Use of Antibiotics in Chronic Obstructive Pulmonary Disease: What is Their Current Role in Older Patients?

abstract：BACKGROUND AND OBJECTIVE:Multiple drug use is common among old, frail nursing home residents who are, as a consequence, susceptible to adverse effects and drug interactions. This study uses the updated Beers criteria for potentially inappropriate drug (PID) use in older adults to determine the extent and nature of PIDs...

journal_title：Drugs & aging

authors： Hosia-Randell HM,Muurinen SM,Pitkälä KH

更新日期：2008-01-01 00:00:00

abstract：:Behavioural disturbances, also termed neuropsychiatric symptoms, are a frequent clinical feature of dementia in Alzheimer's disease (AD). Many AD patients receive treatment with cholinesterase inhibitors (ChEIs). This review examines the evidence for behavioural effects of the four ChEIs that have been approved for th...

journal_title：Drugs & aging

authors： Grimmer T,Kurz A

更新日期：2006-01-01 00:00:00

abstract：:Problems associated with aging will become one of the leading health dilemmas of the next century. Age-associated diseases, including those affecting the neuronal system, are increasing in frequency. Age-related deficiencies in the brain result in impaired motor functions, sleep, behaviour and cognitive functions. Goo...

journal_title：Drugs & aging

authors： Fülöp T Jr,Seres I

更新日期：1994-11-01 00:00:00

abstract：:Erectile dysfunction (ED) is a common medical condition that affects the sexual life of millions of men worldwide. First-line oral therapy for ED includes the use of phosphodiesterase type 5 inhibitors (sildenafil, tadalafil and vardenafil) and sublingual apomorphine. Apomorphine is a dopamine D(1) and D(2) receptor a...

journal_title：Drugs & aging

authors： Briganti A,Chun FK,Salonia A,Zanni G,Dehò F,Barbieri L,Karakiewicz PI,Rigatti P,Montorsi F

更新日期：2006-01-01 00:00:00

abstract：:Sleep problems are an under-emphasised cause of disability in Parkinson's disease (PD) and may be seen independently of PD, associated with primary PD pathology, or as a result of antiparkinsonian medications. Common sleep disorders include excessive daytime sleepiness, rapid eye movement (REM) sleep behaviour disorde...

journal_title：Drugs & aging

authors： Stacy M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Older people often take multiple medications. It is a policy priority to facilitate older people to stay at home longer. Three-quarters of nursing home placements in the US are preceded by a hospitalization. OBJECTIVE:To investigate the association between polypharmacy and medication regimen complexity with...

journal_title：Drugs & aging

authors： Wimmer BC,Dent E,Visvanathan R,Wiese MD,Johnell K,Chapman I,Bell JS

更新日期：2014-08-01 00:00:00

abstract：:Aging per se is associated with abnormalities of the vascular wall linked to both structural and functional changes that can take place at the level of the extracellular matrix, the vascular smooth muscle and the endothelium of blood vessels. Endothelial dysfunction is generally defined as a decrease in the capacity o...

journal_title：Drugs & aging

authors： Matz RL,Andriantsitohaina R

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Use of combination pharmacotherapy, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor antagonists (angiotensin receptor blockers) and β-adrenoceptor antagonists (β-blockers) in the management of heart failure (HF) can reduce mortality, prevent functional decline and red...

journal_title：Drugs & aging

authors： Foebel AD,Heckman GA,Hirdes JP,Tyas SL,Tjam EY,McKelvie RS,Maxwell CJ

更新日期：2011-07-01 00:00:00

abstract：:Influenza causes substantial morbidity across the age spectrum. However, the elderly are especially vulnerable to the serious complications of influenza that might result in hospitalisation or death, and high rates of influenza-associated excess hospitalisation or death that exceed by several-fold the rates seen among...

journal_title：Drugs & aging

authors： Nichol KL

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to gain insights into the attitudes of men with lower urinary tract symptoms towards deprescribing alpha-blockers and to assess their willingness to participate in a planned discontinuation trial. METHODS:This was a cross-sectional questionnaire study. Men aged 30 years and ol...

journal_title：Drugs & aging

authors： Edelman M,Jellema P,Hak E,Denig P,Blanker MH

更新日期：2019-12-01 00:00:00

abstract：:The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1)...

journal_title：Drugs & aging

authors： Andrès E,Vogel T,Federici L,Zimmer J,Kaltenbach G

更新日期：2008-01-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) usually affect adults and older populations. The well recognized clinical (i.e., granulomatosis with polyangiitis [GPA], microscopic polyangiitis, and eosinophilic GPA) and serological phenotypes (i.e., anti-MPO-ANCA, anti-PR3-ANCA and ANCA nega...

journal_title：Drugs & aging

authors： Berti A,Caporali R,Montecucco C,Paolazzi G,Monti S

更新日期：2019-01-01 00:00:00

abstract：:Melatonin prolonged release (PR) 2 mg is approved for the treatment of primary insomnia characterized by poor sleep quality in patients aged ≥55 years in the EU and elsewhere. Patients may receive treatment with melatonin PR for up to 13 weeks. Production of endogenous nocturnal melatonin, which helps regulate circadi...

journal_title：Drugs & aging

authors： Lyseng-Williamson KA

更新日期：2012-11-01 00:00:00

abstract：:Spasticity following stroke reflects a spectrum of clinical problems including increased muscle tone, abnormal limb posture, excessive contraction of antagonist muscles and hyperactive cutaneous and tendon reflexes. The prevalence of stroke-related disability in stroke survivors is high, and spasticity may be a signif...

journal_title：Drugs & aging

authors： O'Brien CF,Seeberger LC,Smith DB

更新日期：1996-11-01 00:00:00

abstract：:The prevalence of intermittent claudication (IC) increases with age; when questioned, older patients consider increased difficulty in walking to be a normal consequence of aging. Although the prognosis for the involved limb with IC is relatively good, IC is an important clinical predictor of increased cardiovascular m...

journal_title：Drugs & aging

authors： Boccalon H

更新日期：1999-04-01 00:00:00

abstract：:Urothelial carcinoma, or bladder cancer, is a malignancy that most commonly affects older patients. The median age at diagnosis is 73 years, and care of these patients requires consideration not just of the disease-related factors such as stage and histology, but also of patient-related factors. Many of these patients...

journal_title：Drugs & aging

authors： Jodon G,Fischer SM,Kessler ER

更新日期：2018-05-01 00:00:00

abstract：:Man and higher primates have adrenals that secrete large amounts of dehydroepiandrosterone (DHEA) [prasterone] and its sulphate (DHEAS) [PB 008]. A remarkable feature of plasma DHEAS levels in humans is their great decrease with aging. Researchers have postulated that this age-related decline of DHEAS levels may expla...

journal_title：Drugs & aging

authors： Legrain S,Girard L

更新日期：2003-01-01 00:00:00

abstract：:As people grow old, their need for medications increases dramatically because of the higher incidence of chronic pain, diabetes mellitus, cardiovascular and neurological diseases in the elderly population. Furthermore, the elderly require special consideration with respect to drug delivery, drug interactions and adher...

journal_title：Drugs & aging

authors： Priano L,Gasco MR,Mauro A

更新日期：2006-01-01 00:00:00

abstract：:High drug consumption among the elderly and inappropriate prescribing practices increase the risk of adverse drug effects in this population. This risk may be decreased by conducting, for example, a medication review alone or as part of a comprehensive geriatric assessment (CGA); however, little is known about the fat...

journal_title：Drugs & aging

authors： Lampela P,Hartikainen S,Lavikainen P,Sulkava R,Huupponen R

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Medication-related problems are common in the growing population of older adults and inappropriate prescribing is a preventable risk factor. Explicit criteria such as the Beers criteria provide a valid instrument for describing the rate of inappropriate medication (IM) prescriptions among older adults. OBJE...

journal_title：Drugs & aging

authors： Blozik E,Born AM,Stuck AE,Benninger U,Gillmann G,Clough-Gorr KM

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Medication non-adherence can exacerbate disease severity, leading to impairments that interfere with self-care activities in older adults, and, ultimately, death. Elder self-neglect is the most common report to Adult Protective Services (APS) across the USA and is a significant risk factor for early mortalit...

journal_title：Drugs & aging

authors： Turner A,Hochschild A,Burnett J,Zulfiqar A,Dyer CB

更新日期：2012-09-01 00:00:00

abstract：:The numbers of patients with dementia and patients with epilepsy are increasing in the global population. In fact, these two conditions are related, and it is estimated that at least 5-10% of seizures or epilepsy in older individuals (aged > 60 years) are caused by a neurodegenerative dementia. In the vast majority, o...

journal_title：Drugs & aging

authors： Cretin B

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:In response to concerns about, and issues pertaining to, medication use practices in residential aged-care facilities (RACFs), the Australian Pharmaceutical Advisory Council (APAC) established a working party on quality use of medicines (QUM) in nursing homes and hostels. The APAC is a representative ministe...

journal_title：Drugs & aging

authors： Cheek J,Gilbert A,Ballantyne A,Penhall R

更新日期：2004-01-01 00:00:00

abstract：:Although a significant proportion of patients receiving nitrates are elderly, surprisingly little published work is available describing the pharmacokinetics and pharmacodynamics of these agents in elderly patients. The lack of pharmacokinetic data is related to the difficulty in assaying nitrates and there are at pre...

journal_title：Drugs & aging

authors： Kelly JG,O'Malley K

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:There is poor evidence supporting the use of any pharmacologic treatments for neuropsychiatric disorders following traumatic brain injury (TBI), especially among older adults. Informed by our recent characterization of psychotropic medication use among Medicare beneficiaries with TBI, the objective of this st...

journal_title：Drugs & aging

authors： Albrecht JS,Rao V,Perfetto EM,Daniel Mullins C

更新日期：2018-08-01 00:00:00

abstract：:Alzheimer's disease is a chronic progressive disease affecting higher intellectual functioning. The clinical diagnosis is made when the onset of illness is insidious, the course slowly progressive and all the treatable causes of dementia have been ruled out. The use of more stringent criteria has improved clinical dia...

journal_title：Drugs & aging

authors： Hermann C,Stern RG,Losonzcy MF,Jaff S,Davidson M

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Age-related changes in the concentration-effect relationship of (+)-O-desmethyl-tramadol [(+)-ODM], tramadol's active metabolite, are not documented in the elderly. OBJECTIVE:The objective of this study was to characterize, in elderly and young subjects, the (+)-ODM pharmacokinetic and pharmacodynamic relat...

journal_title：Drugs & aging

authors： Robertson SS,Mouksassi MS,Varin F

更新日期：2019-08-01 00:00:00

abstract：:It is inevitable that publicly funded, technically sophisticated medical treatments will be increasingly rationed. Other things being equal, there is a greater duty to use them to prolong the lives of younger than older people. Age is therefore an ethical rationing criterion. Denial of this may actually harm older peo...

journal_title：Drugs & aging

authors： Shaw AB

更新日期：1996-12-01 00:00:00

abstract：:Gout in older patients tends to be sub-acute to chronic, often tophaceous, polyarticular, erosive, symmetrical, and causes persistent, recurrent and chronic arthritis. Clinically, it may closely mimic rheumatoid arthritis; thus, a correct diagnosis requires a high index of clinical suspicion and the identification of ...

journal_title：Drugs & aging

authors： Gonzalez EB,Miller SB,Agudelo CA

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...

journal_title：Drugs & aging

authors： Pariente A,Dartigues JF,Benichou J,Letenneur L,Moore N,Fourrier-Réglat A

更新日期：2008-01-01 00:00:00