Update on oral cyanocobalamin (vitamin B12) treatment in elderly patients.

abstract：:Advances in our understanding of the structure, function and distribution of nicotinic acetylcholine receptors in the CNS have provided the impetus for new studies examining the role(s) that these receptors and associated processes may play in CNS functions. Further motivation has come from the realisation that such r...

journal_title：Drugs & aging

authors： Newhouse PA,Potter A,Levin ED

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Poor medication adherence is a major public health problem in older adults often resulting in negative health outcomes. OBJECTIVE:The objective of this review was to provide an updated summary of evidence from randomized controlled studies to determine whether interventions aimed at improving medication adh...

journal_title：Drugs & aging

authors： Marcum ZA,Hanlon JT,Murray MD

更新日期：2017-03-01 00:00:00

abstract：:Unfortunately the sections were published incorrectly in the original article. ...

journal_title：Drugs & aging

authors： Paik J,Scott LJ

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Older adults receiving cytotoxic agents may be more susceptible to hematologic toxicities because of progressive reduction in organ functions and multiple co-morbidities. Because older adults are under-represented in clinical trials, this retrospective study aims to evaluate hematologic toxicity of gemcitabine-...

journal_title：Drugs & aging

authors： Crombag MR,de Vries Schultink AH,Schellens JH,Beijnen JH,Huitema AD

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The importance of optimising medicines management for people with dementia has been emphasised through research and policy. However, evidence is currently lacking regarding how to achieve this in this patient population. OBJECTIVE:The aim was to assess the effectiveness of medicines management interventions...

journal_title：Drugs & aging

authors： McGrattan M,Ryan C,Barry HE,Hughes CM

更新日期：2017-12-01 00:00:00

abstract：:Dopamine agonists (DAs) are frequently used in the management of Parkinson's disease (PD), a complex multisystem disorder influenced substantially by age-related factors. Over 80% of PD patients present after age 60 years and may have clinical features exacerbated by age-related comorbidities or decline in physiologic...

journal_title：Drugs & aging

authors： Latt MD,Lewis S,Zekry O,Fung VSC

更新日期：2019-03-01 00:00:00

abstract：:In general, the pharmacological treatment of non-psychotic major depressive disorder in old age is only partially successful, with only approximately 50% of older depressed adults improving with initial antidepressant monotherapy. Many factors may predict a more difficult-to-treat depression, including coexisting anxi...

journal_title：Drugs & aging

authors： Driscoll HC,Karp JF,Dew MA,Reynolds CF 3rd

更新日期：2007-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has considerable morbidity and mortality in the older adult population. The role of antibiotics in the management of acute exacerbations of COPD (AECOPD) is currently evolving. Despite only mild benefits, most patients with AECOPD in ambulatory settings receive antibiotics ...

journal_title：Drugs & aging

authors： Al-Hasan MN,Al-Jaghbeer MJ

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Because of co-morbidity, older persons are often exposed to use of an excessive number of drugs, which per se implies also use of inappropriate drugs or of potentially interacting drugs ('suboptimal prescribing'). Time trends of suboptimal prescribing in older, community dwellers have been poorly investigate...

journal_title：Drugs & aging

authors： Lapi F,Pozzi C,Mazzaglia G,Ungar A,Fumagalli S,Marchionni N,Geppetti P,Mugelli A,Di Bari M

更新日期：2009-01-01 00:00:00

abstract：:Cerebral deposition of amyloid plaques containing amyloid beta-peptide (Abeta) has traditionally been considered the central feature of Alzheimer's disease (AD). Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase. In the past decade...

journal_title：Drugs & aging

authors： Zimmermann M,Gardoni F,Di Luca M

更新日期：2005-01-01 00:00:00

abstract：:A low bone mineral density (BMD) is presently regarded as the most important risk factor for the development of osteoporosis. BMD is a function of peak bone mass attained during growth and subsequent age-related bone loss. BMD can be measured accurately and precisely, although the rate of bone loss is more difficult t...

journal_title：Drugs & aging

authors： Hough S

更新日期：1998-01-01 00:00:00

abstract：:Asthma is a common airway disease found in people of all ages, although most studies of asthma therapies are focused on adolescent and young adults. Little information exists on the use of asthma therapeutics in the older patient (>65 years of age). The newest therapeutic class to be released in the US for the treatme...

journal_title：Drugs & aging

authors： Grayson MH,Korenblat PE

更新日期：2006-01-01 00:00:00

abstract：:Attempts to control pneumococcal infection by vaccination, undertaken initially in 1911, have gone through 3 phases during the subsequent 8 decades. Initially, vaccines of killed pneumococcal cells prepared in a variety of ways were used in epidemic settings with inconclusive results, although administered to approxim...

journal_title：Drugs & aging

authors： Austrian R

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the primary treatment option, especially in the elderly. But this therapeutic approach may include risks for adverse drug effects and drug-drug intera...

journal_title：Drugs & aging

authors： Huber M,Kölzsch M,Stahlmann R,Hofmann W,Bolbrinker J,Dräger D,Kreutz R

更新日期：2013-01-01 00:00:00

abstract：:Overactive bladder (OAB) is a common constellation of lower urinary tract storage symptoms that causes a significant impact on a person's quality of life. The elderly may be disproportionally impacted by these symptoms due to concomitant poor mobility, comorbid conditions such as diabetes and heart failure, and polyph...

journal_title：Drugs & aging

authors： McFerren SC,Gomelsky A

更新日期：2015-10-01 00:00:00

abstract：:Urothelial carcinoma, or bladder cancer, is a malignancy that most commonly affects older patients. The median age at diagnosis is 73 years, and care of these patients requires consideration not just of the disease-related factors such as stage and histology, but also of patient-related factors. Many of these patients...

journal_title：Drugs & aging

authors： Jodon G,Fischer SM,Kessler ER

更新日期：2018-05-01 00:00:00

abstract：:Extended-release oxybutynin (Ditropan XL) uses an osmotic system (OROS) to deliver a controlled amount of oxybutynin chloride into the gastrointestinal tract over a 24-hour period when taken once daily. Oxybutynin binds to M3 muscarinic receptors on the detrusor muscle of the bladder, preventing acetylcholinergic acti...

journal_title：Drugs & aging

authors： Comer AM,Goa KL

更新日期：2000-02-01 00:00:00

abstract：:Elderly rheumatoid arthritis (RA) is classified into two clinical subsets, elderly-onset RA (EORA) and younger-onset elderly RA. With the improvement of life expectancy in the general population and advent of the super-aging society, the number of patients with EORA is anticipated to increase. Both large and small joi...

journal_title：Drugs & aging

authors： Sugihara T,Harigai M

更新日期：2016-02-01 00:00:00

abstract：:We conducted a review of drugs that were most commonly associated with inducing seizures in the elderly population. The method for determining the risk of these agents includes evaluating the utilisation and the percentage of adverse events in previous studies and case reports. Classes of medications, such as anti-psy...

journal_title：Drugs & aging

authors： Franson KL,Hay DP,Neppe V,Dahdal WY,Mirza WU,Grossberg GT,Chatel DM,Szwabo PA,Kotegal S

更新日期：1995-07-01 00:00:00

abstract：:Management of hypertension in the elderly should take into account, in particular, the possible negative impact of antihypertensive drugs on the patient's quality of life, the deterioration of which may result in a loss of independence and reduced treatment compliance. Quality of life is recognised as a multifactorial...

journal_title：Drugs & aging

authors： Fogari R,Zoppi A

更新日期：2004-01-01 00:00:00

abstract：:The prevalence of neuropathic pain in the older population has been reported to be very high and is most commonly localized to a circumscribed area. Treatment failure is frequent in neuropathic pain and is accompanied by central side effects with recommended oral drugs acting on the central nervous system. A number of...

journal_title：Drugs & aging

authors： Pickering G,Lucchini C

更新日期：2020-02-01 00:00:00

abstract：:Lisinopril, the lysine analogue of enalaprilat, is a long-acting angiotensin converting enzyme (ACE) inhibitor which is administered once daily by mouth. The efficacy of lisinopril in reducing blood pressure is well established in younger populations, and many trials now show it to be effective in lowering blood press...

journal_title：Drugs & aging

authors： Langtry HD,Markham A

更新日期：1997-02-01 00:00:00

abstract：:Blood pressure levels are strongly predictive of the risks of first-ever and recurrent stroke. The benefits of blood pressure-lowering therapy for the prevention of fatal and non-fatal stroke in middle-aged individuals are well established. However, until recently, there has been uncertainty about the consistency of s...

journal_title：Drugs & aging

authors： Ratnasabapathy Y,Lawes CM,Anderson CS

更新日期：2003-01-01 00:00:00

abstract：:Restenosis in the months following a successful percutaneous transluminal coronary angioplasty (PTCA) remains the main limitation to this technique for myocardial revascularisation. Despite intensive investigation in this area, no pharmacological therapy has yet been found to be useful in preventing restenosis after c...

journal_title：Drugs & aging

authors： Hamon M,Lécluse E,Monassier JP,Grollier G,Potier JC

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Use of combination pharmacotherapy, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor antagonists (angiotensin receptor blockers) and β-adrenoceptor antagonists (β-blockers) in the management of heart failure (HF) can reduce mortality, prevent functional decline and red...

journal_title：Drugs & aging

authors： Foebel AD,Heckman GA,Hirdes JP,Tyas SL,Tjam EY,McKelvie RS,Maxwell CJ

更新日期：2011-07-01 00:00:00

abstract：:It is inevitable that publicly funded, technically sophisticated medical treatments will be increasingly rationed. Other things being equal, there is a greater duty to use them to prolong the lives of younger than older people. Age is therefore an ethical rationing criterion. Denial of this may actually harm older peo...

journal_title：Drugs & aging

authors： Shaw AB

更新日期：1996-12-01 00:00:00

abstract：:Electronic storage of and access to medical data is becoming increasingly common. Advances in computer technology and telecommunications have made it possible to store vast amounts of information in databases and transmit this information rapidly to any place on the globe. At the forefront of this technology is the In...

journal_title：Drugs & aging

authors： Glowniak J

更新日期：1997-03-01 00:00:00

abstract：:The finding of fungal growth in the urine (funguria) of elderly patients is becoming increasingly common. It has been reported in both acute and chronic care settings. Risk factors for the development of funguria include the use of broad spectrum antibiotics, corticosteroids and indwelling bladder catheters, as well a...

journal_title：Drugs & aging

authors： Jacobs LG

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Improvement in renal function and decreases in serum uric acid (SUA) have been reported following prolonged high-intensity statin (HMG-CoA reductase inhibitor) therapy. This post hoc analysis of the SAGE trial examined the effect of intensive versus less intensive statin therapy on renal function, safety, an...

journal_title：Drugs & aging

authors： Deedwania PC,Stone PH,Fayyad RS,Laskey RE,Wilson DJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Potentially inappropriate medications (PIMs) are defined by the American Geriatric Society as medications that should be avoided in the elderly in general, or in specific situations. However, PIM use remains high among aging populations and may result in increased utilization of healthcare resources. OBJECT...

journal_title：Drugs & aging

authors： Weeda ER,AlDoughaim M,Criddle S

更新日期：2020-07-01 00:00:00