Treatment of systemic fungal infections in older patients: achieving optimal outcomes.

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting 1 to 3% of individuals over the age of 65 years. While effective therapy exists for treating the bradykinesia, rigidity and tremor associated with the disease, the cause is unknown. There is no treatment available to prevent or slo...

journal_title：Drugs & aging

authors： Ross GW,Petrovitch H

更新日期：2001-01-01 00:00:00

abstract：:Although the frequency of physician consultations and the sale of over-the-counter remedies establish the high prevalence of acute cough in the elderly, epidemiological studies have tended to be imprecise. However, respiratory tract infections in nose, larynx and/or bronchi, either viral or bacterial or both, are by f...

journal_title：Drugs & aging

authors： Widdicombe J,Kamath S

更新日期：2004-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic movement disorder typically coupled to progressive degeneration of dopaminergic neurons in the substantia nigra (SN). The treatments currently available are satisfactory for symptomatic management, but the efficacy tends to decrease as neuronal loss progresses. Neurotrophic factor...

journal_title：Drugs & aging

authors： Rodrigues TM,Jerónimo-Santos A,Outeiro TF,Sebastião AM,Diógenes MJ

更新日期：2014-04-01 00:00:00

abstract：:Osteoporosis is a common disease that affects 1 in 3 women. Family and twin studies have demonstrated that there is a strong genetic component to this condition. Potential candidate genes examined for their regulatory effect on bone mass include those for collagen type I, estrogen and vitamin D receptors, and various ...

journal_title：Drugs & aging

authors： Keen RW,Kelly PJ

更新日期：1997-11-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) usually affect adults and older populations. The well recognized clinical (i.e., granulomatosis with polyangiitis [GPA], microscopic polyangiitis, and eosinophilic GPA) and serological phenotypes (i.e., anti-MPO-ANCA, anti-PR3-ANCA and ANCA nega...

journal_title：Drugs & aging

authors： Berti A,Caporali R,Montecucco C,Paolazzi G,Monti S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Medication non-adherence can exacerbate disease severity, leading to impairments that interfere with self-care activities in older adults, and, ultimately, death. Elder self-neglect is the most common report to Adult Protective Services (APS) across the USA and is a significant risk factor for early mortalit...

journal_title：Drugs & aging

authors： Turner A,Hochschild A,Burnett J,Zulfiqar A,Dyer CB

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Medication for elderly patients is often complex and problematic. Several criteria for classifying inappropriate prescribing exist. In 2010, the Swedish National Board of Health and Welfare published the document "Indicators of appropriate drug therapy in the elderly" as a guideline for improving prescribing...

journal_title：Drugs & aging

authors： Hovstadius B,Petersson G,Hellström L,Ericson L

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Increased life expectancy is associated with an increased prevalence of chronic diseases and drug consumption. Changes often occur in the medication regimen after hospitalization. The extent and nature of these changes and the adherence of elderly patients have not yet been fully investigated. OBJECTIVE:To ...

journal_title：Drugs & aging

authors： Mansur N,Weiss A,Hoffman A,Gruenewald T,Beloosesky Y

更新日期：2008-01-01 00:00:00

abstract：:Alzheimer's disease is the most common major neurocognitive disorder with substantial social and economic impacts. This article is an update on current pharmacotherapy, advancements in biomarker use, and drugs in the pipeline for this disease. To date, no new drug has qualified to be added to the current therapeutic a...

journal_title：Drugs & aging

authors： Khoury R,Patel K,Gold J,Hinds S,Grossberg GT

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Pharmacotherapy with statins (HMG-CoA reductase inhibitors) is the cornerstone for lipid management in individuals with or at risk of developing cardiovascular diseases. Although the clinical benefits of statins are established for both women and men, there is evidence of a gender difference in their use. Th...

journal_title：Drugs & aging

authors： Bhattacharjee S,Findley PA,Sambamoorthi U

更新日期：2012-12-01 00:00:00

abstract：:Neuropathic pain (NeP) is a significant medical and socioeconomic burden with limited therapeutic options. Elderly patients exhibit a higher incidence of several NeP conditions and pose a particular challenge due to age-related pharmacokinetic and pharmacodynamic issues, comorbid conditions, and polypharmacy, as well ...

journal_title：Drugs & aging

authors： Sawynok J

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the primary treatment option, especially in the elderly. But this therapeutic approach may include risks for adverse drug effects and drug-drug intera...

journal_title：Drugs & aging

authors： Huber M,Kölzsch M,Stahlmann R,Hofmann W,Bolbrinker J,Dräger D,Kreutz R

更新日期：2013-01-01 00:00:00

abstract：:Felodipine is a dihydropyridine calcium antagonist which may be administered once daily in an extended release (ER) formulation. As monotherapy in older patients with mild to moderate essential hypertension, felodipine ER once daily provides effective control of blood pressure (BP). The drug has also been effective, e...

journal_title：Drugs & aging

authors： Faulds D,Sorkin EM

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Remifentanil used in combination with propofol provides adequate conditions for tracheal intubation without muscle relaxants. Delivery of the optimal dose is important to prevent poor intubation conditions and drug-related complications. No previous study has investigated the use of a remifentanil-propofol c...

journal_title：Drugs & aging

authors： Goo EK,Oh AY,Cho SJ,Seo KS,Jeon YT

更新日期：2012-11-01 00:00:00

abstract：:Giant cell arteritis (GCA) is an inflammatory vasculopathy that involves large- and medium-sized arteries and can cause vision loss, stroke and aneurysms. GCA occurs in people aged >50 years and is more common in women. A higher incidence of the disease is observed in populations from Northern European countries. Poly...

journal_title：Drugs & aging

authors： Schmidt J,Warrington KJ

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Limited data are available on the prevalence of inappropriate prescribing of renally cleared drugs in elderly patients in Australia. OBJECTIVES:To quantify and compare the extent of inappropriate prescribing (defined as at least one drug prescribed in an excessive dose or when contraindicated with respect t...

journal_title：Drugs & aging

authors： Khanal A,Peterson GM,Castelino RL,Jose MD

更新日期：2015-05-01 00:00:00

abstract：:Age is a major source of variation in drug response. Social, medical and physiological heterogeneity intertwines to complicate geriatric pharmacotherapy. Inappropriate and excessive use of medication may be the most significant treatable health problem in the elderly. Older people are especially sensitive to antipsych...

journal_title：Drugs & aging

authors： Pollock BG,Mulsant BH

更新日期：1995-04-01 00:00:00

abstract：:The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...

journal_title：Drugs & aging

authors： Valencia WM,Florez HJ,Palacio AM

更新日期：2019-12-01 00:00:00

abstract：:Extended-release oxybutynin (Ditropan XL) uses an osmotic system (OROS) to deliver a controlled amount of oxybutynin chloride into the gastrointestinal tract over a 24-hour period when taken once daily. Oxybutynin binds to M3 muscarinic receptors on the detrusor muscle of the bladder, preventing acetylcholinergic acti...

journal_title：Drugs & aging

authors： Comer AM,Goa KL

更新日期：2000-02-01 00:00:00

abstract：:Nadroparin (nadroparin calcium) is a low molecular weight heparin with a mean molecular weight of 4.5 kD. Compared with unfractionated heparin (UFH), nadroparin has a greater ratio of anti-factor Xa to anti-factor Ha activity, greater bioavailability and a longer duration of action, allowing it to be administered by s...

journal_title：Drugs & aging

authors： Davis R,Faulds D

更新日期：1997-04-01 00:00:00

abstract：:Large bowel cancer is not only the third most frequent cancer in the world but is one of the most common human malignancies in Western countries, including North America. In recent years, multidisciplinary research in epidemiology, molecular biology, and laboratory animal model studies have contributed much to our und...

journal_title：Drugs & aging

authors： Reddy BS,Rao CV

更新日期：2000-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) and osteoarthritis are chronic diseases that result in cartilage degradation and loss of joint function. Currently available drugs are predominantly directed towards the control of pain and/or the inflammation associated with joint synovitis but they do little to reduce joint destruction. In ...

journal_title：Drugs & aging

authors： Elliott S,Cawston T

更新日期：2001-01-01 00:00:00

abstract：:The number of older adults with diabetes is rapidly increasing worldwide. A variety of factors contribute to the age-related increase in the incidence of diabetes. The lack of empiric evidence in the field has limited the management guidelines to mostly expert opinion. Given uncertainty over the rate at which to lower...

journal_title：Drugs & aging

authors： Mooradian AD

更新日期：2018-12-01 00:00:00

abstract：:Nitric oxide (NO) is involved in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity. Depending on the redox state of NO, it can act as a neurotoxin or it can have a neuroprotective action. Data suggest that NO may have a role in the pathogenesis of neurodegenerati...

journal_title：Drugs & aging

authors： Molina JA,Jiménez-Jiménez FJ,Ortí-Pareja M,Navarro JA

更新日期：1998-04-01 00:00:00

abstract：:Over four-fifths of all strokes are due to thrombotic or embolic occlusion of cerebral arteries. There is a strong rationale for considering antithrombotic therapy for the treatment of patients with acute ischaemic stroke. Antiplatelet therapy with 150 to 300 mg of aspirin (acetylsalicylic acid) started within the fir...

journal_title：Drugs & aging

authors： Gubitz GJ,Sandercock PA

更新日期：1999-07-01 00:00:00

abstract：INTRODUCTION:Congestive heart failure (CHF), which typically affects older people, is characterized by high short- and mid-term mortality rates. However, despite accumulating evidence showing that administration of β-blockers (β-adrenoceptor antagonists) can improve the clinical status of CHF patients, use of these age...

journal_title：Drugs & aging

authors： Antonicelli R,Mazzanti I,Abbatecola AM,Parati G

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Use of combination pharmacotherapy, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor antagonists (angiotensin receptor blockers) and β-adrenoceptor antagonists (β-blockers) in the management of heart failure (HF) can reduce mortality, prevent functional decline and red...

journal_title：Drugs & aging

authors： Foebel AD,Heckman GA,Hirdes JP,Tyas SL,Tjam EY,McKelvie RS,Maxwell CJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Frailty is a clinical phenotype that is associated with adverse health outcomes. Since frail patients may be more prone for adverse drug events and about 15-20 % of commonly prescribed drugs are metabolized by CYP2D6, we hypothesized that CYP2D6 metabolism is decreased in frail patients compared with healthy...

journal_title：Drugs & aging

authors： Opdam FL,Modak AS,Mooijaart SP,Louwerens M,de Waal MW,Gelderblom H,Guchelaar HJ

更新日期：2015-12-01 00:00:00

abstract：:There is ample evidence for the involvement of aberrant protein phosphorylation reactions in aging and age-associated neurological disorders. Alzheimer's disease (AD) in particular. The exact nature of this involvement, however, is not yet elucidated. In the brain tissue of AD patients, there are numerous examples of ...

journal_title：Drugs & aging

authors： Jin LW,Saitoh T

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a common cause of disability and death in elderly men and women. Until 2007, Australian Government-subsidized use of oral bisphosphonates, raloxifene and calcitriol (1alpha,25-dihydroxycholecalciferol) was limited to secondary prevention (requiring x-ray evidence of previous low-trauma fractu...

journal_title：Drugs & aging

authors： Hollingworth SA,Gunanti I,Nissen LM,Duncan EL

更新日期：2010-03-01 00:00:00