Age-related changes in male gonadal function. Implications for therapy.

abstract：:The elderly population has much to gain from the advances of molecular medicine, although at present genetic pharmacology remains mostly at the conceptual level. Cancer, in particular, is an increasing health burden and the majority (over 70%) of gene therapy trials are aimed at tackling this problem. Available strate...

journal_title：Drugs & aging

authors： Szlosarek PW,Dalgleish AG

更新日期：2000-08-01 00:00:00

abstract：:Cutaneous adverse drug reactions comprise a significant proportion of all adverse drug reactions. They may mimic other dermatologic or systemic illnesses and may cause significant morbidity or mortality. Seven morphologic groups encompass the most commonly encountered cutaneous drug reaction syndromes: exanthematous (...

journal_title：Drugs & aging

authors： Young JWS,Shear NH

更新日期：2017-09-01 00:00:00

abstract：:Colorectal cancer ranks third in incidence in both men and women after lung, breast and prostate cancer. The prevalence of colorectal cancer increases significantly with age, with 40% of patients in Europe being >75 years of age at the time of initial diagnosis. Furthermore, the number of elderly patients with colorec...

journal_title：Drugs & aging

authors： Meulenbeld HJ,Creemers GJ

更新日期：2007-01-01 00:00:00

abstract：:Vitreous haemorrhage can be caused by a disruption of normal retinal vessels, bleeding from diseased retinal vessels, bleeding from abnormal new vessels or extension of haemorrhage through the retina from other sources. In the elderly, vitreous haemorrhage usually occurs spontaneously and only occurs occasionally as a...

journal_title：Drugs & aging

authors： Manuchehri K,Kirkby G

更新日期：2003-01-01 00:00:00

abstract：:Disease-modifying antirheumatic drugs (DMARDs) are frequently used in rheumatoid arthritis. A number of physiological changes occur in the elderly which may modify the use of these medications. The most commonly used DMARDs are antimalarial drugs (particularly hydroxychloroquine), sulfasalazine and methotrexate. The p...

journal_title：Drugs & aging

authors： Gardner G,Furst DE

更新日期：1995-12-01 00:00:00

abstract：:Nitric oxide (NO) is involved in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity. Depending on the redox state of NO, it can act as a neurotoxin or it can have a neuroprotective action. Data suggest that NO may have a role in the pathogenesis of neurodegenerati...

journal_title：Drugs & aging

authors： Molina JA,Jiménez-Jiménez FJ,Ortí-Pareja M,Navarro JA

更新日期：1998-04-01 00:00:00

abstract：:Hyperuricaemia is an independent risk factor for renal function decline. Evidence is emerging that urate-lowering therapy might be beneficial in subjects with renal impairment. We  review the association between renal impairment and gout, some of the related pathogenic processes and the possible impact of gout treatme...

journal_title：Drugs & aging

authors： Pascual E,Sivera F,Andrés M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE:The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors assoc...

journal_title：Drugs & aging

authors： Musich S,Wang SS,Slindee LB,Saphire L,Wicker E

更新日期：2018-05-01 00:00:00

abstract：:Influenza infection is an acute respiratory disease with a high morbidity and significant mortality, particularly among the elderly and individuals with chronic diseases. The majority of countries now recommend annual influenza vaccination for all people aged 65 years or older, and for those with high risk conditions....

journal_title：Drugs & aging

authors： Corrigan EM,Clancy RL

更新日期：1999-09-01 00:00:00

abstract：:Etidronic acid is an orally and intravenously active bisphosphonate, which is believed to inhibit resorption of bone via a number of cellular mechanisms, including alteration of osteoclastic activity. In studies of patients with symptomatic Paget's disease, etidronic acid 5 to 20 mg/kg/day administered orally rapidly ...

journal_title：Drugs & aging

authors： Dunn CJ,Fitton A,Sorkin EM

更新日期：1994-12-01 00:00:00

abstract：:Type 2 diabetes mellitus is a complex heterogenous metabolic disorder in which peripheral insulin resistance and impaired insulin release are the main pathogenetic factors. The rapid response of the pancreatic beta-cells to glucose is already markedly disturbed in the early stages of type 2 diabetes mellitus. The cons...

journal_title：Drugs & aging

authors： Landgraf R

更新日期：2000-11-01 00:00:00

abstract：:Cardiovascular disease has been inseparable from aging in developed societies and, as a result, it is the commonest cause of mortality in elderly populations. Atherosclerosis is associated with the progressive vascular accumulation of cholesterol-laden lipoproteins, and is linearly associated with the plasma level of ...

journal_title：Drugs & aging

authors： Playford DA,Watts GF

更新日期：1997-06-01 00:00:00

abstract：:There has been a growing recognition that pulsatile stimulation of dopamine receptors may be an important mechanism in the generation of the motor fluctuations that often develop and compromise the effectiveness of long-term levodopa administration in persons with Parkinson's disease (PD). This has prompted investigat...

journal_title：Drugs & aging

authors： Pfeiffer RF

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...

journal_title：Drugs & aging

authors： Pariente A,Dartigues JF,Benichou J,Letenneur L,Moore N,Fourrier-Réglat A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Patients with congestive heart failure (CHF) have a high prevalence of cognitive impairment and the association is multifactorial. In general, the burden of anticholinergic drugs has consistently been shown to be a risk factor for cognitive impairment in the elderly. The aim of this study was to a...

journal_title：Drugs & aging

authors： Shaukat A,Habib A,Lane KA,Shen C,Khan S,Hellman YM,Boustani M,Malik AS

更新日期：2014-10-01 00:00:00

abstract：:Urothelial carcinoma, or bladder cancer, is a malignancy that most commonly affects older patients. The median age at diagnosis is 73 years, and care of these patients requires consideration not just of the disease-related factors such as stage and histology, but also of patient-related factors. Many of these patients...

journal_title：Drugs & aging

authors： Jodon G,Fischer SM,Kessler ER

更新日期：2018-05-01 00:00:00

abstract：:Research into the use of clozapine in older people is somewhat scarce. Clozapine is associated with serious adverse effects such as agranulocytosis, seizures, myocarditis and metabolic syndrome. Other common undesirable effects such as sedation, constipation (which can be fatal), urinary incontinence and hypersalivati...

journal_title：Drugs & aging

authors： Bishara D,Taylor D

更新日期：2014-01-01 00:00:00

abstract：:Giant cell arteritis (GCA) is an inflammatory vasculopathy that involves large- and medium-sized arteries and can cause vision loss, stroke and aneurysms. GCA occurs in people aged >50 years and is more common in women. A higher incidence of the disease is observed in populations from Northern European countries. Poly...

journal_title：Drugs & aging

authors： Schmidt J,Warrington KJ

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the primary treatment option, especially in the elderly. But this therapeutic approach may include risks for adverse drug effects and drug-drug intera...

journal_title：Drugs & aging

authors： Huber M,Kölzsch M,Stahlmann R,Hofmann W,Bolbrinker J,Dräger D,Kreutz R

更新日期：2013-01-01 00:00:00

abstract：:Decitabine (Dacogen(®)) is a deoxynucleoside analogue of cytidine that selectively inhibits DNA methyltransferases. Decitabine administered at a dose of 20 mg/m(2) by a 1-h intravenous infusion for 5 consecutive days of a 4-week cycle has been approved by the European Medicines Agency (EMA) for use in adult patients a...

journal_title：Drugs & aging

authors： Curran MP

更新日期：2013-06-01 00:00:00

abstract：:Foot and ankle osteoarthritis (OA) is a common and disabling problem that adversely affects physical function and significantly reduces quality of life. Although the knee was considered to be the lower-limb site most often affected by OA, recent population data showed foot OA is as prevalent as knee OA, and rates incr...

journal_title：Drugs & aging

authors： Paterson KL,Gates L

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Remifentanil used in combination with propofol provides adequate conditions for tracheal intubation without muscle relaxants. Delivery of the optimal dose is important to prevent poor intubation conditions and drug-related complications. No previous study has investigated the use of a remifentanil-propofol c...

journal_title：Drugs & aging

authors： Goo EK,Oh AY,Cho SJ,Seo KS,Jeon YT

更新日期：2012-11-01 00:00:00

abstract：:An increasing number of elderly patients are exposed to cardiovascular drugs for the treatment of acute and/or chronic conditions. This is a result of the progressive aging of the population, a common feature in most industrialised countries, and an improvement in primary and secondary cardiovascular prevention strate...

journal_title：Drugs & aging

authors： Mangoni AA

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Falls are a primary cause of injury and disability in the nursing home environment and can be costly to treat. We propose a taxonomy of nursing home falls that accounts for both the severity of fall consequences and the duration of the treatment episode. No other systematic approach of this kind has been pre...

journal_title：Drugs & aging

authors： Sorensen SV,de Lissovoy G,Kunaprayoon D,Resnick B,Rupnow MF,Studenski S

更新日期：2006-01-01 00:00:00

abstract：:Despite the availability of angiotensin converting enzyme (ACE) inhibitors for patients with congestive heart failure (CHF), mortality and morbidity remains unacceptably high. CHF is thought to progress as a result of activation of endogenous neurohormonal systems which are activated by the initial myocardial injury. ...

journal_title：Drugs & aging

authors： Tsuyuki RT,McAlister FA,Teo KK

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not prev...

journal_title：Drugs & aging

authors： Corsonello A,Pedone C,Lattanzio F,Onder G,Antonelli Incalzi R,Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA).

更新日期：2011-05-01 00:00:00

abstract：:As people grow old, their need for medications increases dramatically because of the higher incidence of chronic pain, diabetes mellitus, cardiovascular and neurological diseases in the elderly population. Furthermore, the elderly require special consideration with respect to drug delivery, drug interactions and adher...

journal_title：Drugs & aging

authors： Priano L,Gasco MR,Mauro A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The practice of hiding medicines in nursing home patients' food or beverages is described in only a few scientific papers. An earlier study conducted in 1999/2000 showed that covert medication was common in Norwegian nursing homes, with 11% of patients in regular nursing home units (RUs) and 17...

journal_title：Drugs & aging

authors： Kirkevold O,Engedal K

更新日期：2009-01-01 00:00:00

abstract：:Aflibercept is a fully human, recombinant fusion protein that acts as a soluble decoy receptor for vascular endothelial growth factor (VEGF) family members, including VEGF-A, VEGF-B and placental growth factor (P1GF), thereby inhibiting downstream signalling mediated by these ligands. Aflibercept binds all isoforms of...

journal_title：Drugs & aging

authors： Yang LP,McKeage K

更新日期：2014-05-01 00:00:00

abstract：:A progressive accumulation of atherosclerotic lesions beginning early in life puts elderly persons at a greater absolute risk of cardiovascular disease and coronary events than other segments of the population. HMG-CoA reductase inhibitor (statin) therapy has been shown to be both efficacious and well tolerated in mos...

journal_title：Drugs & aging

authors： Davidson MH

更新日期：2007-01-01 00:00:00