Update on oral cyanocobalamin (vitamin B12) treatment in elderly patients.


:The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1) and prospective studies in a well defined population (n=5) provide evidence that oral cobalamin therapy may adequately treat cobalamin deficiency in elderly patients. However, the current literature does not suggest a strategy in terms of the form (hydroxy- or cyanocobalamin), frequency and duration of the treatment. This review confirms the previously reported efficacy of oral cobalamin treatment in elderly patients. Oral cobalamin treatment avoids the discomfort, inconvenience and cost of monthly injections.


Drugs Aging


Drugs & aging


Andrès E,Vogel T,Federici L,Zimmer J,Kaltenbach G




Has Abstract


2008-01-01 00:00:00














  • Pneumococcal polysaccharide conjugate vaccine (13-valent, adsorbed): a guide to its use in older adults.

    abstract::Pneumococcal polysaccharide conjugate vaccine (13-valent, adsorbed) (PCV13; Prevenar 13(®); Prevnar 13(®)) is approved in adults aged ≥50 years (focus of review) and in children aged 6 weeks to 5 years for protection against pneumococcal diseases caused by Streptococcus pneumoniae in numerous countries worldwide, incl...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Scott LJ,Sanford M

    更新日期:2012-10-01 00:00:00

  • Ophthalmic drugs as part of polypharmacy in nursing home residents with glaucoma.

    abstract:BACKGROUND:Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the primary treatment option, especially in the elderly. But this therapeutic approach may include risks for adverse drug effects and drug-drug intera...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Huber M,Kölzsch M,Stahlmann R,Hofmann W,Bolbrinker J,Dräger D,Kreutz R

    更新日期:2013-01-01 00:00:00

  • Secondary prevention of osteoporosis in Australia: analysis of government-dispensed prescription data.

    abstract:BACKGROUND:Osteoporosis is a common cause of disability and death in elderly men and women. Until 2007, Australian Government-subsidized use of oral bisphosphonates, raloxifene and calcitriol (1alpha,25-dihydroxycholecalciferol) was limited to secondary prevention (requiring x-ray evidence of previous low-trauma fractu...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Hollingworth SA,Gunanti I,Nissen LM,Duncan EL

    更新日期:2010-03-01 00:00:00

  • Diagnostic and pharmacological approaches in Alzheimer's disease.

    abstract::Alzheimer's disease is a chronic progressive disease affecting higher intellectual functioning. The clinical diagnosis is made when the onset of illness is insidious, the course slowly progressive and all the treatable causes of dementia have been ruled out. The use of more stringent criteria has improved clinical dia...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Hermann C,Stern RG,Losonzcy MF,Jaff S,Davidson M

    更新日期:1991-03-01 00:00:00

  • Associations between the Drug Burden Index, Potentially Inappropriate Medications and Quality of Life in Residential Aged Care.

    abstract:BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Harrison SL,Kouladjian O'Donnell L,Bradley CE,Milte R,Dyer SM,Gnanamanickam ES,Liu E,Hilmer SN,Crotty M

    更新日期:2018-01-01 00:00:00

  • Trends in the Dispensing and Costs of Glucose-Lowering Medications Among Older Australians: Findings from National Claims Data.

    abstract:BACKGROUND:Temporal changes in the dispensing of glucose-lowering drugs (GLD) and their associated costs among elderly populations is unclear. This information is especially relevant to countries in which medications are partly or fully government subsidized. OBJECTIVE:Our objective was to estimate the trends in preva...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Chin KL,Hidayat FM,Ofori-Asenso R,Ilomäki J,Bell JS,Zoungas S,Liew D

    更新日期:2020-05-01 00:00:00

  • Age-related changes in signal transduction. Implications for neuronal transmission and potential for drug intervention.

    abstract::Problems associated with aging will become one of the leading health dilemmas of the next century. Age-associated diseases, including those affecting the neuronal system, are increasing in frequency. Age-related deficiencies in the brain result in impaired motor functions, sleep, behaviour and cognitive functions. Goo...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Fülöp T Jr,Seres I

    更新日期:1994-11-01 00:00:00

  • Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly.

    abstract::Although use of NSAIDs and aspirin (acetylsalicylic acid) is well known to be associated with gastrointestinal (GI) complications and potential mortality, these medications continue to be widely prescribed in the elderly. Age is a significant risk factor for NSAID-induced GI events; indeed, patients >75 years of age c...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Lanas A,Ferrandez A

    更新日期:2007-01-01 00:00:00

  • Rational approach to the antibiotic treatment of pneumonia in the elderly.

    abstract::The incidence of pneumonia is highest among the aged compared with other adult populations, and causes significant morbidity and mortality among this group. Most episodes of pneumonia are caused by aspiration of oropharyngeal flora into the lungs and failure of lung defence mechanisms to eliminate the aspirated bacter...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Mylotte JM,Ksiazek S,Bentley DW

    更新日期:1994-01-01 00:00:00

  • Impact of home patient telemonitoring on use of β-blockers in congestive heart failure.

    abstract:INTRODUCTION:Congestive heart failure (CHF), which typically affects older people, is characterized by high short- and mid-term mortality rates. However, despite accumulating evidence showing that administration of β-blockers (β-adrenoceptor antagonists) can improve the clinical status of CHF patients, use of these age...

    journal_title:Drugs & aging

    pub_type: 杂志文章,随机对照试验


    authors: Antonicelli R,Mazzanti I,Abbatecola AM,Parati G

    更新日期:2010-10-01 00:00:00

  • Lower Prescription Rates in Centenarians with Heart Failure and Heart Failure and Kidney Disease Combined: Findings from a Longitudinal Cohort Study of Very Old Patients.

    abstract:BACKGROUND:Centenarians are considered as models of successful aging and represent a special group of patients. The aim of this study was to analyze heart failure epidemiology and treatment trajectories in centenarians compared to nonagenarians (90-99 years of age) and octogenarians (80-89 years of age) with heart fail...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Schmidt IM,Kreutz R,Dräger D,Zwillich C,Hörter S,Kuhlmey A,Gellert P

    更新日期:2018-10-01 00:00:00

  • Lisinopril. A review of its pharmacology and clinical efficacy in elderly patients.

    abstract::Lisinopril, the lysine analogue of enalaprilat, is a long-acting angiotensin converting enzyme (ACE) inhibitor which is administered once daily by mouth. The efficacy of lisinopril in reducing blood pressure is well established in younger populations, and many trials now show it to be effective in lowering blood press...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Langtry HD,Markham A

    更新日期:1997-02-01 00:00:00

  • Use of beta-adrenoceptor antagonists in older patients with chronic obstructive pulmonary disease and cardiovascular co-morbidity: safety issues.

    abstract::The incidence of and mortality from both chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) increase with age. In addition, the average age of patients with COPD and CVD is also increasing as a result of improvements in both pharmacological and non-pharmacological treatments. Coronary artery...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Andrus MR,Loyed JV

    更新日期:2008-01-01 00:00:00

  • Cost-effectiveness of pharmaceutical management for osteoarthritis pain: a systematic review of the literature and recommendations for future economic evaluation.

    abstract:BACKGROUND AND OBJECTIVE:Osteoarthritis (OA) is a highly prevalent and chronic condition characterized by pain and physical disability. Currently, many treatments are available, and they primarily target pain relief. The objectives of this study were to systematically review economic evaluations for pharmaceutical mana...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Xie F,Tanvejsilp P,Campbell K,Gaebel K

    更新日期:2013-05-01 00:00:00

  • Trends in inappropriate drug therapy prescription in the elderly in Sweden from 2006 to 2013: assessment using national indicators.

    abstract:BACKGROUND:Medication for elderly patients is often complex and problematic. Several criteria for classifying inappropriate prescribing exist. In 2010, the Swedish National Board of Health and Welfare published the document "Indicators of appropriate drug therapy in the elderly" as a guideline for improving prescribing...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Hovstadius B,Petersson G,Hellström L,Ericson L

    更新日期:2014-05-01 00:00:00

  • Sedative load and mortality among residents of long-term care facilities: a prospective cohort study.

    abstract:BACKGROUND:Older people are often prescribed multiple drugs with sedative properties. Most research has focused on specific classes of sedative and psychotropic drugs. The cumulative effect of taking multiple drugs with sedative properties has been termed 'sedative load'. Few previous studies have investigated the seda...

    journal_title:Drugs & aging

    pub_type: 临床试验,杂志文章


    authors: Taipale HT,Bell JS,Soini H,Pitkälä KH

    更新日期:2009-01-01 00:00:00

  • Nadroparin calcium. A review of its pharmacology and clinical use in the prevention and treatment of thromboembolic disorders.

    abstract::Nadroparin (nadroparin calcium) is a low molecular weight heparin with a mean molecular weight of 4.5 kD. Compared with unfractionated heparin (UFH), nadroparin has a greater ratio of anti-factor Xa to anti-factor Ha activity, greater bioavailability and a longer duration of action, allowing it to be administered by s...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Davis R,Faulds D

    更新日期:1997-04-01 00:00:00

  • Polymyalgia rheumatica and giant cell arteritis in older patients: diagnosis and pharmacological management.

    abstract::Giant cell arteritis (GCA) is an inflammatory vasculopathy that involves large- and medium-sized arteries and can cause vision loss, stroke and aneurysms. GCA occurs in people aged >50 years and is more common in women. A higher incidence of the disease is observed in populations from Northern European countries. Poly...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Schmidt J,Warrington KJ

    更新日期:2011-08-01 00:00:00

  • Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in older patients with depressive illness.

    abstract::The selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor fluoxetine is an effective antidepressant in elderly patients. Its efficacy is similar to that of other frequently used antidepressants, such as the tricyclic antidepressants. However, compared with the tricyclic antidepressants, fluoxetine has a m...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Harris MG,Benfield P

    更新日期:1995-01-01 00:00:00

  • Beta-blockers for congestive heart failure: what is the current consensus?

    abstract::Despite the availability of angiotensin converting enzyme (ACE) inhibitors for patients with congestive heart failure (CHF), mortality and morbidity remains unacceptably high. CHF is thought to progress as a result of activation of endogenous neurohormonal systems which are activated by the initial myocardial injury. ...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Tsuyuki RT,McAlister FA,Teo KK

    更新日期:2000-01-01 00:00:00

  • Anticholinergic component of the Drug Burden Index and the Anticholinergic Drug Scale as measures of anticholinergic exposure in older people in New Zealand: a population-level study.

    abstract:BACKGROUND:Older people are exposed to multiple medicines that possess anticholinergic properties. The use of anticholinergic medicines is associated with the risk of morbidity, mortality and cognitive decline, particularly in older people. Anticholinergic exposure can be measured using tools such as the Drug Burden In...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Narayan SW,Hilmer SN,Horsburgh S,Nishtala PS

    更新日期:2013-11-01 00:00:00

  • Diagnosis and treatment of dyspepsia in the elderly.

    abstract::Although dyspeptic symptoms are very common, the vast majority of patients have modest symptoms and rarely seek medical advice. The major organic causes of dyspepsia are chronic peptic ulcer disease, gastro-oesophageal reflux disease and malignancy. Functional dyspepsia is very common. In the fit elderly patient, prom...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Pound SE,Heading RC

    更新日期:1995-11-01 00:00:00

  • Severity and management of drug-drug interactions in acute geriatric patients.

    abstract:BACKGROUND:Previous studies have investigated the prevalence of drug-drug interactions (DDIs) among the elderly in different care settings, but data describing the frequency and management of DDIs among acute geriatric patients appear to be absent. OBJECTIVE:The aim of this study was to investigate the severity and in...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Lea M,Rognan SE,Koristovic R,Wyller TB,Molden E

    更新日期:2013-09-01 00:00:00

  • Pharmacological factors influencing anticancer drug selection in the elderly.

    abstract::Persons over the age of 65 years are the fastest growing segment of the US population. In the next 30 years this segment will represent more than 20% of the population. Fifty percent of all cancers occur in this age group and therefore the total cancer burden is expected to rise. Data are becoming available that will ...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: John V,Mashru S,Lichtman S

    更新日期:2003-01-01 00:00:00

  • Incidence of hematologic toxicity in older adults treated with gemcitabine or a gemcitabine-containing regimen in routine clinical practice: a multicenter retrospective cohort study.

    abstract:PURPOSE:Older adults receiving cytotoxic agents may be more susceptible to hematologic toxicities because of progressive reduction in organ functions and multiple co-morbidities. Because older adults are under-represented in clinical trials, this retrospective study aims to evaluate hematologic toxicity of gemcitabine-...

    journal_title:Drugs & aging

    pub_type: 杂志文章,多中心研究


    authors: Crombag MR,de Vries Schultink AH,Schellens JH,Beijnen JH,Huitema AD

    更新日期:2014-10-01 00:00:00

  • Pharmacology and therapeutic effects of dehydroepiandrosterone in older subjects.

    abstract::Man and higher primates have adrenals that secrete large amounts of dehydroepiandrosterone (DHEA) [prasterone] and its sulphate (DHEAS) [PB 008]. A remarkable feature of plasma DHEAS levels in humans is their great decrease with aging. Researchers have postulated that this age-related decline of DHEAS levels may expla...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Legrain S,Girard L

    更新日期:2003-01-01 00:00:00

  • Anticholinergic medications: an additional contributor to cognitive impairment in the heart failure population?

    abstract:BACKGROUND/OBJECTIVES:Patients with congestive heart failure (CHF) have a high prevalence of cognitive impairment and the association is multifactorial. In general, the burden of anticholinergic drugs has consistently been shown to be a risk factor for cognitive impairment in the elderly. The aim of this study was to a...

    journal_title:Drugs & aging

    pub_type: 杂志文章


    authors: Shaukat A,Habib A,Lane KA,Shen C,Khan S,Hellman YM,Boustani M,Malik AS

    更新日期:2014-10-01 00:00:00

  • Optimal remifentanil dosage for intubation without muscle relaxants in elderly patients.

    abstract:BACKGROUND:Remifentanil used in combination with propofol provides adequate conditions for tracheal intubation without muscle relaxants. Delivery of the optimal dose is important to prevent poor intubation conditions and drug-related complications. No previous study has investigated the use of a remifentanil-propofol c...

    journal_title:Drugs & aging

    pub_type: 临床试验,杂志文章


    authors: Goo EK,Oh AY,Cho SJ,Seo KS,Jeon YT

    更新日期:2012-11-01 00:00:00

  • Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations.

    abstract::An increasing number of elderly patients are exposed to cardiovascular drugs for the treatment of acute and/or chronic conditions. This is a result of the progressive aging of the population, a common feature in most industrialised countries, and an improvement in primary and secondary cardiovascular prevention strate...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Mangoni AA

    更新日期:2005-01-01 00:00:00

  • Metronomic chemotherapy for metastatic prostate cancer: a 'young' concept for old patients?

    abstract::Prostate cancer is a common disease in the elderly, and the number of older prostate cancer patients will probably increase with both the aging of the population and the increased rate of screening. In elderly patients with several co-morbidities, cancer management can be complex, and the risk of administering toxic t...

    journal_title:Drugs & aging

    pub_type: 杂志文章,评审


    authors: Fontana A,Falcone A,Derosa L,Di Desidero T,Danesi R,Bocci G

    更新日期:2010-09-01 00:00:00