Optimal remifentanil dosage for intubation without muscle relaxants in elderly patients.

abstract：BACKGROUND:Although compelling evidence exists supporting statins (HMG-CoA reductase inhibitors) for secondary prevention in older patients with clinical atherosclerotic diseases, the same cannot be said for primary prevention. OBJECTIVES:The objectives of this study were to estimate the frequency of potential statin ...

journal_title：Drugs & aging

authors： Borne E,Meyer N,Rybarczyck-Vigouret MC,Blanchard O,Lombard M,Lang PO,Vogel T,Michel B

更新日期：2019-10-01 00:00:00

abstract：:Gout in older patients tends to be sub-acute to chronic, often tophaceous, polyarticular, erosive, symmetrical, and causes persistent, recurrent and chronic arthritis. Clinically, it may closely mimic rheumatoid arthritis; thus, a correct diagnosis requires a high index of clinical suspicion and the identification of ...

journal_title：Drugs & aging

authors： Gonzalez EB,Miller SB,Agudelo CA

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:In the presence of multimorbidity and limited life expectancy (LLE), the need for continued use of preventive medicines becomes uncertain as they may neither improve health nor confer continued health benefits. OBJECTIVE:Our objective was to systematically review the literature to examine the discontinuatio...

journal_title：Drugs & aging

authors： Narayan SW,Nishtala PS

更新日期：2017-10-01 00:00:00

abstract：:Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug reg...

journal_title：Drugs & aging

authors： Petrovic M,van der Cammen T,Onder G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Multimorbidity is common in older patients with heart failure (HF), complicating therapeutic management and increasing the risk of harm. OBJECTIVE:This study sought to examine the prevalence of medicines for the treatment of comorbid conditions potentially associated with harm in older people, before and af...

journal_title：Drugs & aging

authors： Caughey GE,Shakib S,Barratt JD,Roughead EE

更新日期：2019-05-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is characterised by cardinal clinical features and specific pathological findings. It is possible to detect PD early on in the course of the disease, and certain laboratory studies may identify preclinical stages. Based on this...

journal_title：Drugs & aging

authors： Di Paola R,Uitti RJ

更新日期：1996-09-01 00:00:00

abstract：:Despite a sharp decline in the incidence of gastric cancer during the second half of the 20th century, this malignancy remains the second leading cause of cancer mortality in the world. The incidence and mortality rate of gastric cancer increase with age; at present, the median ages at diagnosis are 67 years for men a...

journal_title：Drugs & aging

authors： Wagner AD,Wedding U

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...

journal_title：Drugs & aging

authors： Harrison SL,Kouladjian O'Donnell L,Bradley CE,Milte R,Dyer SM,Gnanamanickam ES,Liu E,Hilmer SN,Crotty M

更新日期：2018-01-01 00:00:00

abstract：:Intracavernous alprostadil (synthetic prostaglandin E1) is a vasodilating agent which acts by relaxing the smooth muscles of the corpus cavernosum and by increasing the diameter of cavernous arteries; this leads to erection. Following intracavernous administration, alprostadil is either locally metabolised or rapidly ...

journal_title：Drugs & aging

authors： Lea AP,Bryson HM,Balfour JA

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Previous studies have investigated the prevalence of drug-drug interactions (DDIs) among the elderly in different care settings, but data describing the frequency and management of DDIs among acute geriatric patients appear to be absent. OBJECTIVE:The aim of this study was to investigate the severity and in...

journal_title：Drugs & aging

authors： Lea M,Rognan SE,Koristovic R,Wyller TB,Molden E

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Age-related changes in the concentration-effect relationship of (+)-O-desmethyl-tramadol [(+)-ODM], tramadol's active metabolite, are not documented in the elderly. OBJECTIVE:The objective of this study was to characterize, in elderly and young subjects, the (+)-ODM pharmacokinetic and pharmacodynamic relat...

journal_title：Drugs & aging

authors： Robertson SS,Mouksassi MS,Varin F

更新日期：2019-08-01 00:00:00

abstract：:Erectile dysfunction (ED) is a common medical condition that affects the sexual life of millions of men worldwide. First-line oral therapy for ED includes the use of phosphodiesterase type 5 inhibitors (sildenafil, tadalafil and vardenafil) and sublingual apomorphine. Apomorphine is a dopamine D(1) and D(2) receptor a...

journal_title：Drugs & aging

authors： Briganti A,Chun FK,Salonia A,Zanni G,Dehò F,Barbieri L,Karakiewicz PI,Rigatti P,Montorsi F

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...

journal_title：Drugs & aging

authors： Andrès E,Zimmer J,Noel E,Kaltenbach G,Koumarianou A,Maloisel F

更新日期：2003-01-01 00:00:00

abstract：:The incidence of both systolic and diastolic hypertension is increased in elderly patients, therefore antihypertensive drugs are commonly used in this population. In addition to changes in blood pressure, the aging process also causes numerous changes in other physiological parameters, resulting in altered pharmacokin...

journal_title：Drugs & aging

authors： Piepho RW,Fendler KJ

更新日期：1991-05-01 00:00:00

abstract：:Foot and ankle osteoarthritis (OA) is a common and disabling problem that adversely affects physical function and significantly reduces quality of life. Although the knee was considered to be the lower-limb site most often affected by OA, recent population data showed foot OA is as prevalent as knee OA, and rates incr...

journal_title：Drugs & aging

authors： Paterson KL,Gates L

更新日期：2019-03-01 00:00:00

abstract：:Attempts to control pneumococcal infection by vaccination, undertaken initially in 1911, have gone through 3 phases during the subsequent 8 decades. Initially, vaccines of killed pneumococcal cells prepared in a variety of ways were used in epidemic settings with inconclusive results, although administered to approxim...

journal_title：Drugs & aging

authors： Austrian R

更新日期：1999-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) and osteoarthritis are chronic diseases that result in cartilage degradation and loss of joint function. Currently available drugs are predominantly directed towards the control of pain and/or the inflammation associated with joint synovitis but they do little to reduce joint destruction. In ...

journal_title：Drugs & aging

authors： Elliott S,Cawston T

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Patients hospitalised with severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2; coronavirus 2019 disease (COVID-19)] infection are frequently older with co-morbidities and receiving polypharmacy, all of which are known risk factors for drug-drug interactions (DDIs). The pharmacological burden may be ...

journal_title：Drugs & aging

authors： Cattaneo D,Pasina L,Maggioni AP,Giacomelli A,Oreni L,Covizzi A,Bradanini L,Schiuma M,Antinori S,Ridolfo A,Gervasoni C

更新日期：2020-12-01 00:00:00

abstract：:Nadroparin (nadroparin calcium) is a low molecular weight heparin with a mean molecular weight of 4.5 kD. Compared with unfractionated heparin (UFH), nadroparin has a greater ratio of anti-factor Xa to anti-factor Ha activity, greater bioavailability and a longer duration of action, allowing it to be administered by s...

journal_title：Drugs & aging

authors： Davis R,Faulds D

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE:The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors assoc...

journal_title：Drugs & aging

authors： Musich S,Wang SS,Slindee LB,Saphire L,Wicker E

更新日期：2018-05-01 00:00:00

abstract：:The alcohol withdrawal syndrome is common in elderly individuals who are alcohol dependent and who decrease or stop their alcohol intake. While there have been few clinical studies to directly support or refute the hypothesis that withdrawal symptom severity, delirium and seizures increase with advancing age, several ...

journal_title：Drugs & aging

authors： Kraemer KL,Conigliaro J,Saitz R

更新日期：1999-06-01 00:00:00

abstract：:Elderly people with renal impairment are at high risk for venous thromboembolism (VTE) and acute coronary syndromes (ACS); however, they are also at increased risk for bleeding complications. Evidence-based data for the management of anticoagulation in elderly patients with severe renal impairment, in particular, are ...

journal_title：Drugs & aging

authors： Samama MM

更新日期：2011-03-01 00:00:00

abstract：:Complex interactive effects of genetic predisposition, neurochemical changes and disease comorbidity have been elucidated in the genesis of dementia syndromes. Alzheimer's disease is the most prevalent type of dementia in developed Western countries. In Alzheimer's disease, pharmacological treatment aims at symptomati...

journal_title：Drugs & aging

authors： Marksteiner J,Schmidt R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Adverse drug reactions are a major cause of hospital admissions in older individuals, with the majority potentially preventable. Despite the apparent magnitude of this problem, little is known about rates of repeat admission to hospital as a result of adverse drug reactions. OBJECTIVES:The objectives of thi...

journal_title：Drugs & aging

authors： Parameswaran Nair N,Chalmers L,Bereznicki BJ,Curtain CM,Bereznicki LR

更新日期：2017-10-01 00:00:00

abstract：:Unfortunately the sections were published incorrectly in the original article. ...

journal_title：Drugs & aging

authors： Paik J,Scott LJ

更新日期：2020-11-01 00:00:00

abstract：:Large bowel cancer is not only the third most frequent cancer in the world but is one of the most common human malignancies in Western countries, including North America. In recent years, multidisciplinary research in epidemiology, molecular biology, and laboratory animal model studies have contributed much to our und...

journal_title：Drugs & aging

authors： Reddy BS,Rao CV

更新日期：2000-05-01 00:00:00

abstract：:Colorectal cancer ranks third in incidence in both men and women after lung, breast and prostate cancer. The prevalence of colorectal cancer increases significantly with age, with 40% of patients in Europe being >75 years of age at the time of initial diagnosis. Furthermore, the number of elderly patients with colorec...

journal_title：Drugs & aging

authors： Meulenbeld HJ,Creemers GJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Since 1998, a prospective payment system (PPS) for Medicare services provided by nursing homes in the US has been in operation. Concerns have been expressed that the PPS may affect the quality of care delivered to residents. This study evaluates the impact of the PPS on pharmacological secondary ischaemic st...

journal_title：Drugs & aging

authors： Lapane KL,Hughes CM

更新日期：2006-01-01 00:00:00

abstract：:Urothelial carcinoma, or bladder cancer, is a malignancy that most commonly affects older patients. The median age at diagnosis is 73 years, and care of these patients requires consideration not just of the disease-related factors such as stage and histology, but also of patient-related factors. Many of these patients...

journal_title：Drugs & aging

authors： Jodon G,Fischer SM,Kessler ER

更新日期：2018-05-01 00:00:00

abstract：:Neuropathic pain (NeP) is a significant medical and socioeconomic burden with limited therapeutic options. Elderly patients exhibit a higher incidence of several NeP conditions and pose a particular challenge due to age-related pharmacokinetic and pharmacodynamic issues, comorbid conditions, and polypharmacy, as well ...

journal_title：Drugs & aging

authors： Sawynok J

更新日期：2014-12-01 00:00:00