Diagnosis and treatment of patients with severe Alzheimer's disease.

abstract：:Gout in older patients tends to be sub-acute to chronic, often tophaceous, polyarticular, erosive, symmetrical, and causes persistent, recurrent and chronic arthritis. Clinically, it may closely mimic rheumatoid arthritis; thus, a correct diagnosis requires a high index of clinical suspicion and the identification of ...

journal_title：Drugs & aging

authors： Gonzalez EB,Miller SB,Agudelo CA

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Use of combination pharmacotherapy, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor antagonists (angiotensin receptor blockers) and β-adrenoceptor antagonists (β-blockers) in the management of heart failure (HF) can reduce mortality, prevent functional decline and red...

journal_title：Drugs & aging

authors： Foebel AD,Heckman GA,Hirdes JP,Tyas SL,Tjam EY,McKelvie RS,Maxwell CJ

更新日期：2011-07-01 00:00:00

abstract：:Although use of NSAIDs and aspirin (acetylsalicylic acid) is well known to be associated with gastrointestinal (GI) complications and potential mortality, these medications continue to be widely prescribed in the elderly. Age is a significant risk factor for NSAID-induced GI events; indeed, patients >75 years of age c...

journal_title：Drugs & aging

authors： Lanas A,Ferrandez A

更新日期：2007-01-01 00:00:00

abstract：:Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties. Whether its analgesic effects are linked to its mood-altering activity or attributable to a discrete pharmacological action (or a combination of both) is unknown. Clinical trials demonstrate that oral amitriptyline achieves at least...

journal_title：Drugs & aging

authors： Bryson HM,Wilde MI

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...

journal_title：Drugs & aging

authors： Andrès E,Zimmer J,Noel E,Kaltenbach G,Koumarianou A,Maloisel F

更新日期：2003-01-01 00:00:00

abstract：:Aging is associated with a myriad of hormonal changes. The mechanisms underlying these changes are variable. Aging is associated with anatomic changes of the endocrine glands, notably as a result of programmed cell death, autoimmune mediated destruction of the gland, or neoplastic transformation of glandular tissue. A...

journal_title：Drugs & aging

authors： Mooradian AD

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:In response to concerns about, and issues pertaining to, medication use practices in residential aged-care facilities (RACFs), the Australian Pharmaceutical Advisory Council (APAC) established a working party on quality use of medicines (QUM) in nursing homes and hostels. The APAC is a representative ministe...

journal_title：Drugs & aging

authors： Cheek J,Gilbert A,Ballantyne A,Penhall R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Inappropriate medications are often used in older adults despite their unfavourable risk-to-benefit profile. Although many of the medications in the American Geriatrics Society (AGS) Beers list are potentially inappropriate because of their anticholinergic properties, little is known regarding the nature and...

journal_title：Drugs & aging

authors： Kachru N,Carnahan RM,Johnson ML,Aparasu RR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Age-related changes in the concentration-effect relationship of (+)-O-desmethyl-tramadol [(+)-ODM], tramadol's active metabolite, are not documented in the elderly. OBJECTIVE:The objective of this study was to characterize, in elderly and young subjects, the (+)-ODM pharmacokinetic and pharmacodynamic relat...

journal_title：Drugs & aging

authors： Robertson SS,Mouksassi MS,Varin F

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Certain medications have been linked to falls. One of the most severe fall-related injuries in the elderly is a hip fracture. OBJECTIVE:The objective of this study was to examine the use of medications known to increase fall risk that were prescribed on an outpatient basis to veterans prior to hospital admi...

journal_title：Drugs & aging

authors： French DD,Campbell R,Spehar A,Cunningham F,Foulis P

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Adverse drug reactions (ADRs) represent a major public health problem in the aged. In order to better evaluate this problem in Brazil, this study was designed to assess the prevalence of ADRs in an elderly hospitalised population, identify the most common ADRs and the principal medications involved, evaluate ...

journal_title：Drugs & aging

authors： Passarelli MC,Jacob-Filho W,Figueras A

更新日期：2005-01-01 00:00:00

abstract：:The number of older adults with diabetes is rapidly increasing worldwide. A variety of factors contribute to the age-related increase in the incidence of diabetes. The lack of empiric evidence in the field has limited the management guidelines to mostly expert opinion. Given uncertainty over the rate at which to lower...

journal_title：Drugs & aging

authors： Mooradian AD

更新日期：2018-12-01 00:00:00

abstract：:Overactive bladder (OAB) is a common constellation of lower urinary tract storage symptoms that causes a significant impact on a person's quality of life. The elderly may be disproportionally impacted by these symptoms due to concomitant poor mobility, comorbid conditions such as diabetes and heart failure, and polyph...

journal_title：Drugs & aging

authors： McFerren SC,Gomelsky A

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Older people are often prescribed multiple drugs with sedative properties. Most research has focused on specific classes of sedative and psychotropic drugs. The cumulative effect of taking multiple drugs with sedative properties has been termed 'sedative load'. Few previous studies have investigated the seda...

journal_title：Drugs & aging

authors： Taipale HT,Bell JS,Soini H,Pitkälä KH

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:In the presence of multimorbidity and limited life expectancy (LLE), the need for continued use of preventive medicines becomes uncertain as they may neither improve health nor confer continued health benefits. OBJECTIVE:Our objective was to systematically review the literature to examine the discontinuatio...

journal_title：Drugs & aging

authors： Narayan SW,Nishtala PS

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:By using the findings obtained from the PREPARED study, we aimed to estimate the cost effectiveness of ropinirole prolonged release (PR) [Requip-Modutab(®)] in Parkinson's disease (PD) versus ropinirole immediate release (IR). In the PREPARED study, ropinirole PR provided a significantly greater improvement ...

journal_title：Drugs & aging

authors： van Boven JF,Novak A,Driessen MT,Boersma C,Boomsma MM,Postma MJ

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:To determine the association between changes in complete blood counts and grade 3 or 4 toxicities from cycle 1 to cycle 2 during adjuvant chemotherapy in women > or =65 years of age with breast cancer. DESIGN AND METHODS:A retrospective review was performed on 1405 patients > or =65 years of age who were treat...

journal_title：Drugs & aging

authors： Hurria A,Brogan K,Panageas KS,Jakubowski A,Zauderer M,Pearce C,Norton L,Howard J,Hudis C

更新日期：2005-01-01 00:00:00

abstract：:Cerebral deposition of amyloid plaques containing amyloid beta-peptide (Abeta) has traditionally been considered the central feature of Alzheimer's disease (AD). Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase. In the past decade...

journal_title：Drugs & aging

authors： Zimmermann M,Gardoni F,Di Luca M

更新日期：2005-01-01 00:00:00

abstract：:The incidence of pneumonia is highest among the aged compared with other adult populations, and causes significant morbidity and mortality among this group. Most episodes of pneumonia are caused by aspiration of oropharyngeal flora into the lungs and failure of lung defence mechanisms to eliminate the aspirated bacter...

journal_title：Drugs & aging

authors： Mylotte JM,Ksiazek S,Bentley DW

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Our objectives were to (1) describe the evolution of the underuse of anticoagulants in older people with atrial fibrillation (AF) and a CHADS2 score ≥ 2 since direct oral anticoagulants (DOACs) were introduced to the market and (2) describe factors associated with this underuse. METHODS:We conducted a retros...

journal_title：Drugs & aging

authors： Henrard S,Vandenabeele C,Marien S,Boland B,Dalleur O

更新日期：2017-11-01 00:00:00

abstract：:An increasing number of elderly patients are exposed to cardiovascular drugs for the treatment of acute and/or chronic conditions. This is a result of the progressive aging of the population, a common feature in most industrialised countries, and an improvement in primary and secondary cardiovascular prevention strate...

journal_title：Drugs & aging

authors： Mangoni AA

更新日期：2005-01-01 00:00:00

abstract：:Decitabine (Dacogen(®)) is a deoxynucleoside analogue of cytidine that selectively inhibits DNA methyltransferases. Decitabine administered at a dose of 20 mg/m(2) by a 1-h intravenous infusion for 5 consecutive days of a 4-week cycle has been approved by the European Medicines Agency (EMA) for use in adult patients a...

journal_title：Drugs & aging

authors： Curran MP

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Despite evidence of effective combination drug therapy for secondary prevention of coronary heart disease (CHD), older adults with this condition remain undertreated. OBJECTIVE:To describe time trends (1992-2003) in the adoption of combination cardiac drug therapies (beta-blockers [beta-adrenoceptor antagon...

journal_title：Drugs & aging

authors： Tjia J,Briesacher B,Xie D,Fu J,Goldberg RJ

更新日期：2010-02-01 00:00:00

abstract：:Restenosis in the months following a successful percutaneous transluminal coronary angioplasty (PTCA) remains the main limitation to this technique for myocardial revascularisation. Despite intensive investigation in this area, no pharmacological therapy has yet been found to be useful in preventing restenosis after c...

journal_title：Drugs & aging

authors： Hamon M,Lécluse E,Monassier JP,Grollier G,Potier JC

更新日期：1998-10-01 00:00:00

abstract：:The 2013 American College of Cardiology (ACC) and American Heart Association (AHA) practice guidelines for the treatment of blood cholesterol significantly changed the paradigm of how providers should prescribe statin therapy, especially for older adults. While the evidence supports statin therapy for older adults wit...

journal_title：Drugs & aging

authors： Weinberger Y,Han BH

更新日期：2015-02-01 00:00:00

abstract：:The median age for breast cancer diagnosis is 62 years, but a disproportionate number of patients are over the age of 75 years and the majority of those have hormone receptor-positive, human epidermal growth factor receptor-2 (HER2)-negative cancers. This review provides a logical algorithm to guide providers through ...

journal_title：Drugs & aging

authors： Sammons S,Sedrak MS,Kimmick GG

更新日期：2020-05-01 00:00:00

abstract：:Vitreous haemorrhage can be caused by a disruption of normal retinal vessels, bleeding from diseased retinal vessels, bleeding from abnormal new vessels or extension of haemorrhage through the retina from other sources. In the elderly, vitreous haemorrhage usually occurs spontaneously and only occurs occasionally as a...

journal_title：Drugs & aging

authors： Manuchehri K,Kirkby G

更新日期：2003-01-01 00:00:00

abstract：:A progressive accumulation of atherosclerotic lesions beginning early in life puts elderly persons at a greater absolute risk of cardiovascular disease and coronary events than other segments of the population. HMG-CoA reductase inhibitor (statin) therapy has been shown to be both efficacious and well tolerated in mos...

journal_title：Drugs & aging

authors： Davidson MH

更新日期：2007-01-01 00:00:00

abstract：:Spasticity following stroke reflects a spectrum of clinical problems including increased muscle tone, abnormal limb posture, excessive contraction of antagonist muscles and hyperactive cutaneous and tendon reflexes. The prevalence of stroke-related disability in stroke survivors is high, and spasticity may be a signif...

journal_title：Drugs & aging

authors： O'Brien CF,Seeberger LC,Smith DB

更新日期：1996-11-01 00:00:00

abstract：:Older adults with chronic kidney disease (CKD) often experience polypharmacy, a recognized predictor of prescribing problems including inappropriately dosed medications, drug-drug and drug-disease interactions, morbidity and mortality. Polypharmacy is also associated with nonadherence, which leads to recurrent hospita...

journal_title：Drugs & aging

authors： Triantafylidis LK,Hawley CE,Perry LP,Paik JM

更新日期：2018-11-01 00:00:00