Effects of cholinesterase inhibitors on behavioural disturbances in Alzheimer's disease: a systematic review.


:Behavioural disturbances, also termed neuropsychiatric symptoms, are a frequent clinical feature of dementia in Alzheimer's disease (AD). Many AD patients receive treatment with cholinesterase inhibitors (ChEIs). This review examines the evidence for behavioural effects of the four ChEIs that have been approved for the treatment of mild to moderate AD. A systematic search of the MEDLINE and EMBASE databases and the Cochrane Library was conducted to identify clinical trials that had a randomised, placebo-controlled design. Studies were included in this review if they enrolled patients who had received a diagnosis of probable AD, involved at least one ChEI, and used an appropriate instrument for the assessment of behavioural disturbances. Fourteen studies that matched the selection criteria were identified in the literature. A statistically significant difference between active treatment and placebo with regard to behavioural symptoms was observed in three of the 14 studies. Treatment effects varied between 2.0 and 6.2 points on the Neuropsychiatric Inventory. ChEIs have moderate effects when used as a blanket treatment for the cluster of behavioural disturbances in AD. With regard to the limitations of the available trials, and in view of the risks that are associated with the use of atypical antipsychotics, the potential of ChEIs for the management of specific neuropsychiatric symptoms in patients with AD should be explored in further studies.


Drugs Aging


Drugs & aging


Grimmer T,Kurz A




Has Abstract


2006-01-01 00:00:00














  • Nitrates in the elderly. Pharmacological considerations.

    abstract::Although a significant proportion of patients receiving nitrates are elderly, surprisingly little published work is available describing the pharmacokinetics and pharmacodynamics of these agents in elderly patients. The lack of pharmacokinetic data is related to the difficulty in assaying nitrates and there are at pre...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Kelly JG,O'Malley K

    更新日期:1992-01-01 00:00:00

  • Statins for Primary Prevention of Cardiovascular Disease in Elderly Patients: Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Statins have been shown to be beneficial in primary and secondary prevention settings; however, their role in the elderly remains a clinical conundrum, given that age-related factors could alter the risk-benefit ratio of statin treatment. This study aimed to critically evaluate the efficacy and safety of sta...

    journal_title:Drugs & aging

    pub_type: 杂志文章,meta分析,评审


    authors: Teng M,Lin L,Zhao YJ,Khoo AL,Davis BR,Yong QW,Yeo TC,Lim BP

    更新日期:2015-08-01 00:00:00

  • A brief history of pneumococcal vaccines.

    abstract::Attempts to control pneumococcal infection by vaccination, undertaken initially in 1911, have gone through 3 phases during the subsequent 8 decades. Initially, vaccines of killed pneumococcal cells prepared in a variety of ways were used in epidemic settings with inconclusive results, although administered to approxim...

    journal_title:Drugs & aging

    pub_type: 历史文章,杂志文章


    authors: Austrian R

    更新日期:1999-01-01 00:00:00

  • Impact of home patient telemonitoring on use of β-blockers in congestive heart failure.

    abstract:INTRODUCTION:Congestive heart failure (CHF), which typically affects older people, is characterized by high short- and mid-term mortality rates. However, despite accumulating evidence showing that administration of β-blockers (β-adrenoceptor antagonists) can improve the clinical status of CHF patients, use of these age...

    journal_title:Drugs & aging

    pub_type: 杂志文章,随机对照试验


    authors: Antonicelli R,Mazzanti I,Abbatecola AM,Parati G

    更新日期:2010-10-01 00:00:00

  • Potential of transdermal drug delivery in Parkinson's disease.

    abstract::There has been a growing recognition that pulsatile stimulation of dopamine receptors may be an important mechanism in the generation of the motor fluctuations that often develop and compromise the effectiveness of long-term levodopa administration in persons with Parkinson's disease (PD). This has prompted investigat...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Pfeiffer RF

    更新日期:2002-01-01 00:00:00

  • Fast and slow bone losers. Relevance to the management of osteoporosis.

    abstract::A low bone mineral density (BMD) is presently regarded as the most important risk factor for the development of osteoporosis. BMD is a function of peak bone mass attained during growth and subsequent age-related bone loss. BMD can be measured accurately and precisely, although the rate of bone loss is more difficult t...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Hough S

    更新日期:1998-01-01 00:00:00

  • Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics.

    abstract::Advances in our understanding of the structure, function and distribution of nicotinic acetylcholine receptors in the CNS have provided the impetus for new studies examining the role(s) that these receptors and associated processes may play in CNS functions. Further motivation has come from the realisation that such r...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Newhouse PA,Potter A,Levin ED

    更新日期:1997-09-01 00:00:00

  • Safety of Antidepressant Classes Used Following Traumatic Brain Injury Among Medicare Beneficiaries: A Retrospective Cohort Study.

    abstract:OBJECTIVE:There is poor evidence supporting the use of any pharmacologic treatments for neuropsychiatric disorders following traumatic brain injury (TBI), especially among older adults. Informed by our recent characterization of psychotropic medication use among Medicare beneficiaries with TBI, the objective of this st...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Albrecht JS,Rao V,Perfetto EM,Daniel Mullins C

    更新日期:2018-08-01 00:00:00

  • Characterisation of patients with postmenopausal osteoporosis in French primary healthcare.

    abstract:BACKGROUND:The public health burden of osteoporosis is high, principally because of increased risk of fractures and associated morbidity, handicap and mortality. Osteoporotic fracture prevention is therefore an important public health goal. General practitioners (GPs) play a key role in the management of osteoporosis, ...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Blotman F,Cortet B,Hilliquin P,Avouac B,Allaert FA,Pouchain D,Gaudin AF,Cotté FE,El Hasnaoui A

    更新日期:2007-01-01 00:00:00

  • Sedative load and mortality among residents of long-term care facilities: a prospective cohort study.

    abstract:BACKGROUND:Older people are often prescribed multiple drugs with sedative properties. Most research has focused on specific classes of sedative and psychotropic drugs. The cumulative effect of taking multiple drugs with sedative properties has been termed 'sedative load'. Few previous studies have investigated the seda...

    journal_title:Drugs & aging

    pub_type: 临床试验,杂志文章


    authors: Taipale HT,Bell JS,Soini H,Pitkälä KH

    更新日期:2009-01-01 00:00:00

  • Treatment of Seizures in Older Patients with Dementia.

    abstract::The numbers of patients with dementia and patients with epilepsy are increasing in the global population. In fact, these two conditions are related, and it is estimated that at least 5-10% of seizures or epilepsy in older individuals (aged > 60 years) are caused by a neurodegenerative dementia. In the vast majority, o...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Cretin B

    更新日期:2020-12-14 00:00:00

  • Pharmacological Treatment of Post-Prostatectomy Incontinence: What is the Evidence?

    abstract::Urinary incontinence is a common and debilitating problem, and post-prostatectomy incontinence (PPI) is becoming an increasing problem, with a higher risk among elderly men. Current treatment options for PPI include pelvic floor muscle exercises and surgery. Conservative treatment has disputable effects, and surgical ...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Løvvik A,Müller S,Patel HR

    更新日期:2016-08-01 00:00:00

  • Once-daily trospium chloride 60 mg extended release in subjects with overactive bladder syndrome who use multiple concomitant medications: Post hoc analysis of pooled data from two randomized, placebo-controlled trials.

    abstract:BACKGROUND:Overactive bladder syndrome (OAB) is associated with various co-morbidities; treatment of these frequently results in multiple medication use (MMU) and the potential for drug-drug interactions, which may lead to adverse events and altered efficacy. With the aging population, the prevalence of MMU is likely t...

    journal_title:Drugs & aging

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sand PK,Rovner ES,Watanabe JH,Oefelein MG

    更新日期:2011-02-01 00:00:00

  • Treating asthma in the older patient: is there a place for leukotriene modifiers?

    abstract::Asthma is a common airway disease found in people of all ages, although most studies of asthma therapies are focused on adolescent and young adults. Little information exists on the use of asthma therapeutics in the older patient (>65 years of age). The newest therapeutic class to be released in the US for the treatme...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Grayson MH,Korenblat PE

    更新日期:2006-01-01 00:00:00

  • Management of secondary hyperparathyroidism in the elderly patient with chronic kidney disease.

    abstract::Patients with chronic kidney disease (CKD) are generally affected by secondary hyperparathyroidism (SHPT). High phosphate, low calcium and vitamin D deficiency represent the classical 'triad' involved into the pathogenesis of SHPT in renal insufficiency, in which downregulation of the parathyroid vitamin D receptor an...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Cozzolino M,Gallieni M,Pasho S,Fallabrino G,Ciceri P,Volpi EM,Olivi L,Brancaccio D

    更新日期:2009-01-01 00:00:00

  • Population Pharmacokinetic/Pharmacodynamic Modeling of O-Desmethyltramadol in Young and Elderly Healthy Volunteers.

    abstract:BACKGROUND:Age-related changes in the concentration-effect relationship of (+)-O-desmethyl-tramadol [(+)-ODM], tramadol's active metabolite, are not documented in the elderly. OBJECTIVE:The objective of this study was to characterize, in elderly and young subjects, the (+)-ODM pharmacokinetic and pharmacodynamic relat...

    journal_title:Drugs & aging

    pub_type: 杂志文章,随机对照试验


    authors: Robertson SS,Mouksassi MS,Varin F

    更新日期:2019-08-01 00:00:00

  • Transdermal treatment options for neurological disorders: impact on the elderly.

    abstract::As people grow old, their need for medications increases dramatically because of the higher incidence of chronic pain, diabetes mellitus, cardiovascular and neurological diseases in the elderly population. Furthermore, the elderly require special consideration with respect to drug delivery, drug interactions and adher...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Priano L,Gasco MR,Mauro A

    更新日期:2006-01-01 00:00:00

  • Epidemiology and optimal management of polymyalgia rheumatica.

    abstract::Polymyalgia rheumatica (PMR) is a disease of unknown aetiology that occurs in elderly patients, predominantly affecting the Caucasian population. The disease has a slightly higher prevalence in women than in men. There is ongoing discussion regarding the relationship between PMR and giant cell arteritis; an increasing...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Labbe P,Hardouin P

    更新日期:1998-08-01 00:00:00

  • Managing Gout in the Patient with Renal Impairment.

    abstract::Hyperuricaemia is an independent risk factor for renal function decline. Evidence is emerging that urate-lowering therapy might be beneficial in subjects with renal impairment. We  review the association between renal impairment and gout, some of the related pathogenic processes and the possible impact of gout treatme...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Pascual E,Sivera F,Andrés M

    更新日期:2018-04-01 00:00:00

  • Suitable Use of Injectable Agents to Overcome Hypoglycemia Risk, Barriers, and Clinical Inertia in Community-Dwelling Older Adults with Type 2 Diabetes Mellitus.

    abstract::The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Valencia WM,Florez HJ,Palacio AM

    更新日期:2019-12-01 00:00:00

  • Approaches to Deprescribing Psychotropic Medications for Changed Behaviours in Long-Term Care Residents Living with Dementia.

    abstract::Psychotropic medications have a high risk of serious adverse events and small effect size for changed behaviours for people with dementia. Non-pharmacological approaches are recommended as first-line treatment for changed behaviours, yet psychotropic medications remain highly prevalent in long-term aged care settings....

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Harrison SL,Cations M,Jessop T,Hilmer SN,Sawan M,Brodaty H

    更新日期:2019-02-01 00:00:00

  • Drug therapy of prostatic cancer.

    abstract::While hormonal therapy has been the usual and appropriate treatment of advanced or metastatic prostatic cancer for the past 50 years, the recent development of new therapeutic agents as medical alternatives to orchidectomy has drastically altered the options and perspectives in the treatment of this disease. Estrogens...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Huben RP,Perrapato SD

    更新日期:1991-09-01 00:00:00

  • Improvement in Renal Function and Reduction in Serum Uric Acid with Intensive Statin Therapy in Older Patients: A Post Hoc Analysis of the SAGE Trial.

    abstract:BACKGROUND:Improvement in renal function and decreases in serum uric acid (SUA) have been reported following prolonged high-intensity statin (HMG-CoA reductase inhibitor) therapy. This post hoc analysis of the SAGE trial examined the effect of intensive versus less intensive statin therapy on renal function, safety, an...

    journal_title:Drugs & aging

    pub_type: 杂志文章,随机对照试验


    authors: Deedwania PC,Stone PH,Fayyad RS,Laskey RE,Wilson DJ

    更新日期:2015-12-01 00:00:00

  • Discontinuation of Preventive Medicines in Older People with Limited Life Expectancy: A Systematic Review.

    abstract:BACKGROUND:In the presence of multimorbidity and limited life expectancy (LLE), the need for continued use of preventive medicines becomes uncertain as they may neither improve health nor confer continued health benefits. OBJECTIVE:Our objective was to systematically review the literature to examine the discontinuatio...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Narayan SW,Nishtala PS

    更新日期:2017-10-01 00:00:00

  • Idiopathic thrombocytopenic purpura: a retrospective analysis in 139 patients of the influence of age on the response to corticosteroids, splenectomy and danazol.

    abstract:OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Andrès E,Zimmer J,Noel E,Kaltenbach G,Koumarianou A,Maloisel F

    更新日期:2003-01-01 00:00:00

  • Understanding gender differences in statin use among elderly Medicare beneficiaries: an application of decomposition technique.

    abstract:BACKGROUND:Pharmacotherapy with statins (HMG-CoA reductase inhibitors) is the cornerstone for lipid management in individuals with or at risk of developing cardiovascular diseases. Although the clinical benefits of statins are established for both women and men, there is evidence of a gender difference in their use. Th...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Bhattacharjee S,Findley PA,Sambamoorthi U

    更新日期:2012-12-01 00:00:00

  • Underuse of Anticoagulation in Older Patients with Atrial Fibrillation and CHADS2 Score ≥ 2: Are We Doing Better Since the Marketing of Direct Oral Anticoagulants?

    abstract:OBJECTIVE:Our objectives were to (1) describe the evolution of the underuse of anticoagulants in older people with atrial fibrillation (AF) and a CHADS2 score ≥ 2 since direct oral anticoagulants (DOACs) were introduced to the market and (2) describe factors associated with this underuse. METHODS:We conducted a retros...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Henrard S,Vandenabeele C,Marien S,Boland B,Dalleur O

    更新日期:2017-11-01 00:00:00

  • Drug-induced seizures in the elderly. Causative agents and optimal management.

    abstract::We conducted a review of drugs that were most commonly associated with inducing seizures in the elderly population. The method for determining the risk of these agents includes evaluating the utilisation and the percentage of adverse events in previous studies and case reports. Classes of medications, such as anti-psy...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Franson KL,Hay DP,Neppe V,Dahdal WY,Mirza WU,Grossberg GT,Chatel DM,Szwabo PA,Kotegal S

    更新日期:1995-07-01 00:00:00

  • Association Between Potentially Inappropriate Medications and Hospital Encounters Among Older Adults: A Meta-Analysis.

    abstract:BACKGROUND:Potentially inappropriate medications (PIMs) are defined by the American Geriatric Society as medications that should be avoided in the elderly in general, or in specific situations. However, PIM use remains high among aging populations and may result in increased utilization of healthcare resources. OBJECT...

    journal_title:Drugs & aging

    pub_type: 杂志文章,meta分析


    authors: Weeda ER,AlDoughaim M,Criddle S

    更新日期:2020-07-01 00:00:00

  • Anticholinergic medications: an additional contributor to cognitive impairment in the heart failure population?

    abstract:BACKGROUND/OBJECTIVES:Patients with congestive heart failure (CHF) have a high prevalence of cognitive impairment and the association is multifactorial. In general, the burden of anticholinergic drugs has consistently been shown to be a risk factor for cognitive impairment in the elderly. The aim of this study was to a...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Shaukat A,Habib A,Lane KA,Shen C,Khan S,Hellman YM,Boustani M,Malik AS

    更新日期:2014-10-01 00:00:00