Understanding patient compliance and persistence with osteoporosis therapy.

abstract：BACKGROUND AND OBJECTIVE:Multiple drug use is common among old, frail nursing home residents who are, as a consequence, susceptible to adverse effects and drug interactions. This study uses the updated Beers criteria for potentially inappropriate drug (PID) use in older adults to determine the extent and nature of PIDs...

journal_title：Drugs & aging

authors： Hosia-Randell HM,Muurinen SM,Pitkälä KH

更新日期：2008-01-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) are generally affected by secondary hyperparathyroidism (SHPT). High phosphate, low calcium and vitamin D deficiency represent the classical 'triad' involved into the pathogenesis of SHPT in renal insufficiency, in which downregulation of the parathyroid vitamin D receptor an...

journal_title：Drugs & aging

authors： Cozzolino M,Gallieni M,Pasho S,Fallabrino G,Ciceri P,Volpi EM,Olivi L,Brancaccio D

更新日期：2009-01-01 00:00:00

abstract：:Despite the availability of an efficient vaccine, chronic hepatitis B virus (HBV) infection remains a major public health problem worldwide. The World Health Organization estimates that there are still 350 million chronic carriers of the virus who are at risk of developing chronic hepatitis, liver cirrhosis and hepato...

journal_title：Drugs & aging

authors： Merle P,Trépo C,Zoulim F

更新日期：2001-01-01 00:00:00

abstract：:Over four-fifths of all strokes are due to thrombotic or embolic occlusion of cerebral arteries. There is a strong rationale for considering antithrombotic therapy for the treatment of patients with acute ischaemic stroke. Antiplatelet therapy with 150 to 300 mg of aspirin (acetylsalicylic acid) started within the fir...

journal_title：Drugs & aging

authors： Gubitz GJ,Sandercock PA

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Inappropriate prescribing is an important and possibly preventable risk factor for adverse drug reactions (ADRs) in the elderly, and hospital-based studies have shown that a large proportion of admissions is a result of ADRs. However, little is known about how inappropriate drug use (IDU) affec...

journal_title：Drugs & aging

authors： Klarin I,Wimo A,Fastbom J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Medication non-adherence can exacerbate disease severity, leading to impairments that interfere with self-care activities in older adults, and, ultimately, death. Elder self-neglect is the most common report to Adult Protective Services (APS) across the USA and is a significant risk factor for early mortalit...

journal_title：Drugs & aging

authors： Turner A,Hochschild A,Burnett J,Zulfiqar A,Dyer CB

更新日期：2012-09-01 00:00:00

abstract：:Osteoporosis is a common disease that affects 1 in 3 women. Family and twin studies have demonstrated that there is a strong genetic component to this condition. Potential candidate genes examined for their regulatory effect on bone mass include those for collagen type I, estrogen and vitamin D receptors, and various ...

journal_title：Drugs & aging

authors： Keen RW,Kelly PJ

更新日期：1997-11-01 00:00:00

abstract：:Despite a sharp decline in the incidence of gastric cancer during the second half of the 20th century, this malignancy remains the second leading cause of cancer mortality in the world. The incidence and mortality rate of gastric cancer increase with age; at present, the median ages at diagnosis are 67 years for men a...

journal_title：Drugs & aging

authors： Wagner AD,Wedding U

更新日期：2009-01-01 00:00:00

abstract：:The prevalence of neuropathic pain in the older population has been reported to be very high and is most commonly localized to a circumscribed area. Treatment failure is frequent in neuropathic pain and is accompanied by central side effects with recommended oral drugs acting on the central nervous system. A number of...

journal_title：Drugs & aging

authors： Pickering G,Lucchini C

更新日期：2020-02-01 00:00:00

abstract：:Colorectal cancer ranks third in incidence in both men and women after lung, breast and prostate cancer. The prevalence of colorectal cancer increases significantly with age, with 40% of patients in Europe being >75 years of age at the time of initial diagnosis. Furthermore, the number of elderly patients with colorec...

journal_title：Drugs & aging

authors： Meulenbeld HJ,Creemers GJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The importance of optimising medicines management for people with dementia has been emphasised through research and policy. However, evidence is currently lacking regarding how to achieve this in this patient population. OBJECTIVE:The aim was to assess the effectiveness of medicines management interventions...

journal_title：Drugs & aging

authors： McGrattan M,Ryan C,Barry HE,Hughes CM

更新日期：2017-12-01 00:00:00

abstract：:Generalised pruritus is common in the elderly. Idiopathic 'senile pruritus' is a diagnosis of exclusion, and an underlying systemic disorder should be sought. Thyroid disease, haematological malignancy, iron deficiency, cholestasis or renal impairment may be responsible for pruritus. Rarely pruritus may occur after ce...

journal_title：Drugs & aging

authors： Lonsdale-Eccles A,Carmichael AJ

更新日期：2003-01-01 00:00:00

abstract：:Influenza causes substantial morbidity across the age spectrum. However, the elderly are especially vulnerable to the serious complications of influenza that might result in hospitalisation or death, and high rates of influenza-associated excess hospitalisation or death that exceed by several-fold the rates seen among...

journal_title：Drugs & aging

authors： Nichol KL

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Centenarians are considered as models of successful aging and represent a special group of patients. The aim of this study was to analyze heart failure epidemiology and treatment trajectories in centenarians compared to nonagenarians (90-99 years of age) and octogenarians (80-89 years of age) with heart fail...

journal_title：Drugs & aging

authors： Schmidt IM,Kreutz R,Dräger D,Zwillich C,Hörter S,Kuhlmey A,Gellert P

更新日期：2018-10-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting 1 to 3% of individuals over the age of 65 years. While effective therapy exists for treating the bradykinesia, rigidity and tremor associated with the disease, the cause is unknown. There is no treatment available to prevent or slo...

journal_title：Drugs & aging

authors： Ross GW,Petrovitch H

更新日期：2001-01-01 00:00:00

abstract：:Asthma is a common airway disease found in people of all ages, although most studies of asthma therapies are focused on adolescent and young adults. Little information exists on the use of asthma therapeutics in the older patient (>65 years of age). The newest therapeutic class to be released in the US for the treatme...

journal_title：Drugs & aging

authors： Grayson MH,Korenblat PE

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Adverse drug reactions are a major cause of hospital admissions in older individuals, with the majority potentially preventable. Despite the apparent magnitude of this problem, little is known about rates of repeat admission to hospital as a result of adverse drug reactions. OBJECTIVES:The objectives of thi...

journal_title：Drugs & aging

authors： Parameswaran Nair N,Chalmers L,Bereznicki BJ,Curtain CM,Bereznicki LR

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Immunosenescence makes the elderly more susceptible to influenza complications and less responsive to vaccination. An intradermal formulation (IDflu) is one of several strategies being investigated to increase the immunogenicity of influenza vaccines. OBJECTIVE:The overall goal of the study was to assess ...

journal_title：Drugs & aging

authors： Pileggi C,Mascaro V,Bianco A,Nobile CG,Pavia M

更新日期：2015-10-01 00:00:00

abstract：:The incidence of both systolic and diastolic hypertension is increased in elderly patients, therefore antihypertensive drugs are commonly used in this population. In addition to changes in blood pressure, the aging process also causes numerous changes in other physiological parameters, resulting in altered pharmacokin...

journal_title：Drugs & aging

authors： Piepho RW,Fendler KJ

更新日期：1991-05-01 00:00:00

abstract：:Electronic storage of and access to medical data is becoming increasingly common. Advances in computer technology and telecommunications have made it possible to store vast amounts of information in databases and transmit this information rapidly to any place on the globe. At the forefront of this technology is the In...

journal_title：Drugs & aging

authors： Glowniak J

更新日期：1997-03-01 00:00:00

abstract：:Many quantities assayed in clinical laboratories demonstrate age-related changes. Particularly important periods are early life, adolescence, old age, and after the menopause in females. The changes that occur until adulthood are well documented. Fewer data are available on elderly people even though they consume a la...

journal_title：Drugs & aging

authors： Fraser CG

更新日期：1993-05-01 00:00:00

abstract：:Although use of NSAIDs and aspirin (acetylsalicylic acid) is well known to be associated with gastrointestinal (GI) complications and potential mortality, these medications continue to be widely prescribed in the elderly. Age is a significant risk factor for NSAID-induced GI events; indeed, patients >75 years of age c...

journal_title：Drugs & aging

authors： Lanas A,Ferrandez A

更新日期：2007-01-01 00:00:00

abstract：:Although the frequency of physician consultations and the sale of over-the-counter remedies establish the high prevalence of acute cough in the elderly, epidemiological studies have tended to be imprecise. However, respiratory tract infections in nose, larynx and/or bronchi, either viral or bacterial or both, are by f...

journal_title：Drugs & aging

authors： Widdicombe J,Kamath S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Inappropriate medications are often used in older adults despite their unfavourable risk-to-benefit profile. Although many of the medications in the American Geriatrics Society (AGS) Beers list are potentially inappropriate because of their anticholinergic properties, little is known regarding the nature and...

journal_title：Drugs & aging

authors： Kachru N,Carnahan RM,Johnson ML,Aparasu RR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...

journal_title：Drugs & aging

authors： Pariente A,Dartigues JF,Benichou J,Letenneur L,Moore N,Fourrier-Réglat A

更新日期：2008-01-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) usually affect adults and older populations. The well recognized clinical (i.e., granulomatosis with polyangiitis [GPA], microscopic polyangiitis, and eosinophilic GPA) and serological phenotypes (i.e., anti-MPO-ANCA, anti-PR3-ANCA and ANCA nega...

journal_title：Drugs & aging

authors： Berti A,Caporali R,Montecucco C,Paolazzi G,Monti S

更新日期：2019-01-01 00:00:00

abstract：:Primary hyperparathyroidism is a common metabolic bone disease and currently presents a significant management dilemma. Most of the patients have few relevant symptoms and surgical parathyroidectomy offers the prospect of cure with freedom from the risk of long-term complications or the need for a follow-up. However, ...

journal_title：Drugs & aging

authors： Sims R,Ubhi C,Hosking D

更新日期：2004-01-01 00:00:00

abstract：:The consumption of medications with anticholinergic activity has been suggested to result in the adverse effects of mental confusion, visual disturbance, and muscle weakness, which may lead to falls. Existing published evidence linking anticholinergic drugs with falls, however, remains weak. This study was conducted t...

journal_title：Drugs & aging

authors： Tan MP,Tan GJ,Mat S,Luben RN,Wareham NJ,Khaw KT,Myint PK

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The use of proton pump inhibitors (PPIs) in older adults is high, often inappropriate, and may cause harm. Deprescribing is defined as the reduction, withdrawal, or discontinuation of inappropriate medication. OBJECTIVE:We conducted a systematic review to determine the effectiveness of interventions to depr...

journal_title：Drugs & aging

authors： Wilsdon TD,Hendrix I,Thynne TR,Mangoni AA

更新日期：2017-04-01 00:00:00

abstract：:Behavioural disturbances, also termed neuropsychiatric symptoms, are a frequent clinical feature of dementia in Alzheimer's disease (AD). Many AD patients receive treatment with cholinesterase inhibitors (ChEIs). This review examines the evidence for behavioural effects of the four ChEIs that have been approved for th...

journal_title：Drugs & aging

authors： Grimmer T,Kurz A

更新日期：2006-01-01 00:00:00