be useful in preventing restenosis after c...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199813040-00005
更新日期:1998-10-01 00:00:00
abstract::This paper reviews the burden and economic consequences of glaucoma upon healthcare systems and patients, especially elderly patients. An extensive review of the literature was conducted, primarily using MEDLINE, but also by examining selected article reference lists, relevant websites and the proceedings of specialis...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522040-00004
更新日期:2005-01-01 00:00:00
abstract::The alcohol withdrawal syndrome is common in elderly individuals who are alcohol dependent and who decrease or stop their alcohol intake. While there have been few clinical studies to directly support or refute the hypothesis that withdrawal symptom severity, delirium and seizures increase with advancing age, several ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199914060-00002
更新日期:1999-06-01 00:00:00
abstract::Despite a sharp decline in the incidence of gastric cancer during the second half of the 20th century, this malignancy remains the second leading cause of cancer mortality in the world. The incidence and mortality rate of gastric cancer increase with age; at present, the median ages at diagnosis are 67 years for men a...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11315740-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::It is inevitable that publicly funded, technically sophisticated medical treatments will be increasingly rationed. Other things being equal, there is a greater duty to use them to prolong the lives of younger than older people. Age is therefore an ethical rationing criterion. Denial of this may actually harm older peo...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-199609060-00003
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Inappropriate prescribing is an important and possibly preventable risk factor for adverse drug reactions (ADRs) in the elderly, and hospital-based studies have shown that a large proportion of admissions is a result of ADRs. However, little is known about how inappropriate drug use (IDU) affec...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200522010-00005
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Optimal use of digoxin in the elderly population requires information about the drug's pharmacokinetics and the influence of various factors on the drug's disposition. However, because of sampling restrictions, it is often difficult to perform traditional pharmacokinetic studies in elderly patients. OBJECTI...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11594230-000000000-00000
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:By using the findings obtained from the PREPARED study, we aimed to estimate the cost effectiveness of ropinirole prolonged release (PR) [Requip-Modutab(®)] in Parkinson's disease (PD) versus ropinirole immediate release (IR). In the PREPARED study, ropinirole PR provided a significantly greater improvement ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-013-0150-4
更新日期:2014-03-01 00:00:00
abstract::Many quantities assayed in clinical laboratories demonstrate age-related changes. Particularly important periods are early life, adolescence, old age, and after the menopause in females. The changes that occur until adulthood are well documented. Fewer data are available on elderly people even though they consume a la...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199303030-00006
更新日期:1993-05-01 00:00:00
abstract::Constipation is a common problem in elderly persons, with prevalence ranging from 15% to 20% in the community-dwelling elderly population and up to 50% in some studies of nursing home residents. In these patients, constipation results from a combination of risk factors, such as reduced fibre and fluid intake, decrease...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421140-00002
更新日期:2004-01-01 00:00:00
abstract::Osteoarthritis (OA) is a major cause of pain and physical disability in adults, and an increasingly common disease given its associations with aging and a growing obese/overweight population. Paracetamol is widely recommended for analgesia at an early stage in the management of OA, and, although frequently prescribed,...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00658-9
更新日期:2019-04-01 00:00:00
abstract::Behavioural disturbances, also termed neuropsychiatric symptoms, are a frequent clinical feature of dementia in Alzheimer's disease (AD). Many AD patients receive treatment with cholinesterase inhibitors (ChEIs). This review examines the evidence for behavioural effects of the four ChEIs that have been approved for th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200623120-00003
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Multiple drug use is common among old, frail nursing home residents who are, as a consequence, susceptible to adverse effects and drug interactions. This study uses the updated Beers criteria for potentially inappropriate drug (PID) use in older adults to determine the extent and nature of PIDs...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825080-00005
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Medication-related admissions are an important cause of hospital admissions in older people. The scope for prevention is less clear. OBJECTIVES:To characterize medication-related hospital admissions in older people and assess their preventability. METHODS:This was a cross-sectional, observational study con...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11316750-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::The consumption of medications with anticholinergic activity has been suggested to result in the adverse effects of mental confusion, visual disturbance, and muscle weakness, which may lead to falls. Existing published evidence linking anticholinergic drugs with falls, however, remains weak. This study was conducted t...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-019-00731-3
更新日期:2020-02-01 00:00:00
abstract::Felodipine is a dihydropyridine calcium antagonist which may be administered once daily in an extended release (ER) formulation. As monotherapy in older patients with mild to moderate essential hypertension, felodipine ER once daily provides effective control of blood pressure (BP). The drug has also been effective, e...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199202050-00002
更新日期:1992-09-01 00:00:00
abstract::High drug consumption among the elderly and inappropriate prescribing practices increase the risk of adverse drug effects in this population. This risk may be decreased by conducting, for example, a medication review alone or as part of a comprehensive geriatric assessment (CGA); however, little is known about the fat...
journal_title:Drugs & aging
pub_type: 杂志文章,随机对照试验
doi:10.2165/11536650-000000000-00000
更新日期:2010-06-01 00:00:00
abstract::Relaxation of the upper age limits for solid organ transplantation coupled with improvements in post-transplant survival have resulted in greater numbers of elderly patients receiving immunosuppressant drugs such as tacrolimus. Tacrolimus is a potent agent with a narrow therapeutic window and large inter- and intraind...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522070-00001
更新日期:2005-01-01 00:00:00
abstract::The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00706-4
更新日期:2019-12-01 00:00:00
abstract::Skin and soft tissue infections are quite common in elderly people. A number of special conditions and circumstances need to be considered in the diagnosis and therapy. It is important to try to establish the causative organism, exclude other cutaneous disorders and identify precipitating factors. Treatment modalities...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219050-00002
更新日期:2002-01-01 00:00:00