Cyproterone. A review of its pharmacology and therapeutic efficacy in prostate cancer.

abstract：:Although the frequency of physician consultations and the sale of over-the-counter remedies establish the high prevalence of acute cough in the elderly, epidemiological studies have tended to be imprecise. However, respiratory tract infections in nose, larynx and/or bronchi, either viral or bacterial or both, are by f...

journal_title：Drugs & aging

authors： Widdicombe J,Kamath S

更新日期：2004-01-01 00:00:00

abstract：:Giant cell arteritis (GCA) is an inflammatory vasculopathy that involves large- and medium-sized arteries and can cause vision loss, stroke and aneurysms. GCA occurs in people aged >50 years and is more common in women. A higher incidence of the disease is observed in populations from Northern European countries. Poly...

journal_title：Drugs & aging

authors： Schmidt J,Warrington KJ

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Patient transitions, such as transfers between acute and long-term care (LTC), aposare times when the likelihood of communication failure between healthcare providers is increased. Employing appropriate health quality indicators helps support improvement efforts. To date, few quality indicators that evaluate...

journal_title：Drugs & aging

authors： Bell CM,Brener SS,Comrie R,Anderson GM,Bronskill SE

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...

journal_title：Drugs & aging

authors： Andrès E,Zimmer J,Noel E,Kaltenbach G,Koumarianou A,Maloisel F

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Frailty is a clinical phenotype that is associated with adverse health outcomes. Since frail patients may be more prone for adverse drug events and about 15-20 % of commonly prescribed drugs are metabolized by CYP2D6, we hypothesized that CYP2D6 metabolism is decreased in frail patients compared with healthy...

journal_title：Drugs & aging

authors： Opdam FL,Modak AS,Mooijaart SP,Louwerens M,de Waal MW,Gelderblom H,Guchelaar HJ

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Older adults receiving cytotoxic agents may be more susceptible to hematologic toxicities because of progressive reduction in organ functions and multiple co-morbidities. Because older adults are under-represented in clinical trials, this retrospective study aims to evaluate hematologic toxicity of gemcitabine-...

journal_title：Drugs & aging

authors： Crombag MR,de Vries Schultink AH,Schellens JH,Beijnen JH,Huitema AD

更新日期：2014-10-01 00:00:00

abstract：:Although a significant proportion of patients receiving nitrates are elderly, surprisingly little published work is available describing the pharmacokinetics and pharmacodynamics of these agents in elderly patients. The lack of pharmacokinetic data is related to the difficulty in assaying nitrates and there are at pre...

journal_title：Drugs & aging

authors： Kelly JG,O'Malley K

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To assess, by smoothness index (SI), distribution of the antihypertensive effect of extended-release (ER) felodipine over 24 hours in elderly patients with hypertension. METHODS:After a 4-week washout phase, 35 elderly patients (mean age 69 +/- 4 years) with mild-to-moderate hypertension received 2 weeks' tr...

journal_title：Drugs & aging

authors： Antonicelli R,Omboni S,Giovanni DC,Ansuini R,Mori A,Gesuita R,Parati G,Paciaroni E

更新日期：2002-01-01 00:00:00

abstract：:Although inflammatory bowel disease (IBD) is generally considered a disease of young adults, it can occur in elderly individuals. The clinical features and treatment considerations in older patients are similar to those in younger patients, with some notable exceptions, which are reviewed in this article. Consideratio...

journal_title：Drugs & aging

authors： Hussain SW,Pardi DS

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Medication-related admissions are an important cause of hospital admissions in older people. The scope for prevention is less clear. OBJECTIVES:To characterize medication-related hospital admissions in older people and assess their preventability. METHODS:This was a cross-sectional, observational study con...

journal_title：Drugs & aging

authors： Rogers S,Wilson D,Wan S,Griffin M,Rai G,Farrell J

更新日期：2009-01-01 00:00:00

abstract：:This paper reviews the burden and economic consequences of glaucoma upon healthcare systems and patients, especially elderly patients. An extensive review of the literature was conducted, primarily using MEDLINE, but also by examining selected article reference lists, relevant websites and the proceedings of specialis...

journal_title：Drugs & aging

authors： Rouland JF,Berdeaux G,Lafuma A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The public health burden of osteoporosis is high, principally because of increased risk of fractures and associated morbidity, handicap and mortality. Osteoporotic fracture prevention is therefore an important public health goal. General practitioners (GPs) play a key role in the management of osteoporosis, ...

journal_title：Drugs & aging

authors： Blotman F,Cortet B,Hilliquin P,Avouac B,Allaert FA,Pouchain D,Gaudin AF,Cotté FE,El Hasnaoui A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Since 1998, a prospective payment system (PPS) for Medicare services provided by nursing homes in the US has been in operation. Concerns have been expressed that the PPS may affect the quality of care delivered to residents. This study evaluates the impact of the PPS on pharmacological secondary ischaemic st...

journal_title：Drugs & aging

authors： Lapane KL,Hughes CM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Limited data are available on the prevalence of inappropriate prescribing of renally cleared drugs in elderly patients in Australia. OBJECTIVES:To quantify and compare the extent of inappropriate prescribing (defined as at least one drug prescribed in an excessive dose or when contraindicated with respect t...

journal_title：Drugs & aging

authors： Khanal A,Peterson GM,Castelino RL,Jose MD

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:In response to concerns about, and issues pertaining to, medication use practices in residential aged-care facilities (RACFs), the Australian Pharmaceutical Advisory Council (APAC) established a working party on quality use of medicines (QUM) in nursing homes and hostels. The APAC is a representative ministe...

journal_title：Drugs & aging

authors： Cheek J,Gilbert A,Ballantyne A,Penhall R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Improvement in renal function and decreases in serum uric acid (SUA) have been reported following prolonged high-intensity statin (HMG-CoA reductase inhibitor) therapy. This post hoc analysis of the SAGE trial examined the effect of intensive versus less intensive statin therapy on renal function, safety, an...

journal_title：Drugs & aging

authors： Deedwania PC,Stone PH,Fayyad RS,Laskey RE,Wilson DJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). OBJECTIVE:Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. METHODS:We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November...

journal_title：Drugs & aging

authors： Samii A,Etminan M,Wiens MO,Jafari S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Statins have been associated with later life, long-term care admission in observational studies. However, by preventing vascular events, statins may also prevent or delay admission. We wished to determine statin and long-term care admission associations in a randomised controlled trial context, and describe ...

journal_title：Drugs & aging

authors： Burton JK,Papworth R,Haig C,McCowan C,Ford I,Stott DJ,Quinn TJ

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Medicines are potentially modifiable risk factors for postoperative delirium. However, the extent to which preoperative medicines are included in risk prediction models (RPMs) is unknown. OBJECTIVE:This systematic review aimed to assess the extent of inclusion of preoperative medications in RPMs for postope...

journal_title：Drugs & aging

authors： Kassie GM,Nguyen TA,Kalisch Ellett LM,Pratt NL,Roughead EE

更新日期：2018-03-01 00:00:00

abstract：:As people grow old, their need for medications increases dramatically because of the higher incidence of chronic pain, diabetes mellitus, cardiovascular and neurological diseases in the elderly population. Furthermore, the elderly require special consideration with respect to drug delivery, drug interactions and adher...

journal_title：Drugs & aging

authors： Priano L,Gasco MR,Mauro A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Adverse drug reactions are a major cause of hospital admissions in older individuals, with the majority potentially preventable. Despite the apparent magnitude of this problem, little is known about rates of repeat admission to hospital as a result of adverse drug reactions. OBJECTIVES:The objectives of thi...

journal_title：Drugs & aging

authors： Parameswaran Nair N,Chalmers L,Bereznicki BJ,Curtain CM,Bereznicki LR

更新日期：2017-10-01 00:00:00

abstract：:New treatments and treatment protocols for diseases affecting the elderly are evolving as we strive to meet the needs of an aging society. To help you keep up to date with the latest advances worldwide on all aspects of drug therapy and patient management, this section of the journal brings you information selected fr...

journal_title：Drugs & aging

authors：

更新日期：2006-01-01 00:00:00

abstract：:Osteoporosis is a common disease that affects 1 in 3 women. Family and twin studies have demonstrated that there is a strong genetic component to this condition. Potential candidate genes examined for their regulatory effect on bone mass include those for collagen type I, estrogen and vitamin D receptors, and various ...

journal_title：Drugs & aging

authors： Keen RW,Kelly PJ

更新日期：1997-11-01 00:00:00

abstract：:The consumption of medications with anticholinergic activity has been suggested to result in the adverse effects of mental confusion, visual disturbance, and muscle weakness, which may lead to falls. Existing published evidence linking anticholinergic drugs with falls, however, remains weak. This study was conducted t...

journal_title：Drugs & aging

authors： Tan MP,Tan GJ,Mat S,Luben RN,Wareham NJ,Khaw KT,Myint PK

更新日期：2020-02-01 00:00:00

abstract：:In general, the pharmacological treatment of non-psychotic major depressive disorder in old age is only partially successful, with only approximately 50% of older depressed adults improving with initial antidepressant monotherapy. Many factors may predict a more difficult-to-treat depression, including coexisting anxi...

journal_title：Drugs & aging

authors： Driscoll HC,Karp JF,Dew MA,Reynolds CF 3rd

更新日期：2007-01-01 00:00:00

abstract：:Psoriatic arthritis (PsA) can start in subjects aged over 60 years, defined as late-onset PsA. In late-onset PsA, the weight of family history and genetic background appears less significant when compared with younger onset PsA, whereas obesity and smoking have been suggested as potential risk factors. In patients wit...

journal_title：Drugs & aging

authors： Caso F,Tasso M,Chimenti MS,Navarini L,Perricone C,Girolimetto N,Peluso R,Del Puente A,Afeltra A,Perricone R,Punzi L,Scarpa R,Costa L

更新日期：2019-10-01 00:00:00

abstract：:The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...

journal_title：Drugs & aging

authors： Valencia WM,Florez HJ,Palacio AM

更新日期：2019-12-01 00:00:00

abstract：:Decitabine (Dacogen(®)) is a deoxynucleoside analogue of cytidine that selectively inhibits DNA methyltransferases. Decitabine administered at a dose of 20 mg/m(2) by a 1-h intravenous infusion for 5 consecutive days of a 4-week cycle has been approved by the European Medicines Agency (EMA) for use in adult patients a...

journal_title：Drugs & aging

authors： Curran MP

更新日期：2013-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is typically diagnosed in the second or third decade of life. It is generally believed that over the last few decades the life expectancy of patients with adult onset MS (AOMS) has approached that of the general population as a r...

journal_title：Drugs & aging

authors： Awad A,Stüve O

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Patients with congestive heart failure (CHF) have a high prevalence of cognitive impairment and the association is multifactorial. In general, the burden of anticholinergic drugs has consistently been shown to be a risk factor for cognitive impairment in the elderly. The aim of this study was to a...

journal_title：Drugs & aging

authors： Shaukat A,Habib A,Lane KA,Shen C,Khan S,Hellman YM,Boustani M,Malik AS

更新日期：2014-10-01 00:00:00