Abstract:
:There is ample evidence for the involvement of aberrant protein phosphorylation reactions in aging and age-associated neurological disorders. Alzheimer's disease (AD) in particular. The exact nature of this involvement, however, is not yet elucidated. In the brain tissue of AD patients, there are numerous examples of altered protein phosphorylation pathways. Individual protein kinases and phosphorylation by these kinases in AD brain tissues have been found to be altered. Protein kinases studied include protein kinase C (PKC), protein tyrosine kinase (PTK), casein kinase II (CKII), Ca++/calmodulin-dependent kinase II and mitogen-activated protein (MAP) kinases, all of which are thought to be necessary for cell survival. Interestingly, different protein kinases are involved in different aspects of AD pathology. It is postulated that the perturbation of amyloid beta/A4-protein precursor (APP) metabolism triggers abnormal protein phosphorylation reactions responsible for dysfunction and eventual death of neurons in the brain. The association of APP mutation with certain familial types of AD strongly suggests that there might be a link between aberrant APP metabolism, protein phosphorylation cascades and the eventual expression of AD pathology (plaques and tangles) and neurodegeneration. In summary, recent studies emphasise the prime importance of protein phosphorylation in aging and AD. This raises the possibility that future pharmacological interventions might be devised to interfere with this kinase cascade for the prevention or treatment of age-associated neurological disorders.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Jin LW,Saitoh Tdoi
10.2165/00002512-199506020-00006subject
Has Abstractpub_date
1995-02-01 00:00:00pages
136-49issue
2eissn
1170-229Xissn
1179-1969journal_volume
6pub_type
杂志文章,评审相关文献
DRUGS & AGING文献大全abstract::The consumption of medications with anticholinergic activity has been suggested to result in the adverse effects of mental confusion, visual disturbance, and muscle weakness, which may lead to falls. Existing published evidence linking anticholinergic drugs with falls, however, remains weak. This study was conducted t...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-019-00731-3
更新日期:2020-02-01 00:00:00
abstract::High drug consumption among the elderly and inappropriate prescribing practices increase the risk of adverse drug effects in this population. This risk may be decreased by conducting, for example, a medication review alone or as part of a comprehensive geriatric assessment (CGA); however, little is known about the fat...
journal_title:Drugs & aging
pub_type: 杂志文章,随机对照试验
doi:10.2165/11536650-000000000-00000
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Falls are a primary cause of injury and disability in the nursing home environment and can be costly to treat. We propose a taxonomy of nursing home falls that accounts for both the severity of fall consequences and the duration of the treatment episode. No other systematic approach of this kind has been pre...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200623030-00007
更新日期:2006-01-01 00:00:00
abstract::In contrast with the earlier stages and, in particular, the predementia stage, of Alzheimer's disease (AD), severe dementia is often neglected. However, the advanced stages of dementia are just as important as the earlier stages because of their frequency, their impact on the lives of patients and their caregivers, an...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/0002512-200926020-00005
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Centenarians are considered as models of successful aging and represent a special group of patients. The aim of this study was to analyze heart failure epidemiology and treatment trajectories in centenarians compared to nonagenarians (90-99 years of age) and octogenarians (80-89 years of age) with heart fail...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0581-z
更新日期:2018-10-01 00:00:00
abstract::Older adults with chronic kidney disease (CKD) often experience polypharmacy, a recognized predictor of prescribing problems including inappropriately dosed medications, drug-drug and drug-disease interactions, morbidity and mortality. Polypharmacy is also associated with nonadherence, which leads to recurrent hospita...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-018-0593-8
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320110-00005
更新日期:2003-01-01 00:00:00
abstract::Advances in our understanding of the structure, function and distribution of nicotinic acetylcholine receptors in the CNS have provided the impetus for new studies examining the role(s) that these receptors and associated processes may play in CNS functions. Further motivation has come from the realisation that such r...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711030-00005
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Osteoarthritis (OA) is a highly prevalent and chronic condition characterized by pain and physical disability. Currently, many treatments are available, and they primarily target pain relief. The objectives of this study were to systematically review economic evaluations for pharmaceutical mana...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-013-0062-3
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Osteoporosis is a common cause of disability and death in elderly men and women. Until 2007, Australian Government-subsidized use of oral bisphosphonates, raloxifene and calcitriol (1alpha,25-dihydroxycholecalciferol) was limited to secondary prevention (requiring x-ray evidence of previous low-trauma fractu...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11318400-000000000-00000
更新日期:2010-03-01 00:00:00
abstract::The elderly population has much to gain from the advances of molecular medicine, although at present genetic pharmacology remains mostly at the conceptual level. Cancer, in particular, is an increasing health burden and the majority (over 70%) of gene therapy trials are aimed at tackling this problem. Available strate...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200017020-00004
更新日期:2000-08-01 00:00:00
abstract::Gout in older patients tends to be sub-acute to chronic, often tophaceous, polyarticular, erosive, symmetrical, and causes persistent, recurrent and chronic arthritis. Clinically, it may closely mimic rheumatoid arthritis; thus, a correct diagnosis requires a high index of clinical suspicion and the identification of ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199404020-00005
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Several studies have shown that the mortality of elderly hip fracture patients is higher than that in the general population, and is higher in male than in female hip fracture patients. OBJECTIVE:The objective of this study was to investigate factors affecting overall mortality at a minimum of 11 years foll...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-015-0267-8
更新日期:2015-06-01 00:00:00
abstract::The use of antimicrobial agents has increased in recent years as treatments have diversified and resistant bacteria have appeared. With increased use of antimicrobial agents, elderly patients are prone to adverse drug reactions (ADRs) as a result of factors such as drug-drug interactions, polypharmacy, long-term use, ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-014-0232-y
更新日期:2015-01-01 00:00:00
abstract::Man and higher primates have adrenals that secrete large amounts of dehydroepiandrosterone (DHEA) [prasterone] and its sulphate (DHEAS) [PB 008]. A remarkable feature of plasma DHEAS levels in humans is their great decrease with aging. Researchers have postulated that this age-related decline of DHEAS levels may expla...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320130-00001
更新日期:2003-01-01 00:00:00
abstract::Asthma is a common airway disease found in people of all ages, although most studies of asthma therapies are focused on adolescent and young adults. Little information exists on the use of asthma therapeutics in the older patient (>65 years of age). The newest therapeutic class to be released in the US for the treatme...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200623060-00002
更新日期:2006-01-01 00:00:00
abstract::Influenza is a major cause of morbidity and mortality in the elderly. Influenza vaccine is recommended for people aged 65 years and older and those in long term care. Currently only 30% of high risk persons are vaccinated. Vaccination generally stimulates an adequate immune response, is well tolerated and is to be enc...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199101060-00003
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Treatment of postherpetic neuralgia (PHN) is more complicated in elderly patients, and multiple daily dosing, complex titration, and high incidences of adverse events can be limiting for many pharmacological treatment options. OBJECTIVE:The aim of this study was to determine whether the efficacy and tolerab...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-013-0126-4
更新日期:2013-12-01 00:00:00
abstract::Relaxation of the upper age limits for solid organ transplantation coupled with improvements in post-transplant survival have resulted in greater numbers of elderly patients receiving immunosuppressant drugs such as tacrolimus. Tacrolimus is a potent agent with a narrow therapeutic window and large inter- and intraind...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522070-00001
更新日期:2005-01-01 00:00:00
abstract::Aflibercept is a fully human, recombinant fusion protein that acts as a soluble decoy receptor for vascular endothelial growth factor (VEGF) family members, including VEGF-A, VEGF-B and placental growth factor (P1GF), thereby inhibiting downstream signalling mediated by these ligands. Aflibercept binds all isoforms of...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-014-0176-2
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-017-0513-3
更新日期:2018-01-01 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is characterised by cardinal clinical features and specific pathological findings. It is possible to detect PD early on in the course of the disease, and certain laboratory studies may identify preclinical stages. Based on this...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199609030-00002
更新日期:1996-09-01 00:00:00
abstract::Faecal incontinence occurs in up to 10% of community dwelling persons > or = 65 years of age and approximately 50% of nursing home residents. It is a vastly under-reported problem that has a devastating effect on those who experience it as well as their spouses and caregivers. There are three broad categories of faeca...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522020-00004
更新日期:2005-01-01 00:00:00
abstract::Large bowel cancer is not only the third most frequent cancer in the world but is one of the most common human malignancies in Western countries, including North America. In recent years, multidisciplinary research in epidemiology, molecular biology, and laboratory animal model studies have contributed much to our und...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200016050-00002
更新日期:2000-05-01 00:00:00
abstract::The prevalence of intermittent claudication (IC) increases with age; when questioned, older patients consider increased difficulty in walking to be a normal consequence of aging. Although the prognosis for the involved limb with IC is relatively good, IC is an important clinical predictor of increased cardiovascular m...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199914040-00002
更新日期:1999-04-01 00:00:00
abstract::This paper reviews the burden and economic consequences of glaucoma upon healthcare systems and patients, especially elderly patients. An extensive review of the literature was conducted, primarily using MEDLINE, but also by examining selected article reference lists, relevant websites and the proceedings of specialis...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522040-00004
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Older cancer patients are possibly at an increased risk of medication-related problems because, typically, they receive many medications during their cancer treatment, both for the cancer itself and for supportive care. OBJECTIVES:The aim of this study was to describe the number and severity of potential ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11537310-000000000-00000
更新日期:2010-07-01 00:00:00
abstract::In general, the pharmacological treatment of non-psychotic major depressive disorder in old age is only partially successful, with only approximately 50% of older depressed adults improving with initial antidepressant monotherapy. Many factors may predict a more difficult-to-treat depression, including coexisting anxi...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724100-00002
更新日期:2007-01-01 00:00:00
abstract::We conducted a review of drugs that were most commonly associated with inducing seizures in the elderly population. The method for determining the risk of these agents includes evaluating the utilisation and the percentage of adverse events in previous studies and case reports. Classes of medications, such as anti-psy...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199507010-00005
更新日期:1995-07-01 00:00:00
abstract::Dopamine agonists (DAs) are frequently used in the management of Parkinson's disease (PD), a complex multisystem disorder influenced substantially by age-related factors. Over 80% of PD patients present after age 60 years and may have clinical features exacerbated by age-related comorbidities or decline in physiologic...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0629-0
更新日期:2019-03-01 00:00:00