Anticholinergic medications: an additional contributor to cognitive impairment in the heart failure population?

abstract：:The focus of this review is hormone replacement therapy (HRT) with continuous oral 17 beta-estradiol (herein referred to as estradiol) 2 mg/day plus sequential oral dydrogesterone 10 or 20 mg/day for 14 days of each 28-day cycle. According to data from nonblind trials, this regimen relieves climacteric symptoms, prese...

journal_title：Drugs & aging

authors： Foster RH,Balfour JA

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to gain insights into the attitudes of men with lower urinary tract symptoms towards deprescribing alpha-blockers and to assess their willingness to participate in a planned discontinuation trial. METHODS:This was a cross-sectional questionnaire study. Men aged 30 years and ol...

journal_title：Drugs & aging

authors： Edelman M,Jellema P,Hak E,Denig P,Blanker MH

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Older people are often prescribed multiple drugs with sedative properties. Most research has focused on specific classes of sedative and psychotropic drugs. The cumulative effect of taking multiple drugs with sedative properties has been termed 'sedative load'. Few previous studies have investigated the seda...

journal_title：Drugs & aging

authors： Taipale HT,Bell JS,Soini H,Pitkälä KH

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Medication-related problems are common in the growing population of older adults and inappropriate prescribing is a preventable risk factor. Explicit criteria such as the Beers criteria provide a valid instrument for describing the rate of inappropriate medication (IM) prescriptions among older adults. OBJE...

journal_title：Drugs & aging

authors： Blozik E,Born AM,Stuck AE,Benninger U,Gillmann G,Clough-Gorr KM

更新日期：2010-12-01 00:00:00

abstract：:While hormonal therapy has been the usual and appropriate treatment of advanced or metastatic prostatic cancer for the past 50 years, the recent development of new therapeutic agents as medical alternatives to orchidectomy has drastically altered the options and perspectives in the treatment of this disease. Estrogens...

journal_title：Drugs & aging

authors： Huben RP,Perrapato SD

更新日期：1991-09-01 00:00:00

abstract：:The use of antimicrobial agents has increased in recent years as treatments have diversified and resistant bacteria have appeared. With increased use of antimicrobial agents, elderly patients are prone to adverse drug reactions (ADRs) as a result of factors such as drug-drug interactions, polypharmacy, long-term use, ...

journal_title：Drugs & aging

authors： Mizokami F,Mizuno T

更新日期：2015-01-01 00:00:00

abstract：:Cardiovascular disease has been inseparable from aging in developed societies and, as a result, it is the commonest cause of mortality in elderly populations. Atherosclerosis is associated with the progressive vascular accumulation of cholesterol-laden lipoproteins, and is linearly associated with the plasma level of ...

journal_title：Drugs & aging

authors： Playford DA,Watts GF

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Although compelling evidence exists supporting statins (HMG-CoA reductase inhibitors) for secondary prevention in older patients with clinical atherosclerotic diseases, the same cannot be said for primary prevention. OBJECTIVES:The objectives of this study were to estimate the frequency of potential statin ...

journal_title：Drugs & aging

authors： Borne E,Meyer N,Rybarczyck-Vigouret MC,Blanchard O,Lombard M,Lang PO,Vogel T,Michel B

更新日期：2019-10-01 00:00:00

abstract：:Systemic fungal infections are an increasing problem in older adults. For several of the endemic mycoses, this increase is the result of increased travel and leisure activities in areas endemic for these fungi. Immunosuppressive agents, care in an intensive care unit, and invasive devices all contribute to infection w...

journal_title：Drugs & aging

authors： Kauffman CA,Hedderwick SA

更新日期：2001-01-01 00:00:00

abstract：:It is inevitable that publicly funded, technically sophisticated medical treatments will be increasingly rationed. Other things being equal, there is a greater duty to use them to prolong the lives of younger than older people. Age is therefore an ethical rationing criterion. Denial of this may actually harm older peo...

journal_title：Drugs & aging

authors： Shaw AB

更新日期：1996-12-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting 1 to 3% of individuals over the age of 65 years. While effective therapy exists for treating the bradykinesia, rigidity and tremor associated with the disease, the cause is unknown. There is no treatment available to prevent or slo...

journal_title：Drugs & aging

authors： Ross GW,Petrovitch H

更新日期：2001-01-01 00:00:00

abstract：:Xerostomia and salivary gland hypofunction (SGH) are prevalent in elderly populations, causing much discomfort and even difficulties in eating. SGH also increases the occurrence and severity of oral diseases and makes the patient susceptible to candidiasis. The principal causes of SGH and xerostomia are systemic disea...

journal_title：Drugs & aging

authors： Närhi TO,Meurman JH,Ainamo A

更新日期：1999-08-01 00:00:00

abstract：:Type 2 diabetes mellitus is a complex heterogenous metabolic disorder in which peripheral insulin resistance and impaired insulin release are the main pathogenetic factors. The rapid response of the pancreatic beta-cells to glucose is already markedly disturbed in the early stages of type 2 diabetes mellitus. The cons...

journal_title：Drugs & aging

authors： Landgraf R

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Patients hospitalised with severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2; coronavirus 2019 disease (COVID-19)] infection are frequently older with co-morbidities and receiving polypharmacy, all of which are known risk factors for drug-drug interactions (DDIs). The pharmacological burden may be ...

journal_title：Drugs & aging

authors： Cattaneo D,Pasina L,Maggioni AP,Giacomelli A,Oreni L,Covizzi A,Bradanini L,Schiuma M,Antinori S,Ridolfo A,Gervasoni C

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Older cancer patients are possibly at an increased risk of medication-related problems because, typically, they receive many medications during their cancer treatment, both for the cancer itself and for supportive care. OBJECTIVES:The aim of this study was to describe the number and severity of potential ...

journal_title：Drugs & aging

authors： Puts MT,Monette J,Girre V,Costa-Lima B,Wolfson C,Batist G,Bergman H

更新日期：2010-07-01 00:00:00

abstract：:Persons over the age of 65 years are the fastest growing segment of the US population. In the next 30 years this segment will represent more than 20% of the population. Fifty percent of all cancers occur in this age group and therefore the total cancer burden is expected to rise. Data are becoming available that will ...

journal_title：Drugs & aging

authors： John V,Mashru S,Lichtman S

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The choice of induction immunosuppression for kidney transplantation in elderly recipients is dictated by the consideration of the risk of infection as well as efficacy in the prevention of acute rejection, thus allowing a reduction in subsequent maintenance immunosuppression and its attendant long-term adve...

journal_title：Drugs & aging

authors： Heifets M,Saeed MI,Parikh MH,Sierka D,Kumar MS

更新日期：2004-01-01 00:00:00

abstract：:Cerebral deposition of amyloid plaques containing amyloid beta-peptide (Abeta) has traditionally been considered the central feature of Alzheimer's disease (AD). Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase. In the past decade...

journal_title：Drugs & aging

authors： Zimmermann M,Gardoni F,Di Luca M

更新日期：2005-01-01 00:00:00

abstract：:Alzheimer's disease is a chronic progressive disease affecting higher intellectual functioning. The clinical diagnosis is made when the onset of illness is insidious, the course slowly progressive and all the treatable causes of dementia have been ruled out. The use of more stringent criteria has improved clinical dia...

journal_title：Drugs & aging

authors： Hermann C,Stern RG,Losonzcy MF,Jaff S,Davidson M

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:The importance of optimising medicines management for people with dementia has been emphasised through research and policy. However, evidence is currently lacking regarding how to achieve this in this patient population. OBJECTIVE:The aim was to assess the effectiveness of medicines management interventions...

journal_title：Drugs & aging

authors： McGrattan M,Ryan C,Barry HE,Hughes CM

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Older adults receiving cytotoxic agents may be more susceptible to hematologic toxicities because of progressive reduction in organ functions and multiple co-morbidities. Because older adults are under-represented in clinical trials, this retrospective study aims to evaluate hematologic toxicity of gemcitabine-...

journal_title：Drugs & aging

authors： Crombag MR,de Vries Schultink AH,Schellens JH,Beijnen JH,Huitema AD

更新日期：2014-10-01 00:00:00

abstract：:Many quantities assayed in clinical laboratories demonstrate age-related changes. Particularly important periods are early life, adolescence, old age, and after the menopause in females. The changes that occur until adulthood are well documented. Fewer data are available on elderly people even though they consume a la...

journal_title：Drugs & aging

authors： Fraser CG

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Certain medications have been linked to falls. One of the most severe fall-related injuries in the elderly is a hip fracture. OBJECTIVE:The objective of this study was to examine the use of medications known to increase fall risk that were prescribed on an outpatient basis to veterans prior to hospital admi...

journal_title：Drugs & aging

authors： French DD,Campbell R,Spehar A,Cunningham F,Foulis P

更新日期：2005-01-01 00:00:00

abstract：:The atypical antipsychotics are a new class of agents with great promise for use in the elderly because of their reduced propensity to cause acute extrapyramidal adverse effects. Treatment of older patients with these agents, however, needs to take into consideration age-related changes in pharmacokinetics and the ris...

journal_title：Drugs & aging

authors： Sweet RA,Pollock BG

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Patient transitions, such as transfers between acute and long-term care (LTC), aposare times when the likelihood of communication failure between healthcare providers is increased. Employing appropriate health quality indicators helps support improvement efforts. To date, few quality indicators that evaluate...

journal_title：Drugs & aging

authors： Bell CM,Brener SS,Comrie R,Anderson GM,Bronskill SE

更新日期：2012-04-01 00:00:00

abstract：:New treatments and treatment protocols for diseases affecting the elderly are evolving as we strive to meet the needs of an aging society. To help you keep up to date with the latest advances worldwide on all aspects of drug therapy and patient management, this section of the journal brings you information selected fr...

journal_title：Drugs & aging

authors：

更新日期：2006-01-01 00:00:00

abstract：:Spasticity following stroke reflects a spectrum of clinical problems including increased muscle tone, abnormal limb posture, excessive contraction of antagonist muscles and hyperactive cutaneous and tendon reflexes. The prevalence of stroke-related disability in stroke survivors is high, and spasticity may be a signif...

journal_title：Drugs & aging

authors： O'Brien CF,Seeberger LC,Smith DB

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...

journal_title：Drugs & aging

authors： Andrès E,Zimmer J,Noel E,Kaltenbach G,Koumarianou A,Maloisel F

更新日期：2003-01-01 00:00:00

abstract：:Cataract surgery is the most frequent surgical procedure requiring anaesthesia in developed countries. It is performed mainly in elderly patients, who present with many coexisting diseases that induce subsequent hazards from general anaesthesia. Cataract anaesthesia is performed following various techniques of regiona...

journal_title：Drugs & aging

authors： Nouvellon E,Cuvillon P,Ripart J,Viel EJ

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Increased life expectancy is associated with an increased prevalence of chronic diseases and drug consumption. Changes often occur in the medication regimen after hospitalization. The extent and nature of these changes and the adherence of elderly patients have not yet been fully investigated. OBJECTIVE:To ...

journal_title：Drugs & aging

authors： Mansur N,Weiss A,Hoffman A,Gruenewald T,Beloosesky Y

更新日期：2008-01-01 00:00:00