Abstract:
BACKGROUND:The number of elderly patients with oesophageal cancer is expected to increase with the aging of the population and the rapidly increasing incidence of adenocarcinoma. Surgical resection is standard treatment for patients with localized disease considered fit for operation. However, elderly patients with oesophageal cancer are rarely referred for surgery. The aim of this prospective, single-arm, phase II study was to evaluate the feasibility and efficacy (tumour response) of chemoradiotherapy in the treatment of elderly patients with localized oesophageal cancer. Secondary endpoints were progression-free survival (PFS) and quality of life (QOL).
METHODS:The main study inclusion criteria were: patients aged >or=75 years; oesophageal cancer disease stage II-III; Charlson co-morbidity index score journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
相关文献
DRUGS & AGING文献大全abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting 1 to 3% of individuals over the age of 65 years. While effective therapy exists for treating the bradykinesia, rigidity and tremor associated with the disease, the cause is unknown. There is no treatment available to prevent or slo...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200118110-00001
更新日期:2001-01-01 00:00:00
abstract::Systemic fungal infections are an increasing problem in older adults. For several of the endemic mycoses, this increase is the result of increased travel and leisure activities in areas endemic for these fungi. Immunosuppressive agents, care in an intensive care unit, and invasive devices all contribute to infection w...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200118050-00002
更新日期:2001-01-01 00:00:00
abstract::Globally, the number of drug prescriptions is increasing causing more adverse drug events, which is now a significant cause of mortality, morbidity, and disability that has reached epidemic proportions. The risk of adverse drug events is correlated to very old age, multiple co-morbidities, dementia, frailty, and limit...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0554-2
更新日期:2018-07-01 00:00:00
abstract::Blood pressure levels are strongly predictive of the risks of first-ever and recurrent stroke. The benefits of blood pressure-lowering therapy for the prevention of fatal and non-fatal stroke in middle-aged individuals are well established. However, until recently, there has been uncertainty about the consistency of s...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320040-00001
更新日期:2003-01-01 00:00:00
abstract::Polymyalgia rheumatica (PMR) is a disease of unknown aetiology that occurs in elderly patients, predominantly affecting the Caucasian population. The disease has a slightly higher prevalence in women than in men. There is ongoing discussion regarding the relationship between PMR and giant cell arteritis; an increasing...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199813020-00003
更新日期:1998-08-01 00:00:00
abstract::Although inflammatory bowel disease (IBD) is generally considered a disease of young adults, it can occur in elderly individuals. The clinical features and treatment considerations in older patients are similar to those in younger patients, with some notable exceptions, which are reviewed in this article. Consideratio...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11537340-000000000-00000
更新日期:2010-08-01 00:00:00
abstract::Skin and soft tissue infections are quite common in elderly people. A number of special conditions and circumstances need to be considered in the diagnosis and therapy. It is important to try to establish the causative organism, exclude other cutaneous disorders and identify precipitating factors. Treatment modalities...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219050-00002
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Pharmacotherapy with statins (HMG-CoA reductase inhibitors) is the cornerstone for lipid management in individuals with or at risk of developing cardiovascular diseases. Although the clinical benefits of statins are established for both women and men, there is evidence of a gender difference in their use. Th...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-012-0032-1
更新日期:2012-12-01 00:00:00
abstract::Felodipine is a dihydropyridine calcium antagonist which may be administered once daily in an extended release (ER) formulation. As monotherapy in older patients with mild to moderate essential hypertension, felodipine ER once daily provides effective control of blood pressure (BP). The drug has also been effective, e...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199202050-00002
更新日期:1992-09-01 00:00:00
abstract::Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties. Whether its analgesic effects are linked to its mood-altering activity or attributable to a discrete pharmacological action (or a combination of both) is unknown. Clinical trials demonstrate that oral amitriptyline achieves at least...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199608060-00008
更新日期:1996-06-01 00:00:00
abstract::Faecal incontinence occurs in up to 10% of community dwelling persons > or = 65 years of age and approximately 50% of nursing home residents. It is a vastly under-reported problem that has a devastating effect on those who experience it as well as their spouses and caregivers. There are three broad categories of faeca...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522020-00004
更新日期:2005-01-01 00:00:00
abstract::The alcohol withdrawal syndrome is common in elderly individuals who are alcohol dependent and who decrease or stop their alcohol intake. While there have been few clinical studies to directly support or refute the hypothesis that withdrawal symptom severity, delirium and seizures increase with advancing age, several ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199914060-00002
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Overactive bladder syndrome (OAB) is associated with various co-morbidities; treatment of these frequently results in multiple medication use (MMU) and the potential for drug-drug interactions, which may lead to adverse events and altered efficacy. With the aging population, the prevalence of MMU is likely t...
journal_title:Drugs & aging
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2165/11586740-000000000-00000
更新日期:2011-02-01 00:00:00
abstract::Most western countries have influenza vaccination programmes for citizens aged > or = 65 years. This paper reviews the available evidence on whether elderly influenza vaccination is worthwhile from a pharmacoeconomic point of view. A search on Medline and EMBASE resulted in a primary selection of approximately 100 stu...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200017030-00005
更新日期:2000-09-01 00:00:00
abstract:PURPOSE:To determine the association between changes in complete blood counts and grade 3 or 4 toxicities from cycle 1 to cycle 2 during adjuvant chemotherapy in women > or =65 years of age with breast cancer. DESIGN AND METHODS:A retrospective review was performed on 1405 patients > or =65 years of age who were treat...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200522080-00007
更新日期:2005-01-01 00:00:00
abstract::Relaxation of the upper age limits for solid organ transplantation coupled with improvements in post-transplant survival have resulted in greater numbers of elderly patients receiving immunosuppressant drugs such as tacrolimus. Tacrolimus is a potent agent with a narrow therapeutic window and large inter- and intraind...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522070-00001
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Increased life expectancy is associated with an increased prevalence of chronic diseases and drug consumption. Changes often occur in the medication regimen after hospitalization. The extent and nature of these changes and the adherence of elderly patients have not yet been fully investigated. OBJECTIVE:To ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825100-00005
更新日期:2008-01-01 00:00:00
abstract::The focus of this review is hormone replacement therapy (HRT) with continuous oral 17 beta-estradiol (herein referred to as estradiol) 2 mg/day plus sequential oral dydrogesterone 10 or 20 mg/day for 14 days of each 28-day cycle. According to data from nonblind trials, this regimen relieves climacteric symptoms, prese...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711040-00006
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe. METHODS:We conducted a cross...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0521-y
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Medicines are potentially modifiable risk factors for postoperative delirium. However, the extent to which preoperative medicines are included in risk prediction models (RPMs) is unknown. OBJECTIVE:This systematic review aimed to assess the extent of inclusion of preoperative medications in RPMs for postope...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-018-0526-6
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Adverse drug reactions (ADRs) represent a major public health problem in the aged. In order to better evaluate this problem in Brazil, this study was designed to assess the prevalence of ADRs in an elderly hospitalised population, identify the most common ADRs and the principal medications involved, evaluate ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200522090-00005
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-017-0513-3
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:In response to concerns about, and issues pertaining to, medication use practices in residential aged-care facilities (RACFs), the Australian Pharmaceutical Advisory Council (APAC) established a working party on quality use of medicines (QUM) in nursing homes and hostels. The APAC is a representative ministe...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421120-00005
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Statins have been shown to be beneficial in primary and secondary prevention settings; however, their role in the elderly remains a clinical conundrum, given that age-related factors could alter the risk-benefit ratio of statin treatment. This study aimed to critically evaluate the efficacy and safety of sta...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40266-015-0290-9
更新日期:2015-08-01 00:00:00
abstract::Periods of intense hormonal fluctuations have been associated with heightened prevalence and exacerbation of underlying psychiatric illness, particularly the occurrence of premenstrual dysphoria, puerperal depression and depressive symptoms during perimenopause. It has been speculated that sex steroids such as estroge...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320020-00001
更新日期:2003-01-01 00:00:00
abstract::In general, the pharmacological treatment of non-psychotic major depressive disorder in old age is only partially successful, with only approximately 50% of older depressed adults improving with initial antidepressant monotherapy. Many factors may predict a more difficult-to-treat depression, including coexisting anxi...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724100-00002
更新日期:2007-01-01 00:00:00
abstract::Despite a sharp decline in the incidence of gastric cancer during the second half of the 20th century, this malignancy remains the second leading cause of cancer mortality in the world. The incidence and mortality rate of gastric cancer increase with age; at present, the median ages at diagnosis are 67 years for men a...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11315740-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::The median age for breast cancer diagnosis is 62 years, but a disproportionate number of patients are over the age of 75 years and the majority of those have hormone receptor-positive, human epidermal growth factor receptor-2 (HER2)-negative cancers. This review provides a logical algorithm to guide providers through ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-020-00748-z
更新日期:2020-05-01 00:00:00
abstract::Cataract surgery is the most frequent surgical procedure requiring anaesthesia in developed countries. It is performed mainly in elderly patients, who present with many coexisting diseases that induce subsequent hazards from general anaesthesia. Cataract anaesthesia is performed following various techniques of regiona...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11318590-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::NSAIDs are a widely used class of analgesic and anti-inflammatory drugs that act by inhibiting the cyclo-oxygenase (COX) enzyme. However, because of their nonspecificity of action, use of these agents as long-term therapy for chronic pain in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA) is often d...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724060-00001
更新日期:2007-01-01 00:00:00