Abstract:
BACKGROUND:Early studies using HIV protease inhibitors (PI) showed regression of Kaposi's sarcoma (KS) lesions in some patients. OBJECTIVE:Our purpose was to determine prospectively the influence of PI on HIV-related KS. METHODS:KS lesions of nine patients with progressive cutaneous disease were prospectively evaluated clinically and by means of epiluminescence microscopy before and during PI therapy. HIV viremia and CD4 cell count were measured in parallel. RESULTS:All patients experienced reduction or initial stabilization of KS lesions during the first 4 to 8 weeks of HIV-1 PI therapy. After a median follow-up of 7 months and according to AIDS Clinical Trials Groups criteria, six patients had a partial response, two showed stable disease, and in one noncompliant patient KS progressed, requiring chemotherapy. With epiluminescence microscopy, a reduction in skin surface alterations, lesional size, and color intensity was demonstrated in six of nine patients. PI induced a median decrease in viremia of 1.66 log and a median increase in the CD4 count of 49 cells/mm3. CONCLUSION:In this series, HIV PI therapy reduced or stabilized KS. The efficacy of HIV-1 PI in KS may result from the improvement in cellular immunity. These results suggest the use of PI in AIDS-related KS regardless of the level of CD4 lymphocyte count and HIV viremia.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Krischer J,Rutschmann O,Hirschel B,Vollenweider-Roten S,Saurat JH,Pechère Mdoi
10.1016/s0190-9622(98)70124-0subject
Has Abstractpub_date
1998-04-01 00:00:00pages
594-8issue
4eissn
0190-9622issn
1097-6787pii
S0190-9622(98)70124-0journal_volume
38pub_type
杂志文章abstract::Granuloma annulare typically affects the hands and the feet, sparing the volar surfaces. A case of granuloma annulare localized to the palms is described. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(99)70365-8
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Onychomycosis is an increasing problem with limited therapeutic options. OBJECTIVE:We evaluated the safety and efficacy, of oral terbinafine, a new fungicidal antimycotic, in patients with toenail onychomycosis. METHODS:A North American multicenter, double-blind, placebo-controlled study evaluated the myco...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0190-9622(97)70111-7
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Curcuminoids are components of turmeric (Curcuma longa) that possess anti-inflammatory properties. OBJECTIVE:We sought to study the efficacy of curcuminoids in controlling the signs and symptoms of oral lichen planus, at doses of 6000 mg/d (3 divided doses), and their safety at this dose. METHODS:Twenty co...
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abstract:BACKGROUND:Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disorder of unknown origin. OBJECTIVE:We conducted an investigation of skin biopsy specimens from 7 patients with NXG for the presence of Borrelia by focus-floating microscopy. METHODS:Focus-floating microscopy is a recently described, modified immuno...
journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/j.jaad.2007.05.016
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Some hereditary palmoplantar keratodermas (PPK) have been defined at the molecular level. OBJECTIVE:Our purpose was to establish the cause of a hereditary PPK with unique histopathologic findings in the epidermis. METHODS:Investigative studies included light and electron microscopy and determination of gen...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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abstract:BACKGROUND:Sézary syndrome is a cutaneous T-cell lymphoma characterized by erythroderma and leukemic involvement. OBJECTIVE:We sought to define the clinical, biologic, and histopathologic features of Sézary syndrome without erythroderma. METHODS:Features of patients with Sézary syndrome and normal-appearing skin or s...
journal_title:Journal of the American Academy of Dermatology
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更新日期:2015-06-01 00:00:00
abstract::A systematic, uniform evaluation of 102 patients with, or at risk for, neurofibromatosis has shown that café au lait spots (CLS), even in large numbers, may not be sufficient to diagnose this disorder, and that several other dermatologic features may provide clues to its pathogenesis. These features include pruritus a...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1985-09-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(85)70125-9
更新日期:1985-06-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1991-06-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
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更新日期:2000-02-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(92)70010-d
更新日期:1992-01-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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abstract::We describe a 48-year-old woman with a 12-year history of porphyria cutanea tarda who showed a remarkable exacerbation of her eruptions accompanied by high serum levels of iron and ferritin at menopause. As iron storage is known to be a triggering factor of porphyria cutanea tarda, the possible role of menstruation as...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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abstract::It has previously been reported that interferon alfa injection sites may develop pyoderma gangrenosum, interface dermatitis, vasculitis, or, more commonly, ulcers characterized by intravascular thrombi and a mixed inflammatory cell infiltrate. We describe 2 patients in whom granulomatous and suppurative dermatitis dev...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jaad.2018.05.040
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Recent studies have shown a higher prevalence of cardiovascular (CV) risk factors in patients with rosacea. However, it remains unknown whether rosacea represents an independent CV risk factor. OBJECTIVE:We evaluated the risk of myocardial infarction, stroke, CV death, major adverse CV events, and all-cause...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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journal_title:Journal of the American Academy of Dermatology
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abstract::We report two cases of mycosis fungoides with marked, pleomorphic follicular manifestations. Follicular hyperkeratosis, comedo-like lesions, acquired epidermal cysts, and patchy alopecia developed in various locations in both patients. Findings of histopathologic and immunohistochemical studies showed atypical CD4+ T ...
journal_title:Journal of the American Academy of Dermatology
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更新日期:1993-08-01 00:00:00
abstract::Thyroid autoimmunity has been increasingly reported to be associated with chronic urticaria and angioedema. The administration of thyroid hormone may alleviate chronic urticaria and/or angioedema in selected patients. This review focuses on the association of thyroid autoimmunity with chronic urticaria and/or angioede...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(99)70193-3
更新日期:1999-02-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:In recent years there has been an increasing focus on human subject protection and on documentation of ethical review in published clinical research. The JAAD clearly states in its instructions to authors, which adhere to the guidelines set forth by the International Committee of Medical Journal Editors, "st...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2006.08.072
更新日期:2007-02-01 00:00:00
abstract::This article reports the cases of two patients in whom a widespread dermatophyte infection mimicked the cutaneous lesions of their underlying collagen vascular disease. Griseofulvin may be associated with an increased incidence of adverse cutaneous reactions in patients with systemic lupus erythematosus. One patient w...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(90)70303-y
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