当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Detection of spirochetal micro-organisms by focus-floating microscopy in necrobiotic xanthogranuloma.

Detection of spirochetal micro-organisms by focus-floating microscopy in necrobiotic xanthogranuloma.

Abstract：

BACKGROUND:Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disorder of unknown origin. OBJECTIVE:We conducted an investigation of skin biopsy specimens from 7 patients with NXG for the presence of Borrelia by focus-floating microscopy. METHODS:Focus-floating microscopy is a recently described, modified immunohistochemical technique in which the sections of a slide are simultaneously scanned both horizontally and vertically. Focus-floating microscopy is more sensitive for the detection of micro-organisms than polymerase chain reaction. RESULTS:Borrelia could be detected as single, paired, or clusters of spirochetes in 6 cases of NXG whereas two cases investigated with a Borrelia-specific polymerase chain reaction (23s-RNA) remained negative. LIMITATIONS:Limited biopsy material in each patient prohibited a more detailed study of the life history of cutaneous lesions in NXG. CONCLUSIONS:The detection of this micro-organism in NXG points to a specific involvement of B burgdorferi or other similar strains in the development of or as a trigger of this disease.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Zelger B,Eisendle K,Mensing C,Zelger B

doi

10.1016/j.jaad.2007.05.016

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

1026-30

issue

6

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(07)00882-1

journal_volume

57

pub_type

杂志文章

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