Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations.


:An increasing number of elderly patients are exposed to cardiovascular drugs for the treatment of acute and/or chronic conditions. This is a result of the progressive aging of the population, a common feature in most industrialised countries, and an improvement in primary and secondary cardiovascular prevention strategies with increased survival rates. Traditionally, most elderly patients receiving cardiovascular drugs had advanced cardiac, liver and kidney disease that significantly influenced drug pharmacokinetic and pharmacodynamic parameters. Currently, however, many patients without significant organ impairment receive cardiovascular therapy for primary or early secondary prevention (i.e. increased vascular risk, asymptomatic left ventricular dysfunction, poststroke phase, type 2 diabetes mellitus), highlighting the need for a better understanding of specific age-related pharmacokinetic and pharmacodynamic effects. A systematic review has been conducted on the specific effects of aging, in the absence of major co-morbidities, on the pharmacokinetic and pharmacodynamic properties of traditional and newer cardiovascular drugs. Currently, the evidence available is poor or nonexisting for several drugs and mainly derived from very small and underpowered studies, thus limiting data interpretation. In particular, there is very little information on patients >80 years of age, thus raising important concerns about the correct use of these drugs in this constantly growing population.


Drugs Aging


Drugs & aging


Mangoni AA




Has Abstract


2005-01-01 00:00:00














  • Adverse drug reactions in an elderly hospitalised population: inappropriate prescription is a leading cause.

    abstract:OBJECTIVE:Adverse drug reactions (ADRs) represent a major public health problem in the aged. In order to better evaluate this problem in Brazil, this study was designed to assess the prevalence of ADRs in an elderly hospitalised population, identify the most common ADRs and the principal medications involved, evaluate ...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Passarelli MC,Jacob-Filho W,Figueras A

    更新日期:2005-01-01 00:00:00

  • Quality measures for medication continuity in long-term care facilities, using a structured panel process.

    abstract:BACKGROUND:Patient transitions, such as transfers between acute and long-term care (LTC), aposare times when the likelihood of communication failure between healthcare providers is increased. Employing appropriate health quality indicators helps support improvement efforts. To date, few quality indicators that evaluate...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Bell CM,Brener SS,Comrie R,Anderson GM,Bronskill SE

    更新日期:2012-04-01 00:00:00

  • Meglitinide analogues in the treatment of type 2 diabetes mellitus.

    abstract::Type 2 diabetes mellitus is a complex heterogenous metabolic disorder in which peripheral insulin resistance and impaired insulin release are the main pathogenetic factors. The rapid response of the pancreatic beta-cells to glucose is already markedly disturbed in the early stages of type 2 diabetes mellitus. The cons...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Landgraf R

    更新日期:2000-11-01 00:00:00

  • Characterisation of patients with postmenopausal osteoporosis in French primary healthcare.

    abstract:BACKGROUND:The public health burden of osteoporosis is high, principally because of increased risk of fractures and associated morbidity, handicap and mortality. Osteoporotic fracture prevention is therefore an important public health goal. General practitioners (GPs) play a key role in the management of osteoporosis, ...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Blotman F,Cortet B,Hilliquin P,Avouac B,Allaert FA,Pouchain D,Gaudin AF,Cotté FE,El Hasnaoui A

    更新日期:2007-01-01 00:00:00

  • Multiple sclerosis in the elderly patient.

    abstract::Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is typically diagnosed in the second or third decade of life. It is generally believed that over the last few decades the life expectancy of patients with adult onset MS (AOMS) has approached that of the general population as a r...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Awad A,Stüve O

    更新日期:2010-04-01 00:00:00

  • Improving elder care by integrating geriatric expertise into medicare: a proposal.

    abstract::The Medicare programme already funds a large proportion of the medical care for older Americans. However, geriatricians are an underutilized resource for improving the quality of care delivered with Medicare funding, particularly to the most complex patients. Recent legislative changes will increase the involvement of...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Nusbaum NJ

    更新日期:2005-01-01 00:00:00

  • Impact of home patient telemonitoring on use of β-blockers in congestive heart failure.

    abstract:INTRODUCTION:Congestive heart failure (CHF), which typically affects older people, is characterized by high short- and mid-term mortality rates. However, despite accumulating evidence showing that administration of β-blockers (β-adrenoceptor antagonists) can improve the clinical status of CHF patients, use of these age...

    journal_title:Drugs & aging

    pub_type: 杂志文章,随机对照试验


    authors: Antonicelli R,Mazzanti I,Abbatecola AM,Parati G

    更新日期:2010-10-01 00:00:00

  • Correction to: Romosozumab: A Review in Postmenopausal Osteoporosis.

    abstract::Unfortunately the sections were published incorrectly in the original article. ...

    journal_title:Drugs & aging

    pub_type: 已发布勘误


    authors: Paik J,Scott LJ

    更新日期:2020-11-01 00:00:00

  • Recent Progress in the Pharmacotherapy of Alzheimer's Disease.

    abstract::Alzheimer's disease is the most common major neurocognitive disorder with substantial social and economic impacts. This article is an update on current pharmacotherapy, advancements in biomarker use, and drugs in the pipeline for this disease. To date, no new drug has qualified to be added to the current therapeutic a...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Khoury R,Patel K,Gold J,Hinds S,Grossberg GT

    更新日期:2017-11-01 00:00:00

  • Safety of Paracetamol in Osteoarthritis: What Does the Literature Say?

    abstract::Osteoarthritis (OA) is a major cause of pain and physical disability in adults, and an increasingly common disease given its associations with aging and a growing obese/overweight population. Paracetamol is widely recommended for analgesia at an early stage in the management of OA, and, although frequently prescribed,...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Conaghan PG,Arden N,Avouac B,Migliore A,Rizzoli R

    更新日期:2019-04-01 00:00:00

  • Gerontology forum: an update on the literature.

    abstract::New treatments and treatment protocols for diseases affecting the elderly are evolving as we strive to meet the needs of an aging society. To help you keep up to date with the latest advances worldwide on all aspects of drug therapy and patient management, this section of the journal brings you information selected fr...

    journal_title:Drugs & aging




    更新日期:2006-01-01 00:00:00

  • Fast and slow bone losers. Relevance to the management of osteoporosis.

    abstract::A low bone mineral density (BMD) is presently regarded as the most important risk factor for the development of osteoporosis. BMD is a function of peak bone mass attained during growth and subsequent age-related bone loss. BMD can be measured accurately and precisely, although the rate of bone loss is more difficult t...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Hough S

    更新日期:1998-01-01 00:00:00

  • Psychotropic drug-induced falls in older people: a review of interventions aimed at reducing the problem.

    abstract::Falls are a common health problem for older people, and psychotropic medications have been identified as an important independent fall risk factor. The objective of this paper was to review the literature relating to the effect of psychotropic medications on falls in older people, with a particular focus on evidence s...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Hill KD,Wee R

    更新日期:2012-01-01 00:00:00

  • Acute kidney injury induced by antimicrobial agents in the elderly: awareness and mitigation strategies.

    abstract::The use of antimicrobial agents has increased in recent years as treatments have diversified and resistant bacteria have appeared. With increased use of antimicrobial agents, elderly patients are prone to adverse drug reactions (ADRs) as a result of factors such as drug-drug interactions, polypharmacy, long-term use, ...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Mizokami F,Mizuno T

    更新日期:2015-01-01 00:00:00

  • Prevention and treatment of urinary catheter-related infections in older patients.

    abstract::The elderly population is more likely to have urinary catheters used than younger populations. Most patients with short term indwelling catheters (those in place less than 30 days) will be residents of acute care institutions. The frequency of catheter-acquired bacteriuria is greater with longer durations of catheteri...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Nicolle LE

    更新日期:1994-05-01 00:00:00

  • Interventions to Improve Medicines Management for People with Dementia: A Systematic Review.

    abstract:BACKGROUND:The importance of optimising medicines management for people with dementia has been emphasised through research and policy. However, evidence is currently lacking regarding how to achieve this in this patient population. OBJECTIVE:The aim was to assess the effectiveness of medicines management interventions...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: McGrattan M,Ryan C,Barry HE,Hughes CM

    更新日期:2017-12-01 00:00:00

  • Bacterial skin infections in the elderly: diagnosis and treatment.

    abstract::Skin and soft tissue infections are quite common in elderly people. A number of special conditions and circumstances need to be considered in the diagnosis and therapy. It is important to try to establish the causative organism, exclude other cutaneous disorders and identify precipitating factors. Treatment modalities...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Laube S,Farrell AM

    更新日期:2002-01-01 00:00:00

  • Discontinuation of Preventive Medicines in Older People with Limited Life Expectancy: A Systematic Review.

    abstract:BACKGROUND:In the presence of multimorbidity and limited life expectancy (LLE), the need for continued use of preventive medicines becomes uncertain as they may neither improve health nor confer continued health benefits. OBJECTIVE:Our objective was to systematically review the literature to examine the discontinuatio...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Narayan SW,Nishtala PS

    更新日期:2017-10-01 00:00:00

  • A brief history of pneumococcal vaccines.

    abstract::Attempts to control pneumococcal infection by vaccination, undertaken initially in 1911, have gone through 3 phases during the subsequent 8 decades. Initially, vaccines of killed pneumococcal cells prepared in a variety of ways were used in epidemic settings with inconclusive results, although administered to approxim...

    journal_title:Drugs & aging

    pub_type: 历史文章,杂志文章


    authors: Austrian R

    更新日期:1999-01-01 00:00:00

  • Treatment of Seizures in Older Patients with Dementia.

    abstract::The numbers of patients with dementia and patients with epilepsy are increasing in the global population. In fact, these two conditions are related, and it is estimated that at least 5-10% of seizures or epilepsy in older individuals (aged > 60 years) are caused by a neurodegenerative dementia. In the vast majority, o...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Cretin B

    更新日期:2020-12-14 00:00:00

  • Age-related changes in signal transduction. Implications for neuronal transmission and potential for drug intervention.

    abstract::Problems associated with aging will become one of the leading health dilemmas of the next century. Age-associated diseases, including those affecting the neuronal system, are increasing in frequency. Age-related deficiencies in the brain result in impaired motor functions, sleep, behaviour and cognitive functions. Goo...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Fülöp T Jr,Seres I

    更新日期:1994-11-01 00:00:00

  • Effects of medication assessment as part of a comprehensive geriatric assessment on drug use over a 1-year period: a population-based intervention study.

    abstract::High drug consumption among the elderly and inappropriate prescribing practices increase the risk of adverse drug effects in this population. This risk may be decreased by conducting, for example, a medication review alone or as part of a comprehensive geriatric assessment (CGA); however, little is known about the fat...

    journal_title:Drugs & aging

    pub_type: 杂志文章,随机对照试验


    authors: Lampela P,Hartikainen S,Lavikainen P,Sulkava R,Huupponen R

    更新日期:2010-06-01 00:00:00

  • Age as a basis for healthcare rationing. Support for agist policies.

    abstract::It is inevitable that publicly funded, technically sophisticated medical treatments will be increasingly rationed. Other things being equal, there is a greater duty to use them to prolong the lives of younger than older people. Age is therefore an ethical rationing criterion. Denial of this may actually harm older peo...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Shaw AB

    更新日期:1996-12-01 00:00:00

  • Medication-related admissions in older people: a cross-sectional, observational study.

    abstract:BACKGROUND:Medication-related admissions are an important cause of hospital admissions in older people. The scope for prevention is less clear. OBJECTIVES:To characterize medication-related hospital admissions in older people and assess their preventability. METHODS:This was a cross-sectional, observational study con...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Rogers S,Wilson D,Wan S,Griffin M,Rai G,Farrell J

    更新日期:2009-01-01 00:00:00

  • Donepezil: a review of its use in Alzheimer's disease.

    abstract::Donepezil (E-2020) is a reversible, noncompetitive, piperidine-type cholinesterase inhibitor. It is selective for acetylcholinesterase rather than butyrylcholinesterase. Donepezil 5 and 10 mg/day significantly improved cognition and global clinical function compared with placebo in well designed short term trials (14 ...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Dooley M,Lamb HM

    更新日期:2000-03-01 00:00:00

  • Drug therapy of prostatic cancer.

    abstract::While hormonal therapy has been the usual and appropriate treatment of advanced or metastatic prostatic cancer for the past 50 years, the recent development of new therapeutic agents as medical alternatives to orchidectomy has drastically altered the options and perspectives in the treatment of this disease. Estrogens...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Huben RP,Perrapato SD

    更新日期:1991-09-01 00:00:00

  • Outpatient medications and hip fractures in the US: a national veterans study.

    abstract:BACKGROUND:Certain medications have been linked to falls. One of the most severe fall-related injuries in the elderly is a hip fracture. OBJECTIVE:The objective of this study was to examine the use of medications known to increase fall risk that were prescribed on an outpatient basis to veterans prior to hospital admi...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: French DD,Campbell R,Spehar A,Cunningham F,Foulis P

    更新日期:2005-01-01 00:00:00

  • Sleep disorders in Parkinson's disease: epidemiology and management.

    abstract::Sleep problems are an under-emphasised cause of disability in Parkinson's disease (PD) and may be seen independently of PD, associated with primary PD pathology, or as a result of antiparkinsonian medications. Common sleep disorders include excessive daytime sleepiness, rapid eye movement (REM) sleep behaviour disorde...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Stacy M

    更新日期:2002-01-01 00:00:00

  • Patients' Attitudes Towards Deprescribing Alpha-Blockers and Their Willingness to Participate in a Discontinuation Trial.

    abstract:OBJECTIVE:The objective of this study was to gain insights into the attitudes of men with lower urinary tract symptoms towards deprescribing alpha-blockers and to assess their willingness to participate in a planned discontinuation trial. METHODS:This was a cross-sectional questionnaire study. Men aged 30 years and ol...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Edelman M,Jellema P,Hak E,Denig P,Blanker MH

    更新日期:2019-12-01 00:00:00

  • Late-Onset and Elderly Psoriatic Arthritis: Clinical Aspects and Management.

    abstract::Psoriatic arthritis (PsA) can start in subjects aged over 60 years, defined as late-onset PsA. In late-onset PsA, the weight of family history and genetic background appears less significant when compared with younger onset PsA, whereas obesity and smoking have been suggested as potential risk factors. In patients wit...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Caso F,Tasso M,Chimenti MS,Navarini L,Perricone C,Girolimetto N,Peluso R,Del Puente A,Afeltra A,Perricone R,Punzi L,Scarpa R,Costa L

    更新日期:2019-10-01 00:00:00