NSAID use and the risk of Parkinson's disease: systematic review and meta-analysis of observational studies.

abstract：BACKGROUND:The choice of induction immunosuppression for kidney transplantation in elderly recipients is dictated by the consideration of the risk of infection as well as efficacy in the prevention of acute rejection, thus allowing a reduction in subsequent maintenance immunosuppression and its attendant long-term adve...

journal_title：Drugs & aging

authors： Heifets M,Saeed MI,Parikh MH,Sierka D,Kumar MS

更新日期：2004-01-01 00:00:00

abstract：:Influenza infection is an acute respiratory disease with a high morbidity and significant mortality, particularly among the elderly and individuals with chronic diseases. The majority of countries now recommend annual influenza vaccination for all people aged 65 years or older, and for those with high risk conditions....

journal_title：Drugs & aging

authors： Corrigan EM,Clancy RL

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Several studies have shown that the mortality of elderly hip fracture patients is higher than that in the general population, and is higher in male than in female hip fracture patients. OBJECTIVE:The objective of this study was to investigate factors affecting overall mortality at a minimum of 11 years foll...

journal_title：Drugs & aging

authors： Nurmi-Lüthje I,Lüthje P,Kaukonen JP,Kataja M

更新日期：2015-06-01 00:00:00

abstract：:Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks...

journal_title：Drugs & aging

authors： Ho SB,Hovsepians R,Gupta S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...

journal_title：Drugs & aging

authors： Pariente A,Dartigues JF,Benichou J,Letenneur L,Moore N,Fourrier-Réglat A

更新日期：2008-01-01 00:00:00

abstract：:Colorectal cancer ranks third in incidence in both men and women after lung, breast and prostate cancer. The prevalence of colorectal cancer increases significantly with age, with 40% of patients in Europe being >75 years of age at the time of initial diagnosis. Furthermore, the number of elderly patients with colorec...

journal_title：Drugs & aging

authors： Meulenbeld HJ,Creemers GJ

更新日期：2007-01-01 00:00:00

abstract：:In contrast with the earlier stages and, in particular, the predementia stage, of Alzheimer's disease (AD), severe dementia is often neglected. However, the advanced stages of dementia are just as important as the earlier stages because of their frequency, their impact on the lives of patients and their caregivers, an...

journal_title：Drugs & aging

authors： Voisin T,Vellas B

更新日期：2009-01-01 00:00:00

abstract：:Primary hyperparathyroidism is a common metabolic bone disease and currently presents a significant management dilemma. Most of the patients have few relevant symptoms and surgical parathyroidectomy offers the prospect of cure with freedom from the risk of long-term complications or the need for a follow-up. However, ...

journal_title：Drugs & aging

authors： Sims R,Ubhi C,Hosking D

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Older people are exposed to multiple medicines that possess anticholinergic properties. The use of anticholinergic medicines is associated with the risk of morbidity, mortality and cognitive decline, particularly in older people. Anticholinergic exposure can be measured using tools such as the Drug Burden In...

journal_title：Drugs & aging

authors： Narayan SW,Hilmer SN,Horsburgh S,Nishtala PS

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Age-related changes in the concentration-effect relationship of (+)-O-desmethyl-tramadol [(+)-ODM], tramadol's active metabolite, are not documented in the elderly. OBJECTIVE:The objective of this study was to characterize, in elderly and young subjects, the (+)-ODM pharmacokinetic and pharmacodynamic relat...

journal_title：Drugs & aging

authors： Robertson SS,Mouksassi MS,Varin F

更新日期：2019-08-01 00:00:00

abstract：:The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1)...

journal_title：Drugs & aging

authors： Andrès E,Vogel T,Federici L,Zimmer J,Kaltenbach G

更新日期：2008-01-01 00:00:00

abstract：:Over four-fifths of all strokes are due to thrombotic or embolic occlusion of cerebral arteries. There is a strong rationale for considering antithrombotic therapy for the treatment of patients with acute ischaemic stroke. Antiplatelet therapy with 150 to 300 mg of aspirin (acetylsalicylic acid) started within the fir...

journal_title：Drugs & aging

authors： Gubitz GJ,Sandercock PA

更新日期：1999-07-01 00:00:00

abstract：:CATT (Comparison of Age-related macular degeneration [AMD] Treatment Trials) examined the efficacy of ranibizumab and bevacizumab for the treatment of neovascular AMD. This prospective, randomized, but unblinded trial revealed a significant improvement in vision with both treatments in terms of visual acuity; importan...

journal_title：Drugs & aging

authors： Ziemssen F,Sobolewska B

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Medication for elderly patients is often complex and problematic. Several criteria for classifying inappropriate prescribing exist. In 2010, the Swedish National Board of Health and Welfare published the document "Indicators of appropriate drug therapy in the elderly" as a guideline for improving prescribing...

journal_title：Drugs & aging

authors： Hovstadius B,Petersson G,Hellström L,Ericson L

更新日期：2014-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is typically diagnosed in the second or third decade of life. It is generally believed that over the last few decades the life expectancy of patients with adult onset MS (AOMS) has approached that of the general population as a r...

journal_title：Drugs & aging

authors： Awad A,Stüve O

更新日期：2010-04-01 00:00:00

abstract：:Cutaneous adverse drug reactions comprise a significant proportion of all adverse drug reactions. They may mimic other dermatologic or systemic illnesses and may cause significant morbidity or mortality. Seven morphologic groups encompass the most commonly encountered cutaneous drug reaction syndromes: exanthematous (...

journal_title：Drugs & aging

authors： Young JWS,Shear NH

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Overactive bladder syndrome (OAB) is associated with various co-morbidities; treatment of these frequently results in multiple medication use (MMU) and the potential for drug-drug interactions, which may lead to adverse events and altered efficacy. With the aging population, the prevalence of MMU is likely t...

journal_title：Drugs & aging

authors： Sand PK,Rovner ES,Watanabe JH,Oefelein MG

更新日期：2011-02-01 00:00:00

abstract：:Overactive bladder (OAB) is a common constellation of lower urinary tract storage symptoms that causes a significant impact on a person's quality of life. The elderly may be disproportionally impacted by these symptoms due to concomitant poor mobility, comorbid conditions such as diabetes and heart failure, and polyph...

journal_title：Drugs & aging

authors： McFerren SC,Gomelsky A

更新日期：2015-10-01 00:00:00

abstract：:A low bone mineral density (BMD) is presently regarded as the most important risk factor for the development of osteoporosis. BMD is a function of peak bone mass attained during growth and subsequent age-related bone loss. BMD can be measured accurately and precisely, although the rate of bone loss is more difficult t...

journal_title：Drugs & aging

authors： Hough S

更新日期：1998-01-01 00:00:00

abstract：:Electronic storage of and access to medical data is becoming increasingly common. Advances in computer technology and telecommunications have made it possible to store vast amounts of information in databases and transmit this information rapidly to any place on the globe. At the forefront of this technology is the In...

journal_title：Drugs & aging

authors： Glowniak J

更新日期：1997-03-01 00:00:00

abstract：:Decitabine (Dacogen(®)) is a deoxynucleoside analogue of cytidine that selectively inhibits DNA methyltransferases. Decitabine administered at a dose of 20 mg/m(2) by a 1-h intravenous infusion for 5 consecutive days of a 4-week cycle has been approved by the European Medicines Agency (EMA) for use in adult patients a...

journal_title：Drugs & aging

authors： Curran MP

更新日期：2013-06-01 00:00:00

abstract：:Most western countries have influenza vaccination programmes for citizens aged > or = 65 years. This paper reviews the available evidence on whether elderly influenza vaccination is worthwhile from a pharmacoeconomic point of view. A search on Medline and EMBASE resulted in a primary selection of approximately 100 stu...

journal_title：Drugs & aging

authors： Postma MJ,Baltussen RM,Heijnen ML,de Berg LT,Jager JC

更新日期：2000-09-01 00:00:00

abstract：:beta-Adrenoceptor antagonists (beta-blockers) reduce mortality and recurrent myocardial infarction (MI) in older patients after both Q-wave MI and non-Q-wave MI. The effects of beta-blockers are to: (i) reduce complex ventricular arrhythmias, including ventricular tachycardia; (ii) increase the ventricular fibrillatio...

journal_title：Drugs & aging

authors： Aronow WS

更新日期：1997-12-01 00:00:00

abstract：:The Medicare programme already funds a large proportion of the medical care for older Americans. However, geriatricians are an underutilized resource for improving the quality of care delivered with Medicare funding, particularly to the most complex patients. Recent legislative changes will increase the involvement of...

journal_title：Drugs & aging

authors： Nusbaum NJ

更新日期：2005-01-01 00:00:00

abstract：:Although the frequency of physician consultations and the sale of over-the-counter remedies establish the high prevalence of acute cough in the elderly, epidemiological studies have tended to be imprecise. However, respiratory tract infections in nose, larynx and/or bronchi, either viral or bacterial or both, are by f...

journal_title：Drugs & aging

authors： Widdicombe J,Kamath S

更新日期：2004-01-01 00:00:00

abstract：:Complex interactive effects of genetic predisposition, neurochemical changes and disease comorbidity have been elucidated in the genesis of dementia syndromes. Alzheimer's disease is the most prevalent type of dementia in developed Western countries. In Alzheimer's disease, pharmacological treatment aims at symptomati...

journal_title：Drugs & aging

authors： Marksteiner J,Schmidt R

更新日期：2004-01-01 00:00:00

abstract：:Restenosis in the months following a successful percutaneous transluminal coronary angioplasty (PTCA) remains the main limitation to this technique for myocardial revascularisation. Despite intensive investigation in this area, no pharmacological therapy has yet been found to be useful in preventing restenosis after c...

journal_title：Drugs & aging

authors： Hamon M,Lécluse E,Monassier JP,Grollier G,Potier JC

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:The aims of the study were to evaluate usage rates of warfarin in stroke prophylaxis and the association with assessed stages of stroke and bleeding risk in long-term care (LTC) residents with atrial fibrillation (AFib). METHODS:A cross-sectional analysis of two LTC databases (the National Nursing Home Surv...

journal_title：Drugs & aging

authors： Reardon G,Nelson WW,Patel AA,Philpot T,Neidecker M

更新日期：2013-06-01 00:00:00

abstract：:This paper reviews the burden and economic consequences of glaucoma upon healthcare systems and patients, especially elderly patients. An extensive review of the literature was conducted, primarily using MEDLINE, but also by examining selected article reference lists, relevant websites and the proceedings of specialis...

journal_title：Drugs & aging

authors： Rouland JF,Berdeaux G,Lafuma A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Medication non-adherence can exacerbate disease severity, leading to impairments that interfere with self-care activities in older adults, and, ultimately, death. Elder self-neglect is the most common report to Adult Protective Services (APS) across the USA and is a significant risk factor for early mortalit...

journal_title：Drugs & aging

authors： Turner A,Hochschild A,Burnett J,Zulfiqar A,Dyer CB

更新日期：2012-09-01 00:00:00