Epidemiology of adverse drug events in the nursing home setting.

abstract：BACKGROUND:For physicians dealing with patients with a limited life expectancy, knowing the time to benefit (TTB) of preventive medication is essential to support treatment decisions. OBJECTIVE:The aim of this study was to investigate the usefulness of statistical process control (SPC) for determining the TTB in relat...

journal_title：Drugs & aging

authors： van de Glind EM,Willems HC,Eslami S,Abu-Hanna A,Lems WF,Hooft L,de Rooij SE,Black DM,van Munster BC

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Potentially inappropriate medications (PIMs) are defined by the American Geriatric Society as medications that should be avoided in the elderly in general, or in specific situations. However, PIM use remains high among aging populations and may result in increased utilization of healthcare resources. OBJECT...

journal_title：Drugs & aging

authors： Weeda ER,AlDoughaim M,Criddle S

更新日期：2020-07-01 00:00:00

abstract：:The scabies mite is an ectoparasite able to infest humans. Its clinical presentation is typical, although in immunocompromised, mentally retarded and elderly patients the clinical presentation may be altered. Diagnosis may therefore be difficult in such patient groups, who often reside in nursing homes. Because delay ...

journal_title：Drugs & aging

authors： Tjioe M,Vissers WH

更新日期：2008-01-01 00:00:00

abstract：:Congestive heart failure (CHF) is a common cardiovascular disorder that is characterised, in part, by a decreased cardiac output reserve. Accordingly, there is ongoing interest in the role of positive inotropic agents (e.g. adrenergic agonists and phosphodiesterase type III inhibitors, which mediate their cardiovascul...

journal_title：Drugs & aging

authors： Mathew L,Katz SD

更新日期：1998-03-01 00:00:00

abstract：:Although dyspeptic symptoms are very common, the vast majority of patients have modest symptoms and rarely seek medical advice. The major organic causes of dyspepsia are chronic peptic ulcer disease, gastro-oesophageal reflux disease and malignancy. Functional dyspepsia is very common. In the fit elderly patient, prom...

journal_title：Drugs & aging

authors： Pound SE,Heading RC

更新日期：1995-11-01 00:00:00

abstract：:The focus of this review is hormone replacement therapy (HRT) with continuous oral 17 beta-estradiol (herein referred to as estradiol) 2 mg/day plus sequential oral dydrogesterone 10 or 20 mg/day for 14 days of each 28-day cycle. According to data from nonblind trials, this regimen relieves climacteric symptoms, prese...

journal_title：Drugs & aging

authors： Foster RH,Balfour JA

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:There is poor evidence supporting the use of any pharmacologic treatments for neuropsychiatric disorders following traumatic brain injury (TBI), especially among older adults. Informed by our recent characterization of psychotropic medication use among Medicare beneficiaries with TBI, the objective of this st...

journal_title：Drugs & aging

authors： Albrecht JS,Rao V,Perfetto EM,Daniel Mullins C

更新日期：2018-08-01 00:00:00

abstract：:Although inflammatory bowel disease (IBD) is generally considered a disease of young adults, it can occur in elderly individuals. The clinical features and treatment considerations in older patients are similar to those in younger patients, with some notable exceptions, which are reviewed in this article. Consideratio...

journal_title：Drugs & aging

authors： Hussain SW,Pardi DS

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Statins have been associated with later life, long-term care admission in observational studies. However, by preventing vascular events, statins may also prevent or delay admission. We wished to determine statin and long-term care admission associations in a randomised controlled trial context, and describe ...

journal_title：Drugs & aging

authors： Burton JK,Papworth R,Haig C,McCowan C,Ford I,Stott DJ,Quinn TJ

更新日期：2018-07-01 00:00:00

abstract：:The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...

journal_title：Drugs & aging

authors： Valencia WM,Florez HJ,Palacio AM

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The use of proton pump inhibitors (PPIs) in older adults is high, often inappropriate, and may cause harm. Deprescribing is defined as the reduction, withdrawal, or discontinuation of inappropriate medication. OBJECTIVE:We conducted a systematic review to determine the effectiveness of interventions to depr...

journal_title：Drugs & aging

authors： Wilsdon TD,Hendrix I,Thynne TR,Mangoni AA

更新日期：2017-04-01 00:00:00

abstract：:Felodipine is a dihydropyridine calcium antagonist which may be administered once daily in an extended release (ER) formulation. As monotherapy in older patients with mild to moderate essential hypertension, felodipine ER once daily provides effective control of blood pressure (BP). The drug has also been effective, e...

journal_title：Drugs & aging

authors： Faulds D,Sorkin EM

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE:The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate med...

journal_title：Drugs & aging

authors： Harrison SL,Kouladjian O'Donnell L,Bradley CE,Milte R,Dyer SM,Gnanamanickam ES,Liu E,Hilmer SN,Crotty M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Patients hospitalised with severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2; coronavirus 2019 disease (COVID-19)] infection are frequently older with co-morbidities and receiving polypharmacy, all of which are known risk factors for drug-drug interactions (DDIs). The pharmacological burden may be ...

journal_title：Drugs & aging

authors： Cattaneo D,Pasina L,Maggioni AP,Giacomelli A,Oreni L,Covizzi A,Bradanini L,Schiuma M,Antinori S,Ridolfo A,Gervasoni C

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Multiple drug use is common among old, frail nursing home residents who are, as a consequence, susceptible to adverse effects and drug interactions. This study uses the updated Beers criteria for potentially inappropriate drug (PID) use in older adults to determine the extent and nature of PIDs...

journal_title：Drugs & aging

authors： Hosia-Randell HM,Muurinen SM,Pitkälä KH

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Previous studies of antihypertensive treatment of older patients have focused on blood pressure control, cardiovascular risk or adherence, whereas data on inappropriate antihypertensive prescriptions to older patients are scarce. OBJECTIVES:The aim of the study was to assess inappropriate antihypertensive...

journal_title：Drugs & aging

authors： Márquez PHP,Torres OH,San-José A,Vidal X,Agustí A,Formiga F,López-Soto A,Ramírez-Duque N,Fernández-Moyano A,Garcia-Moreno J,Arroyo JA,Ruiz D,Potentially Inappropriate Prescription in Older Patients in Spain (PIPOPS) Investigators

更新日期：2017-06-01 00:00:00

abstract：:Melatonin prolonged release (PR) 2 mg is approved for the treatment of primary insomnia characterized by poor sleep quality in patients aged ≥55 years in the EU and elsewhere. Patients may receive treatment with melatonin PR for up to 13 weeks. Production of endogenous nocturnal melatonin, which helps regulate circadi...

journal_title：Drugs & aging

authors： Lyseng-Williamson KA

更新日期：2012-11-01 00:00:00

abstract：:High fasting plasma homocysteine levels (> 12 to 15 mumol/L) are commonly encountered in clinical practice and are associated with increased risk of atherothrombotic disease. Treatment with folic acid (1 to 5 mg/day) is inexpensive and effective in normalising plasma homocysteine levels. High plasma homocysteine level...

journal_title：Drugs & aging

authors： Stehouwer DA

更新日期：2000-04-01 00:00:00

abstract：:Despite the availability of angiotensin converting enzyme (ACE) inhibitors for patients with congestive heart failure (CHF), mortality and morbidity remains unacceptably high. CHF is thought to progress as a result of activation of endogenous neurohormonal systems which are activated by the initial myocardial injury. ...

journal_title：Drugs & aging

authors： Tsuyuki RT,McAlister FA,Teo KK

更新日期：2000-01-01 00:00:00

abstract：:NSAIDs are a widely used class of analgesic and anti-inflammatory drugs that act by inhibiting the cyclo-oxygenase (COX) enzyme. However, because of their nonspecificity of action, use of these agents as long-term therapy for chronic pain in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA) is often d...

journal_title：Drugs & aging

authors： Bansal SS,Joshi A,Bansal AK

更新日期：2007-01-01 00:00:00

abstract：:The incidence of and mortality from both chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) increase with age. In addition, the average age of patients with COPD and CVD is also increasing as a result of improvements in both pharmacological and non-pharmacological treatments. Coronary artery...

journal_title：Drugs & aging

authors： Andrus MR,Loyed JV

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Older cancer patients are possibly at an increased risk of medication-related problems because, typically, they receive many medications during their cancer treatment, both for the cancer itself and for supportive care. OBJECTIVES:The aim of this study was to describe the number and severity of potential ...

journal_title：Drugs & aging

authors： Puts MT,Monette J,Girre V,Costa-Lima B,Wolfson C,Batist G,Bergman H

更新日期：2010-07-01 00:00:00

abstract：:Skin and soft tissue infections are quite common in elderly people. A number of special conditions and circumstances need to be considered in the diagnosis and therapy. It is important to try to establish the causative organism, exclude other cutaneous disorders and identify precipitating factors. Treatment modalities...

journal_title：Drugs & aging

authors： Laube S,Farrell AM

更新日期：2002-01-01 00:00:00

abstract：:Donepezil (E-2020) is a reversible, noncompetitive, piperidine-type cholinesterase inhibitor. It is selective for acetylcholinesterase rather than butyrylcholinesterase. Donepezil 5 and 10 mg/day significantly improved cognition and global clinical function compared with placebo in well designed short term trials (14 ...

journal_title：Drugs & aging

authors： Dooley M,Lamb HM

更新日期：2000-03-01 00:00:00

abstract：:Large bowel cancer is not only the third most frequent cancer in the world but is one of the most common human malignancies in Western countries, including North America. In recent years, multidisciplinary research in epidemiology, molecular biology, and laboratory animal model studies have contributed much to our und...

journal_title：Drugs & aging

authors： Reddy BS,Rao CV

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE:The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors assoc...

journal_title：Drugs & aging

authors： Musich S,Wang SS,Slindee LB,Saphire L,Wicker E

更新日期：2018-05-01 00:00:00

abstract：:Age is a major source of variation in drug response. Social, medical and physiological heterogeneity intertwines to complicate geriatric pharmacotherapy. Inappropriate and excessive use of medication may be the most significant treatable health problem in the elderly. Older people are especially sensitive to antipsych...

journal_title：Drugs & aging

authors： Pollock BG,Mulsant BH

更新日期：1995-04-01 00:00:00

abstract：:The atypical antipsychotics are a new class of agents with great promise for use in the elderly because of their reduced propensity to cause acute extrapyramidal adverse effects. Treatment of older patients with these agents, however, needs to take into consideration age-related changes in pharmacokinetics and the ris...

journal_title：Drugs & aging

authors： Sweet RA,Pollock BG

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The practice of hiding medicines in nursing home patients' food or beverages is described in only a few scientific papers. An earlier study conducted in 1999/2000 showed that covert medication was common in Norwegian nursing homes, with 11% of patients in regular nursing home units (RUs) and 17...

journal_title：Drugs & aging

authors： Kirkevold O,Engedal K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The choice of induction immunosuppression for kidney transplantation in elderly recipients is dictated by the consideration of the risk of infection as well as efficacy in the prevention of acute rejection, thus allowing a reduction in subsequent maintenance immunosuppression and its attendant long-term adve...

journal_title：Drugs & aging

authors： Heifets M,Saeed MI,Parikh MH,Sierka D,Kumar MS

更新日期：2004-01-01 00:00:00