Abstract:
BACKGROUND:For physicians dealing with patients with a limited life expectancy, knowing the time to benefit (TTB) of preventive medication is essential to support treatment decisions. OBJECTIVE:The aim of this study was to investigate the usefulness of statistical process control (SPC) for determining the TTB in relation to fracture risk with alendronate versus placebo in postmenopausal women. METHODS:We performed a post hoc analysis of the Fracture Intervention Trial (FIT), a randomized, controlled trial that investigated the effect of alendronate versus placebo on fracture risk in postmenopausal women. We used SPC, a statistical method used for monitoring processes for quality control, to determine if and when the intervention group benefited significantly more than the control group. SPC discriminated between the normal variations over time in the numbers of fractures in both groups and the variations that were attributable to alendronate. The TTB was defined as the time point from which the cumulative difference in the number of clinical fractures remained greater than the upper control limit on the SPC chart. RESULTS:For the total group, the TTB was defined as 11 months. For patients aged ≥70 years, the TTB was 8 months [absolute risk reduction (ARR) = 1.4%]; for patients aged <70 years, it was 19 months (ARR = 0.7%). CONCLUSION:SPC is a clear and understandable graphical method to determine the TTB. Its main advantage is that there is no need to define a prespecified time point, as is the case in traditional survival analyses. Prescribing alendronate to patients who are aged ≥70 years is useful because the TTB shows that they will benefit after 8 months. Investigators should report the TTB to simplify clinical decision making.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
van de Glind EM,Willems HC,Eslami S,Abu-Hanna A,Lems WF,Hooft L,de Rooij SE,Black DM,van Munster BCdoi
10.1007/s40266-016-0344-7subject
Has Abstractpub_date
2016-05-01 00:00:00pages
347-53issue
5eissn
1170-229Xissn
1179-1969pii
10.1007/s40266-016-0344-7journal_volume
33pub_type
杂志文章,随机对照试验相关文献
DRUGS & AGING文献大全abstract:BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825010-00007
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Medicines are potentially modifiable risk factors for postoperative delirium. However, the extent to which preoperative medicines are included in risk prediction models (RPMs) is unknown. OBJECTIVE:This systematic review aimed to assess the extent of inclusion of preoperative medications in RPMs for postope...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-018-0526-6
更新日期:2018-03-01 00:00:00
abstract::Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-017-0436-z
更新日期:2017-03-01 00:00:00
abstract::Most western countries have influenza vaccination programmes for citizens aged > or = 65 years. This paper reviews the available evidence on whether elderly influenza vaccination is worthwhile from a pharmacoeconomic point of view. A search on Medline and EMBASE resulted in a primary selection of approximately 100 stu...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200017030-00005
更新日期:2000-09-01 00:00:00
abstract::Polymyalgia rheumatica (PMR) is a disease of unknown aetiology that occurs in elderly patients, predominantly affecting the Caucasian population. The disease has a slightly higher prevalence in women than in men. There is ongoing discussion regarding the relationship between PMR and giant cell arteritis; an increasing...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199813020-00003
更新日期:1998-08-01 00:00:00
abstract::Pneumococcal polysaccharide conjugate vaccine (13-valent, adsorbed) (PCV13; Prevenar 13(®); Prevnar 13(®)) is approved in adults aged ≥50 years (focus of review) and in children aged 6 weeks to 5 years for protection against pneumococcal diseases caused by Streptococcus pneumoniae in numerous countries worldwide, incl...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-012-0017-0
更新日期:2012-10-01 00:00:00
abstract::Psoriatic arthritis (PsA) can start in subjects aged over 60 years, defined as late-onset PsA. In late-onset PsA, the weight of family history and genetic background appears less significant when compared with younger onset PsA, whereas obesity and smoking have been suggested as potential risk factors. In patients wit...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00688-3
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Medication for elderly patients is often complex and problematic. Several criteria for classifying inappropriate prescribing exist. In 2010, the Swedish National Board of Health and Welfare published the document "Indicators of appropriate drug therapy in the elderly" as a guideline for improving prescribing...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-014-0165-5
更新日期:2014-05-01 00:00:00
abstract::CATT (Comparison of Age-related macular degeneration [AMD] Treatment Trials) examined the efficacy of ranibizumab and bevacizumab for the treatment of neovascular AMD. This prospective, randomized, but unblinded trial revealed a significant improvement in vision with both treatments in terms of visual acuity; importan...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11594720-000000000-00000
更新日期:2011-11-01 00:00:00
abstract::There is ample evidence for the involvement of aberrant protein phosphorylation reactions in aging and age-associated neurological disorders. Alzheimer's disease (AD) in particular. The exact nature of this involvement, however, is not yet elucidated. In the brain tissue of AD patients, there are numerous examples of ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199506020-00006
更新日期:1995-02-01 00:00:00
abstract::The atypical antipsychotics are a new class of agents with great promise for use in the elderly because of their reduced propensity to cause acute extrapyramidal adverse effects. Treatment of older patients with these agents, however, needs to take into consideration age-related changes in pharmacokinetics and the ris...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812020-00004
更新日期:1998-02-01 00:00:00
abstract::The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00706-4
更新日期:2019-12-01 00:00:00
abstract::Cutaneous adverse drug reactions comprise a significant proportion of all adverse drug reactions. They may mimic other dermatologic or systemic illnesses and may cause significant morbidity or mortality. Seven morphologic groups encompass the most commonly encountered cutaneous drug reaction syndromes: exanthematous (...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-017-0483-5
更新日期:2017-09-01 00:00:00
abstract::Rheumatoid arthritis (RA) and osteoarthritis are chronic diseases that result in cartilage degradation and loss of joint function. Currently available drugs are predominantly directed towards the control of pain and/or the inflammation associated with joint synovitis but they do little to reduce joint destruction. In ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200118020-00002
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Overactive bladder syndrome (OAB) is associated with various co-morbidities; treatment of these frequently results in multiple medication use (MMU) and the potential for drug-drug interactions, which may lead to adverse events and altered efficacy. With the aging population, the prevalence of MMU is likely t...
journal_title:Drugs & aging
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2165/11586740-000000000-00000
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320110-00005
更新日期:2003-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) has considerable morbidity and mortality in the older adult population. The role of antibiotics in the management of acute exacerbations of COPD (AECOPD) is currently evolving. Despite only mild benefits, most patients with AECOPD in ambulatory settings receive antibiotics ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-020-00786-7
更新日期:2020-09-01 00:00:00
abstract::The finding of fungal growth in the urine (funguria) of elderly patients is becoming increasingly common. It has been reported in both acute and chronic care settings. Risk factors for the development of funguria include the use of broad spectrum antibiotics, corticosteroids and indwelling bladder catheters, as well a...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199608020-00003
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Potentially inappropriate medications (PIMs) are defined by the American Geriatric Society as medications that should be avoided in the elderly in general, or in specific situations. However, PIM use remains high among aging populations and may result in increased utilization of healthcare resources. OBJECT...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析
doi:10.1007/s40266-020-00770-1
更新日期:2020-07-01 00:00:00
abstract:INTRODUCTION:Immunosenescence makes the elderly more susceptible to influenza complications and less responsive to vaccination. An intradermal formulation (IDflu) is one of several strategies being investigated to increase the immunogenicity of influenza vaccines. OBJECTIVE:The overall goal of the study was to assess ...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析
doi:10.1007/s40266-015-0303-8
更新日期:2015-10-01 00:00:00
abstract::Prostate cancer is a common disease in the elderly, and the number of older prostate cancer patients will probably increase with both the aging of the population and the increased rate of screening. In elderly patients with several co-morbidities, cancer management can be complex, and the risk of administering toxic t...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11537480-000000000-00000
更新日期:2010-09-01 00:00:00
abstract::Periods of intense hormonal fluctuations have been associated with heightened prevalence and exacerbation of underlying psychiatric illness, particularly the occurrence of premenstrual dysphoria, puerperal depression and depressive symptoms during perimenopause. It has been speculated that sex steroids such as estroge...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320020-00001
更新日期:2003-01-01 00:00:00
abstract::Persons over the age of 65 years are the fastest growing segment of the US population. In the next 30 years this segment will represent more than 20% of the population. Fifty percent of all cancers occur in this age group and therefore the total cancer burden is expected to rise. Data are becoming available that will ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320100-00003
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Evidence regarding differences in outcomes between angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) among older nursing home (NH) residents after acute myocardial infarction (AMI) is limited. OBJECTIVES:The purpose of our study was to estimate the post-AMI effects...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-020-00791-w
更新日期:2020-10-01 00:00:00
abstract::Mild hypertension (grade 1 or stage 1 hypertension) is defined as a systolic blood pressure of 140-159 mm Hg or a diastolic pressure of 90-99 mm Hg. According to current guidelines, patients with mild hypertension can be at low, medium, high or very high risk depending on the presence of other risk factors, target org...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421010-00001
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Over three-quarters of the older population take medications that can potentially cause dry mouth. Physicians or pharmacists rarely inform patients about this adverse effect and its potentially severe damage to the teeth, mouth and general health. OBJECTIVES:The objectives of this study were to (1) identify...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-013-0141-5
更新日期:2014-01-01 00:00:00
abstract::Seasonal influenza causes significant morbidity and mortality in the elderly, the very young and those with chronic illness, despite the availability of effective vaccines. The mortality and morbidity attributed annually to seasonal influenza are small in comparison to the potential mortality and morbidity of a novel ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825030-00001
更新日期:2008-01-01 00:00:00
abstract::Colorectal cancer ranks third in incidence in both men and women after lung, breast and prostate cancer. The prevalence of colorectal cancer increases significantly with age, with 40% of patients in Europe being >75 years of age at the time of initial diagnosis. Furthermore, the number of elderly patients with colorec...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724030-00004
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Medication non-adherence can exacerbate disease severity, leading to impairments that interfere with self-care activities in older adults, and, ultimately, death. Elder self-neglect is the most common report to Adult Protective Services (APS) across the USA and is a significant risk factor for early mortalit...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-012-0007-2
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Medication-related admissions are an important cause of hospital admissions in older people. The scope for prevention is less clear. OBJECTIVES:To characterize medication-related hospital admissions in older people and assess their preventability. METHODS:This was a cross-sectional, observational study con...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11316750-000000000-00000
更新日期:2009-01-01 00:00:00