Abstract:
:The numbers of patients with dementia and patients with epilepsy are increasing in the global population. In fact, these two conditions are related, and it is estimated that at least 5-10% of seizures or epilepsy in older individuals (aged > 60 years) are caused by a neurodegenerative dementia. In the vast majority, one of the four following diseases is involved: Alzheimer's disease, Lewy body dementia, frontotemporal dementia, or vascular dementia. These diseases cause, not only seizures or epilepsy in affected patients, but cognitive, behavioral, and motor disorders as well. As a result, the challenges of treating seizures in older patients with neurodegenerative disease go beyond the usual limitations associated with this age group (i.e., lower fluid compartment, lower protein binding, increased risk of drug-drug interactions) by imposing other issues and pitfalls. In this setting, the drug-related potential aggravation of neurodegenerative symptoms must be taken into account. As cognition is particularly vulnerable, the prescription of antiseizure medications in dementia must consider the potential neurocognitive impact and limit it as much as possible. Consequently, the choice of a treatment for seizures in this age group is even more demanding than in younger patients, and therefore more restricted. Based on current but limited evidence, it appears that second-generation antiseizure medications are more likely to be appropriate for the management of older patients with epilepsy with neurodegenerative disease given their more favorable pharmacokinetic profiles. Nevertheless, even newer antiseizure medications are not devoid of any risks, which can however be anticipated and corrected.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Cretin Bdoi
10.1007/s40266-020-00826-2subject
Has Abstractpub_date
2020-12-14 00:00:00eissn
1170-229Xissn
1179-1969pii
10.1007/s40266-020-00826-2pub_type
杂志文章相关文献
DRUGS & AGING文献大全abstract::Prostate cancer is a common disease in the elderly, and the number of older prostate cancer patients will probably increase with both the aging of the population and the increased rate of screening. In elderly patients with several co-morbidities, cancer management can be complex, and the risk of administering toxic t...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11537480-000000000-00000
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The practice of hiding medicines in nursing home patients' food or beverages is described in only a few scientific papers. An earlier study conducted in 1999/2000 showed that covert medication was common in Norwegian nursing homes, with 11% of patients in regular nursing home units (RUs) and 17...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200926040-00004
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:By using the findings obtained from the PREPARED study, we aimed to estimate the cost effectiveness of ropinirole prolonged release (PR) [Requip-Modutab(®)] in Parkinson's disease (PD) versus ropinirole immediate release (IR). In the PREPARED study, ropinirole PR provided a significantly greater improvement ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-013-0150-4
更新日期:2014-03-01 00:00:00
abstract::In contrast with the earlier stages and, in particular, the predementia stage, of Alzheimer's disease (AD), severe dementia is often neglected. However, the advanced stages of dementia are just as important as the earlier stages because of their frequency, their impact on the lives of patients and their caregivers, an...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/0002512-200926020-00005
更新日期:2009-01-01 00:00:00
abstract::The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00706-4
更新日期:2019-12-01 00:00:00
abstract::Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is typically diagnosed in the second or third decade of life. It is generally believed that over the last few decades the life expectancy of patients with adult onset MS (AOMS) has approached that of the general population as a r...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11532120-000000000-00000
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Osteoarthritis (OA) is a highly prevalent and chronic condition characterized by pain and physical disability. Currently, many treatments are available, and they primarily target pain relief. The objectives of this study were to systematically review economic evaluations for pharmaceutical mana...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-013-0062-3
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). OBJECTIVE:Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. METHODS:We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析,评审
doi:10.2165/11316780-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::Aging is associated with a myriad of hormonal changes. The mechanisms underlying these changes are variable. Aging is associated with anatomic changes of the endocrine glands, notably as a result of programmed cell death, autoimmune mediated destruction of the gland, or neoplastic transformation of glandular tissue. A...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199303020-00004
更新日期:1993-03-01 00:00:00
abstract::Spasticity following stroke reflects a spectrum of clinical problems including increased muscle tone, abnormal limb posture, excessive contraction of antagonist muscles and hyperactive cutaneous and tendon reflexes. The prevalence of stroke-related disability in stroke survivors is high, and spasticity may be a signif...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199609050-00004
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE:The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors assoc...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0543-5
更新日期:2018-05-01 00:00:00
abstract::Elderly people with renal impairment are at high risk for venous thromboembolism (VTE) and acute coronary syndromes (ACS); however, they are also at increased risk for bleeding complications. Evidence-based data for the management of anticoagulation in elderly patients with severe renal impairment, in particular, are ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11586730-000000000-00000
更新日期:2011-03-01 00:00:00
abstract::The incidence of pneumonia is highest among the aged compared with other adult populations, and causes significant morbidity and mortality among this group. Most episodes of pneumonia are caused by aspiration of oropharyngeal flora into the lungs and failure of lung defence mechanisms to eliminate the aspirated bacter...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199404010-00003
更新日期:1994-01-01 00:00:00
abstract::The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1)...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/0002512-200825110-00003
更新日期:2008-01-01 00:00:00
abstract::Lithium salts have a well-established role in the treatment of major affective disorders. More recently, experimental and clinical studies have provided evidence that lithium may also exert neuroprotective effects. In animal and cell culture models, lithium has been shown to increase neuronal viability through a combi...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11599180-000000000-00000
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Despite evidence of effective combination drug therapy for secondary prevention of coronary heart disease (CHD), older adults with this condition remain undertreated. OBJECTIVE:To describe time trends (1992-2003) in the adoption of combination cardiac drug therapies (beta-blockers [beta-adrenoceptor antagon...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11532150-000000000-00000
更新日期:2010-02-01 00:00:00
abstract::Skin and soft tissue infections are quite common in elderly people. A number of special conditions and circumstances need to be considered in the diagnosis and therapy. It is important to try to establish the causative organism, exclude other cutaneous disorders and identify precipitating factors. Treatment modalities...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219050-00002
更新日期:2002-01-01 00:00:00
abstract::Congestive heart failure (CHF) is a common cardiovascular disorder that is characterised, in part, by a decreased cardiac output reserve. Accordingly, there is ongoing interest in the role of positive inotropic agents (e.g. adrenergic agonists and phosphodiesterase type III inhibitors, which mediate their cardiovascul...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812030-00003
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Patient transitions, such as transfers between acute and long-term care (LTC), aposare times when the likelihood of communication failure between healthcare providers is increased. Employing appropriate health quality indicators helps support improvement efforts. To date, few quality indicators that evaluate...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11599150-000000000-00000
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825010-00007
更新日期:2008-01-01 00:00:00
abstract::Over four-fifths of all strokes are due to thrombotic or embolic occlusion of cerebral arteries. There is a strong rationale for considering antithrombotic therapy for the treatment of patients with acute ischaemic stroke. Antiplatelet therapy with 150 to 300 mg of aspirin (acetylsalicylic acid) started within the fir...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199915010-00003
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320110-00005
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Remifentanil used in combination with propofol provides adequate conditions for tracheal intubation without muscle relaxants. Delivery of the optimal dose is important to prevent poor intubation conditions and drug-related complications. No previous study has investigated the use of a remifentanil-propofol c...
journal_title:Drugs & aging
pub_type: 临床试验,杂志文章
doi:10.1007/s40266-012-0019-y
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Frailty is a clinical phenotype that is associated with adverse health outcomes. Since frail patients may be more prone for adverse drug events and about 15-20 % of commonly prescribed drugs are metabolized by CYP2D6, we hypothesized that CYP2D6 metabolism is decreased in frail patients compared with healthy...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-015-0319-0
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:The aims of the study were to evaluate usage rates of warfarin in stroke prophylaxis and the association with assessed stages of stroke and bleeding risk in long-term care (LTC) residents with atrial fibrillation (AFib). METHODS:A cross-sectional analysis of two LTC databases (the National Nursing Home Surv...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-013-0067-y
更新日期:2013-06-01 00:00:00
abstract::In general, the pharmacological treatment of non-psychotic major depressive disorder in old age is only partially successful, with only approximately 50% of older depressed adults improving with initial antidepressant monotherapy. Many factors may predict a more difficult-to-treat depression, including coexisting anxi...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724100-00002
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Patients with congestive heart failure (CHF) have a high prevalence of cognitive impairment and the association is multifactorial. In general, the burden of anticholinergic drugs has consistently been shown to be a risk factor for cognitive impairment in the elderly. The aim of this study was to a...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-014-0204-2
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Immunosenescence makes the elderly more susceptible to influenza complications and less responsive to vaccination. An intradermal formulation (IDflu) is one of several strategies being investigated to increase the immunogenicity of influenza vaccines. OBJECTIVE:The overall goal of the study was to assess ...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析
doi:10.1007/s40266-015-0303-8
更新日期:2015-10-01 00:00:00
abstract::Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug reg...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11631760-000000000-00000
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Certain medications have been linked to falls. One of the most severe fall-related injuries in the elderly is a hip fracture. OBJECTIVE:The objective of this study was to examine the use of medications known to increase fall risk that were prescribed on an outpatient basis to veterans prior to hospital admi...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200522100-00006
更新日期:2005-01-01 00:00:00