Management of Ambulatory Anesthesia in Older Adults.

abstract：:Intracavernous alprostadil (synthetic prostaglandin E1) is a vasodilating agent which acts by relaxing the smooth muscles of the corpus cavernosum and by increasing the diameter of cavernous arteries; this leads to erection. Following intracavernous administration, alprostadil is either locally metabolised or rapidly ...

journal_title：Drugs & aging

authors： Lea AP,Bryson HM,Balfour JA

更新日期：1996-01-01 00:00:00

abstract：:Attempts to control pneumococcal infection by vaccination, undertaken initially in 1911, have gone through 3 phases during the subsequent 8 decades. Initially, vaccines of killed pneumococcal cells prepared in a variety of ways were used in epidemic settings with inconclusive results, although administered to approxim...

journal_title：Drugs & aging

authors： Austrian R

更新日期：1999-01-01 00:00:00

abstract：:Primary hyperparathyroidism is a common metabolic bone disease and currently presents a significant management dilemma. Most of the patients have few relevant symptoms and surgical parathyroidectomy offers the prospect of cure with freedom from the risk of long-term complications or the need for a follow-up. However, ...

journal_title：Drugs & aging

authors： Sims R,Ubhi C,Hosking D

更新日期：2004-01-01 00:00:00

abstract：:Antidepressants have long been recognized as a contributory factor to falls and many studies show an association between antidepressants and falls. There are extensive data for tricyclic antidepressants (TCAs) and related drugs, and for selective serotonin reuptake inhibitors (SSRIs), but few data for other classes of...

journal_title：Drugs & aging

authors： Darowski A,Chambers SA,Chambers DJ

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...

journal_title：Drugs & aging

authors： Andrès E,Zimmer J,Noel E,Kaltenbach G,Koumarianou A,Maloisel F

更新日期：2003-01-01 00:00:00

abstract：:A progressive accumulation of atherosclerotic lesions beginning early in life puts elderly persons at a greater absolute risk of cardiovascular disease and coronary events than other segments of the population. HMG-CoA reductase inhibitor (statin) therapy has been shown to be both efficacious and well tolerated in mos...

journal_title：Drugs & aging

authors： Davidson MH

更新日期：2007-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major problem in the elderly population, with approximately 10% of the population affected. Since COPD is an inflammatory disorder of the pulmonary system, corticosteroids might be expected to improve clinical outcomes of the disease. Data from large, well designed ran...

journal_title：Drugs & aging

authors： Sin DD,Man SF

更新日期：2003-01-01 00:00:00

abstract：:Chronic non-terminal diseases, including postmenopausal osteoporosis, are associated with poor treatment compliance and persistence. The longer a patient with osteoporosis complies and persists with treatment, the lower the risk of fracture. Retrospective studies with emphasis on real-world data have led to a greater ...

journal_title：Drugs & aging

authors： Gold DT

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Age-related changes in the concentration-effect relationship of (+)-O-desmethyl-tramadol [(+)-ODM], tramadol's active metabolite, are not documented in the elderly. OBJECTIVE:The objective of this study was to characterize, in elderly and young subjects, the (+)-ODM pharmacokinetic and pharmacodynamic relat...

journal_title：Drugs & aging

authors： Robertson SS,Mouksassi MS,Varin F

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Immunosenescence makes the elderly more susceptible to influenza complications and less responsive to vaccination. An intradermal formulation (IDflu) is one of several strategies being investigated to increase the immunogenicity of influenza vaccines. OBJECTIVE:The overall goal of the study was to assess ...

journal_title：Drugs & aging

authors： Pileggi C,Mascaro V,Bianco A,Nobile CG,Pavia M

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To assess, by smoothness index (SI), distribution of the antihypertensive effect of extended-release (ER) felodipine over 24 hours in elderly patients with hypertension. METHODS:After a 4-week washout phase, 35 elderly patients (mean age 69 +/- 4 years) with mild-to-moderate hypertension received 2 weeks' tr...

journal_title：Drugs & aging

authors： Antonicelli R,Omboni S,Giovanni DC,Ansuini R,Mori A,Gesuita R,Parati G,Paciaroni E

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...

journal_title：Drugs & aging

authors： Harrison SL,Kouladjian O'Donnell L,Bradley CE,Milte R,Dyer SM,Gnanamanickam ES,Liu E,Hilmer SN,Crotty M

更新日期：2018-01-01 00:00:00

abstract：:The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...

journal_title：Drugs & aging

authors： Valencia WM,Florez HJ,Palacio AM

更新日期：2019-12-01 00:00:00

abstract：:Despite the availability of angiotensin converting enzyme (ACE) inhibitors for patients with congestive heart failure (CHF), mortality and morbidity remains unacceptably high. CHF is thought to progress as a result of activation of endogenous neurohormonal systems which are activated by the initial myocardial injury. ...

journal_title：Drugs & aging

authors： Tsuyuki RT,McAlister FA,Teo KK

更新日期：2000-01-01 00:00:00

abstract：:In general, the pharmacological treatment of non-psychotic major depressive disorder in old age is only partially successful, with only approximately 50% of older depressed adults improving with initial antidepressant monotherapy. Many factors may predict a more difficult-to-treat depression, including coexisting anxi...

journal_title：Drugs & aging

authors： Driscoll HC,Karp JF,Dew MA,Reynolds CF 3rd

更新日期：2007-01-01 00:00:00

abstract：:The main characteristic of acute lymphoblastic leukaemia (ALL) in the elderly is its dismal prognosis. However, other than a lower incidence of T-cell ALL and a greater likelihood of unfavourable chromosomal abnormalities, the clinical and biological characteristics of Philadelphia chromosome-negative (Ph-) ALL in the...

journal_title：Drugs & aging

authors： Rousselot P,Delannoy A

更新日期：2011-09-01 00:00:00

abstract：:beta-Adrenoceptor antagonists (beta-blockers) reduce mortality and recurrent myocardial infarction (MI) in older patients after both Q-wave MI and non-Q-wave MI. The effects of beta-blockers are to: (i) reduce complex ventricular arrhythmias, including ventricular tachycardia; (ii) increase the ventricular fibrillatio...

journal_title：Drugs & aging

authors： Aronow WS

更新日期：1997-12-01 00:00:00

abstract：:The fluoroquinolones are antibiotics frequently used in infections that affect elderly individuals. The physiological aging process can profoundly affect the pharmacokinetics of drugs, necessitating adjustment of dosage regimens in the elderly. Changes in pharmacokinetics with age are mainly due to the progressive det...

journal_title：Drugs & aging

authors： Nilsson-Ehle I,Ljungberg B

更新日期：1991-07-01 00:00:00

abstract：:Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks...

journal_title：Drugs & aging

authors： Ho SB,Hovsepians R,Gupta S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:In response to concerns about, and issues pertaining to, medication use practices in residential aged-care facilities (RACFs), the Australian Pharmaceutical Advisory Council (APAC) established a working party on quality use of medicines (QUM) in nursing homes and hostels. The APAC is a representative ministe...

journal_title：Drugs & aging

authors： Cheek J,Gilbert A,Ballantyne A,Penhall R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The practice of hiding medicines in nursing home patients' food or beverages is described in only a few scientific papers. An earlier study conducted in 1999/2000 showed that covert medication was common in Norwegian nursing homes, with 11% of patients in regular nursing home units (RUs) and 17...

journal_title：Drugs & aging

authors： Kirkevold O,Engedal K

更新日期：2009-01-01 00:00:00

abstract：:The incidence of pneumonia is highest among the aged compared with other adult populations, and causes significant morbidity and mortality among this group. Most episodes of pneumonia are caused by aspiration of oropharyngeal flora into the lungs and failure of lung defence mechanisms to eliminate the aspirated bacter...

journal_title：Drugs & aging

authors： Mylotte JM,Ksiazek S,Bentley DW

更新日期：1994-01-01 00:00:00

abstract：:Felodipine is a dihydropyridine calcium antagonist which may be administered once daily in an extended release (ER) formulation. As monotherapy in older patients with mild to moderate essential hypertension, felodipine ER once daily provides effective control of blood pressure (BP). The drug has also been effective, e...

journal_title：Drugs & aging

authors： Faulds D,Sorkin EM

更新日期：1992-09-01 00:00:00

abstract：:Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug reg...

journal_title：Drugs & aging

authors： Petrovic M,van der Cammen T,Onder G

更新日期：2012-06-01 00:00:00

abstract：:Healthcare systems worldwide are facing an unprecedented demographic change as globally, the number of older people will triple to 2 billion by the year 2050. The resulting pressures on acute services have been instrumental in the development of intermediate care (IC) as a new healthcare model, which has its origins i...

journal_title：Drugs & aging

authors： Millar AN,Hughes CM,Passmore AP,Ryan C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The impact of multiple medication exposure on health outcomes among older patients with end-stage kidney disease (ESKD) is unknown. OBJECTIVE:The objective of this study was to identify the impact of medicine exposure on hospitalisation rates and mortality in a prospective longitudinal observational study o...

journal_title：Drugs & aging

authors： Samaranayaka S,Walker RJ,Samaranayaka A,Derrett S,Schollum JWB

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...

journal_title：Drugs & aging

authors： Pariente A,Dartigues JF,Benichou J,Letenneur L,Moore N,Fourrier-Réglat A

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To determine the association between changes in complete blood counts and grade 3 or 4 toxicities from cycle 1 to cycle 2 during adjuvant chemotherapy in women > or =65 years of age with breast cancer. DESIGN AND METHODS:A retrospective review was performed on 1405 patients > or =65 years of age who were treat...

journal_title：Drugs & aging

authors： Hurria A,Brogan K,Panageas KS,Jakubowski A,Zauderer M,Pearce C,Norton L,Howard J,Hudis C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:By using the findings obtained from the PREPARED study, we aimed to estimate the cost effectiveness of ropinirole prolonged release (PR) [Requip-Modutab(®)] in Parkinson's disease (PD) versus ropinirole immediate release (IR). In the PREPARED study, ropinirole PR provided a significantly greater improvement ...

journal_title：Drugs & aging

authors： van Boven JF,Novak A,Driessen MT,Boersma C,Boomsma MM,Postma MJ

更新日期：2014-03-01 00:00:00

abstract：:Rheumatoid arthritis (RA) and osteoarthritis are chronic diseases that result in cartilage degradation and loss of joint function. Currently available drugs are predominantly directed towards the control of pain and/or the inflammation associated with joint synovitis but they do little to reduce joint destruction. In ...

journal_title：Drugs & aging

authors： Elliott S,Cawston T

更新日期：2001-01-01 00:00:00