Abstract:
:Overactive bladder (OAB) is a common constellation of lower urinary tract storage symptoms that causes a significant impact on a person's quality of life. The elderly may be disproportionally impacted by these symptoms due to concomitant poor mobility, comorbid conditions such as diabetes and heart failure, and polypharmacy. While behavioral modification and pelvic floor muscle training should be considered first-line treatment options, pharmacotherapy remains the backbone of the therapeutic regimen. Trospium, oxybutynin, fesoterodine, and darifenacin all have unique properties that may confer certain advantages in the elderly population. The hydrophilicity and quaternary amine structure of trospium may limit its ability to cross the blood-brain barrier and thus minimize impact on cognition in the elderly. In its oral form, oxybutynin may have the most significant effect on cognition; however, the transdermal preparations may be favorable in the elderly population due to the ability to avoid first-pass metabolism and its limited antimuscarinic adverse effects. Fesoterodine may be the most extensively studied OAB medication in the elderly population. Darifenacin has a strong affinity for the M3 receptor in the bladder, while having a weak affinity for the M1 receptor commonly found in the brain. It must be noted that all muscarinic receptor antagonists are associated with common adverse effects to some degree, and frequent re-evaluation of the elderly patient is necessary to confirm the proper benefit-to-risk profile.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
McFerren SC,Gomelsky Adoi
10.1007/s40266-015-0301-xsubject
Has Abstractpub_date
2015-10-01 00:00:00pages
809-19issue
10eissn
1170-229Xissn
1179-1969pii
10.1007/s40266-015-0301-xjournal_volume
32pub_type
杂志文章,评审相关文献
DRUGS & AGING文献大全abstract:BACKGROUND:Osteoporosis is a common cause of disability and death in elderly men and women. Until 2007, Australian Government-subsidized use of oral bisphosphonates, raloxifene and calcitriol (1alpha,25-dihydroxycholecalciferol) was limited to secondary prevention (requiring x-ray evidence of previous low-trauma fractu...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11318400-000000000-00000
更新日期:2010-03-01 00:00:00
abstract::Aging is associated with a myriad of hormonal changes. The mechanisms underlying these changes are variable. Aging is associated with anatomic changes of the endocrine glands, notably as a result of programmed cell death, autoimmune mediated destruction of the gland, or neoplastic transformation of glandular tissue. A...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199303020-00004
更新日期:1993-03-01 00:00:00
abstract::Despite advances in antimicrobial chemotherapy over recent decades, morbidity and mortality secondary to infection continues to rise. In addition, the incidence of infection caused by resistant organisms has also increased. Concurrently, the elderly are living longer than prior generations, often with disabling chroni...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199813060-00004
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:There is poor evidence supporting the use of any pharmacologic treatments for neuropsychiatric disorders following traumatic brain injury (TBI), especially among older adults. Informed by our recent characterization of psychotropic medication use among Medicare beneficiaries with TBI, the objective of this st...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0570-2
更新日期:2018-08-01 00:00:00
abstract::In contrast with women, who experience a complete and abrupt cessation of ovarian function during the menopause, aging men largely maintain their testicular androgen production. Nevertheless, most cross-sectional studies indicate that there is a partial decrease in testosterone levels with aging, although this has not...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711010-00005
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Withdrawal of fall-risk-increasing drugs has been proven to be effective in older persons. However, given the enormous rise in healthcare costs in recent decades, the effect of such withdrawals on healthcare costs also needs to be considered. METHOD:Within a common geriatric outpatient population, patients ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825060-00005
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The public health burden of osteoporosis is high, principally because of increased risk of fractures and associated morbidity, handicap and mortality. Osteoporotic fracture prevention is therefore an important public health goal. General practitioners (GPs) play a key role in the management of osteoporosis, ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200724070-00007
更新日期:2007-01-01 00:00:00
abstract::Prostate cancer is a common disease in the elderly, and the number of older prostate cancer patients will probably increase with both the aging of the population and the increased rate of screening. In elderly patients with several co-morbidities, cancer management can be complex, and the risk of administering toxic t...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11537480-000000000-00000
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Medication-related problems are common in the growing population of older adults and inappropriate prescribing is a preventable risk factor. Explicit criteria such as the Beers criteria provide a valid instrument for describing the rate of inappropriate medication (IM) prescriptions among older adults. OBJE...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11584770-000000000-00000
更新日期:2010-12-01 00:00:00
abstract::Psoriatic arthritis (PsA) can start in subjects aged over 60 years, defined as late-onset PsA. In late-onset PsA, the weight of family history and genetic background appears less significant when compared with younger onset PsA, whereas obesity and smoking have been suggested as potential risk factors. In patients wit...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00688-3
更新日期:2019-10-01 00:00:00
abstract::Management of hypertension in the elderly should take into account, in particular, the possible negative impact of antihypertensive drugs on the patient's quality of life, the deterioration of which may result in a loss of independence and reduced treatment compliance. Quality of life is recognised as a multifactorial...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421060-00003
更新日期:2004-01-01 00:00:00
abstract::An increasing number of elderly patients are exposed to cardiovascular drugs for the treatment of acute and/or chronic conditions. This is a result of the progressive aging of the population, a common feature in most industrialised countries, and an improvement in primary and secondary cardiovascular prevention strate...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522110-00003
更新日期:2005-01-01 00:00:00
abstract::As people grow old, their need for medications increases dramatically because of the higher incidence of chronic pain, diabetes mellitus, cardiovascular and neurological diseases in the elderly population. Furthermore, the elderly require special consideration with respect to drug delivery, drug interactions and adher...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200623050-00001
更新日期:2006-01-01 00:00:00
abstract::High drug consumption among the elderly and inappropriate prescribing practices increase the risk of adverse drug effects in this population. This risk may be decreased by conducting, for example, a medication review alone or as part of a comprehensive geriatric assessment (CGA); however, little is known about the fat...
journal_title:Drugs & aging
pub_type: 杂志文章,随机对照试验
doi:10.2165/11536650-000000000-00000
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Our objectives were to (1) describe the evolution of the underuse of anticoagulants in older people with atrial fibrillation (AF) and a CHADS2 score ≥ 2 since direct oral anticoagulants (DOACs) were introduced to the market and (2) describe factors associated with this underuse. METHODS:We conducted a retros...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-017-0493-3
更新日期:2017-11-01 00:00:00
abstract::High fasting plasma homocysteine levels (> 12 to 15 mumol/L) are commonly encountered in clinical practice and are associated with increased risk of atherothrombotic disease. Treatment with folic acid (1 to 5 mg/day) is inexpensive and effective in normalising plasma homocysteine levels. High plasma homocysteine level...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200016040-00001
更新日期:2000-04-01 00:00:00
abstract::Felodipine is a dihydropyridine calcium antagonist which may be administered once daily in an extended release (ER) formulation. As monotherapy in older patients with mild to moderate essential hypertension, felodipine ER once daily provides effective control of blood pressure (BP). The drug has also been effective, e...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199202050-00002
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Improvement in renal function and decreases in serum uric acid (SUA) have been reported following prolonged high-intensity statin (HMG-CoA reductase inhibitor) therapy. This post hoc analysis of the SAGE trial examined the effect of intensive versus less intensive statin therapy on renal function, safety, an...
journal_title:Drugs & aging
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40266-015-0328-z
更新日期:2015-12-01 00:00:00
abstract::Influenza is a major cause of morbidity and mortality in the elderly. Influenza vaccine is recommended for people aged 65 years and older and those in long term care. Currently only 30% of high risk persons are vaccinated. Vaccination generally stimulates an adequate immune response, is well tolerated and is to be enc...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199101060-00003
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320110-00005
更新日期:2003-01-01 00:00:00
abstract::Lisinopril, the lysine analogue of enalaprilat, is a long-acting angiotensin converting enzyme (ACE) inhibitor which is administered once daily by mouth. The efficacy of lisinopril in reducing blood pressure is well established in younger populations, and many trials now show it to be effective in lowering blood press...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199710020-00006
更新日期:1997-02-01 00:00:00
abstract::Systemic fungal infections are an increasing problem in older adults. For several of the endemic mycoses, this increase is the result of increased travel and leisure activities in areas endemic for these fungi. Immunosuppressive agents, care in an intensive care unit, and invasive devices all contribute to infection w...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200118050-00002
更新日期:2001-01-01 00:00:00
abstract::Man and higher primates have adrenals that secrete large amounts of dehydroepiandrosterone (DHEA) [prasterone] and its sulphate (DHEAS) [PB 008]. A remarkable feature of plasma DHEAS levels in humans is their great decrease with aging. Researchers have postulated that this age-related decline of DHEAS levels may expla...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320130-00001
更新日期:2003-01-01 00:00:00
abstract::New treatments and treatment protocols for diseases affecting the elderly are evolving as we strive to meet the needs of an aging society. To help you keep up to date with the latest advances worldwide on all aspects of drug therapy and patient management, this section of the journal brings you information selected fr...
journal_title:Drugs & aging
pub_type:
doi:10.2165/00002512-200623070-00008
更新日期:2006-01-01 00:00:00
abstract::The number of older patients is increasing globally. Combined with the growing number of ambulatory surgeries, many older patients will undergo ambulatory surgery in the future. The ambulatory setting offers many advantages: early mobilization, higher patient satisfaction, lower costs, and a low incidence of several c...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-020-00803-9
更新日期:2020-12-01 00:00:00
abstract::Advances in our understanding of the structure, function and distribution of nicotinic acetylcholine receptors in the CNS have provided the impetus for new studies examining the role(s) that these receptors and associated processes may play in CNS functions. Further motivation has come from the realisation that such r...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711030-00005
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Statins have been associated with later life, long-term care admission in observational studies. However, by preventing vascular events, statins may also prevent or delay admission. We wished to determine statin and long-term care admission associations in a randomised controlled trial context, and describe ...
journal_title:Drugs & aging
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40266-018-0560-4
更新日期:2018-07-01 00:00:00
abstract::The Medicare programme already funds a large proportion of the medical care for older Americans. However, geriatricians are an underutilized resource for improving the quality of care delivered with Medicare funding, particularly to the most complex patients. Recent legislative changes will increase the involvement of...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522050-00002
更新日期:2005-01-01 00:00:00
abstract::Influenza causes substantial morbidity across the age spectrum. However, the elderly are especially vulnerable to the serious complications of influenza that might result in hospitalisation or death, and high rates of influenza-associated excess hospitalisation or death that exceed by several-fold the rates seen among...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析,评审
doi:10.2165/00002512-200522060-00004
更新日期:2005-01-01 00:00:00
abstract::Blood pressure levels are strongly predictive of the risks of first-ever and recurrent stroke. The benefits of blood pressure-lowering therapy for the prevention of fatal and non-fatal stroke in middle-aged individuals are well established. However, until recently, there has been uncertainty about the consistency of s...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320040-00001
更新日期:2003-01-01 00:00:00