Genetic factors in osteoporosis. What are the implications for prevention and treatment?

abstract：:Although inflammatory bowel disease (IBD) is generally considered a disease of young adults, it can occur in elderly individuals. The clinical features and treatment considerations in older patients are similar to those in younger patients, with some notable exceptions, which are reviewed in this article. Consideratio...

journal_title：Drugs & aging

authors： Hussain SW,Pardi DS

更新日期：2010-08-01 00:00:00

abstract：:Relaxation of the upper age limits for solid organ transplantation coupled with improvements in post-transplant survival have resulted in greater numbers of elderly patients receiving immunosuppressant drugs such as tacrolimus. Tacrolimus is a potent agent with a narrow therapeutic window and large inter- and intraind...

journal_title：Drugs & aging

authors： Staatz CE,Tett SE

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The importance of optimising medicines management for people with dementia has been emphasised through research and policy. However, evidence is currently lacking regarding how to achieve this in this patient population. OBJECTIVE:The aim was to assess the effectiveness of medicines management interventions...

journal_title：Drugs & aging

authors： McGrattan M,Ryan C,Barry HE,Hughes CM

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe. METHODS:We conducted a cross...

journal_title：Drugs & aging

authors： Giovannini S,van der Roest HG,Carfì A,Finne-Soveri H,Garms-Homolová V,Declercq A,Jónsson PV,van Hout H,Vetrano DL,Gravina EM,Bernabei R,Onder G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Medication for elderly patients is often complex and problematic. Several criteria for classifying inappropriate prescribing exist. In 2010, the Swedish National Board of Health and Welfare published the document "Indicators of appropriate drug therapy in the elderly" as a guideline for improving prescribing...

journal_title：Drugs & aging

authors： Hovstadius B,Petersson G,Hellström L,Ericson L

更新日期：2014-05-01 00:00:00

abstract：:Despite the availability of an efficient vaccine, chronic hepatitis B virus (HBV) infection remains a major public health problem worldwide. The World Health Organization estimates that there are still 350 million chronic carriers of the virus who are at risk of developing chronic hepatitis, liver cirrhosis and hepato...

journal_title：Drugs & aging

authors： Merle P,Trépo C,Zoulim F

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Antidepressant medications have long been implicated as a cause of falls in older people, but there are few data on the risk of falls associated with exposure to serotonin-norepinephrine (noradrenaline) reuptake inhibitors (SNRIs). OBJECTIVE:The aim of this study was to determine the role of SNRIs in older ...

journal_title：Drugs & aging

authors： Gribbin J,Hubbard R,Gladman J,Smith C,Lewis S

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The practice of hiding medicines in nursing home patients' food or beverages is described in only a few scientific papers. An earlier study conducted in 1999/2000 showed that covert medication was common in Norwegian nursing homes, with 11% of patients in regular nursing home units (RUs) and 17...

journal_title：Drugs & aging

authors： Kirkevold O,Engedal K

更新日期：2009-01-01 00:00:00

abstract：:The consumption of medications with anticholinergic activity has been suggested to result in the adverse effects of mental confusion, visual disturbance, and muscle weakness, which may lead to falls. Existing published evidence linking anticholinergic drugs with falls, however, remains weak. This study was conducted t...

journal_title：Drugs & aging

authors： Tan MP,Tan GJ,Mat S,Luben RN,Wareham NJ,Khaw KT,Myint PK

更新日期：2020-02-01 00:00:00

abstract：:The prevalence of intermittent claudication (IC) increases with age; when questioned, older patients consider increased difficulty in walking to be a normal consequence of aging. Although the prognosis for the involved limb with IC is relatively good, IC is an important clinical predictor of increased cardiovascular m...

journal_title：Drugs & aging

authors： Boccalon H

更新日期：1999-04-01 00:00:00

abstract：:The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1)...

journal_title：Drugs & aging

authors： Andrès E,Vogel T,Federici L,Zimmer J,Kaltenbach G

更新日期：2008-01-01 00:00:00

abstract：:Polymyalgia rheumatica (PMR) is a disease of unknown aetiology that occurs in elderly patients, predominantly affecting the Caucasian population. The disease has a slightly higher prevalence in women than in men. There is ongoing discussion regarding the relationship between PMR and giant cell arteritis; an increasing...

journal_title：Drugs & aging

authors： Labbe P,Hardouin P

更新日期：1998-08-01 00:00:00

abstract：:Erectile dysfunction (ED) is a common medical condition that affects the sexual life of millions of men worldwide. First-line oral therapy for ED includes the use of phosphodiesterase type 5 inhibitors (sildenafil, tadalafil and vardenafil) and sublingual apomorphine. Apomorphine is a dopamine D(1) and D(2) receptor a...

journal_title：Drugs & aging

authors： Briganti A,Chun FK,Salonia A,Zanni G,Dehò F,Barbieri L,Karakiewicz PI,Rigatti P,Montorsi F

更新日期：2006-01-01 00:00:00

abstract：:A low bone mineral density (BMD) is presently regarded as the most important risk factor for the development of osteoporosis. BMD is a function of peak bone mass attained during growth and subsequent age-related bone loss. BMD can be measured accurately and precisely, although the rate of bone loss is more difficult t...

journal_title：Drugs & aging

authors： Hough S

更新日期：1998-01-01 00:00:00

abstract：:Nitric oxide (NO) is involved in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity. Depending on the redox state of NO, it can act as a neurotoxin or it can have a neuroprotective action. Data suggest that NO may have a role in the pathogenesis of neurodegenerati...

journal_title：Drugs & aging

authors： Molina JA,Jiménez-Jiménez FJ,Ortí-Pareja M,Navarro JA

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Several studies have shown that the mortality of elderly hip fracture patients is higher than that in the general population, and is higher in male than in female hip fracture patients. OBJECTIVE:The objective of this study was to investigate factors affecting overall mortality at a minimum of 11 years foll...

journal_title：Drugs & aging

authors： Nurmi-Lüthje I,Lüthje P,Kaukonen JP,Kataja M

更新日期：2015-06-01 00:00:00

abstract：:Despite the availability of angiotensin converting enzyme (ACE) inhibitors for patients with congestive heart failure (CHF), mortality and morbidity remains unacceptably high. CHF is thought to progress as a result of activation of endogenous neurohormonal systems which are activated by the initial myocardial injury. ...

journal_title：Drugs & aging

authors： Tsuyuki RT,McAlister FA,Teo KK

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Despite evidence of effective combination drug therapy for secondary prevention of coronary heart disease (CHD), older adults with this condition remain undertreated. OBJECTIVE:To describe time trends (1992-2003) in the adoption of combination cardiac drug therapies (beta-blockers [beta-adrenoceptor antagon...

journal_title：Drugs & aging

authors： Tjia J,Briesacher B,Xie D,Fu J,Goldberg RJ

更新日期：2010-02-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is characterised by cardinal clinical features and specific pathological findings. It is possible to detect PD early on in the course of the disease, and certain laboratory studies may identify preclinical stages. Based on this...

journal_title：Drugs & aging

authors： Di Paola R,Uitti RJ

更新日期：1996-09-01 00:00:00

abstract：:Older adults with chronic kidney disease (CKD) often experience polypharmacy, a recognized predictor of prescribing problems including inappropriately dosed medications, drug-drug and drug-disease interactions, morbidity and mortality. Polypharmacy is also associated with nonadherence, which leads to recurrent hospita...

journal_title：Drugs & aging

authors： Triantafylidis LK,Hawley CE,Perry LP,Paik JM

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Poor medication adherence is a major public health problem in older adults often resulting in negative health outcomes. OBJECTIVE:The objective of this review was to provide an updated summary of evidence from randomized controlled studies to determine whether interventions aimed at improving medication adh...

journal_title：Drugs & aging

authors： Marcum ZA,Hanlon JT,Murray MD

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Age-related changes in the concentration-effect relationship of (+)-O-desmethyl-tramadol [(+)-ODM], tramadol's active metabolite, are not documented in the elderly. OBJECTIVE:The objective of this study was to characterize, in elderly and young subjects, the (+)-ODM pharmacokinetic and pharmacodynamic relat...

journal_title：Drugs & aging

authors： Robertson SS,Mouksassi MS,Varin F

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to gain insights into the attitudes of men with lower urinary tract symptoms towards deprescribing alpha-blockers and to assess their willingness to participate in a planned discontinuation trial. METHODS:This was a cross-sectional questionnaire study. Men aged 30 years and ol...

journal_title：Drugs & aging

authors： Edelman M,Jellema P,Hak E,Denig P,Blanker MH

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Congestive heart failure (CHF), which typically affects older people, is characterized by high short- and mid-term mortality rates. However, despite accumulating evidence showing that administration of β-blockers (β-adrenoceptor antagonists) can improve the clinical status of CHF patients, use of these age...

journal_title：Drugs & aging

authors： Antonicelli R,Mazzanti I,Abbatecola AM,Parati G

更新日期：2010-10-01 00:00:00

abstract：:Lisinopril, the lysine analogue of enalaprilat, is a long-acting angiotensin converting enzyme (ACE) inhibitor which is administered once daily by mouth. The efficacy of lisinopril in reducing blood pressure is well established in younger populations, and many trials now show it to be effective in lowering blood press...

journal_title：Drugs & aging

authors： Langtry HD,Markham A

更新日期：1997-02-01 00:00:00

abstract：:Dopamine agonists (DAs) are frequently used in the management of Parkinson's disease (PD), a complex multisystem disorder influenced substantially by age-related factors. Over 80% of PD patients present after age 60 years and may have clinical features exacerbated by age-related comorbidities or decline in physiologic...

journal_title：Drugs & aging

authors： Latt MD,Lewis S,Zekry O,Fung VSC

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Because of co-morbidity, older persons are often exposed to use of an excessive number of drugs, which per se implies also use of inappropriate drugs or of potentially interacting drugs ('suboptimal prescribing'). Time trends of suboptimal prescribing in older, community dwellers have been poorly investigate...

journal_title：Drugs & aging

authors： Lapi F,Pozzi C,Mazzaglia G,Ungar A,Fumagalli S,Marchionni N,Geppetti P,Mugelli A,Di Bari M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Older people often take multiple medications. It is a policy priority to facilitate older people to stay at home longer. Three-quarters of nursing home placements in the US are preceded by a hospitalization. OBJECTIVE:To investigate the association between polypharmacy and medication regimen complexity with...

journal_title：Drugs & aging

authors： Wimmer BC,Dent E,Visvanathan R,Wiese MD,Johnell K,Chapman I,Bell JS

更新日期：2014-08-01 00:00:00

abstract：:Aging per se is associated with abnormalities of the vascular wall linked to both structural and functional changes that can take place at the level of the extracellular matrix, the vascular smooth muscle and the endothelium of blood vessels. Endothelial dysfunction is generally defined as a decrease in the capacity o...

journal_title：Drugs & aging

authors： Matz RL,Andriantsitohaina R

更新日期：2003-01-01 00:00:00

abstract：:Alzheimer's disease is the most common major neurocognitive disorder with substantial social and economic impacts. This article is an update on current pharmacotherapy, advancements in biomarker use, and drugs in the pipeline for this disease. To date, no new drug has qualified to be added to the current therapeutic a...

journal_title：Drugs & aging

authors： Khoury R,Patel K,Gold J,Hinds S,Grossberg GT

更新日期：2017-11-01 00:00:00