Abstract:
:Aflibercept is a fully human, recombinant fusion protein that acts as a soluble decoy receptor for vascular endothelial growth factor (VEGF) family members, including VEGF-A, VEGF-B and placental growth factor (P1GF), thereby inhibiting downstream signalling mediated by these ligands. Aflibercept binds all isoforms of VEGF-A with high affinity, and a markedly higher affinity than that of ranibizumab or bevacizumab. A formulation of aflibercept developed specifically for intravitreal injection (Eylea(®)) is approved for use in several countries for the treatment of patients with macular oedema secondary to central retinal vein occlusion (CRVO). In clinical trials (GALILEO and COPERNICUS) in patients with this condition, intravitreal aflibercept 2 mg every month improved best corrected visual acuity (BCVA), as measured by the proportion of study eyes with a gain of ≥15 Early Treatment Diabetic Retinopathy Study letters from baseline, significantly more than sham injections at week 24 (primary analysis). The significant improvements achieved with intravitreal aflibercept compared with sham in the first 6 months were maintained in the second 6 months with as-needed (prn) dosing and monthly monitoring. Continued prn dosing with a reduced monitoring frequency was associated with decreased improvements. More data are needed to confirm the optimal monitoring frequency for use with prn dosing, subsequent to initial monthly injections, in order to maintain long-term efficacy. Intravitreal aflibercept was generally well tolerated in clinical trials and there is little potential for systemic drug accumulation. Thus, intravitreal aflibercept is an effective and generally well tolerated agent that extends the options available for the treatment of macular oedema secondary to CRVO.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Yang LP,McKeage Kdoi
10.1007/s40266-014-0176-2subject
Has Abstractpub_date
2014-05-01 00:00:00pages
395-404issue
5eissn
1170-229Xissn
1179-1969journal_volume
31pub_type
杂志文章,评审相关文献
DRUGS & AGING文献大全abstract::Although the frequency of physician consultations and the sale of over-the-counter remedies establish the high prevalence of acute cough in the elderly, epidemiological studies have tended to be imprecise. However, respiratory tract infections in nose, larynx and/or bronchi, either viral or bacterial or both, are by f...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421040-00003
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Pharmacotherapy with statins (HMG-CoA reductase inhibitors) is the cornerstone for lipid management in individuals with or at risk of developing cardiovascular diseases. Although the clinical benefits of statins are established for both women and men, there is evidence of a gender difference in their use. Th...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-012-0032-1
更新日期:2012-12-01 00:00:00
abstract::Advances in our understanding of the structure, function and distribution of nicotinic acetylcholine receptors in the CNS have provided the impetus for new studies examining the role(s) that these receptors and associated processes may play in CNS functions. Further motivation has come from the realisation that such r...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711030-00005
更新日期:1997-09-01 00:00:00
abstract::Over four-fifths of all strokes are due to thrombotic or embolic occlusion of cerebral arteries. There is a strong rationale for considering antithrombotic therapy for the treatment of patients with acute ischaemic stroke. Antiplatelet therapy with 150 to 300 mg of aspirin (acetylsalicylic acid) started within the fir...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199915010-00003
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825010-00007
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Falls are a primary cause of injury and disability in the nursing home environment and can be costly to treat. We propose a taxonomy of nursing home falls that accounts for both the severity of fall consequences and the duration of the treatment episode. No other systematic approach of this kind has been pre...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200623030-00007
更新日期:2006-01-01 00:00:00
abstract::Prostate cancer is a common disease in the elderly, and the number of older prostate cancer patients will probably increase with both the aging of the population and the increased rate of screening. In elderly patients with several co-morbidities, cancer management can be complex, and the risk of administering toxic t...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11537480-000000000-00000
更新日期:2010-09-01 00:00:00
abstract::Sleep problems are an under-emphasised cause of disability in Parkinson's disease (PD) and may be seen independently of PD, associated with primary PD pathology, or as a result of antiparkinsonian medications. Common sleep disorders include excessive daytime sleepiness, rapid eye movement (REM) sleep behaviour disorde...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219100-00002
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Despite evidence of effective combination drug therapy for secondary prevention of coronary heart disease (CHD), older adults with this condition remain undertreated. OBJECTIVE:To describe time trends (1992-2003) in the adoption of combination cardiac drug therapies (beta-blockers [beta-adrenoceptor antagon...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11532150-000000000-00000
更新日期:2010-02-01 00:00:00
abstract::A low bone mineral density (BMD) is presently regarded as the most important risk factor for the development of osteoporosis. BMD is a function of peak bone mass attained during growth and subsequent age-related bone loss. BMD can be measured accurately and precisely, although the rate of bone loss is more difficult t...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812001-00001
更新日期:1998-01-01 00:00:00
abstract::Felodipine is a dihydropyridine calcium antagonist which may be administered once daily in an extended release (ER) formulation. As monotherapy in older patients with mild to moderate essential hypertension, felodipine ER once daily provides effective control of blood pressure (BP). The drug has also been effective, e...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199202050-00002
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Medication for elderly patients is often complex and problematic. Several criteria for classifying inappropriate prescribing exist. In 2010, the Swedish National Board of Health and Welfare published the document "Indicators of appropriate drug therapy in the elderly" as a guideline for improving prescribing...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-014-0165-5
更新日期:2014-05-01 00:00:00
abstract::Giant cell arteritis (GCA) is an inflammatory vasculopathy that involves large- and medium-sized arteries and can cause vision loss, stroke and aneurysms. GCA occurs in people aged >50 years and is more common in women. A higher incidence of the disease is observed in populations from Northern European countries. Poly...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11592500-000000000-00000
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe. METHODS:We conducted a cross...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0521-y
更新日期:2018-02-01 00:00:00
abstract::Despite the availability of angiotensin converting enzyme (ACE) inhibitors for patients with congestive heart failure (CHF), mortality and morbidity remains unacceptably high. CHF is thought to progress as a result of activation of endogenous neurohormonal systems which are activated by the initial myocardial injury. ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200016010-00001
更新日期:2000-01-01 00:00:00
abstract::Hyperuricaemia is an independent risk factor for renal function decline. Evidence is emerging that urate-lowering therapy might be beneficial in subjects with renal impairment. We review the association between renal impairment and gout, some of the related pathogenic processes and the possible impact of gout treatme...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-018-0517-7
更新日期:2018-04-01 00:00:00
abstract::Streptococcus pneumoniae has been recognised as a major cause of pneumonia since the time of Sir William Osler. Drug-resistant S. pneumoniae (DRSP), which have gradually become resistant to penicillins as well as more recently developed macrolides and fluoroquinolones, have emerged as a consequence of indiscriminate u...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421130-00003
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Because of co-morbidity, older persons are often exposed to use of an excessive number of drugs, which per se implies also use of inappropriate drugs or of potentially interacting drugs ('suboptimal prescribing'). Time trends of suboptimal prescribing in older, community dwellers have been poorly investigate...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11319390-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::The incidence of both systolic and diastolic hypertension is increased in elderly patients, therefore antihypertensive drugs are commonly used in this population. In addition to changes in blood pressure, the aging process also causes numerous changes in other physiological parameters, resulting in altered pharmacokin...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199101030-00004
更新日期:1991-05-01 00:00:00
abstract::Atrial fibrillation confers a 5-fold increase in risk of stroke. A number of drugs aimed at reducing this risk have been tested in randomized controlled trials. These include antiplatelet agents (singly and in combination); anticoagulants, including vitamin K antagonists and direct thrombin inhibitors; and anticoagula...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11538620-000000000-00000
更新日期:2010-11-01 00:00:00
abstract::Although a significant proportion of patients receiving nitrates are elderly, surprisingly little published work is available describing the pharmacokinetics and pharmacodynamics of these agents in elderly patients. The lack of pharmacokinetic data is related to the difficulty in assaying nitrates and there are at pre...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199202010-00003
更新日期:1992-01-01 00:00:00
abstract::Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is typically diagnosed in the second or third decade of life. It is generally believed that over the last few decades the life expectancy of patients with adult onset MS (AOMS) has approached that of the general population as a r...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11532120-000000000-00000
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The public health burden of osteoporosis is high, principally because of increased risk of fractures and associated morbidity, handicap and mortality. Osteoporotic fracture prevention is therefore an important public health goal. General practitioners (GPs) play a key role in the management of osteoporosis, ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200724070-00007
更新日期:2007-01-01 00:00:00
abstract::Many quantities assayed in clinical laboratories demonstrate age-related changes. Particularly important periods are early life, adolescence, old age, and after the menopause in females. The changes that occur until adulthood are well documented. Fewer data are available on elderly people even though they consume a la...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199303030-00006
更新日期:1993-05-01 00:00:00
abstract::Lithium salts have a well-established role in the treatment of major affective disorders. More recently, experimental and clinical studies have provided evidence that lithium may also exert neuroprotective effects. In animal and cell culture models, lithium has been shown to increase neuronal viability through a combi...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11599180-000000000-00000
更新日期:2012-05-01 00:00:00
abstract::Type 2 diabetes mellitus is a complex heterogenous metabolic disorder in which peripheral insulin resistance and impaired insulin release are the main pathogenetic factors. The rapid response of the pancreatic beta-cells to glucose is already markedly disturbed in the early stages of type 2 diabetes mellitus. The cons...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200017050-00007
更新日期:2000-11-01 00:00:00
abstract::In contrast with women, who experience a complete and abrupt cessation of ovarian function during the menopause, aging men largely maintain their testicular androgen production. Nevertheless, most cross-sectional studies indicate that there is a partial decrease in testosterone levels with aging, although this has not...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711010-00005
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Multiple drug use is common among old, frail nursing home residents who are, as a consequence, susceptible to adverse effects and drug interactions. This study uses the updated Beers criteria for potentially inappropriate drug (PID) use in older adults to determine the extent and nature of PIDs...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825080-00005
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Poor medication adherence is a major public health problem in older adults often resulting in negative health outcomes. OBJECTIVE:The objective of this review was to provide an updated summary of evidence from randomized controlled studies to determine whether interventions aimed at improving medication adh...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-016-0433-7
更新日期:2017-03-01 00:00:00
abstract::Despite the availability of an efficient vaccine, chronic hepatitis B virus (HBV) infection remains a major public health problem worldwide. The World Health Organization estimates that there are still 350 million chronic carriers of the virus who are at risk of developing chronic hepatitis, liver cirrhosis and hepato...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200118100-00002
更新日期:2001-01-01 00:00:00