Beta-blockers for congestive heart failure: what is the current consensus?

abstract：BACKGROUND:Older people are exposed to multiple medicines that possess anticholinergic properties. The use of anticholinergic medicines is associated with the risk of morbidity, mortality and cognitive decline, particularly in older people. Anticholinergic exposure can be measured using tools such as the Drug Burden In...

journal_title：Drugs & aging

authors： Narayan SW,Hilmer SN,Horsburgh S,Nishtala PS

更新日期：2013-11-01 00:00:00

abstract：:Alzheimer's disease is a chronic progressive disease affecting higher intellectual functioning. The clinical diagnosis is made when the onset of illness is insidious, the course slowly progressive and all the treatable causes of dementia have been ruled out. The use of more stringent criteria has improved clinical dia...

journal_title：Drugs & aging

authors： Hermann C,Stern RG,Losonzcy MF,Jaff S,Davidson M

更新日期：1991-03-01 00:00:00

abstract：:This paper reviews the burden and economic consequences of glaucoma upon healthcare systems and patients, especially elderly patients. An extensive review of the literature was conducted, primarily using MEDLINE, but also by examining selected article reference lists, relevant websites and the proceedings of specialis...

journal_title：Drugs & aging

authors： Rouland JF,Berdeaux G,Lafuma A

更新日期：2005-01-01 00:00:00

abstract：:Despite the availability of an efficient vaccine, chronic hepatitis B virus (HBV) infection remains a major public health problem worldwide. The World Health Organization estimates that there are still 350 million chronic carriers of the virus who are at risk of developing chronic hepatitis, liver cirrhosis and hepato...

journal_title：Drugs & aging

authors： Merle P,Trépo C,Zoulim F

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Remifentanil used in combination with propofol provides adequate conditions for tracheal intubation without muscle relaxants. Delivery of the optimal dose is important to prevent poor intubation conditions and drug-related complications. No previous study has investigated the use of a remifentanil-propofol c...

journal_title：Drugs & aging

authors： Goo EK,Oh AY,Cho SJ,Seo KS,Jeon YT

更新日期：2012-11-01 00:00:00

abstract：:Aflibercept is a fully human, recombinant fusion protein that acts as a soluble decoy receptor for vascular endothelial growth factor (VEGF) family members, including VEGF-A, VEGF-B and placental growth factor (P1GF), thereby inhibiting downstream signalling mediated by these ligands. Aflibercept binds all isoforms of...

journal_title：Drugs & aging

authors： Yang LP,McKeage K

更新日期：2014-05-01 00:00:00

abstract：:The numbers of patients with dementia and patients with epilepsy are increasing in the global population. In fact, these two conditions are related, and it is estimated that at least 5-10% of seizures or epilepsy in older individuals (aged > 60 years) are caused by a neurodegenerative dementia. In the vast majority, o...

journal_title：Drugs & aging

authors： Cretin B

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:The choice of induction immunosuppression for kidney transplantation in elderly recipients is dictated by the consideration of the risk of infection as well as efficacy in the prevention of acute rejection, thus allowing a reduction in subsequent maintenance immunosuppression and its attendant long-term adve...

journal_title：Drugs & aging

authors： Heifets M,Saeed MI,Parikh MH,Sierka D,Kumar MS

更新日期：2004-01-01 00:00:00

abstract：:Despite a sharp decline in the incidence of gastric cancer during the second half of the 20th century, this malignancy remains the second leading cause of cancer mortality in the world. The incidence and mortality rate of gastric cancer increase with age; at present, the median ages at diagnosis are 67 years for men a...

journal_title：Drugs & aging

authors： Wagner AD,Wedding U

更新日期：2009-01-01 00:00:00

abstract：:A low bone mineral density (BMD) is presently regarded as the most important risk factor for the development of osteoporosis. BMD is a function of peak bone mass attained during growth and subsequent age-related bone loss. BMD can be measured accurately and precisely, although the rate of bone loss is more difficult t...

journal_title：Drugs & aging

authors： Hough S

更新日期：1998-01-01 00:00:00

abstract：:In contrast with the earlier stages and, in particular, the predementia stage, of Alzheimer's disease (AD), severe dementia is often neglected. However, the advanced stages of dementia are just as important as the earlier stages because of their frequency, their impact on the lives of patients and their caregivers, an...

journal_title：Drugs & aging

authors： Voisin T,Vellas B

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Inappropriate medications are often used in older adults despite their unfavourable risk-to-benefit profile. Although many of the medications in the American Geriatrics Society (AGS) Beers list are potentially inappropriate because of their anticholinergic properties, little is known regarding the nature and...

journal_title：Drugs & aging

authors： Kachru N,Carnahan RM,Johnson ML,Aparasu RR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Patients with congestive heart failure (CHF) have a high prevalence of cognitive impairment and the association is multifactorial. In general, the burden of anticholinergic drugs has consistently been shown to be a risk factor for cognitive impairment in the elderly. The aim of this study was to a...

journal_title：Drugs & aging

authors： Shaukat A,Habib A,Lane KA,Shen C,Khan S,Hellman YM,Boustani M,Malik AS

更新日期：2014-10-01 00:00:00

abstract：:Alzheimer's disease is the most common major neurocognitive disorder with substantial social and economic impacts. This article is an update on current pharmacotherapy, advancements in biomarker use, and drugs in the pipeline for this disease. To date, no new drug has qualified to be added to the current therapeutic a...

journal_title：Drugs & aging

authors： Khoury R,Patel K,Gold J,Hinds S,Grossberg GT

更新日期：2017-11-01 00:00:00

abstract：:Influenza is a major cause of morbidity and mortality in the elderly. Influenza vaccine is recommended for people aged 65 years and older and those in long term care. Currently only 30% of high risk persons are vaccinated. Vaccination generally stimulates an adequate immune response, is well tolerated and is to be enc...

journal_title：Drugs & aging

authors： Gross PA

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Patients hospitalised with severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2; coronavirus 2019 disease (COVID-19)] infection are frequently older with co-morbidities and receiving polypharmacy, all of which are known risk factors for drug-drug interactions (DDIs). The pharmacological burden may be ...

journal_title：Drugs & aging

authors： Cattaneo D,Pasina L,Maggioni AP,Giacomelli A,Oreni L,Covizzi A,Bradanini L,Schiuma M,Antinori S,Ridolfo A,Gervasoni C

更新日期：2020-12-01 00:00:00

abstract：:In general, the pharmacological treatment of non-psychotic major depressive disorder in old age is only partially successful, with only approximately 50% of older depressed adults improving with initial antidepressant monotherapy. Many factors may predict a more difficult-to-treat depression, including coexisting anxi...

journal_title：Drugs & aging

authors： Driscoll HC,Karp JF,Dew MA,Reynolds CF 3rd

更新日期：2007-01-01 00:00:00

abstract：:Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties. Whether its analgesic effects are linked to its mood-altering activity or attributable to a discrete pharmacological action (or a combination of both) is unknown. Clinical trials demonstrate that oral amitriptyline achieves at least...

journal_title：Drugs & aging

authors： Bryson HM,Wilde MI

更新日期：1996-06-01 00:00:00

abstract：:Cerebral deposition of amyloid plaques containing amyloid beta-peptide (Abeta) has traditionally been considered the central feature of Alzheimer's disease (AD). Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase. In the past decade...

journal_title：Drugs & aging

authors： Zimmermann M,Gardoni F,Di Luca M

更新日期：2005-01-01 00:00:00

abstract：:Urothelial carcinoma, or bladder cancer, is a malignancy that most commonly affects older patients. The median age at diagnosis is 73 years, and care of these patients requires consideration not just of the disease-related factors such as stage and histology, but also of patient-related factors. Many of these patients...

journal_title：Drugs & aging

authors： Jodon G,Fischer SM,Kessler ER

更新日期：2018-05-01 00:00:00

abstract：:Urinary incontinence is a common and debilitating problem, and post-prostatectomy incontinence (PPI) is becoming an increasing problem, with a higher risk among elderly men. Current treatment options for PPI include pelvic floor muscle exercises and surgery. Conservative treatment has disputable effects, and surgical ...

journal_title：Drugs & aging

authors： Løvvik A,Müller S,Patel HR

更新日期：2016-08-01 00:00:00

abstract：:Melatonin prolonged release (PR) 2 mg is approved for the treatment of primary insomnia characterized by poor sleep quality in patients aged ≥55 years in the EU and elsewhere. Patients may receive treatment with melatonin PR for up to 13 weeks. Production of endogenous nocturnal melatonin, which helps regulate circadi...

journal_title：Drugs & aging

authors： Lyseng-Williamson KA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Falls are a primary cause of injury and disability in the nursing home environment and can be costly to treat. We propose a taxonomy of nursing home falls that accounts for both the severity of fall consequences and the duration of the treatment episode. No other systematic approach of this kind has been pre...

journal_title：Drugs & aging

authors： Sorensen SV,de Lissovoy G,Kunaprayoon D,Resnick B,Rupnow MF,Studenski S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Adverse drug reactions are a major cause of hospital admissions in older individuals, with the majority potentially preventable. Despite the apparent magnitude of this problem, little is known about rates of repeat admission to hospital as a result of adverse drug reactions. OBJECTIVES:The objectives of thi...

journal_title：Drugs & aging

authors： Parameswaran Nair N,Chalmers L,Bereznicki BJ,Curtain CM,Bereznicki LR

更新日期：2017-10-01 00:00:00

abstract：:Colorectal cancer ranks third in incidence in both men and women after lung, breast and prostate cancer. The prevalence of colorectal cancer increases significantly with age, with 40% of patients in Europe being >75 years of age at the time of initial diagnosis. Furthermore, the number of elderly patients with colorec...

journal_title：Drugs & aging

authors： Meulenbeld HJ,Creemers GJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Since 1998, a prospective payment system (PPS) for Medicare services provided by nursing homes in the US has been in operation. Concerns have been expressed that the PPS may affect the quality of care delivered to residents. This study evaluates the impact of the PPS on pharmacological secondary ischaemic st...

journal_title：Drugs & aging

authors： Lapane KL,Hughes CM

更新日期：2006-01-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) usually affect adults and older populations. The well recognized clinical (i.e., granulomatosis with polyangiitis [GPA], microscopic polyangiitis, and eosinophilic GPA) and serological phenotypes (i.e., anti-MPO-ANCA, anti-PR3-ANCA and ANCA nega...

journal_title：Drugs & aging

authors： Berti A,Caporali R,Montecucco C,Paolazzi G,Monti S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Statins have been associated with later life, long-term care admission in observational studies. However, by preventing vascular events, statins may also prevent or delay admission. We wished to determine statin and long-term care admission associations in a randomised controlled trial context, and describe ...

journal_title：Drugs & aging

authors： Burton JK,Papworth R,Haig C,McCowan C,Ford I,Stott DJ,Quinn TJ

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Withdrawal of fall-risk-increasing drugs has been proven to be effective in older persons. However, given the enormous rise in healthcare costs in recent decades, the effect of such withdrawals on healthcare costs also needs to be considered. METHOD:Within a common geriatric outpatient population, patients ...

journal_title：Drugs & aging

authors： van der Velde N,Meerding WJ,Looman CW,Pols HA,van der Cammen TJ

更新日期：2008-01-01 00:00:00

abstract：:The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...

journal_title：Drugs & aging

authors： Valencia WM,Florez HJ,Palacio AM

更新日期：2019-12-01 00:00:00