Management of secondary hyperparathyroidism in the elderly patient with chronic kidney disease.

abstract：BACKGROUND:Frailty is a clinical phenotype that is associated with adverse health outcomes. Since frail patients may be more prone for adverse drug events and about 15-20 % of commonly prescribed drugs are metabolized by CYP2D6, we hypothesized that CYP2D6 metabolism is decreased in frail patients compared with healthy...

journal_title：Drugs & aging

authors： Opdam FL,Modak AS,Mooijaart SP,Louwerens M,de Waal MW,Gelderblom H,Guchelaar HJ

更新日期：2015-12-01 00:00:00

abstract：:Decitabine (Dacogen(®)) is a deoxynucleoside analogue of cytidine that selectively inhibits DNA methyltransferases. Decitabine administered at a dose of 20 mg/m(2) by a 1-h intravenous infusion for 5 consecutive days of a 4-week cycle has been approved by the European Medicines Agency (EMA) for use in adult patients a...

journal_title：Drugs & aging

authors： Curran MP

更新日期：2013-06-01 00:00:00

abstract：:The atypical antipsychotics are a new class of agents with great promise for use in the elderly because of their reduced propensity to cause acute extrapyramidal adverse effects. Treatment of older patients with these agents, however, needs to take into consideration age-related changes in pharmacokinetics and the ris...

journal_title：Drugs & aging

authors： Sweet RA,Pollock BG

更新日期：1998-02-01 00:00:00

abstract：:Despite the availability of angiotensin converting enzyme (ACE) inhibitors for patients with congestive heart failure (CHF), mortality and morbidity remains unacceptably high. CHF is thought to progress as a result of activation of endogenous neurohormonal systems which are activated by the initial myocardial injury. ...

journal_title：Drugs & aging

authors： Tsuyuki RT,McAlister FA,Teo KK

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The importance of optimising medicines management for people with dementia has been emphasised through research and policy. However, evidence is currently lacking regarding how to achieve this in this patient population. OBJECTIVE:The aim was to assess the effectiveness of medicines management interventions...

journal_title：Drugs & aging

authors： McGrattan M,Ryan C,Barry HE,Hughes CM

更新日期：2017-12-01 00:00:00

abstract：:Man and higher primates have adrenals that secrete large amounts of dehydroepiandrosterone (DHEA) [prasterone] and its sulphate (DHEAS) [PB 008]. A remarkable feature of plasma DHEAS levels in humans is their great decrease with aging. Researchers have postulated that this age-related decline of DHEAS levels may expla...

journal_title：Drugs & aging

authors： Legrain S,Girard L

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the primary treatment option, especially in the elderly. But this therapeutic approach may include risks for adverse drug effects and drug-drug intera...

journal_title：Drugs & aging

authors： Huber M,Kölzsch M,Stahlmann R,Hofmann W,Bolbrinker J,Dräger D,Kreutz R

更新日期：2013-01-01 00:00:00

abstract：:Type 2 diabetes mellitus is a complex heterogenous metabolic disorder in which peripheral insulin resistance and impaired insulin release are the main pathogenetic factors. The rapid response of the pancreatic beta-cells to glucose is already markedly disturbed in the early stages of type 2 diabetes mellitus. The cons...

journal_title：Drugs & aging

authors： Landgraf R

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Over three-quarters of the older population take medications that can potentially cause dry mouth. Physicians or pharmacists rarely inform patients about this adverse effect and its potentially severe damage to the teeth, mouth and general health. OBJECTIVES:The objectives of this study were to (1) identify...

journal_title：Drugs & aging

authors： Nguyen CT,MacEntee MI,Mintzes B,Perry TL

更新日期：2014-01-01 00:00:00

abstract：:Elderly rheumatoid arthritis (RA) is classified into two clinical subsets, elderly-onset RA (EORA) and younger-onset elderly RA. With the improvement of life expectancy in the general population and advent of the super-aging society, the number of patients with EORA is anticipated to increase. Both large and small joi...

journal_title：Drugs & aging

authors： Sugihara T,Harigai M

更新日期：2016-02-01 00:00:00

abstract：:Attempts to control pneumococcal infection by vaccination, undertaken initially in 1911, have gone through 3 phases during the subsequent 8 decades. Initially, vaccines of killed pneumococcal cells prepared in a variety of ways were used in epidemic settings with inconclusive results, although administered to approxim...

journal_title：Drugs & aging

authors： Austrian R

更新日期：1999-01-01 00:00:00

abstract：:Although use of NSAIDs and aspirin (acetylsalicylic acid) is well known to be associated with gastrointestinal (GI) complications and potential mortality, these medications continue to be widely prescribed in the elderly. Age is a significant risk factor for NSAID-induced GI events; indeed, patients >75 years of age c...

journal_title：Drugs & aging

authors： Lanas A,Ferrandez A

更新日期：2007-01-01 00:00:00

abstract：:The focus of this review is hormone replacement therapy (HRT) with continuous oral 17 beta-estradiol (herein referred to as estradiol) 2 mg/day plus sequential oral dydrogesterone 10 or 20 mg/day for 14 days of each 28-day cycle. According to data from nonblind trials, this regimen relieves climacteric symptoms, prese...

journal_title：Drugs & aging

authors： Foster RH,Balfour JA

更新日期：1997-10-01 00:00:00

abstract：:The numbers of patients with dementia and patients with epilepsy are increasing in the global population. In fact, these two conditions are related, and it is estimated that at least 5-10% of seizures or epilepsy in older individuals (aged > 60 years) are caused by a neurodegenerative dementia. In the vast majority, o...

journal_title：Drugs & aging

authors： Cretin B

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Multiple drug use is common among old, frail nursing home residents who are, as a consequence, susceptible to adverse effects and drug interactions. This study uses the updated Beers criteria for potentially inappropriate drug (PID) use in older adults to determine the extent and nature of PIDs...

journal_title：Drugs & aging

authors： Hosia-Randell HM,Muurinen SM,Pitkälä KH

更新日期：2008-01-01 00:00:00

abstract：:Erectile dysfunction (ED) is a common medical condition that affects the sexual life of millions of men worldwide. First-line oral therapy for ED includes the use of phosphodiesterase type 5 inhibitors (sildenafil, tadalafil and vardenafil) and sublingual apomorphine. Apomorphine is a dopamine D(1) and D(2) receptor a...

journal_title：Drugs & aging

authors： Briganti A,Chun FK,Salonia A,Zanni G,Dehò F,Barbieri L,Karakiewicz PI,Rigatti P,Montorsi F

更新日期：2006-01-01 00:00:00

abstract：:Intracavernous alprostadil (synthetic prostaglandin E1) is a vasodilating agent which acts by relaxing the smooth muscles of the corpus cavernosum and by increasing the diameter of cavernous arteries; this leads to erection. Following intracavernous administration, alprostadil is either locally metabolised or rapidly ...

journal_title：Drugs & aging

authors： Lea AP,Bryson HM,Balfour JA

更新日期：1996-01-01 00:00:00

abstract：:The main characteristic of acute lymphoblastic leukaemia (ALL) in the elderly is its dismal prognosis. However, other than a lower incidence of T-cell ALL and a greater likelihood of unfavourable chromosomal abnormalities, the clinical and biological characteristics of Philadelphia chromosome-negative (Ph-) ALL in the...

journal_title：Drugs & aging

authors： Rousselot P,Delannoy A

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a common cause of disability and death in elderly men and women. Until 2007, Australian Government-subsidized use of oral bisphosphonates, raloxifene and calcitriol (1alpha,25-dihydroxycholecalciferol) was limited to secondary prevention (requiring x-ray evidence of previous low-trauma fractu...

journal_title：Drugs & aging

authors： Hollingworth SA,Gunanti I,Nissen LM,Duncan EL

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Antidepressant medications have long been implicated as a cause of falls in older people, but there are few data on the risk of falls associated with exposure to serotonin-norepinephrine (noradrenaline) reuptake inhibitors (SNRIs). OBJECTIVE:The aim of this study was to determine the role of SNRIs in older ...

journal_title：Drugs & aging

authors： Gribbin J,Hubbard R,Gladman J,Smith C,Lewis S

更新日期：2011-11-01 00:00:00

abstract：:Influenza infection is an acute respiratory disease with a high morbidity and significant mortality, particularly among the elderly and individuals with chronic diseases. The majority of countries now recommend annual influenza vaccination for all people aged 65 years or older, and for those with high risk conditions....

journal_title：Drugs & aging

authors： Corrigan EM,Clancy RL

更新日期：1999-09-01 00:00:00

abstract：:Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks...

journal_title：Drugs & aging

authors： Ho SB,Hovsepians R,Gupta S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not prev...

journal_title：Drugs & aging

authors： Corsonello A,Pedone C,Lattanzio F,Onder G,Antonelli Incalzi R,Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA).

更新日期：2011-05-01 00:00:00

abstract：:Unfortunately the sections were published incorrectly in the original article. ...

journal_title：Drugs & aging

authors： Paik J,Scott LJ

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Medication-related admissions are an important cause of hospital admissions in older people. The scope for prevention is less clear. OBJECTIVES:To characterize medication-related hospital admissions in older people and assess their preventability. METHODS:This was a cross-sectional, observational study con...

journal_title：Drugs & aging

authors： Rogers S,Wilson D,Wan S,Griffin M,Rai G,Farrell J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The number of elderly patients with oesophageal cancer is expected to increase with the aging of the population and the rapidly increasing incidence of adenocarcinoma. Surgical resection is standard treatment for patients with localized disease considered fit for operation. However, elderly patients with oes...

journal_title：Drugs & aging

authors： Servagi-Vernat S,Bosset M,Crehange G,Buffet-Miny J,Puyraveau M,Maingon P,Mercier M,Bosset JF

更新日期：2009-01-01 00:00:00

abstract：:Periods of intense hormonal fluctuations have been associated with heightened prevalence and exacerbation of underlying psychiatric illness, particularly the occurrence of premenstrual dysphoria, puerperal depression and depressive symptoms during perimenopause. It has been speculated that sex steroids such as estroge...

journal_title：Drugs & aging

authors： Soares CN,Poitras JR,Prouty J

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Previous studies have investigated the prevalence of drug-drug interactions (DDIs) among the elderly in different care settings, but data describing the frequency and management of DDIs among acute geriatric patients appear to be absent. OBJECTIVE:The aim of this study was to investigate the severity and in...

journal_title：Drugs & aging

authors： Lea M,Rognan SE,Koristovic R,Wyller TB,Molden E

更新日期：2013-09-01 00:00:00

abstract：:Chronic pain occurs in 45-85% of the geriatric population and the need to treat chronic pain is growing substantially. Unfortunately, treatment for chronic pain is not always correctly targeted, which leads to a reduced quality of life, with decreased socialization, depression, sleep disturbances, cognitive impairment...

journal_title：Drugs & aging

authors： Gianni W,Ceci M,Bustacchini S,Corsonello A,Abbatecola AM,Brancati AM,Assisi A,Scuteri A,Cipriani L,Lattanzio F

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...

journal_title：Drugs & aging

authors： Harrison SL,Kouladjian O'Donnell L,Bradley CE,Milte R,Dyer SM,Gnanamanickam ES,Liu E,Hilmer SN,Crotty M

更新日期：2018-01-01 00:00:00