Abstract:
:The use of antimicrobial agents has increased in recent years as treatments have diversified and resistant bacteria have appeared. With increased use of antimicrobial agents, elderly patients are prone to adverse drug reactions (ADRs) as a result of factors such as drug-drug interactions, polypharmacy, long-term use, and over- or under-dosage. In particular, elderly patients using antimicrobials are at increased risk to develop drug-induced acute kidney injury (AKI), which is the most common severe ADR in such patients. AKI is a serious problem that is associated with mortality amongst hospitalized patients. Antimicrobial-induced AKI can be classified into three different types: acute tubular necrosis (ATN), acute interstitial nephritis (AIN), and renal tubule lumen obstruction. AKI can generally be prevented by proper maintenance of fluid balance. To design dosage regimens that ensure efficient drug excretion via the kidney, it is necessary to accurately estimate renal function; however, the kidney undergoes age-dependent structural and functional alterations over time. Therefore, proper management of antimicrobial agents by an antimicrobial stewardship team may lead to decreased incidence of AKI. This article reviews antimicrobial-induced AKI and discusses potential strategies for increasing awareness of AKI and mitigating its clinical effects.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Mizokami F,Mizuno Tdoi
10.1007/s40266-014-0232-ysubject
Has Abstractpub_date
2015-01-01 00:00:00pages
1-12issue
1eissn
1170-229Xissn
1179-1969journal_volume
32pub_type
杂志文章,评审相关文献
DRUGS & AGING文献大全abstract::Gout in older patients tends to be sub-acute to chronic, often tophaceous, polyarticular, erosive, symmetrical, and causes persistent, recurrent and chronic arthritis. Clinically, it may closely mimic rheumatoid arthritis; thus, a correct diagnosis requires a high index of clinical suspicion and the identification of ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199404020-00005
更新日期:1994-02-01 00:00:00
abstract::An increasing number of elderly patients are exposed to cardiovascular drugs for the treatment of acute and/or chronic conditions. This is a result of the progressive aging of the population, a common feature in most industrialised countries, and an improvement in primary and secondary cardiovascular prevention strate...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522110-00003
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Medication non-adherence can exacerbate disease severity, leading to impairments that interfere with self-care activities in older adults, and, ultimately, death. Elder self-neglect is the most common report to Adult Protective Services (APS) across the USA and is a significant risk factor for early mortalit...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-012-0007-2
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Treatment of postherpetic neuralgia (PHN) is more complicated in elderly patients, and multiple daily dosing, complex titration, and high incidences of adverse events can be limiting for many pharmacological treatment options. OBJECTIVE:The aim of this study was to determine whether the efficacy and tolerab...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-013-0126-4
更新日期:2013-12-01 00:00:00
abstract::Dopamine agonists (DAs) are frequently used in the management of Parkinson's disease (PD), a complex multisystem disorder influenced substantially by age-related factors. Over 80% of PD patients present after age 60 years and may have clinical features exacerbated by age-related comorbidities or decline in physiologic...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0629-0
更新日期:2019-03-01 00:00:00
abstract::Spasticity following stroke reflects a spectrum of clinical problems including increased muscle tone, abnormal limb posture, excessive contraction of antagonist muscles and hyperactive cutaneous and tendon reflexes. The prevalence of stroke-related disability in stroke survivors is high, and spasticity may be a signif...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199609050-00004
更新日期:1996-11-01 00:00:00
abstract::Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties. Whether its analgesic effects are linked to its mood-altering activity or attributable to a discrete pharmacological action (or a combination of both) is unknown. Clinical trials demonstrate that oral amitriptyline achieves at least...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199608060-00008
更新日期:1996-06-01 00:00:00
abstract::The elderly population is more likely to have urinary catheters used than younger populations. Most patients with short term indwelling catheters (those in place less than 30 days) will be residents of acute care institutions. The frequency of catheter-acquired bacteriuria is greater with longer durations of catheteri...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199404050-00003
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The importance of optimising medicines management for people with dementia has been emphasised through research and policy. However, evidence is currently lacking regarding how to achieve this in this patient population. OBJECTIVE:The aim was to assess the effectiveness of medicines management interventions...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-017-0505-3
更新日期:2017-12-01 00:00:00
abstract::There has been a growing recognition that pulsatile stimulation of dopamine receptors may be an important mechanism in the generation of the motor fluctuations that often develop and compromise the effectiveness of long-term levodopa administration in persons with Parkinson's disease (PD). This has prompted investigat...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219080-00002
更新日期:2002-01-01 00:00:00
abstract::Asthma is a common airway disease found in people of all ages, although most studies of asthma therapies are focused on adolescent and young adults. Little information exists on the use of asthma therapeutics in the older patient (>65 years of age). The newest therapeutic class to be released in the US for the treatme...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200623060-00002
更新日期:2006-01-01 00:00:00
abstract::Chronic pain occurs in 45-85% of the geriatric population and the need to treat chronic pain is growing substantially. Unfortunately, treatment for chronic pain is not always correctly targeted, which leads to a reduced quality of life, with decreased socialization, depression, sleep disturbances, cognitive impairment...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11534670-000000000-00000
更新日期:2009-12-01 00:00:00
abstract::Osteoporosis is a common disease that affects 1 in 3 women. Family and twin studies have demonstrated that there is a strong genetic component to this condition. Potential candidate genes examined for their regulatory effect on bone mass include those for collagen type I, estrogen and vitamin D receptors, and various ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711050-00001
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Osteoporosis is a common cause of disability and death in elderly men and women. Until 2007, Australian Government-subsidized use of oral bisphosphonates, raloxifene and calcitriol (1alpha,25-dihydroxycholecalciferol) was limited to secondary prevention (requiring x-ray evidence of previous low-trauma fractu...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11318400-000000000-00000
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Despite evidence of effective combination drug therapy for secondary prevention of coronary heart disease (CHD), older adults with this condition remain undertreated. OBJECTIVE:To describe time trends (1992-2003) in the adoption of combination cardiac drug therapies (beta-blockers [beta-adrenoceptor antagon...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11532150-000000000-00000
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Limited data are available on the prevalence of inappropriate prescribing of renally cleared drugs in elderly patients in Australia. OBJECTIVES:To quantify and compare the extent of inappropriate prescribing (defined as at least one drug prescribed in an excessive dose or when contraindicated with respect t...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-015-0261-1
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The number of elderly patients with oesophageal cancer is expected to increase with the aging of the population and the rapidly increasing incidence of adenocarcinoma. Surgical resection is standard treatment for patients with localized disease considered fit for operation. However, elderly patients with oes...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200926030-00006
更新日期:2009-01-01 00:00:00
abstract::Antidepressants have long been recognized as a contributory factor to falls and many studies show an association between antidepressants and falls. There are extensive data for tricyclic antidepressants (TCAs) and related drugs, and for selective serotonin reuptake inhibitors (SSRIs), but few data for other classes of...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200926050-00002
更新日期:2009-01-01 00:00:00
abstract::Foot and ankle osteoarthritis (OA) is a common and disabling problem that adversely affects physical function and significantly reduces quality of life. Although the knee was considered to be the lower-limb site most often affected by OA, recent population data showed foot OA is as prevalent as knee OA, and rates incr...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00639-y
更新日期:2019-03-01 00:00:00
abstract::beta-Adrenoceptor antagonists (beta-blockers) reduce mortality and recurrent myocardial infarction (MI) in older patients after both Q-wave MI and non-Q-wave MI. The effects of beta-blockers are to: (i) reduce complex ventricular arrhythmias, including ventricular tachycardia; (ii) increase the ventricular fibrillatio...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711060-00002
更新日期:1997-12-01 00:00:00
abstract::Although inflammatory bowel disease (IBD) is generally considered a disease of young adults, it can occur in elderly individuals. The clinical features and treatment considerations in older patients are similar to those in younger patients, with some notable exceptions, which are reviewed in this article. Consideratio...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11537340-000000000-00000
更新日期:2010-08-01 00:00:00
abstract::Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is typically diagnosed in the second or third decade of life. It is generally believed that over the last few decades the life expectancy of patients with adult onset MS (AOMS) has approached that of the general population as a r...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11532120-000000000-00000
更新日期:2010-04-01 00:00:00
abstract::The elderly patient may show normal physiological changes of the cardiovascular and respiratory systems that accompany aging, as well as features of intrinsic cardiac disease. The latter include: a past history of myocardial infarction or ischaemic heart disease; history of congestive cardiac failure; angina; arterial...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219060-00003
更新日期:2002-01-01 00:00:00
abstract::In contrast with women, who experience a complete and abrupt cessation of ovarian function during the menopause, aging men largely maintain their testicular androgen production. Nevertheless, most cross-sectional studies indicate that there is a partial decrease in testosterone levels with aging, although this has not...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711010-00005
更新日期:1997-07-01 00:00:00
abstract::Most western countries have influenza vaccination programmes for citizens aged > or = 65 years. This paper reviews the available evidence on whether elderly influenza vaccination is worthwhile from a pharmacoeconomic point of view. A search on Medline and EMBASE resulted in a primary selection of approximately 100 stu...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200017030-00005
更新日期:2000-09-01 00:00:00
abstract::Congestive heart failure (CHF) is a common cardiovascular disorder that is characterised, in part, by a decreased cardiac output reserve. Accordingly, there is ongoing interest in the role of positive inotropic agents (e.g. adrenergic agonists and phosphodiesterase type III inhibitors, which mediate their cardiovascul...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812030-00003
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Medicines are potentially modifiable risk factors for postoperative delirium. However, the extent to which preoperative medicines are included in risk prediction models (RPMs) is unknown. OBJECTIVE:This systematic review aimed to assess the extent of inclusion of preoperative medications in RPMs for postope...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-018-0526-6
更新日期:2018-03-01 00:00:00
abstract::Cyproterone (cyproterone acetate) is a steroidal antiandrogenic agent that inhibits the action of adrenal and testicular androgens on prostatic cells. Additionally, its progestogenic activity causes a centrally mediated reduction in testicular secretion of androgens. Studies have demonstrated the effectiveness of cypr...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199405010-00006
更新日期:1994-07-01 00:00:00
abstract::The median age for breast cancer diagnosis is 62 years, but a disproportionate number of patients are over the age of 75 years and the majority of those have hormone receptor-positive, human epidermal growth factor receptor-2 (HER2)-negative cancers. This review provides a logical algorithm to guide providers through ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-020-00748-z
更新日期:2020-05-01 00:00:00
abstract::Behavioural disturbances, also termed neuropsychiatric symptoms, are a frequent clinical feature of dementia in Alzheimer's disease (AD). Many AD patients receive treatment with cholinesterase inhibitors (ChEIs). This review examines the evidence for behavioural effects of the four ChEIs that have been approved for th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200623120-00003
更新日期:2006-01-01 00:00:00